Cited by 723Influenza Virus Research StudiesRespiratory viral infections researchPneumonia and Respiratory Infections

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The co-pathogenesis of influenza viruses with bacteria in the lung.

McCullers, Jonathan A.·2014·Nature Reviews Microbiology

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Abstract

Concern that a highly pathogenic virus might cause the next influenza pandemic has spurred recent research into influenza and its complications. Bacterial superinfection in the lungs of people suffering from influenza is a key element that promotes severe disease and mortality. This co-pathogenesis is characterized by complex interactions between co-infecting pathogens and the host, leading to the disruption of physical barriers, dysregulation of immune responses and delays in a return to homeostasis. The net effect of this cascade can be the outgrowth of the pathogens, immune-mediated pathology and increased morbidity. In this Review, advances in our understanding of the underlying mechanisms are discussed, and the key questions that will drive the field forwards are articulated.

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Authors: McCullers, J. A.
Affiliations: St. Jude Children's Research Hospital (US)
Corresponding author: McCullers, Jonathan A.
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2014-03-03
Volume: 12
Issue: 4
Pages: 252-262
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/nrmicro3231
OpenAlex: W2076298858
Semantic Scholar: 6eb404402ff0d8d99a34a2cf97e6a417c97de878
Cited by: 722
References: 167
Citations by year: 2026: 46 · 2025: 42 · 2024: 56 · 2023: 60 · 2022: 67 · 2021: 91 · 2020: 71 · 2019: 70 · 2018: 58 · 2017: 38 · 2016: 56 · 2015: 42 · 2014: 23
FWCI: 7.07
Type: journal article
Language: en
Open access: closed
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords: influenza virus, bacterial co-infection, secondary bacterial infection, lung, virulence factors, immune dysregulation, host-pathogen interaction, immune-mediated pathology, pandemic influenza
MeSH terms: Bacterial Infections, Humans, Influenza, Human, Lung, Pneumonia, Viral, Superinfection, Pneumonia, Bacterial, Coinfection

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The co-pathogenesis of influenza viruses with bacteria in the lung.

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