Cited by 77Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanismsNeurogenesis and neuroplasticity mechanisms

Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

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Kaplan, Eitan S, Cooke, Sam F, Komorowski, Robert W, Chubykin, Alexander A, Thomazeau, Aurore, Khibnik, Lena A, Gavornik, Jeffrey P, Bear, Mark F·2016·eLife

Abstract

The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from enriched visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells, reversibly inhibited by the psychotomimetic drug ketamine, play a critical role in SRP, but not in the induction or expression of adult OD plasticity.

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Authors
Kaplan, E. S., Cooke, S. F., Komorowski, R. W., Chubykin, A. A., Thomazeau, A., Khibnik, L. A., Gavornik, J. P., & Bear, M. F.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, United States
  • Purdue University West Lafayette (US)
  • Sanford Health (US)
  • Boston University (US)
Corresponding author
Bear, Mark F
Venue
eLife
Published
2016-03-04
Volume
5
ISSN
2050-084X (ISSN-L)
OpenAlex
W2293414805
Cited by
77
References
54
Citations by year
2026: 3 · 2025: 10 · 2024: 3 · 2023: 10 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 3
FWCI
4.49
Type
journal article
Language
en
Open access
Locations
  • eLife (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-sa)
Funders
  • National Eye Institute (5R01EYO23037)
  • National Institute of Mental Health (1T32MH074249)
  • Howard Hughes Medical Institute
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
GABAergic interneurons, experience-dependent plasticity, primary visual cortex, ocular dominance plasticity, monocular deprivation, NMDA receptor, ketamine, adult visual cortex
MeSH terms
Animals, Neuronal Plasticity, Parvalbumins, Visual Cortex, Receptors, N-Methyl-D-Aspartate, Mice, GABAergic Neurons

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