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Branching out: mechanisms of dendritic arborization
Open accessAbstract
Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.
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“Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [11]
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Cites
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009 · cited 1×
“These small GTPases also influence the dynamics and plus-end capture of microtubule”
BackgroundLee, T., & Luo, L. (1999) · Neuron · doi:10.1016/s0896-6273(00)80701-1 · Cited by 2,540 · cited 1×
“dar5 encodes a transferin-like factor and functions non-cell autonomously, whereas the other four function cell autonomously and regulate dendrite growth, as determined by studies using MARCM (mosaic analysis with a repressible cell marker”
Experience-dependent structural synaptic plasticity in the mammalian brain
Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934 · cited 1×
“, and NMDA ( N -methyl- D -aspartate) receptor-mediated signalling that affects dendrite organization in the somatosensory cortex during development and in the mature nervous syste”
BackgroundAdvances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Pyramidal neurons: dendritic structure and synaptic integration
Spruston, N. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2286 · Cited by 1,688 · cited 1×
“Second, the branching pattern and density of dendrites must be suitable for sampling and processing the signals that converge onto the dendritic fiel”
BackgroundIntellectual ability and cortical development in children and adolescents
Shaw, P., Greenstein, D., Lerch, J., Clasen, L., Lenroot, R., Gogtay, N., Evans, A., Rapoport, J., & Giedd, J. (2006) · Nature · doi:10.1038/nature04513 · Cited by 1,543
Long-term dendritic spine stability in the adult cortex
Grutzendler, J., Kasthuri, N., & Gan, W.-B. (2002) · Nature · doi:10.1038/nature01276 · Cited by 1,198 · cited 1×
“Extended time-lapse analyses of mouse cortical neurons have revealed that, following a period of juvenile plasticity during which neurons establish normal dendritic fields, dendrites become stable with most neurons maintaining their dendritic fields for the remainder of their lifespa”
BackgroundDrosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
Schmucker, D., Clemens, J. C., Shu, H., Worby, C. A., Xiao, J. Y., Muda, M., Dixon, J. E., & Zipursky, S. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80878-8 · Cited by 1,105 · cited 1×
“Extensive alternative splicing can potentially generate over 38,000 isoform”
BackgroundFunctional architecture of the mammalian retina
Wässle, H., & Boycott, B. B. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.2.447 · Cited by 1,093 · cited 1×
“First, a neuron's dendrites need to cover the area (its dendritic field ) that encompasses its sensory and/or synaptic input”
BackgroundNeuregulin 1 in neural development, synaptic plasticity and schizophrenia
Mei, L., & Xiong, W.-C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2392 · Cited by 1,030
Research works printed but not linked: 2
- Bestman, J., Silva, J. S. D. & Cline, H. T. in Dendrites (Eds G. Stuart, N. Spruston & M. Häusser) 69–94 (Oxford University Press, Oxford, 2008).
- Polleux, F. & Ghosh, A. in Dendrites (Eds G. Stuart, N. Spruston & M. Häusser) 95–115 (Oxford University Press, Oxford, 2008).
Cited by
Sorted by citations
Items 301–400 of 691
Molecular mechanisms of tiling and self-avoidance in neural development
Cameron, S., & Rao, Y. (2010) · Molecular Brain · doi:10.1186/1756-6606-3-28 · Cited by 24
“These interactions have been shown to play important roles in regulating a variety of processes such as axonal guidance, dendrite morphogenesis and synaptogenesis [ 1-3 ].”
BackgroundActin Aggregations Mark the Sites of Neurite Initiation
Zhang, S.-X., Duan, L., Qian, H., & Yu, X. (2016) · Neuroscience Bulletin · doi:10.1007/s12264-016-0012-2 · Cited by 27
Kitatani, Y., Tezuka, A., Hasegawa, E., Yanagi, S., Togashi, K., Tsuji, M., Kondo, S., Parrish, J. Z., & Emoto, K. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008942 · Cited by 24
Tempes, A., Węsławski, J., Brzozowska, A., & Jaworski, J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15010 · Cited by 24
“Mammalian hippocampal and cortical neurons and Drosophila larval dendritic arborization (da) neurons are the most widely used models (Corty, Matthews, & Grueber, 2009; Jan & Jan, 2010; Urbanska et al., 2008).”
BackgroundMethodCATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching
Feng, Z., Zhao, Y., Li, T., Nie, W., Yang, X., Wang, X., Wu, J., Liao, J., & Zou, Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108101 · Cited by 24
Chen, Y., Fu, W., Ip, J. P. K., Ye, T., Fu, A. K. Y., Chao, M. V., & Ip, N. Y. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1264-12.2012 · Cited by 23
“Dendrites serve as the primary sites on neurons for receiving information from their presynaptic partners, and the complexity of dendritic branching controls functional connectivity between neurons (Jan and Jan, 2003, 2010).”
BackgroundSalzberg, Y., Coleman, A. J., Celestrin, K., Cohen-Berkman, M., Biederer, T., Henis‐Korenblit, S., & Bülow, H. E. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006579 · Cited by 23
Liu, H., Sang, S., Lu, Y. F., Wang, Z., Yu, X., & Zhong, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-05476-w · Cited by 23
Lira, M., Arancibia, D., Orrego, P. R., Montenegro‐Venegas, C., Cruz, Y., García, J., Leal‐Ortiz, S., Godoy, J. A., Gundelfinger, E. D., Inestrosa, N. C., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1378-0 · Cited by 23
Distinct Relations of Microtubules and Actin Filaments with Dendritic Architecture
Nanda, S., Bhattacharjee, S., Cox, D. N., & Ascoli, G. A. (2020) · iScience · doi:10.1016/j.isci.2020.101865 · Cited by 23
“…arborization (da) neurons have proven to be an exceptionally powerful model for investigating these questions, revealing mechanistic underpinnings of numerous structural dynamics including tiling, remodeling, outgrowth and subtype-specific branching (Jan and Jan, 2010; Nanda et al., 2017).”
BackgroundConverging evidence does not support GIT1 as an ADHD risk gene
Klein, M., van der Voet, M., Harich, B., van Hulzen, K. J. E., Onnink, A. M. H., Hoogman, M., Guadalupe, T. M., Zwiers, M. P., Groothuismink, J. M., Verberkt, A., et al. (2015) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32327 · Cited by 23
“Drosophila class IV dendritic arborization (da) neurons are complex and provide a good model for studying dendritic morphology [Jan and Jan 2010].”
BackgroundHu, C., Kanellopoulos, A. K., Richter, M., Petersen, M., Konietzny, A., Tenedini, F. M., Hoyer, N., Cheng, L., Poon, C. L. C., Harvey, K. F., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1846-19.2020 · Cited by 20
“Shaping of dendritic branching relies on intrinsic and extrinsic control of cellular pathways that ultimately regulate cytoskeletal dynamics (Jan and Jan, 2010; Dong et al., 2015).”
BackgroundAntonacci, S., Forand, D., Wolf, M., Tyus, C., Barney, J., Kellogg, L., Simon, M. A., Kerr, G., Wells, K. L., Younes, S., et al. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.017327 · Cited by 22
“Dendritic morphogenesis is a critical step in nervous system development, learning, and memory such that dendritic defects are associated with myriad neurologic disorders such as autism, Alzheimer disease, and schizophrenia (Jan and Jan 2010; Kulkarni and Firestein 2012).”
BackgroundYasunaga, K.-I., Tezuka, A., Ishikawa, N., Dairyo, Y., Togashi, K., Koizumi, H., & Emoto, K. (2015) · Genes & Development · doi:10.1101/gad.262592.115 · Cited by 22
Geometric Theory Predicts Bifurcations in Minimal Wiring Cost Trees in Biology Are Flat
Kim, Y., Sinclair, R. M., Chindapol, N., Kaandorp, J. A., & Schutter, E. D. (2012) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002474 · Cited by 24
“Bifurcations are observed widely in nature [1], such as in dendrites and axons of neurons [2], plants [3], rivers, capillaries [4,5,6], bronchi and tracheal systems [7,8,9] and octo- and scleractinian corals [10,11].”
BackgroundSperandeo, A., Tamburini, C., Noakes, Z., de la Fuente, D. C., Keefe, F., Petter, O., Plumbly, W., Clifton, N. E., Li, M., & Peall, K. J. (2022) · Brain · doi:10.1093/brain/awac365 · Cited by 22
“37,38 Using sparse labelling of neurons with a GFP expression vector (Supplementary Fig.”
BackgroundFour‐dimensional analysis of nucleogenesis of the pontine nucleus in the hindbrain
Shinohara, M., Zhu, Y., & Murakami, F. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23353 · Cited by 23
Nano-volume drop patterning for rapid on-chip neuronal connect-ability assays
Petrelli, A., Marconi, E., Salerno, M., Tonelli, D. D. P., Berdondini, L., & Dante, S. (2013) · Lab on a Chip · doi:10.1039/c3lc50564b · Cited by 22
RIM3γ and RIM4γ Are Key Regulators of Neuronal Arborization
Álvarez‐Barón, E., Michel, K., Mittelstaedt, T., Opitz, T., Schmitz, F., Beck, H., Dietrich, D., Becker, A. J., & Schoch, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2229-12.2013 · Cited by 23
“Another factor equally important for neurite as well as Golgi morphogenesis is the regulation of cytoskeletal dynamics, as actin and microtubules are the major structural components underlying dendrite and axon as well as Golgi morphology (Jan and Jan, 2010; Poulain and Sobel, 2010).”
BackgroundCox, D. J., & Racca, C. (2013) · The Journal of Comparative Neurology · doi:10.1002/cne.23292 · Cited by 23
“It is known that there exists a strict correlation of dendrite number and branching with the function of a neuron and the geometry of the connections it receives (Jan and Jan, 2010; Branco and Hausser, 2010).”
BackgroundJacobs, S. A., Cheng, C., & Doering, L. C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.011 · Cited by 25
Nutrient‐dependent increased dendritic arborization of somatosensory neurons
Watanabe, K., Furumizo, Y., Usui, T., Hattori, Y., & Uemura, T. (2016) · Genes to Cells · doi:10.1111/gtc.12451 · Cited by 21
Sweet, E. S., Tseng, C., & Firestein, B. L. (2011) · BioArchitecture · doi:10.4161/bioa.1.2.15469 · Cited by 21
Theoretical Models of Neural Development
Goodhill, G. J. (2018) · iScience · doi:10.1016/j.isci.2018.09.017 · Cited by 19
“Once neurons have reached their destinations and become polarized, their axons grow over often long distances to find their appropriate targets (Dickson, 2002; Chédotal and Richards, 2010) and their dendrites often branch into highly elaborate tree structures (Jan and Jan, 2010).”
BackgroundChou, S.-M., Li, K., Huang, M., Chen, C., King, Y.-H. L., Li, G. G., Zhou, W., Teo, C. F., Jan, Y. N., Jan, L. Y., et al. (2021) · eLife · doi:10.7554/elife.58779 · Cited by 20
“BDNF plays a multifaceted role in the central nervous system, including promoting synaptogenesis, axonal guidance, dendrite outgrowth, and postnatal neurogenesis (Jan and Jan, 2010; Jeanneteau et al., 2010; Liu and Nusslock, 2018).”
BackgroundSelf-citationA two-step actin polymerization mechanism drives dendrite branching
Shi, R., Kramer, D. A., Chen, B., & Shen, K. (2021) · Neural Development · doi:10.1186/s13064-021-00154-0 · Cited by 19
The branching code: A model of actin-driven dendrite arborization
Stürner, T., Castro, A. F., Philipps, M., Cuntz, H., & Tavosanis, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110746 · Cited by 20
Neural precursor cells tune striatal connectivity through the release of IGFBPL1
Butti, E., Cattaneo, S., Bacigaluppi, M., Cambiaghi, M., Scotti, G. M., Brambilla, E., Ruffini, F., Sferruzza, G., Ripamonti, M., Simeoni, F., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-35341-y · Cited by 22
“1e – g) compared to control mice 25,26 .”
Input density tunes Kenyon cell sensory responses in the Drosophila mushroom body
Ahmed, M., Rajagopalan, A. E., Pan, Y., Li, Y., Williams, D. L., Pedersen, E. A., Thakral, M., Previero, A., Close, K. C., Christoforou, C. P., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.05.064 · Cited by 24
“100 In our experiments, we ectopically expressed a single Dscam1 [TM1] isoform, which traffics to dendrites, across all KCs. 103 In this condition, elongating dendritic neurites of KCs might experience a terrain similar to that encountered by the train Tootle when he jumps off the tracks: everywhere…”
BackgroundDystroglycan controls dendritic morphogenesis of hippocampal neurons in vitro
Bijata, M., Włodarczyk, J., & Figiel, I. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00199 · Cited by 20
“Appropriate dendritic branching is driven by numerous extracellular signals, including neurotrophic factors, cell adhesion molecules, and neuronal activity, which lead to changes in cytoskeletal organization (Jan and Jan, 2010; Arikkath, 2012).”
Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins
Ghiretti, A. E., & Paradis, S. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.05.003 · Cited by 20
Control of Dendritic Morphogenesis by Trio in Drosophila melanogaster
Shivalkar, M., & Giniger, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033737 · Cited by 20
“Extensive research in vertebrates and in Drosophila has revealed a variety of molecules that influence different features of dendritic morphogenesis [1,2,3].”
BackgroundDu, Y., Ge, M.-M., Xue, W., Yang, Q., Wang, S., Xu, Y., & Wang, H.-L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138112 · Cited by 20
“It has been demonstrated that NDR plays an essential role in dendrite maintenance[29].”
BackgroundYin, J., Gibbs, M., Long, C., Rosenthal, J., Kim, H. S., Kim, A., Sheng, C., Ding, P., Javed, U., & Yuan, Q. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.016 · Cited by 17
“This is an open access article under the CC BY-N (Dong et al., 2015; Jan and Jan, 2010; Yin and Yuan, 2015).”
Spontaneous Differentiation of Human Neural Stem Cells on Nanodiamonds
Taylor, A. C., González, C. H., Ferretti, P., & Jackman, R. B. (2019) · Advanced Biosystems · doi:10.1002/adbi.201800299 · Cited by 20
Learning in the machine: To share or not to share?
Ott, J., Linstead, E. J., LaHaye, N., & Baldi, P. (2020) · Neural Networks · doi:10.1016/j.neunet.2020.03.016 · Cited by 22
Jia, D., Fujishita, Y., Li, C., Todo, Y., & Dai, H. (2020) · Electronics · doi:10.3390/electronics9050792 · Cited by 20
FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons
Machamer, J. B., Woolums, B. M., Fuller, G. G., & Lloyd, T. E. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.037 · Cited by 19
“…that have stereotyped development of neuronal projections that have been extensively used to study neuronal development and function (Jan and Jan, 2010) in addition to neurodegeneration (Lee et al., 2011), due to their morphological complexity, experimental accessibility and genetic…”
Fraga, D. B., Camargo, A., Olescowicz, G., Padilha, D. A., Mina, F., Budni, J., Brocardo, P. S., & Rodrigues, A. L. S. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00743-2 · Cited by 19
Pesaola, F. N., Quassollo, G., Venier, A. C., Paul, A. L. D., de Halac, I. N., & Bisbal, M. (2021) · Biology of the Cell · doi:10.1111/boc.202000016 · Cited by 19
“The implications of ELS dynamics in the development of the dendritic tree have been widely described (Jan and Jan, 2010).”
BackgroundInfluence of Isoflurane on Neuronal Death and Outcome in a Rat Model of Traumatic Brain Injury
Hertle, D. N., Beynon, C., Zweckberger, K., Vienenkötter, B., Jung, C. S., Kiening, K. L., Unterberg, A. W., & Sakowitz, O. W. (2012) · Acta neurochirurgica. Supplementum · doi:10.1007/978-3-7091-0956-4_74 · Cited by 19
The Pseudophosphatase MK-STYX Induces Neurite-Like Outgrowths in PC12 Cells
Flowers, B. M., Rusnak, L., Wong, K. E., Banks, D. A., Munyikwa, M. R., McFarland, A. G., & Hinton, S. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114535 · Cited by 22
“When primary neurites (extension connected to the cell body) divide further, this process is referred to as ‘‘branching out’’ [41].”
BackgroundSex hormones and proteins involved in brain plasticity
Camacho‐Arroyo, I., Piña-Medina, A. G., Bello‐Alvarez, C., & Zamora-Sánchez, C. J. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2020.04.002 · Cited by 21
Furusawa, K., & Emoto, K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.613320 · Cited by 19
“…extensive plasticity in which connectivity can be modified in response to neural inputs and/or hormonal regulation (Parrish et al., 2007a; Jan and Jan, 2010; Emoto, 2011; Batista and Hensch, 2019; Frontiers in Cellular Neuroscience | www.frontiersin.org 1 January 2021 | Volume 14 | Article…”
BackgroundStructural, Functional, and Genetic Changes Surrounding Electrodes Implanted in the Brain
Gupta, B., Saxena, A., Perillo, M. L., Wade-Kleyn, L. C., Thompson, C. H., & Purcell, E. K. (2024) · Accounts of Chemical Research · doi:10.1021/acs.accounts.4c00057 · Cited by 19
Assessment of Hippocampal Dendritic Complexity in Aged Mice Using the Golgi-Cox Method
Groves, T. R., Wang, J., Boerma, M., & Allen, A. R. (2017) · Journal of Visualized Experiments · doi:10.3791/55696 · Cited by 21
Neuroprotective Activity of p DING in Response to HIV ‐1 Tat
Darbinian, N., Khalili, K., & Amini, S. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24392 · Cited by 18
“…enhancer factor 2 (MEF2) to multiple signaling pathways, including neuronal cells survival, neuronal differentiation, and synapse development (Zhao et al., 1999; McKinsey et al., 2002; Shalizi and Bonni, 2005; Flavell and Greenberg, 2008; Finegan et al., 2009; Jan and Jan, 2010; Tian et al., 2010).”
BackgroundPowell, G. L., Gaddy, J. L., Xu, F., Fregosi, R. F., & Levine, R. B. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22379 · Cited by 18
Zhang, Y., Sung, H.-H., Ziegler, A. B., Wu, Y., Viais, R., Sánchez-Huertas, C., Kilo, L., Agircan, F. G., Cheng, Y.-J., Mouri, K., et al. (2024) · Journal of Cell Science · doi:10.1242/jcs.261512 · Cited by 17
Copf, T. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2014.07.002 · Cited by 17
Lauterborn, J. C., Kramár, E. A., Rice, J. D., Babayan, A. H., Cox, C. D., Karsten, C. A., Gall, C. M., & LYNCH, G. S. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw088 · Cited by 17
LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice
Gao, T., Wang, Y., Liu, L., Wang, J., Wang, Y., Guan, W., Chen, T., Zhao, J., & Jiang, B. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa067 · Cited by 17
“Development of neuronal networks is a multistep process consisting of primary neurite formation, axon and dendrite specification, neurite extension and arborization, and spine formation and maturation (Scott and Luo, 2001; Whitford et al., 2002; Jan and Jan, 2010).”
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Laule, C. F., & Rahmouni, K. (2024) · Comprehensive physiology · doi:10.1002/cph4.8 · Cited by 19
Wnt5 and Drl/Ryk Gradients Pattern theDrosophilaOlfactory Dendritic Map
Wu, Y., Helt, J.-C. P., Wexler, E., Petrova, I. M., Noordermeer, J. N., Fradkin, L. G., & Hing, H. K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2676-14.2014 · Cited by 20
“Indeed, the proper targeting of dendrites is important for the development and function of the nervous system (Corty et al., 2009; Jan and Jan, 2010).”
BackgroundÖzsoy, Ş., Vujovic, F., Simonian, M. R., Valova, V. A., Hunter, N., & Farahani, R. H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108942 · Cited by 16
The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning
Tang, L. T. H., Trivedi, M., Freund, J. R., Salazar, C. J., Ramírez-Suárez, N. J., Lee, G. A., Rahman, M., Wang, Y., Grant, B. D., & Bülow, H. E. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009475 · Cited by 17
“Third, the often elaborately sculpted dendrites, a neuron’s receiving cellular structures, are patterned by dedicated pathways that originate from different tissues and act both cellautonomously and non-autonomously [5-7].”
BackgroundGatford, N. J. F., Deans, P. J. M., Duarte, R. R. R., Chennell, G., Sellers, K. J., Raval, P., & Srivastava, D. P. (2021) · Human Molecular Genetics · doi:10.1093/hmg/ddab277 · Cited by 16
“In mature neurons, axo-dendritic structure is an essential aspect of neuronal function as this is a defining component of neural network connectivity (1).”
BackgroundInfluentialWang, Y., Ding, Z., Cheng, Y.-J., Chien, C., & Huang, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.577315 · Cited by 13
“We also examined stabilized microtubules by performing immunostaining for the microtubule-associated protein Futsch, the Drosophila ortholog of MAP1B in human (Hummel et al., 2000; Roos et al., 2000; Jinushi-Nakao et al., 2007).”
MethodYajima, H., Amano, I., Ishii, S., Sadakata, T., Miyazaki, W., Takatsuru, Y., & Koibuchi, N. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.629100 · Cited by 16
“Appropriate dendrite development represents a key element in generating neuronal networks required for normal brain function (21).”
BackgroundBagley, J. A., Yan, Z., Zhang, W., Wildonger, J., Jan, L. Y., & Jan, Y. N. (2014) · Genes & Development · doi:10.1101/gad.239962.114 · Cited by 16
“One idea posits that neuron subtype-specific morphology arises from expression of specific combinations of molecules (Jan and Jan 2010).”
BackgroundSelf-citationPrimary Postnatal Dorsal Root Ganglion Culture from Conventionally Slaughtered Calves
Fadda, A., Bärtschi, M., Hemphill, A. F., Widmer, H. R., Zurbriggen, A., Perona, P., Vidondo, B., & Oevermann, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168228 · Cited by 15
“Although the present study investigated in vitro cultures of neurons in absence of target tissue as seen in vivo, our results show that the number of branching neurites is proportional to the number of non-dividing terminal branches produced by a neuron at any time point indicating that branching activity remains cons…”
BackgroundResultGoikolea-Vives, A., & Stolp, H. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158220 · Cited by 15
“Interestingly, it appears that dendrite maturation and expression of behavioural symptoms of some neurodevelopmental disorders are temporally correlated [41].”
BackgroundNguyen, C., & Thompson-Peer, K. L. (2021) · Neuroinformatics · doi:10.1007/s12021-021-09532-9 · Cited by 15
“Drosophila da neurons are categorized based on gene expression and morphology of their dendritic arbors, which vary in branching complexity across different classes (Jan & Jan, 2010).”
BackgroundHuber, N., Hoffmann, D. B., Giniatullina, R., Rostalski, H., Leskelä, S., Takalo, M., Natunen, T., Solje, E., Remes, A. M., Giniatullin, R. A., et al. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105584 · Cited by 17
“The dendritic morphology of neurons has important functional implications in determining which signals the neurons receive and how these signals are integrated (Jan and Jan, 2010), suggesting that branching deficits lead to disturbed neuronal communication.”
BackgroundInhibition of CDKL3 downregulates STAT1 thus suppressing prostate cancer development
Jiang, Q., Li, J., Wang, J., & Zhang, W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05694-3 · Cited by 15
“Early studies have shown that lossof CDKL3 function can lead to abnormal brain function by affecting neuronal process morphological development [19].”
BackgroundTat, L., Cannizzaro, N., Schaaf, Z. A., Racherla, S., Bottiglieri, T., Green, R., & Zarbalis, K. S. (2023) · Communications Biology · doi:10.1038/s42003-023-05492-9 · Cited by 19
“The complexity of dendritic arbors can be a proxy for neuronal circuit complexity and signi fi cant changes may be associated with neuronal dysfunction 50 – 52 .”
Characterisation of neurons derived from a cortical human neural stem cell line CTX0E16
Anderson, G. W., Deans, P. J. M., Taylor, R. D. T., Raval, P., Chen, D., Lowder, H., Murkerji, S., Andreae, L. C., Williams, B. P., & Srivastava, D. P. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0136-8 · Cited by 15
“It is now well-established that neuronal activity is a crucial modulator of neurodevelopment [43, 44, 53], and has a profound effect on neurite outgrowth as well as on dendritic and axonal formation and branching [44, 53, 54].”
BackgroundRegulatory mechanisms underlying the differential growth of dendrites and axons
Wang, X., Sterne, G. R., & Ye, B. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1447-3 · Cited by 15
“Second, the existence of transcriptional programs that differentially regulate dendrite and axon development also supports the notion that the differential growth phase is controlled by de novo mechanisms and not simply by the cell-biological differences established during the specifi cation phase([8-13]).”
Griener, A., Dyck, J. R. B., & Gosgnach, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.070 · Cited by 15
Receptor tyrosine phosphatase CLR-1 acts in skin cells to promote sensory dendrite outgrowth
Liu, X., Wang, X., & Shen, K. (2016) · Developmental Biology · doi:10.1016/j.ydbio.2016.03.001 · Cited by 15
Schulz, J., Franke, K., Frick, M., & Schumacher, S. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13735 · Cited by 15
Park, J. H., Chung, C. G., Seo, J., Lee, B., Lee, Y., Kweon, J. H., & Lee, S. B. (2020) · PubMed Central · doi:10.14348/molcells.2020.0130 · Cited by 15
“The usefulness of the C4 da neuronal system stems from its sharing similar mechanisms for dendritic arborization with mammalian neurons and its amenability to in vivo single cell imaging (Jan and Jan, 2010; Kweon et al., 2017).”
Fujishima, K., Kurisu, J., Yamada, M., & Kengaku, M. (2020) · Development · doi:10.1242/dev.194530 · Cited by 14
Reese, B. E., Keeley, P. W., Lee, S., & Whitney, I. E. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20903 · Cited by 15
Imaging circuit formation in zebrafish
Nikolaou, N., & Meyer, M. P. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20874 · Cited by 15
Lovick, J. K., Kong, A., Omoto, J. J., Ngo, K., Younossi‐Hartenstein, A., & Hartenstein, V. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22325 · Cited by 15
Pcdh11x Negatively Regulates Dendritic Branching
Wu, C., Niu, L., Yan, Z., Wang, C., Liu, N., Dai, Y., Zhang, P., & Xu, R. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0515-8 · Cited by 15
Taniguchi, H., & Moore, A. W. (2014) · BioEssays · doi:10.1002/bies.201400087 · Cited by 17
“as important as the outcome of genetic interactions between multiple loci [73, 74].”
BackgroundGolgi during DevelopmentPreprint
Zhong, W. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005363 · Cited by 14
“Jan and colleagues used forward genetic screens in Drosophila to isolate mutants defective in dendrite development focusing on a class of neurons, class IV da neurons, that are morphologically similar to mammalian neurons (reviewed in Jan and Jan 2010).”
BackgroundEndocannabinoid markers in autism spectrum disorder: A scoping review of human studies
Pol, M. D., & Kolla, N. J. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114256 · Cited by 15
PP2A phosphatase regulates cell-type specific cytoskeletal organization to drive dendrite diversity
Bhattacharjee, S., Lottes, E. N., Nanda, S., Golshir, A., Patel, A. A., Ascoli, G. A., & Cox, D. N. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.926567 · Cited by 13
“In Drosophila melanogaster, TFs act both individually and in a combinatorial fashion to give rise to subtype-specific dendritic architecture in larval multidendritic (md) sensory neurons (Grueber et al., 2003; Li et al., 2004; Sugimura et al., 2004; Parrish et al., 2006; Hattori et al., 2007, 2013; Jan and Jan, 2010;…”
BackgroundSculpting the dendritic landscape: Actin, microtubules, and the art of arborization
Ouzounidis, V. R., Prevo, B., & Cheerambathur, D. K. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102214 · Cited by 14
Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X
Mossa, A., Dierdorff, L., Lukin, J., García-Forn, M., Wang, W., Mamashli, F., Park, Y., Fiorenzani, C., Akpinar, Z., Kamps, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59680-8 · Cited by 17
“Importantly, dendritic growth, de novo synapse formation, and synapse maturation continue to be plastically reshaped during post-natal periods, including in response to experience 84 – 86 , thus offering a more feasible window for therapeutic intervention.”
The Lamellar Structure of the Brain Fiber Pathways
Galinsky, V. L., & Frank, L. R. (2016) · Neural Computation · doi:10.1162/neco_a_00896 · Cited by 14
Neurodegeneration, Neuroregeneration, and Neuroprotection in Psychiatric Disorders
Tang, S. W., Helmeste, D. M., & Leonard, B. E. (2017) · Modern trends in psychiatry · doi:10.1159/000470811 · Cited by 15
Tumor suppressor protein CYLD regulates morphogenesis of dendrites and spines
Li, J., Sekine‐Aizawa, Y., Ebrahimi, S., Tanaka, S., & Okabe, S. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14421 · Cited by 14
“Development of dendritic arborization is determined by cell autonomous factors and influences of extracellular signaling mechanisms (De La Torre‐Ubieta & Bonni, 2011; Jan & Jan, 2010; Puram & Bonni, 2013; Urbanska, Blazejczyk, & Jaworski, 2008; Valnegri, Puram, & Bonni, 2015).”
BackgroundAlizzi, R. A., Xu, D. C., Tenenbaum, C. M., Wang, W., & Gavis, E. R. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1009235 · Cited by 14
“The execution of dendrite branching relies on cell biological processes integral to the neuron including membrane trafficking and cytoskeletal dynamics [1,2].”
BackgroundGrubisha, M. J., Sun, T., Eisenman, L. R., Erickson, S. L., Chou, S., Helmer, C., Trudgen, M. T., Ding, Y., Homanics, G. E., Penzes, P., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2022546118 · Cited by 14
“Among the genes found to influence dendritic morphogenesis (16, 28) is Kalrn .”
Li, Q., Zhang, Y., Zou, J., Qi, F., Yang, J., Yuan, Q., & Yao, Z. (2015) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1056954 · Cited by 15
“Accumulating evidence has indicated that dendritic growth is remarkably dynamic and responsive to environmental signals.(21,22) Dendrites grow through a multistage process of extension and branching.”
BackgroundKanaoka, Y., Skibbe, H., Hayashi, Y., Uemura, T., & Hattori, Y. (2019) · Genes to Cells · doi:10.1111/gtc.12700 · Cited by 14
“Previous studies showed that dendritic morphology of class IV neurons is regulated by both genetic and environmental factors (Dong, Shen, & Bülow, 2015; Jan & Jan, 2010; Valnegri, Puram, & Bonni, 2015; Watanabe, Furumizo, Usui, Hattori, & Uemura, 2017; Yang & Chien, 2019).”
BackgroundEOM Pulleys and Sequelae: A Critical Review
Miller, J. M. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-28156 · Cited by 14
Extrinsic Factors Regulating Dendritic Patterning
Lin, T., Chen, P., Yu, H., Hsu, C., & Lee, C. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.622808 · Cited by 14
“In addition, stereotypical dendritogenesis sites on aCC neurons are well suited for investigating the molecular mechanisms that control selection of dendritic branch points (Kamiyama et al., 2015).”
BackgroundA-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors
Samelson, B. K., Gore, B. B., Whiting, J. L., Nygren, P. J., Purkey, A., Colledge, M., Langeberg, L. K., Dell’Acqua, M. L., Zweifel, L. S., & Scott, J. D. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.637470 · Cited by 14
“the postsynaptic densities of mature neurons (1-3).”
Nanda, S., Das, R., Cox, D. N., & Ascoli, G. A. (2017) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-52067-4_1 · Cited by 13
Rapid cell type-specific nascent proteome labeling in Drosophila
Villalobos-Cantor, S., Barrett, R. M., Condon, A. F., Arreola-Bustos, A., Rodriguez, K. M., Cohen, M. S., & Martin, I. (2023) · eLife · doi:10.7554/elife.83545 · Cited by 13
Mukherjee, A., Jeske, Y. A., Bécam, I., Taïeb, A., Brooks, P. S., Aouad, J., Monguillon, C., & Conduit, P. T. (2024) · Journal of Cell Science · doi:10.1242/jcs.261534 · Cited by 13
Huang, Y. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1038711 · Cited by 13
Types and density of calbindin D28k-immunoreactive ganglion cells in mouse retina
Gu, Y.-N., Lee, E.-S., & Jeon, C. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2016.02.001 · Cited by 13
Chen, Y., Huang, Y., Ho, C. T., Yang, J.-M., Chao, J., Li, M., & Hwang, E. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01389 · Cited by 14
Clinical and Neurobiological Aspects of TAO Kinase Family in Neurodevelopmental Disorders
Hu, C., Feng, P., Yang, Q., & Xiao, L. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.655037 · Cited by 13
“…at whole larval developmental stages and in adults (Hu et al., 2020). da sensory neurons are a well-characterized model system to study neuronal development and functions (Grueber et al., 2002; Williams and Truman, 2004; Shimono et al., 2009; Jan and Jan, 2010; Im and Galko, 2012; Copf, 2015).”
Background
Metadata
- Authors
- Jan, Y.-N., & Jan, L. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 316-328
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3079328
- OpenAlex
- W2065943966
- Cited by
- 693
- References
- 162
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 24 · 2023: 29 · 2022: 33 · 2021: 41 · 2020: 71 · 2019: 41 · 2018: 45 · 2017: 49 · 2016: 52 · 2015: 38 · 2014: 58 · 2013: 53 · 2012: 53
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (R01MH084234)
- National Institute of Neurological Disorders and Stroke (R37NS040929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- dendritic branching, dendrite morphogenesis, dendritic morphology, Drosophila melanogaster, transcription factors, ligand-receptor interactions, signaling pathways, local translation, cytoskeleton, endosomes, autism spectrum disorder, neurodevelopmental disorders, neural circuits
- MeSH terms
- Animals, Axons, Dendrites, Humans, Models, Neurological, Morphogenesis, Neurons, Signal Transduction
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