Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia
Open accessAbstract
Clinical studies report associations between cannabis use during adolescence and later onset of schizophrenia. We examined the causal relationship between developmental cannabinoid administration and long-term behavioral and molecular alterations in mice. Mice were administered either WIN 55,212-2 (WIN), a cannabinoid receptor 1 (CB1) agonist or vehicle (Veh) during adolescence (postnatal day 30-35) or early adulthood (postnatal day 63-70). Behavioral testing was conducted after postnatal day 120 followed by biochemical assays. Adolescent cannabinoid treatment (ACU) leads to deficits in prepulse inhibition and fear conditioning in adulthood. Metabotropic glutamate receptors type 5 (mGluR5), a receptor critically involved in fear conditioning and endocannabinoid (eCB) signaling, is significantly reduced in the ACU mouse hippocampus. Next, we examined expression profiles of genes involved in eCB synthesis (diacylglycerol lipase (DGL)) and uptake (monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH)) in the experimental mice. We find evidence of increased MGL and FAAH in ACU mice, reflecting increases in eCB uptake and degradation. These data suggest that administration of cannabinoids during adolescence leads to a behavioral phenotype associated with a rodent model of schizophrenia, as indexed by alterations in sensorimotor gating and hippocampal-dependent learning and memory deficits. Further, these deficits are associated with a reduction in hippocampal mGluR5 and a sustained change in eCB turnover, suggesting reduced eCB signaling in the ACU hippocampus. These data suggest that significant cannabis use during adolescence may be a contributory causal factor in the development of certain features of schizophrenia and may offer mGluR5 as a potential therapeutic target.
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Cites
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
Localization of cannabinoid receptor mRNA in rat brain
Matsuda, L. A., Bonner, T. I., & Lolait, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903270406 · Cited by 631 · see citing works
Object recognition memory and the rodent hippocampus
Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E. (2010) · Learning & Memory · doi:10.1101/lm.1650110 · Cited by 568 · see citing works
Cannabinoids reveal importance of spike timing coordination in hippocampal function
Robbe, D., Montgomery, S. M., Thome, A., Rueda-Orozco, P. E., McNaughton, B. L., & Buzsaki, G. (2006) · Nature Neuroscience · doi:10.1038/nn1801 · Cited by 333 · see citing works
Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P., & Benes, F. M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.521 · Cited by 322 · see citing works
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Research works printed but not linked: 87
- Andreasson S Allebeck P Engstrom A Rydberg U Cannabis and schizophrenia. A longitudinal study of Swedish conscripts Lancet 1987 2 1483 1486 2892048
- Arseneault L Cannon M Poulton R Murray R Caspi A Moffitt TE Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study BMJ 2002 325 1212 1213 12446537 PMC135493
- van Os J Bak M Hanssen M Bijl RV de Graaf R Verdoux H Cannabis use and psychosis: a longitudinal population-based study Am J Epidemiol 2002 156 319 327 12181101
- Zammit S Allebeck P Andreasson S Lundberg I Lewis G Self reported cannabis use as a risk factor for schizophrenia in Swedish conscripts of 1969: historical cohort study BMJ 2002 325 1199 12446534 PMC135490
- Henquet C Krabbendam L Spauwen J Kaplan C Lieb R Wittchen HU Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people BMJ 2005 330 11 15574485 PMC539839
- Caspi A Moffitt TE Cannon M McClay J Murray R Harrington H Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction Biol Psychiatry 2005 57 1117 1127 15866551
- Moore TH Zammit S Lingford-Hughes A Barnes TR Jones PB Burke M Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review Lancet 2007 370 319 328 17662880
- Kim J Alger BE Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus Nat Neurosci 2004 7 697 698 15184902
- Makara JK Mor M Fegley D Szabo SI Kathuria S Astarita G Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus Nat Neurosci 2005 8 1139 1141 16116451
- Hashimotodani Y Ohno-Shosaku T Kano M Presynaptic monoacylglycerol lipase activity determines basal endocannabinoid tone and terminates retrograde endocannabinoid signaling in the hippocampus J Neurosci 2007 27 1211 1219 17267577 PMC6673197
- Ligresti A Cascio MG Di Marzo V Endocannabinoid metabolic pathways and enzymes Curr Drug Targets CNS Neurol Disord 2005 4 615 623 16375679
- Irving AJ Coutts AA Harvey J Rae MG Mackie K Bewick GS Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons Neuroscience 2000 98 253 262 10854756
- Katona I Sperlagh B Sik A Kafalvi A Vizi ES Mackie K Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons J Neurosci 1999 19 4544 4558 10341254 PMC6782612
- Eggan SM Melchitzky DS Sesack SR Fish KN Lewis DA Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex Neuroscience 169 1651 1661 20542094 PMC3030191
- Spano MS Ellgren M Wang X Hurd YL Prenatal cannabis exposure increases heroin seeking with allostatic changes in limbic enkephalin systems in adulthood Biol Psychiatry 2007 61 554 563 16876136
- Rubino T Realini N Braida D Alberio T Capurro V Vigano D The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex Neurotox Res 2009 15 291 302 19384563
- Schneider M Koch M Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats Neuropsychopharmacology 2003 28 1760 1769 12888772
- Schneider M Koch M The effect of chronic peripubertal cannabinoid treatment on deficient object recognition memory in rats after neonatal mPFC lesion Eur Neuropsychopharmacol 2007 17 180 186 16679004
- Wegener N Koch M Behavioural disturbances and altered Fos protein expression in adult rats after chronic pubertal cannabinoid treatment Brain Res 2009 1253 81 91 19094973
- Ellgren M Spano SM Hurd YL Adolescent cannabis exposure alters opiate intake and opioid limbic neuronal populations in adult rats Neuropsychopharmacology 2007 32 607 615 16823391
- Eggan SM Stoyak SR Verrico CD Lewis DA Cannabinoid CB1 receptor immunoreactivity in the prefrontal cortex: comparison of schizophrenia and major depressive disorder Neuropsychopharmacology Sep 35 2060 2071 PMC2967726 20555313
- Dean B Sundram S Bradbury R Scarr E Copolov D Studies on [3 H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use Neuroscience 2001 103 9 15 11311783
- Zavitsanou K Garrick T Huang XF Selective antagonist [3 H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 2004 28 355 360 14751433
- Koethe D Llenos IC Dulay JR Hoyer C Torrey EF Leweke FM Expression of CB1 cannabinoid receptor in the anterior cingulate cortex in schizophrenia, bipolar disorder, and major depression J Neural Transm 2007 114 1055 1063 17370106
- Lu YM Jia Z Janus C Henderson JT Gerlai R Wojtowicz JM Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP J Neurosci 1997 17 5196 5205 9185557 PMC6573299
- Xu J Zhu Y Contractor A Heinemann SF mGluR5 has a critical role in inhibitory learning J Neurosci 2009 29 3676 3684 19321764 PMC2746052
- Wang H Westin L Nong Y Birnbaum S Bendor J Brismar H Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling Science 2009 326 1554 1557 20007903 PMC2796550
- Swerdlow NR Shoemaker JM Platten A Pitcher L Goins J Auerbach PP Heritable differences in the dopaminergic regulation of sensorimotor gating. I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny Psychopharmacology (Berl) 2004 174 441 451 15300358
- Herkenham M Lynn AB Little MD Johnson MR Melvin LS de Costa BR Cannabinoid receptor localization in brain Proc Natl Acad Sci USA 1990 87 1932 1936 2308954 PMC53598
- Lichtman AH Dimen KR Martin BR Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats Psychopharmacology (Berl) 1995 119 282 290 7675962
- Egashira N Mishima K Iwasaki K Fujiwara M Intracerebral microinjections of delta 9-tetrahydrocannabinol: search for the impairment of spatial memory in the eight-arm radial maze in rats Brain Res 2002 952 239 245 12376185
- Lawston J Borella A Robinson JK Whitaker-Azmitia PM Changes in hippocampal morphology following chronic treatment with the synthetic cannabinoid WIN 55,212-2 Brain Res 2000 877 407 410 10986361
- Tagliaferro P Javier Ramos A Onaivi ES Evrard SG Lujilde J Brusco A Neuronal cytoskeleton and synaptic densities are altered after a chronic treatment with the cannabinoid receptor agonist WIN 55,212-2 Brain Res 2006 1085 163 176 16566907
- Squire LR Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans Psychol Rev 1992 99 195 231 1594723
- Gabrieli JD Cognitive neuroscience of human memory Annu Rev Psychol 1998 49 87 115 9496622
- Eichenbaum HECN From Conditioning to Conscious Recollection: Memory Systems of the Brain Oxford University Press: New York 2001
- Keefe RS Silverman JM Mohs RC Siever LJ Harvey PD Friedman L Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia Arch Gen Psychiatry 1997 54 169 176 9040285
- Ragland JD Cools R Frank M Pizzagalli DA Preston A Ranganath C CNTRICS final task selection: long-term memory Schizophr Bull 2009 35 197 212 18927344 PMC2643960
- Stone M Gabrieli JD Stebbins GT Sullivan EV Working and strategic memory deficits in schizophrenia Neuropsychology 1998 12 278 288 9556774
- Weiss AP Goff D Schacter DL Ditman T Freudenreich O Henderson D Fronto-hippocampal function during temporal context monitoring in schizophrenia Biol Psychiatry 2006 60 1268 1277 17020747
- Shohamy D Mihalakos P Chin R Thomas B Wagner AD Tamminga C Learning and generalization in schizophrenia: effects of disease and antipsychotic drug treatment Biol Psychiatry 67 926 932 20034612 PMC4023678
- Titone D Ditman T Holzman PS Eichenbaum H Levy DL Transitive inference in schizophrenia: impairments in relational memory organization Schizophr Res 2004 68 235 247 15099606
- Aleman A Hijman R de Haan EH Kahn RS Memory impairment in schizophrenia: a meta-analysis Am J Psychiatry 1999 156 1358 1366 10484945
- Danion JM Rizzo L Bruant A Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia Arch Gen Psychiatry 1999 56 639 644 10401510
- Achim AM Bertrand MC Sutton H Montoya A Czechowska Y Malla AK Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis Arch Gen Psychiatry 2007 64 999 1014 17768265
- Heckers S Zalesak M Weiss AP Ditman T Titone D Hippocampal activation during transitive inference in humans Hippocampus 2004 14 153 162 15098721
- Leube DT Rapp A Buchkremer G Bartels M Kircher TT Erb M Hippocampal dysfunction during episodic memory encoding in patients with schizophrenia-an fMRI study Schizophr Res 2003 64 83 85 14511805
- O'Shea M McGregor IS Mallet PE Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar longlasting deficits in object recognition and reduced social interaction in rats J Psychopharmacol 2006 20 611 621 16714325
- O'Shea M Singh ME McGregor IS Mallet PE Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats J Psychopharmacol 2004 18 502 508 15582916
- Quinn HR Matsumoto I Callaghan PD Long LE Arnold JC Gunasekaran N Adolescent rats find repeated Delta(9)-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure Neuropsychopharmacology 2008 33 1113 1126 17581536
- Wise LE Thorpe AJ Lichtman AH Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol Neuropsychopharmacology 2009 34 2072 2080 19322169 PMC2822461
- Nadel L Hardt O The spatial brain Neuropsychology 2004 18 473 476 15291725
- Gray L van den Buuse M Scarr E Dean B Hannan AJ Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation Int J Neuropsychopharmacol 2009 12 45 60 18593507
- Homayoun H Stefani MR Adams BW Tamagan GD Moghaddam B Functional interaction between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release Neuropsychopharmacology 2004 29 1259 1269 15010696
- Kinney GG O'Brien JA Lemaire W Burno M Bickel DJ Clements MK A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models J Pharmacol Exp Ther 2005 313 199 206 15608073
- Chan MH Chiu PH Sou JH Chen HH Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice Psychopharmacology (Berl) 2008 198 141 148 18311557
- Noetzel MJ Rook JM Vinson PN Cho HP Days E Zhou Y Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function Mol Pharmacol Feb 81 120 133 PMC3263948 22021324
- Ellgren M Artmann A Tkalych O Gupta A Hansen HS Hansen SH Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects Eur Neuropsychopharmacol 2008 18 826 834 18674887 PMC2745315
- Rubino T Guidali C Vigano D Realini N Valenti M Massi P CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour Neuropharmacology 2008 54 151 160 17692344
- Chadwick B Saylor AJ Lopez HH Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB(1)R expression or estrous cyclicity Pharmacol Biochem Behav 2011 100 157 164 21777606 PMC3744834
- Hirvonen J Goodwin RS Li CT Terry GE Zoghbi SS Morse C Reversible and regionally selective downregulation of brain cannabinoid CB(1) receptors in chronic daily cannabis smokers Mol Psychiatry 2012 17 642 649 21747398 PMC3223558
- Moore NL Greenleaf AL Acheson SK Wilson WA Swartzwelder HS Kuhn CM Role of cannabinoid receptor type 1 desensitization in greater tetrahydrocannabinol impairment of memory in adolescent rats J Pharmacol Exp Ther 2010 335 294 301 20668056 PMC2967405
- Renthal W Nestler EJ Epigenetic mechanisms in drug addiction Trends Mol Med 2008 14 341 350 18635399 PMC2753378
- Levenson JM O'Riordan KJ Brown KD Trinh MA Molfese DL Sweatt JD Regulation of histone acetylation during memory formation in the hippocampus J Biol Chem 2004 279 40545 40559 15273246
- Mackie K Signaling via CNS cannabinoid receptors Mol Cell Endocrinol 2008 286 (1-2 Suppl 1 S60 S65 18336996 PMC2435200
- Viveros MP Marco EM Llorente R Lopez-Gallardo M Endocannabinoid system and synaptic plasticity: implications for emotional responses Neural Plast 2007 2007 52908 17641734 PMC1906867
- Katona I Sperlagh B Magloczky Z Santha E Kofalvi A Czirjak S GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus Neuroscience 2000 100 797 804 11036213
- Hill EL Gallopin T Ferezou I Cauli B Rossier J Schweitzer P Functional CB1 receptors are broadly expressed in neocortical GABAergic and glutamatergic neurons J Neurophysiol 2007 97 2580 2589 17267760
- Marsicano G Lutz B Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain Eur J Neurosci 1999 11 4213 4225 10594647
- Kegeles LS Mao X Stanford AD Girgis R Ojeil N Xu X Elevated prefrontal cortex gamma-aminobutyric acid and glutamate-glutamine levels in schizophrenia measured in vivo with proton magnetic resonance spectroscopy Arch Gen Psychiatry 2012 69 449 459 22213769
- Arendt M Rosenberg R Foldager L Perto G Munk-Jorgensen P. Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Br J Psychiatry 2005 187 510 515 16319402
- Barnes TR Mutsatsa SH Hutton SB Watt HC Joyce EM Comorbid substance use and age at onset of schizophrenia Br J Psychiatry 2006 188 237 242 16507965
- Caspari D Cannabis and schizophrenia: results of a follow-up study Eur Arch Psychiatry Clin Neurosci 1999 249 45 49 10195343
- Green AI Tohen MF Hamer RM Strakowski SM Lieberman JA Glick I First episode schizophrenia-related psychosis and substance use disorders: acute response to olanzapine and haloperidol Schizophr Res 2004 66 125 135 15061244
- Hambrecht M Hafner H Cannabis, vulnerability, and the onset of schizophrenia: an epidemiological perspective Aust N Z J Psychiatry 2000 34 468 475 10881971
- Degenhardt L Tennant C Gilmour S Schofield D Nash L Hall W The temporal dynamics of relationships between cannabis, psychosis and depression among young adults with psychotic disorders: findings from a 10-month prospective study Psychol Med 2007 37 927 934 17288638
- Grech A Van Os J Jones PB Lewis SW Murray RM Cannabis use and outcome of recent onset psychosis Eur Psychiatry 2005 20 349 353 16018929
- Sevy S Robinson DG Holloway S Alvir JM Woerner MG Bilder R Correlates of substance misuse in patients with first-episode schizophrenia and schizoaffective disorder Acta Psychiatr Scand 2001 104 367 374 11722318
- McCleery A Addington J Addington D Substance misuse and cognitive functioning in early psychosis: a 2 year follow-up Schizophr Res 2006 88 187 191 16942863
- Kumra S Thaden E DeThomas C Kranzler H Correlates of substance abuse in adolescents with treatment-refractory schizophrenia and schizoaffective disorder Schizophr Res 2005 73 369 371 15653284
- Potvin S Briand C Prouteau A Bouchard RH Lipp O Lalonde P CANTAB explicit memory is less impaired in addicted schizophrenia patients Brain Cogn 2005 59 38 42 15913868
- Jockers-Scherubl MC Wolf T Radzei N Schlattmann P Rentzsch J Gomez-Carrillo de Castro A Cannabis induces different cognitive changes in schizophrenic patients and in healthy controls Prog Neuropsychopharmacol Biol Psychiatry 2007 31 1054 1063 17482741
- Schnell T Koethe D Daumann J Gouzoulis-Mayfrank E The role of cannabis in cognitive functioning of patients with schizophrenia Psychopharmacology (Berl) 2009 205 45 52 19326102
- Stirling J White C Lewis S Hopkins R Tantam D Huddy A Neurocognitive function and outcome in first-episode schizophrenia: a 10-year follow-up of an epidemiological cohort Schizophr Res 2003 65 75 86 14630300
- Rodriguez-Sanchez JM Ayesa-Arriola R Mata I Moreno-Calle T Perez-Iglesias R Gonzalez-Blanch C Cannabis use and cognitive functioning in first-episode schizophrenia patients Schizophr Res 2010 124 142 151 20826079
- Carey KB Carey MP Simons JS Correlates of substance use disorder among psychiatric outpatients: focus on cognition, social role functioning, and psychiatric status J Nerv Ment Dis 2003 191 300 308 12819549 PMC2430931
- Yucel M Bora E Lubman DI Solowij N Brewer WJ Cotton SM The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample Schizophr Bull 2012 38 316 330 20660494 PMC3283159
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- Authors
- Gleason, K. A., Birnbaum, S. G., Shukla, A., & Ghose, S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Ghose, S
- ORCID
- Birnbaum, S G
- Venue
- Translational Psychiatry
- Published
- 2012-11-27
- Volume
- 2
- Issue
- 11
- Pages
- e199-e199
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3565769
- OpenAlex
- W2011733759
- Cited by
- 77
- References
- 5
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 2 · 2018: 5 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH-79253, K08MH079253)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adolescent cannabis use, schizophrenia, WIN 55,212-2, hippocampus, prepulse inhibition, fear conditioning, sensorimotor gating, metabotropic glutamate receptor 5, endocannabinoid signaling, diacylglycerol lipase, monoacylglycerol lipase, fatty acid amide hydrolase, learning and memory impairment
- MeSH terms
- Animals, Behavior, Animal, Cannabinoids, Conditioning, Psychological, Disease Models, Animal, Disease Susceptibility, Fear, Hippocampus, Inhibition, Psychological, Mice, Inbred C57BL, Morpholines, Naphthalenes, Schizophrenia, Receptors, Metabotropic Glutamate, Receptor, Cannabinoid, CB1, Benzoxazines, Mice, Receptor, Metabotropic Glutamate 5
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