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New insights into symptoms and neurocircuit function of anorexia nervosa
Open accessAbstract
Individuals with anorexia nervosa have a relentless preoccupation with dieting and weight loss that results in severe emaciation and sometimes death. It is controversial whether such symptoms are secondary to psychosocial influences, are a consequence of obsessions and anxiety or reflect a primary disturbance of brain appetitive circuits. New brain imaging technology provides insights into ventral and dorsal neural circuit dysfunction - perhaps related to altered serotonin and dopamine metabolism - that contributes to the puzzling symptoms found in people with eating disorders. For example, altered insula activity could explain interoceptive dysfunction, and altered striatal activity might shed light on altered reward modulation in people with anorexia nervosa.
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“There are preclinical and human studies pointing at an implication of the serotonin (5HT) system dysfunction in a broad range of psychiatric diseases (Kaye, Fudge, & Paulus, 2009).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Kaye, Fudge, & Paulus, 2009
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“Interoceptive processing occurs across all major biological systems involved in maintaining bodily homeostasis, including the cardiovascular (9,10), pulmonary (11), gastrointestinal (12,13), genitourinary (14), nociceptive (15), chemosensory (16), osmotic (17), thermoregulatory (18), visceral1 (19), immune (20,21), and autonomic systems (22,23) (Table 1).”
From Interoception and Mental Health: A Roadmap. (2018) · cites this paper as [13]
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Metadata
- Authors
- Kaye, W. H., Fudge, J. L., & Paulus, M.
- Affiliations
- University of California San Diego (US)
- University of Rochester Medicine (US)
- Corresponding author
- Kaye, Walter H.
- Venue
- Nature Reviews Neuroscience
- Published
- 2009-07-15
- Volume
- 10
- Issue
- 8
- Pages
- 573-584
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC13038070
- OpenAlex
- W2067637201
- Cited by
- 843
- References
- 173
- Citations by year
- 2026: 38 · 2025: 37 · 2024: 38 · 2023: 38 · 2022: 45 · 2021: 47 · 2020: 49 · 2019: 58 · 2018: 43 · 2017: 59 · 2016: 57 · 2015: 52 · 2014: 58 · 2013: 77 · 2012: 45
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- green
- pmc.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Louis and Harold Price Foundation
- Wellcome Trust (066122)
- U.S. Public Health Service (018307, 001894, 020687, 016663, 046001, 063291, 042984)
- National Institute of Mental Health (R01MH063291)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- anorexia nervosa, eating disorders, neurocircuitry, neurotransmitter systems, serotonin, dopamine, reward processing, interoception, insula, striatum, appetite regulation, neuroimaging
- MeSH terms
- Animals, Anorexia Nervosa, Brain, Brain Mapping, Diagnostic Imaging, Dopamine, Humans, Neural Pathways, Serotonin
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