The DOI matches its Crossref record; 120 of the 123 references it cites were found in a registry or an index.
Cortical inhibitory neurons and schizophrenia
Abstract
Impairments in certain cognitive functions, such as working memory, are core features of schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB neurotrophin receptor leads to reduced GABA (gamma-aminobutyric acid) synthesis in the parvalbumin-containing subpopulation of inhibitory GABA neurons in the dorsolateral prefrontal cortex of individuals with schizophrenia. Despite both pre- and postsynaptic compensatory responses, the resulting alteration in perisomatic inhibition of pyramidal neurons contributes to a diminished capacity for the gamma-frequency synchronized neuronal activity that is required for working memory function. These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reduced expression of GAD67, the main GABA-synthesizing enzyme in the brain, appears to contribute to altered interneuron activity in psychosis [86,87] .”
From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [86]
In the citing paper
“Certain classes of GABA interneurons are altered in individuals with psychosis, in particular reduced density in the anterior cingulate and reduced activity in the dorsolateral prefrontal cortex in the subpopulation expressing parvalbumin [84-86] .”
From The traumagenic neurodevelopmental model of psychosis revisited (2014) · cites this paper as [86]
In the citing paper
“Thus, the correct balance of inhibition and excitation seems to be critical for normative executive function, and conversely, disturbance of this balance is thought to be a fundamental component of psychiatric illness.69, 70”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [69]
In the citing paper
“Moreover, the expression of several GABA receptors and markers of inhibitory synapses are also altered in schizophrenia 50 .”
From Developmental timing and critical windows for the treatment of psychiatric disorders (2016) · cites this paper as [50]
In the citing paper
“Schizophrenia is increasingly recognized as a neurodevelopmental disorder that involves alterations in brain circuits, including dysfunction of parvalbumin (PV)-positive, fast-spiking GABA neurons (1, 2).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [1]
In the citing paper
“its onset is linked to a potential disruption of the physiological maturation of inhibitory neural networks consisting of fast-spiking parvalbumin-positive gamma-aminobutric acid (GABAergic) interneurons”
From Perineuronal nets and schizophrenia: The importance of neuronal coatings (2014) · cites this paper as Lewis et al., 2005
In the citing paper
“Dysfunction and/or deficient inhibitory output from PV interneurons may be a common mechanism of multiple psychiatric disorders, such as schizophrenia (SCZ) (Lewis et al. 2005), autism spectrum disorders (ASD) (Gao and Penzes 2015) and bipolar disorder (BD) (Ruden et al. 2021).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Lewis et al. 2005
In the citing paper
“Specifically, there is growing support for a hypothesis that cortical disinhibition occurs in schizophrenia, due to the disrupted functioning of inhibitory interneurons, which results in elevated E/I ratio (Lewis et al. 2005;Marin 2012).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“The prefrontal cortex is a key node in the distributed cortical network recruited during WM (Owen et al. 2005;Fuster 2008) and exhibits altered inhibitory microcircuitry in schizophrenia (Lewis et al. 2005;Bitanihirwe et al. 2009).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“Elevated prefrontal E/I ratio may result from alterations in multiple pathways that are implicated in schizophrenia.These include GABAergic deficits, such as reduced GAD67 production (Lewis et al. 2005); increased background input from other areas such as the thalamus or hippocampus (Lisman et al. 2008); or abnormal levels of neuromodulators (Laruelle et al. 2003).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
In the citing paper
“Both interneuron cell classes are altered in schizophrenia (Lewis et al. 2005;Morris et al. 2008;Bitanihirwe et al. 2009).”
From Linking microcircuit dysfunction to cognitive impairment: Effects of disinhibition associated with schizophrenia in a cortical working memory model (2014) · cites this paper as Lewis et al. 2005
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803
What are the functional consequences of neurocognitive deficits in schizophrenia?
(1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.3.321 · Cited by 3,516
Interneurons of the neocortical inhibitory system
Markram, H., Toledo-Rodriguez, M., Wang, Y., Gupta, A., Silberberg, G., & Wu, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1519 · Cited by 2,954
Cellular basis of working memory
Goldman-Rakic, P. S. (1995) · Neuron · doi:10.1016/0896-6273(95)90304-6 · Cited by 2,663
Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia
Weinberger, D. R. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020020004 · Cited by 2,025
Principles of Frontal Lobe Function
Stuss, D. T. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.001.0001 · Cited by 1,731
Topography Of Cognition: Parallel Distributed Networks In Primate Association Cortex
Goldman‐Rakic, P. S. (1988) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.11.030188.001033 · Cited by 1,658
Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Glantz, L. A., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.1.65 · Cited by 1,636
Self-citationSynchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498
Diamond, A. (2002) · Principles of Frontal Lobe Function · doi:10.1093/acprof:oso/9780195134971.003.0029 · Cited by 1,248
Fritschy, J., & Mohler, H. (1995) · Journal of Comparative Neurology · doi:10.1002/cne.903590111 · Cited by 1,244
Guidotti, A., Auta, J., Davis, J. M., Gerevini, V. D. G., Dwivedi, Y., Grayson, D. R., Impagnatiello, F., Pandey, G. N., Pesold, C., Sharma, R. P., et al. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.11.1061 · Cited by 1,222
Huang, Z. J., Kirkwood, A., Pizzorusso, T., Porciatti, V., Morales, B., Bear, M. F., Maffei, L., & Tonegawa, S. (1999) · Cell · doi:10.1016/s0092-8674(00)81509-3 · Cited by 1,198
Schizophrenia as a Disorder of Neurodevelopment
Lewis, D. A., & Levitt, P. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142754 · Cited by 1,163
Self-citationEnforcement of Temporal Fidelity in Pyramidal Cells by Somatic Feed-Forward Inhibition
Pouille, F., & Scanziani, M. (2001) · Science · doi:10.1126/science.1060342 · Cited by 1,097
Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia
Saykin, A. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020048005 · Cited by 1,086
GABAergic Interneurons Implications for Understanding Schizophrenia and Bipolar Disorder
Benes, F. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00225-1 · Cited by 1,082
Akbarian, S. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950160008002 · Cited by 1,002
Molecular and neuronal substrate for the selective attenuation of anxiety
Löw, K., Crestani, F., Keist, R., Benke, D., Brünig, I., Benson, J. A., Fritschy, J.-M., Rülicke, T., Bluethmann, H., Möhler, H., et al. (2000) · Science · doi:10.1126/science.290.5489.131 · Cited by 946
Hashimoto, T., Volk, D. W., Eggan, S. M., Mirnics, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06315.2003 · Cited by 938
Self-citationInduced γ-Band Activity during the Delay of a Visual Short-Term Memory Task in Humans
Tallon‐Baudry, C., Bertrand, O., Peronnet, F., & Pernier, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-11-04244.1998 · Cited by 900
Mirnics, K., Middleton, F. A., Marquez, A., Lewis, D. A., & Levitt, P. (2000) · Neuron · doi:10.1016/s0896-6273(00)00085-4 · Cited by 882
Self-citationCognitive Impairment in Schizophrenia Is the Core of the Disorder
Elvevag, B., & Goldberg, T. E. (2000) · Critical Reviews™ in Neurobiology · doi:10.1615/critrevneurobiol.v14.i1.10 · Cited by 835 · cited 1×
“Of the many clinical features of schizophrenia, disturbances in certain cognitive processes, such as impairments in attention, memory and executive functions (that is, the ability to plan, initiate and regulate goal-directed behaviour), might represent the core features of the illnes”
BackgroundLewis, D. A., & Lieberman, J. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00111-2 · Cited by 833
Self-citationSchizophrenia genesis: the origins of madness
(1991) · Choice Reviews Online · doi:10.5860/choice.28-6500 · Cited by 832
Gamma Oscillations Correlate with Working Memory Load in Humans
Howard, M. W. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg084 · Cited by 766
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Impagnatiello, F., Guidotti, A. R., Pesold, C., Dwivedi, Y., Caruncho, H. J., Pisu, M. G., Uzunov, D. P., Smalheiser, N. R., Davis, J. M., Pandey, G. N., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15718 · Cited by 762
Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia
Garey, L. J., Ong, W., Patel, T. S., Kanani, M., Davis, A., Mortimer, A. M., Barnes, T., & Hirsch, S. R. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.65.4.446 · Cited by 719
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.3.237 · Cited by 697
Self-citationEssential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685
Complexity of Prefrontal Cortical Dysfunction in Schizophrenia: More Than Up or Down
Callicott, J. H., Mattay, V. S., Verchinski, B. A., Marenco, S., Egan, M. F., & Weinberger, D. R. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2209 · Cited by 673
To Model a Psychiatric Disorder in Animals Schizophrenia As a Reality Test
Lipska, B. K. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00137-8 · Cited by 663
Relation of Prefrontal Cortex Dysfunction to Working Memory and Symptoms in Schizophrenia
Perlstein, W. M., Carter, C. S., Noll, D. C., & Cohen, J. D. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1105 · Cited by 652
Proximally targeted GABAergic synapses and gap junctions synchronize cortical interneurons
Tamás, G., Buhl, E. H., Lörincz, A., & Somogyi, P. (2000) · Nature Neuroscience · doi:10.1038/73936 · Cited by 648
Abnormal neural synchrony in schizophrenia
Spencer, K. M., Nestor, P. G., Niznikiewicz, M. A., Salisbury, D. F., Shenton, M. E., & McCarley, R. W. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07407.2003 · Cited by 624
Genes, dopamine and cortical signal-to-noise ratio in schizophrenia
Winterer, G., & Weinberger, D. R. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.08.002 · Cited by 610
Neural synchrony indexes disordered perception and cognition in schizophrenia
Spencer, K., Nestor, P. G., Perlmutter, R., Niznikiewicz, M. A., Klump, M. C., Frumin, M., Shenton, M. E., & McCarley, R. W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406074101 · Cited by 601
Structural and functional basis for GABAA receptor heterogeneity
Levitan, E. S., Schofield, P. R., Burt, D. R., Rhee, L. M., Wisden, W., Köhler, M. G., Fujita, N., Rodriguez, H., Stephenson, A., Darlison, M. G., et al. (1988) · Nature · doi:10.1038/335076a0 · Cited by 589
Behavioral and Intellectual Markers for Schizophrenia in Apparently Healthy Male Adolescents
Davidson, M., Reichenberg, A., Rabinowitz, J., Weiser, M., Kaplan, Z., & Mark, M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1328 · Cited by 582
McBain, C. J., & Fisahn, A. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049047 · Cited by 581
Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R.-G., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T., & Obata, K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6496 · Cited by 556
Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia
Weickert, C. S., Hyde, T. M., Lipska, B. K., Herman, M. M., Weinberger, D. R., & Kleinman, J. E. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001308 · Cited by 533
Kawaguchi, Y. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02638.1995 · Cited by 533
Diversity of inhibitory neurotransmission through GABAA receptors
Módy, I., & Pearce, R. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.07.002 · Cited by 532
A specific ‘axo-axonal’ interneuron in the visual cortex of the rat
Somogyi, P. (1977) · Brain Research · doi:10.1016/0006-8993(77)90808-3 · Cited by 530
Condé, F., Lund, J. S., Jacobowitz, D. M., Baimbridge, K. G., & Lewis, D. A. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410109 · Cited by 500
Self-citationA reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
Benes, F. M., Kwok, E. W., Vincent, S. L., & Todtenkopf, M. S. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00138-3 · Cited by 470
Converging Evidence of NMDA Receptor Hypofunction in the Pathophysiology of Schizophrenia
Coyle, J. T., Tsai, G. E., & GOFF, D. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.020 · Cited by 443
Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis
Sitskoorn, M. M., Aleman, A., Ebisch, S. J. H., Appels, M. C. M., & Kahn, R. S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.03.007 · Cited by 443
Woo, T.-U. W., Walsh, J. P., & Benes, F. M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.649 · Cited by 411
A subclass of prefrontal γ-aminobutyric acid axon terminals are selectively altered in schizophrenia
Woo, T.-U. W., Whitehead, R. E., Melchitzky, D. S., & Lewis, D. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5341 · Cited by 410
Self-citationWorking Memory Deficit as a Core Neuropsychological Dysfunction in Schizophrenia
Silver, H., Feldman, P., Bilker, W. B., & Gur, R. C. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.10.1809 · Cited by 410
Rao, S. G., Williams, G. V., & Goldman-Rakic, P. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00485.2000 · Cited by 407
Xu, B., Gottschalk, W., Chow, A., Wilson, R. I., Schnell, E., Zang, K., Wang, D., Nicoll, R. A., Lu, B., & Reichardt, L. F. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06888.2000 · Cited by 404
Bringing Order to the Glutamate Chaos in Schizophrenia
Moghaddam, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00757-8 · Cited by 403
Pesold, C., Impagnatiello, F., Pisu, M. G., Uzunov, D. P., Costa, E., Guidotti, A., & Caruncho, H. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3221 · Cited by 391
Hashimoto, T., Bergen, S. E., Nguyen, Q. L., Xu, B., Monteggia, L. M., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4035-04.2005 · Cited by 386
Self-citationNusser, Z., Sieghart, W., Benke, D., Fritschy, J., & Somogyi, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11939 · Cited by 384
Beasley, C. L., Zhang, Z. J., Patten, I., & Reynolds, G. P. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01360-4 · Cited by 374
A role for inhibition in shaping the temporal flow of information in prefrontal cortex
Constantinidis, C., Williams, G. V., & Goldman-Rakic, P. S. (2002) · Nature Neuroscience · doi:10.1038/nn799 · Cited by 348
The molecular genetics of schizophrenia: new findings promise new insights
Owen, M. J., Williams, N. M., & O’Donovan, M. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001444 · Cited by 328
Heckers, S., Stone, D., Walsh, J., Shick, J., Koul, P., & Benes, F. M. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.6.521 · Cited by 322
Blatow, M., Rozov, A., Katona, I., Hormuzdi, S. G., Meyer, A. H., Whittington, M. A., Caputi, A., & Monyer, H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00300-3 · Cited by 316
Asada, H., Kawamura, Y., Maruyama, K., Kume, H., Ding, R.-G., Ji, F. Y., Kanbara, N., Kuzume, H., Sanbo, M., Yagi, T., et al. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1898 · Cited by 315
PCP: from pharmacology to modelling schizophrenia
MORRIS, B. J., Cochran, S. M., & Pratt, J. A. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.08.008 · Cited by 308
Barch, D. M., Sheline, Y. I., Csernansky, J. G., & Snyder, A. Z. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01674-8 · Cited by 303
Wilson, F. A. W., ÓScalaidhe, S. P., & Goldman‐Rakic, P. S. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4009 · Cited by 303
Kawaguchi, Y., & Kubota, Y. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00685-4 · Cited by 296
Alterations in Chandelier Neuron Axon Terminals in the Prefrontal Cortex of Schizophrenic Subjects
Pierri, J. N., Chaudry, A. S., Woo, T.-U. W., & Lewis, D. A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.11.1709 · Cited by 294
Self-citationBenes, F. M., Vincent, S. L., Marie, A. S., & Khan, Y. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00328-4 · Cited by 276
Vawter, M. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00377-2 · Cited by 275
Volk, D. W. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.10.1063 · Cited by 264
Self-citationBertolino, A., Nawroz, S., Mattay, V. S., Barnett, A. S., Duyn, J. H., MOONEN, C. T. W., Frank, J. A., Tedeschi, G., & Weinberger, D. R. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.12.1554 · Cited by 256
Lewis, D., Volk, D., & Hashimoto, T. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1673-x · Cited by 253
Self-citationYamada, M. K., Nakanishi, K., Ohba, S., Nakamura, T., Ikegaya, Y., Nishiyama, N., & Matsuki, N. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07580.2002 · Cited by 235
Jensen, K., Chiu, C., Sokolova, I., Lester, H. A., & Módy, I. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00240.2003 · Cited by 235
Liu, W., Pesold, C., Rodríguez, M. Á., Carboni, G., Auta, J., Lacor, P. N., Larson, J., Condie, B. G., Guidotti, A., & Costa, E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051614698 · Cited by 226
Volk, D. W., Austin, M. C., Pierri, J. N., Sampson, A. R., & Lewis, D. A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.256 · Cited by 221
Self-citationLewis, D. A., & Lund, J. S. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.902930406 · Cited by 220
Self-citationParvalbumin-Deficiency Facilitates Repetitive IPSCs and Gamma Oscillations in the Hippocampus
Vreugdenhil, M., Jefferys, J. G. R., Celio, M. R., & Schwaller, B. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00576.2002 · Cited by 219
Cotter, D., Landau, S., Beasley, C. L., Stevenson, R. N., Chana, G., MacMillan, L., & Everall, I. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01243-4 · Cited by 211
Lund, J. S., & Lewis, D. A. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903280209 · Cited by 208
Self-citationAddington, A. M., Gornick, M., Duckworth, J., Sporn, A. L., Gogtay, N., Bobb, A., GREENSTEIN, D. K., Lenane, M., Gochman, P., Baker, N., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001599 · Cited by 207
Lavoie, A. M., Tingey, J., Harrison, N. L., Pritchett, D. B., & Twyman, R. E. (1997) · Biophysical Journal · doi:10.1016/s0006-3495(97)78280-8 · Cited by 205
Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons
Woo, T., Miller, J. L., & Lewis, D. A. (1997) · American Journal of Psychiatry · doi:10.1176/ajp.154.7.1013 · Cited by 191
Self-citationLewis, D. A., Cruz, D. A., Melchitzky, D. S., & Pierri, J. N. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.9.1411 · Cited by 190
Self-citationZaitsev, A. V., González‐Burgos, G., Povysheva, N. V., Kröner, S., Lewis, D. A., & Krimer, L. S. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh218 · Cited by 184
Self-citationOhnuma, T., Augood, S. J., Arai, H., McKenna, P. J., & Emson, P. C. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00189-x · Cited by 182
Akbarian, S., Huntsman, M. M., Kim, J. J., Tafazzoli, A., Potkin, S. G., Bunney, W. E., & Jones, E. G. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.6.550 · Cited by 181
Pesold, C., Liu, W. S., Guidotti, A., Costa, E., & Caruncho, H. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3217 · Cited by 160
González‐Burgos, G., Krimer, L. S., Povysheva, N. V., Barrionuevo, G., & Lewis, D. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00787.2004 · Cited by 159
Self-citationSesack, S. R. (1998) · Cerebral Cortex · doi:10.1093/cercor/8.7.614 · Cited by 148
Synapse Density Regulates Independence at Unitary Inhibitory Synapses
Overstreet, L. S., & Westbrook, G. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02618.2003 · Cited by 144
The GABAergic system in schizophrenia.
Blum, B. P., & Mann, J. (2002) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002894 · Cited by 143
[3H]Muscimol binding sites increased in autopsied brains of chronic schizophrenics
Hanada, S., Mita, T., Nishino, N., & Tanaka, C. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90341-9 · Cited by 140
No deficit in total number of neurons in the prefrontal cortex in schizophrenics
Thune, J. J., Uylings, H. B. M., & Pakkenberg, B. (2001) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(00)00043-1 · Cited by 124
Cruz, D. A., Eggan, S. M., & Lewis, D. A. (2003) · Journal of Comparative Neurology · doi:10.1002/cne.10833 · Cited by 118
Self-citationDiazepam Treatment of Early Signs of Exacerbation in Schizophrenia
Carpenter, W. T., Buchanan, R. W., Kirkpatrick, B. W., & Breier, A. F. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.2.299 · Cited by 117
Altered Cortical Glutamate Neurotransmission in Schizophrenia
Lewis, D. A., Glantz, L. A., Pierri, J. N., & Sweet, R. A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.007 · Cited by 113
Self-citationBenes, F. M., Todtenkopf, M. S., Logiotatos, P., & Williams, M. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00105-8 · Cited by 110
Sawaguchi, T., Matsumura, M., & Kubota, K. (1989) · Experimental Brain Research · doi:10.1007/bf00249897 · Cited by 109
Cellerino, A., Maffei, L., & Domenici, L. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01287.x · Cited by 107
Knable, M. B., Barci, B. M., Bartko, J. J., Webster, M. J., & Torrey, Ε. F. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001034 · Cited by 106
Erickson, S. L., & Lewis, D. A. (2002) · Journal of Comparative Neurology · doi:10.1002/cne.10249 · Cited by 104
Self-citationLipska, B. K., Lerman, D. N., Khaing, Z. Z., Weickert, C. S., & Weinberger, D. R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02738.x · Cited by 104
Kondo, M., Sumino, R., & Okado, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-05-01570.1997 · Cited by 104
Dorph‐Petersen, K., Pierri, J. N., Sun, Z., Sampson, A. R., & Lewis, D. A. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20055 · Cited by 102
Self-citationMelchitzky, D. S. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.5.452 · Cited by 84
Sze, P. Y. (1979) · Advances in experimental medicine and biology · doi:10.1007/978-1-4899-5199-1_4 · Cited by 77
Loup, F., Weinmann, O., Yonekawa, Y., Aguzzi, A., Wieser, H. G., & Fritschy, J. (1998) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549804601005 · Cited by 76
Serotonin1A Receptors at the Axon Initial Segment of Prefrontal Pyramidal Neurons in Schizophrenia
Cruz, D. A., Eggan, S. M., Azmitia, E. C., & Lewis, D. A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.739 · Cited by 72
Self-citationSomal size of prefrontal cortical pyramidal neurons in schizophrenia
Pierri, J. N., Volk, C. L. E., Auh, S., Sampson, A. R., & Lewis, D. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00294-4 · Cited by 64
Self-citationJurkevich, A., Barth, S. W., Kuenzel, W. J., K�HLER, A., & Großmann, R. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990524)408:1 · Cited by 60
Synaptic targets of calretinin-containing axon terminals in macaque monkey prefrontal cortex
Melchitzky, D. S., Eggan, S. M., & Lewis, D. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.08.046 · Cited by 50
Self-citationVolk, D. W., & Lewis, D. A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01547-0 · Cited by 25
Self-citationCognitive Neuroscience Society Annual Meeting
Williams, A. N. (2015) · PsyPag Quarterly · doi:10.53841/bpspag.2015.1.96.50 · Cited by 20
Postnatal changes in enzyme activities of rat myocardial adenine nucleotide catabolic pathway
Wang, T., Tan, Z.-T., & Webb, W. R. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90338-9 · Cited by 19
Fischer, G., & Wagner, B. (1983) · PubMed · Cited by 19
Crair (2001) · doi:10.1002/1096-9861(20010205)430:2
Self-citation
Flagged first, then by citations
3 of the 123 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Konopaske, G. T., Sweet, R. A. & Lewis, D. A. GABA transporter-1 immunoreactivity in auditory association cortex in schizophrenia. Soc. Neurosci. Abstr. 34, 110.11 (2004).
- Peters, A. in Cerebral Cortex Vol. 1 (eds Jones, E. G. & Peters, A.) 361–380 (Plenum, New York, 1984).
Cited by
Sorted by citations
Mechanisms of Gamma Oscillations
Buzsáki, G., & Wang, X.-J. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150444 · Cited by 2,796
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
Sohal, V. S., Zhang, F., Yizhar, O., & Deisseroth, K. (2009) · Nature · doi:10.1038/nature07991 · Cited by 2,606
Neocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323
Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology
Uhlhaas, P. J., & Singer, W. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.020 · Cited by 2,194
Metadata
- Authors
- Lewis, D. A., Hashimoto, T., & Volk, D. W.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lewis, David A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2005-04
- Volume
- 6
- Issue
- 4
- Pages
- 312-324
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2089912569
- Cited by
- 2,297
- References
- 123
- Citations by year
- 2026: 36 · 2025: 51 · 2024: 63 · 2023: 48 · 2022: 70 · 2021: 86 · 2020: 77 · 2019: 94 · 2018: 102 · 2017: 89 · 2016: 123 · 2015: 148 · 2014: 132 · 2013: 167 · 2012: 151
- FWCI
- 16.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- schizophrenia, cortical inhibitory neurons, parvalbumin interneurons, GABA synthesis, dorsolateral prefrontal cortex, working memory, perisomatic inhibition, cognitive impairment
- MeSH terms
- Animals, Cerebral Cortex, Humans, Nerve Net, Neural Inhibition, Neurons, Schizophrenia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
