Behavioural phenotyping assays for mouse models of autism

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Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism

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Neuroligins and neurexins link synaptic function to cognitive disease

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A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

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Sociability and preference for social novelty in five inbred strains: an approach to assess autistic‐like behavior in mice

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Sociability in Fruit Flies: Genetic Variation, Heritability and Plasticity

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A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice

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Neuroanatomy and behavior in mice with a haploinsufficiency of AT-rich interactive domain 1B (ARID1B) throughout development

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From Multisensory Assessment to Functional Interpretation of Social Behavioral Phenotype in Transgenic Mouse Models for Autism Spectrum Disorders

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Assessing sociability using the Three-Chamber Social Interaction Test and the Reciprocal Interaction Test in a genetic mouse model of ASD

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Defining the Role of Cerebellar Purkinje Cells in Autism Spectrum Disorders

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Ambra1 Shapes Hippocampal Inhibition/Excitation Balance: Role in Neurodevelopmental Disorders

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A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry

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Exposure to a high dose of amoxicillin causes behavioral changes and oxidative stress in young zebrafish

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Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish

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Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model

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Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice

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Biological implications of genetic variations in autism spectrum disorders from genomics studies

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Mice lacking full length Adgrb1 (Bai1) exhibit social deficits, increased seizure susceptibility, and altered brain development

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KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization

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Methylglyoxal, advanced glycation end products and autism: Is there a connection?

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17-β estradiol increases parvalbumin levels in Pvalb heterozygous mice and attenuates behavioral phenotypes with relevance to autism core symptoms

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Comorbid epilepsy in autism spectrum disorder: Implications of postnatal inflammation for brain excitability

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Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation

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Reversal of ultrasonic vocalization deficits in a mouse model of Fragile X Syndrome with minocycline treatment or genetic reduction of MMP-9

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Long-lasting pseudo-social aggressive behavior in opiate-withdrawn mice

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Berberine Ameliorates Prenatal Dihydrotestosterone Exposure-Induced Autism-Like Behavior by Suppression of Androgen Receptor

Xiang, D., Lu, J., Wei, C., Cai, X., Wang, Y., Liang, Y., Xu, M., Wang, Z., Liu, M., Wang, M., et al. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00087 · Cited by 31

Combined the GABA-A and GABA-B receptor agonists attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism

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Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors

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Persistent autism-relevant behavioral phenotype and social neuropeptide alterations in female mice offspring induced by maternal transfer of PBDE congeners in the commercial mixture DE-71

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Prefrontal circuits guiding social preference: Implications in autism spectrum disorder

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Encoding of social novelty by sparse GABAergic neural ensembles in the prelimbic cortex

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Early-life exposure to endocrine-disrupting chemicals and autistic traits in childhood and adolescence: a systematic review of epidemiological studies

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Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing

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Administration of CoQ10 analogue ameliorates dysfunction of the mitochondrial respiratory chain in a mouse model of Angelman syndrome

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Autism-like behavior in the BTBR mouse model of autism is improved by propofol

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Modelling fragile X syndrome in the laboratory setting: A behavioral perspective

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Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches

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Effects of Cacna1c haploinsufficiency on social interaction behavior and 50-kHz ultrasonic vocalizations in adult female rats

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Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition

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Mice lacking the PSD-95–interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation and impaired contextual fear conditioning

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Adolescent behavioral abnormalities in a Scn1a+/− mouse model of Dravet syndrome

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5'-UTR SNP of FGF13 causes translational defect and intellectual disability

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The Effect of Limosilactobacillus reuteri on Social Behavior Is Independent of the Adaptive Immune System

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Discovery and Validation of Novel Genes in a Large Chinese Autism Spectrum Disorder Cohort

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Structural Abnormalities of Corpus Callosum and Cortical Axonal Tracts Accompanied by Decreased Anxiety-Like Behavior and Lowered Sociability in Spock3-Mutant Mice

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Impaired social behaviors and minimized oxytocin signaling of the adult mice deficient in the N-methyl-d-aspartate receptor GluN3A subunit

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Behavioral Genetics and Animal Science

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The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc

Ambrozkiewicz, M. C., Borisova, E. V., Schwark, M., Ripamonti, S., Schaub, T., Тихоновна, С. А., Weber, A. I., Rhee, H. J., Altas, B., Yilmaz, R., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0714-8 · Cited by 29

Transient developmental imbalance of cortical interneuron subtypes presages long-term changes in behavior

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Altered hippocampal-dependent memory and motor function in neuropilin 2–deficient mice

Shiflett, M. W., Gavin, M., & Tran, T. S. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.17 · Cited by 29

Animal Models of Psychiatric Disorders That Reflect Human Copy Number Variation

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Supplementation of Korean Red Ginseng improves behavior deviations in animal models of autism

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The SocioBox: A Novel Paradigm to Assess Complex Social Recognition in Male Mice

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Using Animal Models to Study the Role of the Gut–Brain Axis in Autism

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Comprehensive Behavioral Analysis of Activating Transcription Factor 5-Deficient Mice

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Early genistein exposure of California mice and effects on the gut microbiota–brain axis

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In tribute to Bob Blanchard: Divergent behavioral phenotypes of 16p11.2 deletion mice reared in same-genotype versus mixed-genotype cages

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Fentanyl induces autism-like behaviours in mice by hypermethylation of the glutamate receptor gene Grin2b

Sheng, Z., Liu, Q., Cheng, C., Li, M., Barash, J., Kofke, W. A., Shen, Y., & Xie, Z. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.04.027 · Cited by 28

Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice

Zheng, F., Kasper, L. H., Bedford, D. C., Lerach, S., Teubner, B. J. W., & Brindle, P. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146366 · Cited by 28

The influence of immune activation at early vs late gestation on fetal NRG1-ErbB4 expression and behavior in juvenile and adult mice offspring

Dabbah‐Assadi, F., Alon, D., Golani, I., Doron, R., Kremer, I., Beloosesky, R., & Shamir, A. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.02.002 · Cited by 28

Brain Structural and Functional Alterations in Mice Prenatally Exposed to LPS Are Only Partially Rescued by Anti-Inflammatory Treatment

Aria, F., Bonini, S. A., Cattaneo, V., Premoli, M., Mastinu, A., Maccarinelli, G., & Memo, M. (2020) · Brain Sciences · doi:10.3390/brainsci10090620 · Cited by 28

Neuropathological Characterization of a Dravet Syndrome Knock-In Mouse Model Useful for Investigating Cannabinoid Treatments

Satta, V., Alonso, C., Díez, P., Martín‐Suárez, S., Rubio, M., Encinas, J. M., Fernández‐Ruíz, J., & Sagredo, O. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.602801 · Cited by 28

Critical Evaluation of Valproic Acid-Induced Rodent Models of Autism: Current and Future Perspectives

Mehra, S., Ahsan, A. U., Seth, E., & Chopra, M. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02033-7 · Cited by 28

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist

Ago, Y., Condro, M. C., Tan, Y., Ghiani, C. A., Colwell, C. S., Cushman, J. D., Fanselow, M. S., Hashimoto, H., & Waschek, J. A. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3848-z · Cited by 28

Social Reward and Empathy as Proximal Contributions to Altruism: The Camaraderie Effect

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The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain

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Melanocortin 4 receptor stimulation improves social deficits in mice through oxytocin pathway

Mastinu, A., Premoli, M., Maccarinelli, G., Grilli, M., Memo, M., & Bonini, S. A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.007 · Cited by 28

Pharmacological (ethanol) and mutation (sam2 KO) induced impairment of novelty preference in zebrafish quantified using a new three-chamber social choice task

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Immunity and ultrasonic vocalization in rodents

Jouda, J., Wöhr, M., & del Rey, A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13931 · Cited by 28

Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms

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Voluntary alcohol binge‐drinking in adolescent C57Bl6 mice induces delayed appearance of behavioural defects in both males and females

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The Human Model: Changing Focus on Autism Research

Muotri, A. R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.012 · Cited by 27

Translational behaviour‐genetic studies of alcohol: are we there yet?

Crabbe, J. C. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00798.x · Cited by 27

Associations among exposure to methylmercury, reduced Reelin expression, and gender in the cerebellum of developing mice

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Corticotropin‐releasing factor receptor 2‐deficiency eliminates social behaviour deficits and vulnerability induced by cocaine

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Increased expression of SLC25A1/CIC causes an autistic-like phenotype with altered neuron morphology

Rigby, M. J., Orefice, N. S., Lawton, A. J., Ma, M., Shapiro, S. L., Yi, S. Y., Dieterich, I. A., Frelka, A., Miles, H. N., Pearce, R. A., et al. (2021) · Brain · doi:10.1093/brain/awab295 · Cited by 27

Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex

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CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors

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Can Mouse Imaging Studies Bring Order to Autism Connectivity Chaos?

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Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co‐occurring traits

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