Postinfluenza bacterial pneumonia: Host defenses gone awry

Ballinger, Megan N.; Standiford, Theodore J.

doi:10.1089/jir.2010.0049

Cited by 103Influenza Virus Research Studiesinterferon and immune responsesImmune Response and Inflammation

Postinfluenza bacterial pneumonia: Host defenses gone awry

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Ballinger, Megan N., Standiford, Theodore J.·2010·Journal of Interferon & Cytokine Research

DOI 10.1089/jir.2010.0049PMC PMC4367524

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Abstract

Influenza is a common respiratory pathogen causing both seasonal and pandemic disease. Influenza infection predisposes the host to secondary bacterial infection of the respiratory tract, which is a major cause of both morbidity and mortality in flu-related disease. In this review, we will discuss innate and adaptive antiviral responses during influenza infection, and review how these responses modulate protective immunity against secondary bacterial pathogens of the lung. Specific emphasis will be placed on implications of bacterial superinfection and mechanisms involved.

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The greater morbidity and mortality associated with influenza in older people occur because dysregulation in the immune response predisposes them to secondary bacterial infection of the respiratory tract (e.g., bronchitis and bacterial pneumonia).
“The greater morbidity and mortality associated with influenza in this age group occur because dysregulation in the immune response predisposes them to secondary bacterial infection of the respiratory tract (e.g., bronchitis and bacterial pneumonia) [68].”
From Immune function and micronutrient requirements change over the life course (2018) · cites this paper as [68]

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Authors: Ballinger, M. N., & Standiford, T. J.
Affiliations: University of Michigan (US)
ORCID: Ballinger, Megan N.
Standiford, Theodore J.
Venue: Journal of Interferon & Cytokine Research
Publisher: SAGE Publications
Published: 2010-09
Volume: 30
Issue: 9
Pages: 643-652
ISSN: 1079-9907 (ISSN-L)
1557-7465
DOI: 10.1089/jir.2010.0049
PMC: PMC4367524
OpenAlex: W2005388865
Cited by: 103
References: 68
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 2 · 2020: 18 · 2019: 6 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 10 · 2012: 5
FWCI: 0.76
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Journal of Interferon & Cytokine Research (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Deep Blue (University of Michigan) (submittedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL097564, R01HL057243)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: influenza, bacterial pneumonia, secondary bacterial infection, superinfection, innate immunity, adaptive immunity, antiviral response, host defense, respiratory infections, influenza-associated pneumonia
MeSH terms: Animals, Disease Models, Animal, Humans, Immunity, Innate, Lung, Orthomyxoviridae Infections, Risk, United States, Superinfection, Immunocompromised Host, Pneumonia, Bacterial, Adaptive Immunity

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Postinfluenza bacterial pneumonia: Host defenses gone awry

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