The DOI matches its Crossref record; 120 of the 123 references it cites were found in a registry or an index.
Cortical inhibitory neurons and schizophrenia
Abstract
Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.
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In the citing paper
“Reduced expression of GAD67, the main GABA-synthesizing enzyme in the brain, appears to contribute to altered interneuron activity in psychosis [86,87] .”
From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [86]
In the citing paper
“Certain classes of GABA interneurons are altered in individuals with psychosis, in particular reduced density in the anterior cingulate and reduced activity in the dorsolateral prefrontal cortex in the subpopulation expressing parvalbumin [84-86] .”
From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [86]
In the citing paper
“Thus, the correct balance of inhibition and excitation seems to be critical for normative executive function, and conversely, disturbance of this balance is thought to be a fundamental component of psychiatric illness.69, 70”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [69]
In the citing paper
“Moreover, the expression of several GABA receptors and markers of inhibitory synapses are also altered in schizophrenia 50 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [50]
In the citing paper
“Schizophrenia is increasingly recognized as a neurodevelopmental disorder that involves alterations in brain circuits, including dysfunction of parvalbumin (PV)-positive, fast-spiking GABA neurons (1, 2).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [1]
In the citing paper
“its onset is linked to a potential disruption of the physiological maturation of inhibitory neural networks consisting of fast-spiking parvalbumin-positive gamma-aminobutric acid (GABAergic) interneurons”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Lewis et al., 2005
In the citing paper
“Dysfunction and/or deficient inhibitory output from PV interneurons may be a common mechanism of multiple psychiatric disorders, such as schizophrenia (SCZ) (Lewis et al. 2005), autism spectrum disorders (ASD) (Gao and Penzes 2015) and bipolar disorder (BD) (Ruden et al. 2021).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Lewis et al. 2005
In the citing paper
“Specifically, there is growing support for a hypothesis that cortical disinhibition occurs in schizophrenia, due to the disrupted functioning of inhibitory interneurons, which results in elevated E/I ratio (Lewis et al. 2005;Marin 2012).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“The prefrontal cortex is a key node in the distributed cortical network recruited during WM (Owen et al. 2005;Fuster 2008) and exhibits altered inhibitory microcircuitry in schizophrenia (Lewis et al. 2005;Bitanihirwe et al. 2009).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“Elevated prefrontal E/I ratio may result from alterations in multiple pathways that are implicated in schizophrenia.These include GABAergic deficits, such as reduced GAD67 production (Lewis et al. 2005); increased background input from other areas such as the thalamus or hippocampus (Lisman et al. 2008); or abnormal levels of neuromodulators (Laruelle et al. 2003).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“Both interneuron cell classes are altered in schizophrenia (Lewis et al. 2005;Morris et al. 2008;Bitanihirwe et al. 2009).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
Principles of Frontal Lobe Function
Stuss, D. T. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.001.0001 · Cited by 1,731
Topography Of Cognition: Parallel Distributed Networks In Primate Association Cortex
Goldman‐Rakic, P. S. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001033 · Cited by 1,658
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Self-citationSynchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498
Research works printed but not linked: 2
- Konopaske, G. T., Sweet, R. A. & Lewis, D. A. GABA transporter-1 immunoreactivity in auditory association cortex in schizophrenia. Soc. Neurosci. Abstr. 34, 110.11 (2004).
- Peters, A. in Cerebral Cortex Vol. 1 (eds Jones, E. G. & Peters, A.) 361–380 (Plenum, New York, 1984).
Cited by
Sorted by citations
Items 601–700 of 1,012
Vazquez, A. L., Fukuda, M., & Kim, S. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy225 · Cited by 84
Efficacy of different types of cognitive enhancers for patients with schizophrenia: a meta-analysis
Sinkeviciute, I., Begemann, M., Prikken, M., Oranje, B., Johnsen, E., Lei, W. U., Hugdahl, K., Kroken, R. A., Rau, C., Jacobs, J. D., et al. (2018) · Schizophrenia · doi:10.1038/s41537-018-0064-6 · Cited by 84
Ni, P., Noh, H., Park, G.-H., Shao, Z., Guan, Y., Park, J. M., Yu, S., Park, J. S., Coyle, J. T., Weinberger, D. R., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0423-3 · Cited by 84
Non-Coding RNAs in Psychiatric Disorders and Suicidal Behavior
Yoshino, Y., & Dwivedi, Y. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.543893 · Cited by 85
Multiple gamma rhythms carry distinct spatial frequency information in primary visual cortex
Han, C., Wang, T., Yang, Y., Wu, Y., Li, Y., Dai, W., Zhang, Y., Wang, B., Yang, G., Cao, Z., et al. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001466 · Cited by 85
Xie, S., Furjanic, M. A., Ferrara, J., McAndrew, N. R., Ardino, E. L., Ngondara, A., Bernstein, Y., Thomas, K. J., Kim, E., Walker, J. M., et al. (2007) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/j.1365-2710.2007.00817.x · Cited by 82
Eastwood, S. L., & Harrison, P. J. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301457 · Cited by 82
Dong, X., Zhang, W., Wang, H.-X., Stradtman, G. G., & Gao, W. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570900042x · Cited by 84
Yuen, E. Y., & Yan, Z. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5050-08.2009 · Cited by 81
Carmeli, C., Knyazeva, M. G., Cuénod, M., & Do, K. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029341 · Cited by 81
Liu, L., Xu, H., Wang, J., Li, J., Tian, Y., Zheng, J., He, M., Xu, T., Wu, Z., Li, W., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay4073 · Cited by 85
Serotonin-2C and -2a receptor co-expression on cells in the rat medial prefrontal cortex
Nocjar, C., Alex, K. D., Sonneborn, A., Abbas, A. I., Roth, B. L., & Pehek, E. A. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.050 · Cited by 82
Phencyclidine/Schizophrenia: One View Toward the Past, The Other to the Future
Domino, E. F., & Luby, E. D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs011 · Cited by 81
Coherent Infomax as a Computational Goal for Neural Systems
Kay, J., & Phillips, W. A. (2010) · Bulletin of Mathematical Biology · doi:10.1007/s11538-010-9564-x · Cited by 80
The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia
Rotaru, D. C., Lewis, D. A., & González‐Burgos, G. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2011-0059 · Cited by 81
Self-citationUrakawa, S., Takamoto, K., Hori, E., Sakai, N., Ono, T., & Nishijo, H. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-13 · Cited by 80
Diwadkar, V. A., Goradia, D. D., Hosanagar, A., Mermon, D., Montrose, D. M., Birmaher, B. B., Axelson, D., Rajarathinem, R., Haddad, L., Amirsadri, A., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.04.009 · Cited by 81
Eggan, S. M., Melchitzky, D. S., Sesack, S. R., Fish, K. N., & Lewis, D. A. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.011 · Cited by 83
Self-citationCannabinoid modulation of the dopaminergic circuitry: Implications for limbic and striatal output
Fitzgerald, M. L., Shobin, E., & Pickel, V. M. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.004 · Cited by 80
Monge-Acuña, A. A., & Fornaguera-Trías, J. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.06.042 · Cited by 80
Dong, E., Tueting, P. A., Matrisciano, F., Grayson, D. R., & Guidotti, A. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.191 · Cited by 83
Večeřa, J., Bártová, E., Krejčí, J., Legartová, S., Komůrková, D., Kučerová, J., Štark, T., Dražanová, E., Kašpárek, T., Šulcová, A., et al. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.25914 · Cited by 80
Molecular signature of extracellular matrix pathology in schizophrenia
Pantazopoulos, H., Katsel, P., Haroutunian, V. H., Chelini, G., Klengel, T., & Berretta, S. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15009 · Cited by 83
Grent-‘t-Jong, T., Gajwani, R., Groß, J., Gumley, A. I., Krishnadas, R., Lawrie, S. M., Schwannauer, M., Schultze‐Lutter, F., & Uhlhaas, P. J. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.03.018 · Cited by 79
Yu, X., & Zečević, N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5249-10.2011 · Cited by 83
Lewis, D. A., Hashimoto, T., & Morris, H. M. (2008) · Neurotoxicity Research · doi:10.1007/bf03033813 · Cited by 80
Self-citationSynaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system
Obata, K. (2013) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.89.139 · Cited by 79
Molecular Influences on Working Memory Circuits in Dorsolateral Prefrontal Cortex
Arnsten, A. F. T., & Jin, L. E. (2014) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-420170-5.00008-8 · Cited by 77
Ben‐Azu, B., Aderibigbe, A. O., Ajayi, A. M., Eneni, A.-E. O., Umukoro, S., & Iwalewa, E. O. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.03.006 · Cited by 80
Li, Y.-C., Kellendonk, C., Simpson, E. H., Kandel, E. R., & Gao, W.-J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109718108 · Cited by 78
Social isolation in rats: effects on animal welfare and molecular markers for neuroplasticity
Begni, V., Sanson, A., Pfeiffer, N., Brandwein, C., Inta, D., Talbot, S. R., Riva, M. A., Gass, P., & Mallien, A. S. (2020) · PLOS ONE · doi:10.1371/journal.pone.0240439 · Cited by 78
Neurons on the Move: Migration and Lamination of Cortical Interneurons
Faux, C. H., Rakić, S., Andrews, W. D., & Britto, J. M. (2012) · Neurosignals · doi:10.1159/000334489 · Cited by 88
Anticevic, A., Cole, M. W., Repovš, G., Savić, A., Driesen, N. R., Yang, G., Cho, Y., Murray, J. D., Glahn, D. C., Wang, X., et al. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00169 · Cited by 80
Thomsen, M. S., Christensen, D. Z., Hansen, H. H., Redrobe, J. P., & Mikkelsen, J. D. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.02.003 · Cited by 78
Targeting NOX enzymes in the central nervous system: therapeutic opportunities
Sorce, S., Krause, K., & Jaquet, V. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1014-5 · Cited by 79
Tiagabine Increases [11C]flumazenil Binding in Cortical Brain Regions in Healthy Control Subjects
Frankle, W. G., Cho, R. Y., Narendran, R., Mason, N. S., Vora, S., Litschge, M. Y., Price, J. C., Lewis, D. A., & Mathis, C. A. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.104 · Cited by 79
Self-citationStan, A. D., Ghose, S., Zhao, C., Hulsey, K., Mihalakos, P., Yanagi, M., Morris, S., Bartko, J. J., Choi, C., & Tamminga, C. A. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.54 · Cited by 79
Gong, N., Li, Y., Cai, G.-Q., Niu, R.-F., Fang, Q., Wu, K., Chen, Z., Lin, L., Xu, L., Fei, J., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4643-09.2009 · Cited by 79
López-Gil, X., Artigas, F., & Adell, A. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790361416 · Cited by 80
Dopamine, fronto-striato-thalamic circuits and risk for psychosis.
Dandash, O., Pantelis, C., & Fornito, A. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2016.08.020 · Cited by 89
Kaplan, E. S., Cooke, S. F., Komorowski, R. W., Chubykin, A. A., Thomazeau, A., Khibnik, L. A., Gavornik, J. P., & Bear, M. F. (2016) · eLife · doi:10.7554/elife.11450 · Cited by 77
Shetty, A. K., & Bates, A. A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.09.019 · Cited by 80
Olig1 Function Is Required to Repress Dlx1/2 and Interneuron Production in Mammalian Brain
Silbereis, J. C., Nobuta, H., Tsai, H., Heine, V. M., McKinsey, G. L., Meijer, D. H., Howard, M. A., Petryniak, M. A., Potter, G. B., Alberta, J. A., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.024 · Cited by 82
Gleason, K. A., Birnbaum, S. G., Shukla, A., & Ghose, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.122 · Cited by 77
Comprehensive review: Computational modelling of schizophrenia
Valton, V., Romaniuk, L., Steele, J. D., Lawrie, S. M., & Seriès, P. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.022 · Cited by 82
Quirk, M. C. (2009) · Frontiers in Systems Neuroscience · doi:10.3389/neuro.06.013.2009 · Cited by 79
Disrupted Cortical Conductivity in Schizophrenia: TMS-EEG Study
Frantseva, M. V., Cui, J., Farzan, F., Chinta, L. V., Velázquez, J. L. P., & Daskalakis, Z. J. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs304 · Cited by 76
Orbitofrontal cortex neurons as a common target for classic and glutamatergic antipsychotic drugs
Homayoun, H., & Moghaddam, B. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0806669105 · Cited by 83
Gomes, F. V., & Grace, A. (2016) · Schizophrenia bulletin · doi:10.1093/schbul/sbw156 · Cited by 84
Oishi, K., Watatani, K., Itoh, Y., Okano, H., Guillemot, F., Nakajima, K., & Gotoh, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808400106 · Cited by 75
Phillips, W. A., & Silverstein, S. M. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00307 · Cited by 75
New drug developments in psychosis: Challenges, opportunities and strategies
Keshavan, M. S., Lawler, A. N., Nasrallah, H. A., & Tandon, R. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.004 · Cited by 79
Park, G.-H., Noh, H., Shao, Z., Ni, P., Qin, Y., Liu, D., Beaudreault, C. P., Park, J. S., Abani, C. P., Park, J. M., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00724-1 · Cited by 75
Gene models of schizophrenia: DISC1 mouse models
Jaaro-Peled, H. (2009) · Progress in brain research · doi:10.1016/s0079-6123(09)17909-8 · Cited by 83
Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia
Coyle, J. T., Balu, D. T., Benneyworth, M. A., Basu, A. C., & Roseman, A. S. (2010) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2010.12.3/jcoyle · Cited by 75
GABA-A Receptor Inhibition of Local Calcium Signaling in Spines and Dendrites
Marlin, J. J., & Carter, A. G. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0869-13.2014 · Cited by 79
Fumagalli, F., Calabrese, F., Luoni, A., Bolis, F., Racagni, G., & Riva, M. A. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000150 · Cited by 77
do Prado, C. H., Narahari, T., Holland, F. H., Lee, H., Murthy, S. K., & Brenhouse, H. C. (2015) · Developmental Psychobiology · doi:10.1002/dev.21390 · Cited by 75
Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency
Labouesse, M. A., Lassalle, O., Richetto, J., Iafrati, J., Weber‐Stadlbauer, U., Notter, T., Gschwind, T., Pujadas, L., Soriano, E., Reichelt, A. C., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.193 · Cited by 79
The mediodorsal thalamic nucleus and schizophrenia
Alelú‐Paz, R., & Giménez‐Amaya, J. M. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0846 · Cited by 75
The Role of Extrastriatal Dopamine D2 Receptors in Schizophrenia
Takahashi, H., Higuchi, M., & Suhara, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.01.022 · Cited by 75
Kikuchi, M., Hashimoto, T., Nagasawa, T., Hirosawa, T., Minabe, Y., Yoshimura, M., Strik, W., Dierks, T., & Koenig, T. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2011.06.003 · Cited by 74
Self-citationTimofeeva, O. A., & Levin, E. D. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.038 · Cited by 74
Lopatina, O. L., Malinovskaya, N. A., Komleva, Y. K., Gorina, Y. V., Shuvaev, A. N., Olovyannikova, R. Y., Belozor, O. S., Belova, O. A., Higashida, H., & Salmina, A. B. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0014 · Cited by 74
Shin, H. S., Lee, S. H., Moon, H. J., So, Y. H., Lee, H. R., Lee, E.-H., & Jung, E.-M. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.131465 · Cited by 74
Clinical applications of EEG power spectra aperiodic component analysis: A mini-review
Pani, S. M., Saba, L., & Fraschini, M. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.08.010 · Cited by 80
Kyriakopoulos, M., Dima, D., Roiser, J. P., Corrigall, R. J., Barker, G. J., & Frangou, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.06.020 · Cited by 74
N-Glycosylation of GABAA Receptor Subunits is Altered in Schizophrenia
Mueller, T., Haroutunian, V. H., & Meador‐Woodruff, J. H. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.190 · Cited by 74
Debost, J.-C., Larsen, J. T., Munk‐Olsen, T., Mortensen, P. B., Meyer, U., & Petersen, L. V. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw083 · Cited by 75
Frontal lobe alterations in schizophrenia: a review
Mubarik, A., & Tohid, H. (2016) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2015-0088 · Cited by 76
Girgis, R. R., Zoghbi, A. W., Javitt, D. C., & Lieberman, J. A. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.07.006 · Cited by 75
Uchida, T., Furukawa, T., Iwata, S., Yanagawa, Y., & Fukuda, A. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.13 · Cited by 74
Genome-Wide Association Study of Schizophrenia in Japanese Population
Yamada, K., Iwayama, Y., Hattori, E., Iwamoto, K., Toyota, T., Ohnishi, T., Ohba, H., Maekawa, M., Kato, T., & Yoshikawa, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020468 · Cited by 74
de la Fuente‐Sandoval, C., Reyes-Madrigal, F., Mao, X., León-Ortíz, P., Rodríguez-Mayoral, O., Jung-Cook, H. H., Solís‐Vivanco, R., Graff‐Guerrero, A., & Shungu, D. C. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.09.028 · Cited by 73
Ren, S., Yao, W., Yan, J.-Z., Jin, C., Yin, J., Yuan, J., Yu, S., & Cheng, Z. (2018) · Scientific Reports · doi:10.1038/s41598-017-18729-5 · Cited by 78
Ueno, H., Takao, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Okamoto, M., Aoki, S., & Ishihara, T. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.001 · Cited by 72
Weickert, C. S., Tiwari, Y., Schofield, P. R., Mowry, B. J., & Fullerton, J. M. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.25 · Cited by 73
Optogenetic Insights into Social Behavior Function
Yizhar, O. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.029 · Cited by 74
Rapid Suppression of Inhibitory Synaptic Transmission by Retinoic Acid
Sarti, F., Zhang, Z., Schroeder, J., & Chen, L. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1710-13.2013 · Cited by 76
Anti-inflammatory signaling in schizophrenia
Meyer, U. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.05.014 · Cited by 72
Santana, N., Troyano‐Rodriguez, E., Mengod, G., Celada, P., & Artigas, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.030 · Cited by 74
Proteomic analysis reveals protein changes within layer 2 of the insular cortex in schizophrenia
Pennington, K., Dicker, P., Dunn, M. J., & Cotter, D. (2008) · PROTEOMICS · doi:10.1002/pmic.200800415 · Cited by 72
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Metadata
- Authors
- Lewis, D. A., Hashimoto, T., & Volk, D. W.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lewis, David A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2005-04
- Volume
- 6
- Issue
- 4
- Pages
- 312-324
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2089912569
- Cited by
- 2,297
- References
- 123
- Citations by year
- 2026: 36 · 2025: 51 · 2024: 63 · 2023: 48 · 2022: 70 · 2021: 86 · 2020: 77 · 2019: 94 · 2018: 102 · 2017: 89 · 2016: 123 · 2015: 148 · 2014: 132 · 2013: 167 · 2012: 151
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, cortical inhibitory neurons, parvalbumin interneurons, GABA synthesis, dorsolateral prefrontal cortex, working memory, perisomatic inhibition, cognitive impairment
- MeSH terms
- Animals, Cerebral Cortex, Humans, Nerve Net, Neural Inhibition, Neurons, Schizophrenia
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