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Orchestration of synaptic functions by WAVE regulatory complex‐mediated actin reorganization

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Han, Kyung Ah, Ko, Jaewon·2023·Experimental & Molecular Medicine
DOI 10.1038/s12276-023-01004-1PMC PMC10318009
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Abstract

The WAVE regulatory complex (WRC), composed of five components—Cyfip1/Sra1, WAVE/Scar, Abi, Nap1/Nckap1, and Brk1/HSPC300—is essential for proper actin cytoskeletal dynamics and remodeling in eukaryotic cells, likely by matching various patterned signals to Arp2/3-mediated actin nucleation. Accumulating evidence from recent studies has revealed diverse functions of the WRC in neurons, demonstrating its crucial role in dictating the assembly of molecular complexes for the patterning of various trans -synaptic signals. In this review, we discuss recent exciting findings on the physiological role of the WRC in regulating synaptic properties and highlight the involvement of WRC dysfunction in various brain disorders.

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  • Many transmembrane cell adhesion molecules and receptors, including protocadherins, ROBOs, netrin receptors, neuroligins, GPCRs and ion channels, may recruit the WAVE complex to membranes via the interaction of CYFIP and ABI with a conserved motif called WIRS.

    “In addition to RAC (or ARF) and acidic phospholipids (PIP2 or PIP3), many transmembrane cell adhesion molecules and receptors, including protocadherins, ROBOs, netrin receptors, neuroligins, GPCRs and ion channels, may recruit the WAVE complex to membranes via the interaction of CYFIP and ABI with a conserved motif called WIRS (WAVE complex interacting receptor sequence)23,28 (Fig. 2).”

    From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [23]

    The section on transduction of extracellular synaptic adhesion signals says that WIRS binds a surface formed by CYFIP and ABI and suggests that WIRS-containing adhesion molecules help recruit the WRC to membranes. Table 1 lists WIRS motifs in protocadherins, ROBOs, netrin receptors, neuroligins and adhesion GPCRs; Fig. 2 likewise describes possible WIRS-mediated recruitment by several receptors. Our copy does not identify ion channels as WIRS-containing recruiters, so that example is unsupported. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • ABI3 is an important regulator of actin assembly.

    “ABI3 is an important regulator of actin assembly 27”

    From Aberrant phase separation from a rare <i>ABI3</i> mutation drives microglial dysfunction and Alzheimer's risk (2026) · cites this paper as [27]

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Cited by

Sorted by citations

Authors
Han, K. A., & Ko, J.
Affiliations
Daegu Gyeongbuk Institute of Science and Technology (KR)
Corresponding author
Ko, Jaewon
ORCID
Venue
Experimental & Molecular Medicine
Publisher
Springer Science and Business Media LLC
Published
2023-06-01
Volume
55
Issue
6
Pages
1065-1075
ISSN
  • 1226-3613 (ISSN-L)
  • 2092-6413
DOI
10.1038/s12276-023-01004-1
PMC
PMC10318009
OpenAlex
W4378905494
Cited by
31
References
14
Citations by year
2026: 11 · 2025: 14 · 2024: 5 · 2023: 1
FWCI
1.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Experimental & Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Research Foundation of Korea (2022R1A3B1077206, 2021R1C1C2010767)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
WAVE regulatory complex, actin cytoskeleton remodeling, synaptic function, Arp2/3 complex, actin nucleation, trans-synaptic signaling, neurons, brain disorders, CYFIP1, ABI, NAP1
MeSH terms
Actins, Carrier Proteins, Neurons, Wiskott-Aldrich Syndrome Protein Family

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