Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity
Open accessAbstract
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.
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Reduction in the inhibitory output of FS basket cells has been shown to reactivate plasticity in the adult visual cortex.
“Reduction in the inhibitory output of FS basket cells has been shown to reactivate plasticity in the adult visual cortex (Kuhlman et al., 2013; Kaplan et al., 2016).”
From Light reintroduction after dark exposure reactivates plasticity in adults via perisynaptic activation of MMP-9 (2017) · cites this paper as Kaplan et al., 2016
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- Authors
- Kaplan, E. S., Cooke, S. F., Komorowski, R. W., Chubykin, A. A., Thomazeau, A., Khibnik, L. A., Gavornik, J. P., & Bear, M. F.
- Affiliations
- Massachusetts Institute of Technology (US)
- Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States
- Purdue University West Lafayette (US)
- Sanford Health (US)
- Boston University (US)
- Corresponding author
- Bear, Mark F
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-03-04
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4786407
- OpenAlex
- W2293414805
- Cited by
- 77
- References
- 54
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 3 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 3
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, cc-by)
- HAL (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Funders
- National Eye Institute (5R01EYO23037)
- National Institute of Mental Health (1T32MH074249)
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- GABAergic interneurons, experience-dependent plasticity, primary visual cortex, ocular dominance plasticity, monocular deprivation, NMDA receptor, ketamine, adult visual cortex
- MeSH terms
- Animals, Neuronal Plasticity, Parvalbumins, Visual Cortex, Receptors, N-Methyl-D-Aspartate, Mice, GABAergic Neurons
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