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Branching out: mechanisms of dendritic arborization
Open accessAbstract
Type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated. During the past two decades, studies on dendritic arborization neurons in Drosophila melanogaster have started to identify mechanisms of dendrite morphogenesis that may have broad applicability to vertebrate species. Transcription factors, receptor-ligand interactions, various signalling pathways, local translational machinery, cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry. Further insight into these mechanisms will improve our understanding of how the nervous system functions and might help to identify the underlying causes of some neurological and neurodevelopmental disorders.
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“Dendritic morphogenesis, synaptogenesis and continued activity-dependent remodelling of synaptic connections are critical for the development and maintenance of functional neuronal networks.11, 12, 13, 14, 15”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [11]
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BackgroundSantiago, N. A., He, B., Howard, S. L., Beaudin, S. A., Strupp, B. J., & Smith, D. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.16.549215 · Cited by 14
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“The plasticity of dendrites plays an important role in the formation of neural circuits (Nudo, 2006; Jan and Jan, 2010; Gidon and Segev, 2012; Wu et al., 2015).”
BackgroundJausoro, I., & Marzolo, M. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24688 · Cited by 11
“…require cytoskeletal and membrane rearrangements (Arimura & Kaibuchi, 2007; Caceres et al., 2012; de Curtis, 2008; GonzalezBillault et al., 2012; Govek, Newey, & Van Aelst, 2005; Jan & Jan, 2003, 2010; Luo, 2000; Luo, Jan, & Jan, 1997; Ng & Luo, 2004; Ng et al., 2002; Zhao, Qi, Li, & Xu, 2012).”
Kanaoka, Y., Onodera, K., Watanabe, K., Hayashi, Y., Usui, T., Uemura, T., & Hattori, Y. (2022) · eLife · doi:10.7554/elife.79461 · Cited by 11
c-Abl Tyrosine Kinase Is Required for BDNF-Induced Dendritic Branching and Growth
Chandía-Cristi, A., Stuardo, N., Trejos, C., Leal, N. R., Urrutia, D., Bronfman, F. C., & Rojas, A. Á. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031944 · Cited by 13
“Development and maintenance of the dendritic arbor are crucial for proper brain function [47].”
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Importance of gene dosage in controlling dendritic arbor formation during development
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“This neuron has been subject to extensive examinations of arbor morphogenesis over the past decades resulting in a substantial body of information (Grueber et al., 2002; Corty et al., 2009; Jan & Jan, 2010; Rolls, 2011).”
BackgroundA compact divisor based on SN P systems along with dendritic behavior
Frias, T., Abarca, M., Díaz, C. A. V., Duchen, G., Perez-Meana, H. M., & Sánchez, G. (2017) · Neurocomputing · doi:10.1016/j.neucom.2017.01.046 · Cited by 12
Glutamate Activity Regulates and Dendritic Development of J-RGCs
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“…plasticity, NMDAR, light deprivation INTRODUCTION Neurons are one of the most morphologically diverse cell types due to the large variety of their dendritic patterns, which are specialized structures for synaptic formation (Whitford et al., 2002; Jan and Jan, 2010; Vaney et al., 2012).”
BackgroundQuantitative Analysis of Neuronal Dendritic Arborization Complexity in Drosophila
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Mice lacking neuronal calcium sensor-1 show social and cognitive deficits
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“…the largest subset of multidendritic neurons in Drosophila, and their stereotyped organization has provided a versatile model system, where we can investigate genetic programs controlling a number of important structural and functional aspects of dendrites (Corty et al. 2009; Jan & Jan 2010).”
BackgroundInfluentialWiring dendrites in layers and columns
Luo, J., McQueen, P. G., Shi, B., Lee, C., & Ting, C. (2016) · Journal of Neurogenetics · doi:10.3109/01677063.2016.1173038 · Cited by 12
“A direct causal link between the combinatorial TF code and dendritic morphology has been demonstrated for fly leg motor neurons (Enriquez et al., 2015) and most prominently, for the peripheral da neurons (reviewed in Jan & Jan, 2010).”
BackgroundBiogenesis and reformation of synaptic vesicles
Bolz, S., & Haucke, V. (2024) · The Journal of Physiology · doi:10.1113/jp286554 · Cited by 12
“…such as the rough endoplasmic reticulum (ER) and the Golgi apparatus, is largely restricted to the somatodendritic domain (Horton et al., 2005; Jan & Jan, 2010), presynaptic vesicle proteins synthesized in the neuronal soma need to be exported into the axon before assembly into mature SVs…”
The membrane protein Raw regulates dendrite pruning via the secretory pathway
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Dysregulated Plasma Membrane Turnover Underlying Dendritic Pathology in Neurodegenerative Diseases
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“Accurate neuronal wiring relies critically on the proper establishment of the dendritic field that is achieved by both structural build-ups of dendritic arbors and functional maturation of synapses (Jan and Jan, 2010).”
BackgroundLi, X., Wang, Y., Wang, H., Liu, T., Guo, J., Yi, W., & Li, Y. (2016) · Molecular Brain · doi:10.1186/s13041-016-0228-0 · Cited by 11
“model system for studying dendrite morphogenesis [3].”
BackgroundTsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels
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“We used dendritic arborization (da) neurons as another assay system (Figure S3A; Shimono et al. 2009; Jan & Jan 2010).”
MethodisoTarget: A Genetic Method for Analyzing the Functional Diversity of Splicing Isoforms In Vivo
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“In homozygous Dscam[TM2] iso-KO (Dscam[TM2]iso-KO) larvae, the axon terminal growth was dramatically impaired in the classIV dendritic arborization (C4 da) neurons (Figures 2A, 2B, and 2H), a widely used model for studying dendrite and axon development (Grueber and Jan, 2004; Grueber et al., 2007; Jan and Jan, 2010; Y…”
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“The growth and complexity of dendritic arbors are central to developing neural circuits, which increase their surface area and connectivity, and impairments in dendrite morphogenesis have been associated with neurodevelopmental disorders [48].”
Wang, X., Cai, X., Xu, F., Zhou, L., Zheng, R., Ma, K.-Y., Xu, Z., & Shen, Y. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00250 · Cited by 10
“Little is known about the consequences of disrupting self-avoidance for circuit function or animal behavior, although the importance of local molecular interactions during dendritic development has been highlighted (Jan and Jan, 2010).”
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“After pyramidal neurons settle at appropriate positions, they further differentiate by creating extensive branches of apical and basal dendrites and forming spines to establish functional connectivity [5].”
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“…RRID: AB_476831; RRID: AB_476737; RRID: AB_477617; RRID: nif-0000–00262; RRID: nif-0000–30467 Neuronal processes, axons and dendrites, are branched and have complex structures with different sizes and shapes of arbors depending on neuron types (Stepanyants and Chklovskii, 2005; Jan and Jan, 2010).”
BackgroundSuperoxide generation via the NR2B‐NMDAR/RasGRF1/NOX2 pathway promotes dendritogenesis
Abarzúa, S., Ampuero, E., & van Zundert, B. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28859 · Cited by 10
“…of postnatal brain development to promote dendrite formation as well as pruning to eliminate excessive and mistargeted branches (Cline & Haas, 2008; Jan & Jan, 2010; Wu & Cline, 2003) with maturation, and dependent on sensory, motor, and cognitive stimuli, dendritic branches stabilize and form…”
BackgroundA Localized Scaffold for cGMP Increase Is Required for Apical Dendrite Development
Szczurkowska, J., Lee, S.-I., Guo, A., Cwetsch, A. W., Khan, T., Rao, S. B., Walz, G., Huber, T. B., Cancedda, L., Pautot, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.03.083 · Cited by 11
“Much effort has also been directed toward elucidation of the mechanisms that control late events in dendrite morphogenesis—growth, branching, and structural plasticity (Jan and Jan, 2010; Parrish et al., 2007; Tran et al., 2009; Zipursky and Grueber, 2013; Zoghbi, 2003).”
NF-κB disinhibition contributes to dendrite defects in fly models of neurodegenerative diseases
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“After elimination of the PBS, the collected fly heads were homogenized in fixation buffer (1.5% formaldehyde, 0.143 M NaCl, 1.43 mM EDTA, 71.45 mM Hepes-KOH, pH 7.5, and 1× protease inhibitor [87786; Thermo Fisher Scientific]) and incubated for 20 min at room temperature to cross-link target TFs with chromatin.”
BackgroundInfluentialCytoskeletal players in single-cell branching morphogenesis
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“For example, neuronal differentiation requires previous specification of undifferentiated cells to become neurons or glia [8], followed by axonal growth [9,10], dendritic growth and branching [11,12] and, finally, by the initiation of synaptic activity [13].”
BackgroundCRH-R1 and CRH-R2 differentially modulate dendritic outgrowth of hippocampal neurons
Sheng, H., Xu, Y., Chen, Y., Zhang, Y., Xu, X., He, C., & Ni, X. (2012) · Endocrine · doi:10.1007/s12020-012-9603-5 · Cited by 10
“The dendritic patterns of a neuron determine the number and arrangement of its synaptic inputs and the way a neuron integrates and processes its inputs [2, 3].”
BackgroundEffects of thioTEPA chemotherapy on cognition and motor coordination
Alexander, T. C., Kiffer, F. C., Groves, T. R., Anderson, J. E., Wang, J., Hayar, A. M., Chen, M. T., Rodriguez, A., & Allen, A. R. (2018) · Synapse · doi:10.1002/syn.22085 · Cited by 10
“…are made through the branches of dendrites, which can be generated by multiple mechanisms: (a) the splitting of a growth cone or (b) new dendrites branching off of existing ones via alterations in actin and other microtubules (Jan & Jan, 2010; Scott & Luo, 2001; Yuste & Bonhoeffer, 2001).”
BackgroundFLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex
Falace, A., Corbières, L., Palminha, C., Guarnieri, F. C., Schaller, F., Buhler, E., Carlo, C. T. D. S., Montheil, A., Watrin, F., Manent, J., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106558 · Cited by 9
“The remainder was incubated with 10 μ g GST-PAK1 PBD fusion protein bound to Glutathione-coupled agarose beads for 1 h at 4 ◦ C. Subsequently, the beads were washed three times in cold Lysis Buffer, and bound proteins were eluted in 2 × Laemmli reducing sample buffer.”
MethodNeurite Branching Regulated by Neuronal Cell Surface Molecules in Caenorhabditis elegans
Jin, H., & Kim, B. (2020) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2020.00059 · Cited by 9
“Several actin regulators, such as Rac and RhoA, and their roles in neurite branching have been extensively studied in invertebrates (Jan and Jan, 2010).”
BackgroundInfluentialVariation in taste ganglion neuron morphology: insights into taste function and plasticity
Ohman, L. C., & Krimm, R. F. (2021) · Current Opinion in Physiology · doi:10.1016/j.cophys.2020.12.011 · Cited by 8
Spatiotemporal changes in microtubule dynamics during dendritic morphogenesis
Hu, C., Feng, P., Chen, M., Tang, Y., & Soba, P. (2021) · Fly · doi:10.1080/19336934.2021.1976033 · Cited by 9
Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons
Jorratt, P., Říčný, J., Leibold, C., & Ovsepian, S. V. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03147-0 · Cited by 9
“Alterations in dendritic geometry and changes in branching by endogenous NMDAR modulators with unchanged synaptic density advocate independent regulation of these important facets of dendritic morphology and functions [40, 57, 58].”
BackgroundDonta, M. S., Srivastava, Y., Mauro, C. M. D., Paulucci-Holthauzen, A. A., Waxham, M. N., & McCrea, P. D. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1151249 · Cited by 9
“While there is much to be discovered about the mechanisms of dendritic arborization, there are several known molecular mechanisms of control (Jan and Jan, 2010; de la Torre-Ubieta and Bonni, 2011; Arikkath, 2012).”
BackgroundAlexander, C. J., Barzik, M., Fujiwara, I., Remmert, K., Wang, Y., Petralia, R. S., Friedman, T. B., & Hammer, J. A. (2020) · The FASEB Journal · doi:10.1096/fj.202001449r · Cited by 9
MRCKβ links Dasm1 to actin rearrangements to promote dendrite development
Wang, X.-X., Zhang, S., Dong, P.-P., Li, Y., Zhang, L., Shi, S., Yu, Z., & Chen, S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100730 · Cited by 9
“During dendritic development, neuronal cell surface receptors receive extracellular cues, followed by interpreting interpret these signals to intracellular pathways and eventually generate distinct dendrite patterns (4, 5).”
BackgroundMethodInfluentialSchoch, S., Quatraccioni, A., Robens, B. K., Maresch, R., van Loo, K. M. J., Cases‐Cunillera, S., Kelly, T., Opitz, T., Borger, V., Dietrich, D., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0352-21.2021 · Cited by 8
Introduction to Dendritic Morphology
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Drosophila Neurobiology: No Escape from ‘Big Data’ Science
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Neuronal Morphogenesis: Golgi Outposts, Acentrosomal Microtubule Nucleation, and Dendritic Branching
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“This is a class of large neurons present in the peripheral nervous system of the larva that has become a model system for the study of dendritic morphogenesis (reviewed Jan and Jan, 2010).”
BackgroundLyons, G. R., Andersen, R., Abdi, K. M., Song, W.-S., & Kuo, C. T. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.003 · Cited by 10
Dendritic tree extraction from noisy maximum intensity projection images in C. elegans
Greenblum, A., Sznitman, R., Fua, P., Arratia, P. E., Oren‐Suissa, M., Podbilewicz, B., & Sznitman, J. (2014) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-13-74 · Cited by 9
“In particular, defective dendritic arborization (see example in Figure 1b) is acknowledged to contribute to neuro-developmental disorders [1,4].”
BackgroundCrybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis
Sun, M., Ahmad, N., Zhang, R., & Graw, J. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.195 · Cited by 9
Quantifying topological invariants of neuronal morphologiesPreprint
Kanari, L., Dłotko, P., Scolamiero, M., Levi, R., Shillcock, J. C., Hess, K. P., & Markram, H. (2016) · arXiv (Cornell University) · doi:10.48550/arxiv.1603.08432 · Cited by 9
“The nervous system is one of the most complex biological systems known, whose fundamental units, neurons, are sophisticated information processing cells possessing highly ramified arborizations [5].”
BackgroundWietek, J., Rodriguez-Rozada, S., Tutas, J., Tenedini, F. M., Grimm, C., Oertner, T. G., Soba, P., Hegemann, P., & Wiegert, J. S. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/156422 · Cited by 9
Topology recapitulates morphogenesis of neuronal dendrites
Liao, M., Bird, A. D., Cuntz, H., & Howard, J. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113268 · Cited by 8
“41 For a branched tree, such as a dendritic arbor, we define the subtree-size distribution 36,48 as the average number, S, of branches that support n dendrite tips (or leaves of the tree).”
BackgroundRahman, A. F. M. T., Bulbule, S. R., Belayet, J. B., Benko, A. M., Gottschalk, C. G., Frick, D. N., Arnold, L. A., Hossain, M. M., & Roy, A. (2024) · Cells · doi:10.3390/cells13231964 · Cited by 8
“Morphological plasticity [1] is a discipline of neuroscience that evaluates the roles of structural components of neurons such as dendritic arborization [2], spine density [3], spine maturation [4], and post-synaptic neurotransmission [5] in the regulation of neuronal function [6].”
The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching
Domingos, H. A., Green, M., Ouzounidis, V. R., Finlayson, C., Prevo, B., & Cheerambathur, D. K. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202311147 · Cited by 8
“Notably, alterations in dendrite morphology and organization are associated with neuro-developmental and neurodegenerative disorders (Jan and Jan, 2010).”
InfluentialRegulation of Dendritic Filopodial Interactions by ZO-1 and Implications for Dendrite Morphogenesis
Komaki, R., Togashi, H., & Takai, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076201 · Cited by 8
Cerebral Damage after Stroke: The Role of Neuroplasticity as Key for Recovery
Muhammad, M., & Hassan, T. M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.95512 · Cited by 8
Drosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them
Kilo, L., Stürner, T., Tavosanis, G., & Ziegler, A. B. (2021) · Cells · doi:10.3390/cells10102777 · Cited by 8
“Dendrites often form a branched arbor, which plays a major role in determining the function and properties of a neuron, as it houses its main input sites [1,2].”
BackgroundPurushotham, S. S., Reddy, N. M. N., D’Souza, M. N., Choudhury, N. R., Ganguly, A., Gopalakrishna, N., Muddashetty, R. S., & Clement, J. P. (2022) · Experimental Brain Research · doi:10.1007/s00221-022-06448-x · Cited by 8
“1 3 and as CaMKII signalling mediators (Jan and Jan 2010; Arimura and Kaibuchi 2007).”
BackgroundCandidate molecular mechanisms for establishing cell identity in the developing retina
Garrett, A. M., & Burgess, R. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20926 · Cited by 8
Influences of non-canonical neurosteroid signaling on developing neural circuits
London, S. E. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.06.018 · Cited by 8
Guajardo, R., Luginbuhl, D. J., Han, S., Luo, L., & Li, J. (2019) · eLife · doi:10.7554/elife.48594 · Cited by 8
Bartelt‐Kirbach, B., Wiegreffe, C., Birk, S., Baur, T., Moron, M., Britsch, S., & Golenhofen, N. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15247 · Cited by 8
“Dendritic branching is initiated by actin-rich filopodial protrusions followed by polymerization and extension of microtubules (Jan & Jan, 2010; Menon & Gupton, 2018; Parrish et al., 2007).”
BackgroundNeuronal Morphogenesis: Worms Get an EFF in Dendritic Arborization
Shrestha, B. R., & Grueber, W. B. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.053 · Cited by 8
Wadhwa, M., Sall, J. W., & Chinn, G. A. (2024) · Journal of Neurosurgical Anesthesiology · doi:10.1097/ana.0000000000000979 · Cited by 7
“Two quanti fi able indicators of synaptogenesis are dendritic arborization 13 and the ultrastructure of dendritic spines, 14 which allow for connectivity and communication with other neurons.”
Neurodevelopmental Implications Underpinning Hereditary Spastic Paraplegia
Zhi, Y., Shi, Y., Lu, D., & Xu, D. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70260 · Cited by 7
“In addition, type-specific dendrite morphology is a hallmark of the neuron and has important functional implications in determining what signals a neuron receives and how these signals are integrated [76].”
IQGAP1 Expression in Spared CA1 Neurons After an Excitotoxic Lesion in the Mouse Hippocampus
Yi, M., Kim, S., Zhang, E., Kang, J. W., Park, J. B., Lee, Y., Chung, C. K., Kim, Y. M., & Kim, D. W. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-9968-x · Cited by 7
“Dendrite development and maintenance involve extensive rearrangements of the microtubule and actin cytoskeleton as well as Rho GTPase activity (Jan and Jan 2010).”
BackgroundInjectable Hydrogel Guides Neurons Growth with Specific Directionality
Tseng, Y., Ma, T.-L., Tan, D.-H., Su, A.-J. A., Washington, K. M., Wang, C., Huang, Y., Wu, M., & Su, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097952 · Cited by 8
“The highly plexiform high-order branching of neural dendrites arises from complex, nonlinear interactions between neural signals [67].”
BackgroundCentella asiatica (Gotu kola) leaves
Thakurdesai, P. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820593-8.00021-5 · Cited by 8
Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization
Nawalpuri, B., Sharma, A., Chattarji, S., & Muddashetty, R. S. (2021) · Journal of Cell Science · doi:10.1242/jcs.258465 · Cited by 7
Quantifying neuronal structural changes over time using dynamic morphometrics
Hogg, P. W., Coleman, P., Toth, T. D., & Haas, K. Z. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.10.011 · Cited by 7
Molecular mechanisms regulating the spatial configuration of neurites
Hasegawa, K., & Kuwako, K.-I. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.02.015 · Cited by 7
Ganguly, S., Trottier, O., Liang, X., Bowne‐Anderson, H., & Howard, J. (2016) · arXiv (Cornell University) · doi:10.48550/arxiv.1611.05918 · Cited by 7
“Since it is easy to identify and image individual da neurons, these neurons have proven to be a powerful model system for studying dendrite morphology [15, 16].”
BackgroundDeterministic and stochastic rules of branching govern dendritic morphogenesis of sensory neuronsPreprint
Palavalli, A., Tizón-Escamilla, N., Rupprecht, J.-F., & Lecuit, T. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.11.198309 · Cited by 7
Repulsions instruct synaptic partner matching in an olfactory circuit
Li, Z., Lyu, C., Xu, C., Hu, Y., Luginbuhl, D. J., Caspi-Lebovic, A. B., Priest, J. M., Özkan, E., & Luo, L. (2025) · Nature · doi:10.1038/s41586-025-09768-4 · Cited by 10
Pinchas, M., & Baranes, D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082083 · Cited by 8
“Overlap of dendritic trees was shown to be a regulated phenomenon, as evinced by specific neuron populations found to innervate targets with substantial territorial overlap [1], and by cellular and molecular cues regulating the spatial arrangements of dendritic branches within and between arbors [2].”
BackgroundPapp, T., Ferenczi, Z., Szilagyi, B., Petró, M., Varga, A., Kókai, É., Berényi, E. L., Oláh, G., Halmos, G., Szűcs, P., et al. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.803356 · Cited by 6
“BDNF has a pivotal role during dendritic arborization, promoting the elaboration of the dendritic tree, while it is not required for the proliferation, survival, or migration (Gorski et al., 2003; Jan and Jan, 2010).”
BackgroundMBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity
Xie, J., Zou, W., Tugizova, M. S., Shen, K., & Wang, X. (2023) · PLoS Genetics · doi:10.1371/journal.pgen.1010941 · Cited by 6
Mukherjee, A., Brooks, P. S., Bernard, F., Guichet, A., & Conduit, P. T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/846832 · Cited by 6
The Role of Protocadherin γ in Adult Sensory Neurons and Skin Reinnervation
Long, R., Ong, H., Wang, W. X., Komirishetty, P., Areti, A., Chandrasekhar, A., Larouche, M., Lefebvre, J. L., & Zochodne, D. W. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1940-22.2023 · Cited by 5
Endocytosis restricts dendrite branching via removing ectopically localized branching ligands
Fang, J., Jiang, W., Zhao, W., Wang, J., Cao, B., Wang, N., Chen, B., Wang, C., & Zou, W. (2024) · Nature Communications · doi:10.1038/s41467-024-53970-3 · Cited by 5
“Knockout of most of the abovementioned regulators often causes reduced dendrite branching, suggesting that most of them are positive regulators 1 – 5 .”
Hita, F. J., Bekinschtein, P., Ledda, F., & Paratcha, G. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22840 · Cited by 5
“As (ASD) and mental retardation are neurodevelopmental diseases often associated with overgrowth or lack of pruning during dendrite development and characterized by deficits in social behavior and cognition (Jan & Jan, 2010).”
BackgroundNeurons exploit stochastic growth to rapidly and economically build dense dendritic arbors
Ouyang, X., Sutradhar, S., Trottier, O., Shree, S., Yu, Q., Tu, Y., & Howard, J. (2025) · Nature Communications · doi:10.1038/s41467-025-60800-7 · Cited by 7
“1a, b) 4,20 .”
Transcriptome analysis in an AEG‑1‑deficient neuronal HT22 cell line
Liu, K., Wan, P., Huang, Y., Wang, B., Wang, X., Zhang, R., & Guo, L. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11607 · Cited by 5
“Defects in the formation or development of dendrites, axons and synapses can lead to a number of diseases, such as Alzheimer's disease and epilepsy (45).”
BackgroundLi, H., Sung, H.-H., Huang, Y., Cheng, Y.-J., Yeh, H.-F., Pi, H., Giniger, E., & Chien, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111372 · Cited by 5
“Golgi outposts (GOPs) are discrete Golgi-like organelles distributed throughout the dendritic arbor and play a pivotal role in dendritic arborization (Ehlers, 2013; Jan and Jan, 2010).”
BackgroundGintonin stimulates dendritic growth in striatal neurons by activating Akt and CREB
Lim, H. K., Kim, K., Son, Y. K., Nah, S.-Y., Ahn, S. M., & Song, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1014497 · Cited by 5
“This process, which is very tightly controlled developmentally, can only be accomplished by organic communication between numerous extrinsic factors and intrinsic components that respond to them (Jan and Jan, 2003; Urbanska et al., 2008; Jan and Jan, 2010).”
BackgroundInberg, S., Iosilevskii, Y., Calatayud-Sanchez, A., Setty, H., Oren‐Suissa, M., Krieg, M., & Podbilewicz, B. (2025) · eLife · doi:10.7554/elife.83973 · Cited by 6
Experience-Dependent Dendritic Arbor Development
Cline, H. T. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_13 · Cited by 5
Digital detection and analysis of branching and cell contacts in neural cell cultures
El-Laithy, K., Knorr, M., Käs, J. A., & Bogdan, M. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.07.007 · Cited by 5
Hacking brain development to test models of sensory codingPreprint
Ahmed, M., Rajagopalan, A. E., Pan, Y., Li, Y., Williams, D. L., Pedersen, E. A., Thakral, M., Previero, A., Close, K. C., Christoforou, C. P., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525425 · Cited by 5
“Different kinds of neurons have diverse dendritic branching patterns, and yet these patterns are specified as an aspect of cell identity and consistent for the same neuron types across animals (Jan and Jan, 2010).”
BackgroundRepulsive interactions instruct synaptic partner matching in an olfactory circuitPreprint
Li, Z., Lyu, C., Xu, C., Hu, Y., Luginbuhl, D. J., Caspi-Lebovic, A. B., Priest, J. M., Özkan, E., & Luo, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.01.640985 · Cited by 5
Metadata
- Authors
- Jan, Y.-N., & Jan, L. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jan, Yuh-Nung
- Venue
- Nature Reviews Neuroscience
- Published
- 2010-05
- Volume
- 11
- Issue
- 5
- Pages
- 316-328
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC3079328
- OpenAlex
- W2065943966
- Cited by
- 693
- References
- 162
- Citations by year
- 2026: 15 · 2025: 41 · 2024: 24 · 2023: 29 · 2022: 33 · 2021: 41 · 2020: 71 · 2019: 41 · 2018: 45 · 2017: 49 · 2016: 52 · 2015: 38 · 2014: 58 · 2013: 53 · 2012: 53
- FWCI
- 4.49
- Type
- journal article
- Language
- en
- Update notices
- erratum (2010-06-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Mental Health (R01MH084234)
- National Institute of Neurological Disorders and Stroke (R37NS040929)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- dendritic branching, dendrite morphogenesis, dendritic morphology, Drosophila melanogaster, transcription factors, ligand-receptor interactions, signaling pathways, local translation, cytoskeleton, endosomes, autism spectrum disorder, neurodevelopmental disorders, neural circuits
- MeSH terms
- Animals, Axons, Dendrites, Humans, Models, Neurological, Morphogenesis, Neurons, Signal Transduction
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