Cited by 286Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase SignalingMemory and Neural Mechanisms

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Integration of biochemical signalling in spines

Kennedy, Mary B., Beale, Holly C., Carlisle, Holly J., Washburn, Lorraine R.·2005·Nature Reviews Neuroscience

DOI 10.1038/nrn1685

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Abstract

Short-term and long-term changes in the strength of synapses in neural networks underlie working memory and long-term memory storage in the brain. These changes are regulated by many biochemical signalling pathways in the postsynaptic spines of excitatory synapses. Recent findings about the roles and regulation of the small GTPases Ras, Rap and Rac in spines provide new insights into the coordination and cooperation of different pathways to effect synaptic plasticity. Here, we present an initial working representation of the interactions of five signalling cascades that are usually studied individually. We discuss their integrated function in the regulation of postsynaptic plasticity.

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Authors: Kennedy, M. B., Beale, H. C., Carlisle, H. J., & Washburn, L. R.
Affiliations: California Institute of Technology (US)
Corresponding author: Kennedy, Mary B.
ORCID: Kennedy, Mary B.
Beale, Holly C.
Carlisle, Holly J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2005-06-01
Volume: 6
Issue: 6
Pages: 423-434
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn1685
OpenAlex: W2005797241
Cited by: 286
References: 127
Citations by year: 2025: 3 · 2024: 7 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 9 · 2019: 11 · 2018: 12 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 38
FWCI: 2.35
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: John Douglas French Alzheimer's Foundation
National Institutes of Health
National Institute on Drug Abuse (R01DA030749)
National Institute of Neurological Disorders and Stroke (P01NS044306)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: postsynaptic spines, synaptic plasticity, Ras, rap, Rac, small GTPases, excitatory synapses, working memory, long-term memory, signaling pathways
MeSH terms: Animals, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Calcium Signaling, Dendritic Spines

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