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Branching out: mechanisms of dendritic arborization
Open accessAbstract
Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.
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“Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [11]
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Makhijani, K., & Brückner, K. (2012) · Cited by 1
Membrane Trafficking Mechanisms: Exocytosis and Endocytosis in Dendrites
Winckler, B. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_4 · Cited by 1
Data-oriented neuron classification from their parts
Cervantes, E. P., Comin, C. H., Junior, R. M. C., & Costa, L. D. F. (2016) · IEEE International Conference on eScience · doi:10.1109/escience.2016.7870905 · Cited by 2
Mechanoreceptors in Drosophila melanogaster
Liang, X., Sun, L., & Liu, Z. (2017) · SpringerBriefs in biochemistry and molecular biology · doi:10.1007/978-981-10-6526-2_3 · Cited by 1
Neuronal Fat and Dendrite Morphogenesis: The Goldilocks Effect
Sundararajan, L., & Miller, D. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.02.011 · Cited by 1
Cline, H. T., Ghosh, A., Jan, Y. N., & Sanes, J. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-385870-2.00020-2 · Cited by 1
Self-citationA biomimetic branching signal-passing tile assembly model with dynamic growth and disassembly
Fu, D., & Reif, J. H. (2024) · Journal of The Royal Society Interface · doi:10.1098/rsif.2023.0755
Nutritional Adaptation and Microbes: Insights From Drosophila
Hattori, Y. (2024) · ZOOLOGICAL SCIENCE · doi:10.2108/zs240057 · Cited by 1
“Cell-autonomous and non-autonomous genetic mechanisms of dendritic morphogenesis in C4da neurons have been studied (Jan and Jan, 2010; Dong et al., 2015; Valnegri et al., 2015).”
Individual lipid alterations at the origin of neuronal Ceramide Synthase defects
Ziegler, A. B., Wesselmann, C., Beckschäfer, K., Wulf, A., Dhiman, N., Soba, P., Thiele, C., Bauer, R., & Tavosanis, G. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011880 · Cited by 1
Soba, P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_8 · Cited by 1
Balancing Dendrite Morphogenesis and Neuronal Migration during Cortical Development
Meltzer, S., & Chen, C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2425-16.2016 · Cited by 1
Campana, M. E. (2012) · Cited by 1
Sheng, C., Javed, U., Rosenthal, J., Yin, J., Qin, B., & Yuan, Q. (2019) · Journal of Visualized Experiments · doi:10.3791/60287 · Cited by 1
CPB-3 and CGH-1 localize to motile particles within dendrites in C. elegans PVD sensory neurons
Spendier, K., Olesnicky, E. C., Forand, D., Wolf, M., & Killian, D. J. (2021) · BMC Research Notes · doi:10.1186/s13104-021-05730-5 · Cited by 1
“The proper development and maintenance of dendritic branches is important for sensory perception, learning, memory, and behavior, and defects in dendrite development are associated with several neurological disorders [1, 2].”
BackgroundBhattacharjee, S., Iyer, E. P. R., Iyer, S. C., Nanda, S., Rubaharan, M., Ascoli, G. A., & Cox, D. N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076344 · Cited by 1
“Studies using this model system have revealed numerous insights into the complex intrinsic and extrinsic regulatory mechanisms underlying cell type-specific dendrite development, including dendritic outgrowth, branching, maintenance, scaling, and tiling [3,5,16].”
MethodThe Effects of Chronic Stress on Neuroanatomy and Cognitive Function
Viradia, N., Paredes, J. M. G., & Hassan, S. A. (2022) · Scholarly Research In Progress · doi:10.64057/001c.142181
“Chronic stress in the basolateral amygdala is also correlated to increased dendritic arborization and spine density in neurons, alongside increased levels of glucocorticoid levels in the blood (29).”
Roles of the Nedd4 Family E3 Ligases in Glial Function and Nerve Cell Development
Altas, B. (2017) · doi:10.53846/goediss-6288 · Cited by 1
Sundararajan, L., Smith, C. J., Watson, J. D., Millis, B. A., Tyska, M. J., & Miller, D. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/492769 · Cited by 1
Goldman, J. S., & Kennedy, T. E. (2011) · Wiley eBooks · doi:10.1002/9781118015759.ch22 · Cited by 1
Fujishima, K., Kurisu, J., Yamada, M., & Kengaku, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.14.945188 · Cited by 1
Chen, Y., Huang, Y., Ho, C. T., Yang, J., Chao, J., Li, M., & Hwang, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.12.196675 · Cited by 1
“play important roles in regulating the processes of axon guidance (Dickson, 2002), axonal/dendritic development (Jan and Jan, 2003), branching (Jan and Jan, 2010; McAllister, 2000), and many others.”
BackgroundNanda, S., Bhattacharjee, S., Cox, D. N., & Ascoli, G. A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.24.529978 · Cited by 1
Saleev, N., Getselter, D., Bartman, J., Gutman, R., Marco, A., & Elliott, E. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.07.588459 · Cited by 1
Quainoo, E., & Gan, L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00056-6 · Cited by 1
“Mitotic” kinesin-5 is a dynamic brake for axonal growthPreprint
Lu, W., Lee, B. S., Deng, H. X. Y., Lakonishok, M., Martı́n-Blanco, E., & Gelfand, V. I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.12.612721 · Cited by 1
“…sNext, we examined the neuronal locali ‐ zation of these transgenes in two types of highly polarized neurons, mushroom body neurons (Figure 4C) and class IV dendritic ar ‐ borization (da) neurons (Figure 4G), both of which have well ‐ characterized axonal and dendritic compartments [55, 56].”
BackgroundOuyang, X., Sutradhar, S., Trottier, O., Shree, S., Yu, Q., Tu, Y., & Howard, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.24.639873 · Cited by 1
“This will be important when relating molecular and genetic processes underlying branching and growth to the phenotypic properties of morphologies (Jan and Jan, 2010; Lefebvre, 2021).”
Influential
Metadata
- Authors
- Jan, Y.-N., & Jan, L. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 316-328
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3079328
- OpenAlex
- W2065943966
- Cited by
- 693
- References
- 162
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 24 · 2023: 29 · 2022: 33 · 2021: 41 · 2020: 71 · 2019: 41 · 2018: 45 · 2017: 49 · 2016: 52 · 2015: 38 · 2014: 58 · 2013: 53 · 2012: 53
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (R01MH084234)
- National Institute of Neurological Disorders and Stroke (R37NS040929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- dendritic branching, dendrite morphogenesis, dendritic morphology, Drosophila melanogaster, transcription factors, ligand-receptor interactions, signaling pathways, local translation, cytoskeleton, endosomes, autism spectrum disorder, neurodevelopmental disorders, neural circuits
- MeSH terms
- Animals, Axons, Dendrites, Humans, Models, Neurological, Morphogenesis, Neurons, Signal Transduction
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