The DOI matches its Crossref record; 121 of the 123 references it cites were found in a registry or an index.
The human orbitofrontal cortex: linking reward to hedonic experience
Abstract
Hedonic experience is arguably at the heart of what makes us human. In recent neuroimaging studies of the cortical networks that mediate hedonic experience in the human brain, the orbitofrontal cortex has emerged as the strongest candidate for linking food and other types of reward to hedonic experience. The orbitofrontal cortex is among the least understood regions of the human brain, but has been proposed to be involved in sensory integration, in representing the affective value of reinforcers, and in decision making and expectation. Here, the functional neuroanatomy of the human orbitofrontal cortex is described and a new integrated model of its functions proposed, including a possible role in the mediation of hedonic experience.
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“The conscious subjective experience of pleasure and reward likely takes place in the orbitofrontal cortex, which has reciprocal links with the mesolimbic system 85, 86.”
From Resilience in mental health: linking psychological and neurobiological perspectives. (2013) · cites this paper as [86]
In the citing paper
“This neural system comprises subcortical and cortical structures that are major sites of dopamine action, and include primarily the striatum (caudate nucleus, putamen and nucleus accumbens) (e.g., Di Chiara, 2002; Di Chiara and Bassareo, 2007; McClure et al., 2004; Schultz et al., 1998; Wise, 2004) and the medial and orbital prefrontal cortices (Jensen et al., 2003; Kringelbach, 2005).”
From A systematic review of fMRI reward paradigms used in studies of adolescents vs. adults: The impact of task design and implications for understanding neurodevelopment (2013) · cites this paper as Kringelbach, 2005
In the citing paper
“However, this pattern is consistent with previous studies related to right lOFC function 39 .”
From Oxytocin modulates social value representations in the amygdala (2019) · cites this paper as [39]
Citations
Cites
James, W. (1891) · Personality Culture Society · doi:10.1037/11059-000 · Cited by 25,876
Investigating causal relations by econometric models and cross-spectral methods
Granger, C. W. J. (1969) · Econometrica · doi:10.2307/1912791 · Cited by 22,989
The expression of the emotions in man and animals.
Darwin, C. D. (1872) · J. Murray eBooks · doi:10.1037/10001-000 · Cited by 12,120
Insensitivity to future consequences following damage to human prefrontal cortex
Bechara, A., Damasio, A. R., Damasio, H., & Anderson, S. W. (1994) · Cognition · doi:10.1016/0010-0277(94)90018-3 · Cited by 6,128
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604
Investigating Causal Relations by Econometric Models and Cross-Spectral Methods
Granger, C. W. J. (2010) · Essays in Econometrics · doi:10.1017/cbo9780511753978.002 · Cited by 4,762
Berti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371
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2 of the 123 references couldn’t be matched to a known paper.
Research works printed but not linked: 5
- Lange, C. G. Über Gemüstbewegungen. (Org. Om Sindsbevægelser) (Theodor Thomas, Leipzig, Germany, 1887).
- Kringelbach, M. L., O'Doherty, J., Rolls, E. T. & Andrews, C. Activation of the human orbitofrontal cortex to a liquid food stimulus is correlated with its subjective pleasantness. Cereb. Cortex 13, 1064–1071 (2003). · DOI · Paper page
- Hornak, J. et al. Changes in emotion after circumscribed surgical lesions of the orbitofrontal and cingulate cortices. Brain 126, 1671–1712 (2003). · DOI · Paper page
- Öngür, D. & Price, J. L. The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans. Cereb. Cortex 10, 206–219 (2000). An important paper proposing that, on neuroanatomical grounds, the orbitofrontal cortex should be considered along with the medial prefrontal cortex as a crucial sensory–visceromotor link for consummatory behaviours. · DOI · Paper page
- Brodmann, K. Neue Ergebnisse ueber die Vergleichende histologische Localisation der Grosshirnfinde mit besonderer Berucksichtigung des Stirnhirns. Anat. Anz. Suppl. 41, 157–216 (1912).
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Sorted by citations
How do you feel — now? The anterior insula and human awareness
(Bud) Craig, A. D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2555 · Cited by 6,657
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
The debate over dopamine’s role in reward: the case for incentive salience
Berridge, K. C. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0578-x · Cited by 2,347
Dissecting components of reward: ‘liking’, ‘wanting’, and learning
Berridge, K. C., Robinson, T. E., & Aldridge, J. W. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.014 · Cited by 1,942
Berridge, K. C., & Kringelbach, M. L. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.018 · Cited by 1,730
Self-citation
Metadata
- Authors
- Kringelbach, M. L.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Kringelbach, Morten L.
- Venue
- Nature Reviews Neuroscience
- Published
- 2005-09
- Volume
- 6
- Issue
- 9
- Pages
- 691-702
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2006819294
- Cited by
- 2,180
- References
- 123
- Citations by year
- 2026: 67 · 2025: 82 · 2024: 78 · 2023: 99 · 2022: 118 · 2021: 101 · 2020: 137 · 2019: 111 · 2018: 107 · 2017: 121 · 2016: 120 · 2015: 119 · 2014: 145 · 2013: 141 · 2012: 126
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- orbitofrontal cortex, hedonic experience, reward, food reward, sensory integration, decision-making, expectations, functional neuroanatomy
- MeSH terms
- Brain Mapping, Frontal Lobe, Humans, Magnetic Resonance Imaging, Philosophy, Reward
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