Cited by 845Eating Disorders and BehaviorsRegulation of Appetite and ObesityNutrition, Health and Food Behavior

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New insights into symptoms and neurocircuit function of anorexia nervosa

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Kaye, Walter H., Fudge, Julie L., Paulus, Martin·2009·Nature Reviews Neuroscience

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Abstract

Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.

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Authors: Kaye, W. H., Fudge, J. L., & Paulus, M.
Affiliations: University of California San Diego (US)
University of Rochester Medicine (US)
Corresponding author: Kaye, Walter H.
ORCID: Kaye, Walter H.
Fudge, Julie L.
Paulus, Martin
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2009-07-15
Volume: 10
Issue: 8
Pages: 573-584
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2682
PMC: PMC13038070
OpenAlex: W2067637201
Cited by: 843
References: 173
Citations by year: 2026: 38 · 2025: 37 · 2024: 38 · 2023: 38 · 2022: 45 · 2021: 47 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 59 · 2016: 57 · 2015: 52 · 2014: 58 · 2013: 77 · 2012: 45
FWCI: 6.52
Type: journal article
Language: en
Open access: green
pmc.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Louis and Harold Price Foundation
Wellcome Trust (066122)
U.S. Public Health Service (018307, 001894, 020687, 016663, 046001, 063291, 042984)
National Institute of Mental Health (R01MH063291)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords: anorexia nervosa, eating disorders, neurocircuitry, neurotransmitter systems, serotonin, dopamine, reward processing, interoception, insula, striatum, appetite regulation, neuroimaging
MeSH terms: Animals, Anorexia Nervosa, Brain, Brain Mapping, Diagnostic Imaging, Dopamine, Humans, Neural Pathways, Serotonin

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New insights into symptoms and neurocircuit function of anorexia nervosa

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