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Branching out: mechanisms of dendritic arborization
Open accessAbstract
Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.
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“Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [11]
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The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance.
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“Moreover, trans-heterozygous flies carrying one mutant copy of a PcG gene and one mutant copy of a Hippo core complex gene display the same dendrite phenotype: the dendrites initially grow and tile normally, but the dendritic fields are not maintained, leading to progressive loss of dendrite branches and large gaps in…”
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Self-citationA Centrosomal Cdc20-APC Pathway Controls Dendrite Morphogenesis in Postmitotic Neurons
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“melanogaster antennal lobe, Semaphorin 1A ( SEMA1A ) is expressed in a graded fashion along the dendrites of projection neurons and functions as a receptor for an as yet unknown ligand that targets these dendrites to the appropriate glomerul”
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“melanogaster homologue of the mammalian aryl hydrocarbon (dioxin) receptor (AHR), Spineless , is expressed in all four classes of dendritic arborization neurons and is essential for the diversification of their dendrite pattern”
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“In early cortical development, coordination of radial migration of mammalian pyramidal neurons is dependent on the Rho family of small GTPases, with the leading process becoming the apical dendrit”
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Self-citationA glimmer of light for neuropsychiatric disorders
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“In addition, the non-canonical Wnt pathway involving catenins and Rac may promote dendrite growth and branchin”
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The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo
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“melanogaster motor neurons do not seem to rely on homotypic repulsion for their placement; these dendrites map myotopically along the antero-posterior axis and the medio-lateral axis, directed by guidance cues and their respective receptors such as Slit–Robo and Netrin–Frazzled for dendritic targetin”
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“Mutation of PcG genes produces phenotypes of impaired dendrite maintenanc”
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“TORC2 components associate physically with the TRC protein and their respective genes interact, suggesting that these proteins act in the same pathway that regulates tilin”
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“melanogaster , the Robo receptor and its ligand, Slit, which is a secreted protein, promote dendrite formation of the motor neurons RP3 and aC”
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“melanogaster motor neurons do not seem to rely on homotypic repulsion for their placement; these dendrites map myotopically along the antero-posterior axis and the medio-lateral axis, directed by guidance cues and their respective receptors such as Slit–Robo and Netrin–Frazzled for dendritic targetin”
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“melanogaster motor neurons do not seem to rely on homotypic repulsion for their placement; these dendrites map myotopically along the antero-posterior axis and the medio-lateral axis, directed by guidance cues and their respective receptors such as Slit–Robo and Netrin–Frazzled for dendritic targetin”
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ネズミのスタウフェン1に対する機能消失対立遺伝子は,樹状突起のStaufen1‐RNP配送や樹状突起棘の形態形成の障害を誘導する
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Flagged first, then by citations
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“Besides, a slightly morphological difference can lead to the notable functional discrepancy, playing a role in filters to determine the types of signals that single neurons receive and the way used to integrate the signals [27].”
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“The molecular mechanisms that regulate the tiling of bipolar cell arbors are unknown, but studies elucidating the signaling mechanisms that drosophila sensory neurons use to populate the larval body wall may be instructive (Emoto et al., 2004; Jan and Jan, 2010).”
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“…neurons mature through a prolonged and sophisticated process that involves dramatic morphological and functional changes in individual neurons as well as formation of synaptic connections between neurons to build intricate neural circuits (Barnes and Polleux 2009; Jan and Jan 2010; Rasband 2010).”
Background
Metadata
- Authors
- Jan, Y.-N., & Jan, L. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 316-328
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3079328
- OpenAlex
- W2065943966
- Cited by
- 693
- References
- 162
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 24 · 2023: 29 · 2022: 33 · 2021: 41 · 2020: 71 · 2019: 41 · 2018: 45 · 2017: 49 · 2016: 52 · 2015: 38 · 2014: 58 · 2013: 53 · 2012: 53
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (R01MH084234)
- National Institute of Neurological Disorders and Stroke (R37NS040929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- dendritic branching, dendrite morphogenesis, dendritic morphology, Drosophila melanogaster, transcription factors, ligand-receptor interactions, signaling pathways, local translation, cytoskeleton, endosomes, autism spectrum disorder, neurodevelopmental disorders, neural circuits
- MeSH terms
- Animals, Axons, Dendrites, Humans, Models, Neurological, Morphogenesis, Neurons, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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