Cited by 1,462Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

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Behavioural phenotyping assays for mouse models of autism

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Silverman, Jill L., Yang, Mu, Lord, Catherine, Crawley, Jacqueline N.·2010·Nature Reviews Neuroscience

DOI 10.1038/nrn2851PMC PMC3087436

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Abstract

Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1 in 100-150 individuals. Diagnosis is based on three categories of behavioural criteria: abnormal social interactions, communication deficits and repetitive behaviours. Strong evidence for a genetic basis has prompted the development of mouse models with targeted mutations in candidate genes for autism. As the diagnostic criteria for autism are behavioural, phenotyping these mouse models requires behavioural assays with high relevance to each category of the diagnostic symptoms. Behavioural neuroscientists are generating a comprehensive set of assays for social interaction, communication and repetitive behaviours to test hypotheses about the causes of autism. Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders.

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Authors: Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N.
Affiliations: National Institute of Mental Health (US)
University of Michigan (US)
Corresponding author: Crawley, Jacqueline N.
ORCID: Silverman, Jill L.
Yang, Mu
Lord, Catherine
Crawley, Jacqueline N.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2010-07
Volume: 11
Issue: 7
Pages: 490-502
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn2851
PMC: PMC3087436
OpenAlex: W2098277878
Cited by: 1,462
References: 180
Citations by year: 2026: 52 · 2025: 74 · 2024: 109 · 2023: 77 · 2022: 116 · 2021: 121 · 2020: 125 · 2019: 108 · 2018: 113 · 2017: 94 · 2016: 101 · 2015: 91 · 2014: 78 · 2013: 66 · 2012: 75
FWCI: 4.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (5rc1mh089721-02)
National Institute of Mental Health (RC1 MH-089721, MH02179, R01MH089390, Z01MH002179, R01MH81873, 1RC1MH089721, ZIAMH002179, R01MH081873)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: autism spectrum disorder, mouse models of autism, behavioral phenotyping, behavioural assays, social interaction deficits, communication difficulties, repetitive behavior, candidate gene mutations, translational research, neurodevelopmental disorders
MeSH terms: Animals, Autistic Disorder, Disease Models, Animal, Diseases in Twins, Humans, Interpersonal Relations, Mutation, Phenotype, Social Behavior Disorders, Mice

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Behavioural phenotyping assays for mouse models of autism

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