The DOI matches its Crossref record; 166 of the 167 references it cites were found in a registry or an index.
The co-pathogenesis of influenza viruses with bacteria in the lung.
Abstract
Concern that a highly pathogenic virus might cause the next influenza pandemic has spurred recent research into influenza and its complications. Bacterial superinfection in the lungs of people suffering from influenza is a key element that promotes severe disease and mortality. This co-pathogenesis is characterized by complex interactions between co-infecting pathogens and the host, leading to the disruption of physical barriers, dysregulation of immune responses and delays in a return to homeostasis. The net effect of this cascade can be the outgrowth of the pathogens, immune-mediated pathology and increased morbidity. In this Review, advances in our understanding of the underlying mechanisms are discussed, and the key questions that will drive the field forwards are articulated.
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In the citing paper
“In fact, bacteria are known to participate in interactions between host cells and viruses.”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as McCullers, 2014
In the citing paper
“Although bacteria are typically secondary invaders during influenza infections, they express virulence factors that promote viral pathogenesis. As a result, viral load increases and clearance rates decline (McCullers, 2014).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as McCullers, 2014
In the citing paper
“Consistent with the prior literature,55, 62 we found that S. pneumoniae was the most frequent bacterial coinfection; however, both S. aureus and other bacterial coinfections were also quite common.”
From The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. (2016) · cites this paper as [62]
In the citing paper
“Consistent with the prior literature,55, 62 we found that S. pneumoniae was the most frequent bacterial coinfection; however, both S. aureus and other bacterial coinfections were also quite common.”
From The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis. (2016) · cites this paper as [62]
Citations
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Microbiota regulates immune defense against respiratory tract influenza A virus infection
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Cited by
Sorted by citations
Pathogenicity and virulence of Staphylococcus aureus
Cheung, G. Y. C., Bae, J. S., & Otto, M. J. (2021) · Virulence · doi:10.1080/21505594.2021.1878688 · Cited by 1,554
Streptococcus pneumoniae: transmission, colonization and invasion
Weiser, J. N., Ferreira, D. M., & Paton, J. C. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0001-8 · Cited by 1,162
Schauwvlieghe, A. F. A. D., Rijnders, B. J. A., Philips, N., Verwijs, R., Vanderbeke, L., Van Tienen, C., Lagrou, K., Verweij, P. E., Van de Veerdonk, F. L., Gommers, D., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30274-1 · Cited by 886
Uyeki, T. M., Bernstein, H. H., Bradley, J. S., Englund, J. A., File, T. M., Fry, A. M., Gravenstein, S., Hayden, F. G., Harper, S. A., Hirshon, J. M., et al. (2018) · Clinical Infectious Diseases · doi:10.1093/cid/ciy866 · Cited by 844
The frequency of influenza and bacterial coinfection: a systematic review and meta-analysis.
Klein, E. Y., Monteforte, B., Gupta, A., Jiang, W., May, L., Hsieh, Y., & Dugas, A. (2016) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12398 · Cited by 574
Metadata
- Authors
- McCullers, J. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Corresponding author
- McCullers, Jonathan A.
- Venue
- Nature Reviews Microbiology
- Published
- 2014-03-03
- Volume
- 12
- Issue
- 4
- Pages
- 252-262
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2076298858
- Semantic Scholar
- 6eb404402ff0d8d99a34a2cf97e6a417c97de878
- Cited by
- 722
- References
- 167
- Citations by year
- 2026: 46 · 2025: 42 · 2024: 56 · 2023: 60 · 2022: 67 · 2021: 91 · 2020: 71 · 2019: 70 · 2018: 58 · 2017: 38 · 2016: 56 · 2015: 42 · 2014: 23
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- influenza virus, bacterial co-infection, secondary bacterial infection, lung, virulence factors, immune dysregulation, host-pathogen interaction, immune-mediated pathology, pandemic influenza
- MeSH terms
- Bacterial Infections, Humans, Influenza, Human, Lung, Pneumonia, Viral, Superinfection, Pneumonia, Bacterial, Coinfection
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