Histone Deacetylases 1 and 2 in Memory Function

The Hallmarks of Aging

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Regulation of chromatin by histone modifications

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Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

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Erasers of Histone Acetylation: The Histone Deacetylase EnzymesPreprint

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Gene regulation and DNA damage in the ageing human brain

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Enriched environments, experience-dependent plasticity and disorders of the nervous system

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HDAC2 negatively regulates memory formation and synaptic plasticity

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Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain

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Recovery of learning and memory is associated with chromatin remodelling

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Histone Deacetylase Inhibitors as Anticancer Drugs

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Regulation of histone acetylation during memory formation in the hippocampus

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

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The biology of the glucocorticoid receptor: New signaling mechanisms in health and disease

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A decade of CDK5

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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

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Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

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An epigenetic blockade of cognitive functions in the neurodegenerating brain

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REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis

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Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

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CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

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Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

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Histone acetylation: molecular mnemonics on the chromatin

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DNA damage and its links to neurodegeneration

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Writers and Readers of Histone Acetylation: Structure, Mechanism, and InhibitionPreprint

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Aging and neurodegeneration are associated with increased mutations in single human neurons

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Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

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Readers of histone modifications

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NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

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Premature Aging in Mice Deficient in DNA Repair and Transcription

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Memory consolidation of Pavlovian fear conditioning: a cellular and molecular perspective

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Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

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In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

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NAD ⁺ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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Synapses and Alzheimer's Disease

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Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons

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S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

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Vorinostat

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Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

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Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression

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AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

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Methods of Behavior Analysis in Neuroscience

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The Role of Histone Acetylation in Memory Formation and Cognitive Impairments

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Dysregulation of Histone Acetylation in the APP/PS1 Mouse Model of Alzheimer's Disease

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Deregulation of HDAC1 by p25/Cdk5 in Neurotoxicity

Kim, D., Frank, C. L., Dobbin, M. M., Tsunemoto, R. K., Tu, W., Peng, P. L., Guan, J.-S., Lee, B.-H., Moy, L. Y., Giusti, P., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.015 · Cited by 286 · see citing works

IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity

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Regulation of NMDA receptors by cyclin-dependent kinase-5

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SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

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Activity-based probes for proteomic profiling of histone deacetylase complexes

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Zinc binding groups for histone deacetylase inhibitors

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Effect of Divalproex Combined with Olanzapine or Risperidone in Patients with an Acute Exacerbation of Schizophrenia

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HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease

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p25/Cyclin-Dependent Kinase 5 Induces Production and Intraneuronal Accumulation of Amyloid βIn Vivo

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Histone deacetylases in memory and cognition

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In vivo somatic cell base editing and prime editing

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HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

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Synergistic Enhancement of Cancer Therapy Using HDAC Inhibitors: Opportunity for Clinical Trials

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How the epigenome integrates information and reshapes the synapse

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DNA strand breaks in Alzheimer’s disease

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Loss of Histone Deacetylase 2 Improves Working Memory and Accelerates Extinction Learning

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Crystal Structure of a Bacterial Class 2 Histone Deacetylase Homologue

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On the Function of the 14 Å Long Internal Cavity of Histone Deacetylase-Like Protein: Implications for the Design of Histone Deacetylase Inhibitors

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Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair

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c-Abl in Neurodegenerative Disease

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A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

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DNA end joining activity is reduced in Alzheimer's disease

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Distinct and redundant functions of histone deacetylases HDAC1 and HDAC2 in proliferation and tumorigenesis

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Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains

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Epigenetic suppression of neuroligin 1 underlies amyloid-induced memory deficiency

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The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

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Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2)

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c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease

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Analogues of trichosтatin a and trapoxin B as histone deacetylase inhibitors

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Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

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Maternal insulin resistance multigenerationally impairs synaptic plasticity and memory via gametic mechanisms

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Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway

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HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction

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Notch signaling functions in lymphatic valve formation

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Histone Acetylation Regulation in Sleep Deprivation-Induced Spatial Memory Impairment

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A neuronal <scp>DNA</scp> damage response is detected at the earliest stages of <scp>A</scp>lzheimer's neuropathology and correlates with cognitive impairment in the <scp>M</scp>edical <scp>R</scp>esearch <scp>C</scp>ouncil's <scp>C</scp>ognitive <scp>F</scp>unction and <scp>A</scp>geing <scp>S</scp>tudy ageing brain cohort

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Complementary roles for histone deacetylases 1, 2, and 3 in differentiation of pluripotent stem cells

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Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

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HDAC1 dysregulation induces aberrant cell cycle and DNA damage in progress of TDP‐43 proteinopathies

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Histone deacetylase-2 is involved in stress-induced cognitive impairment via histone deacetylation and PI3K/AKT signaling pathway modification

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Essential Nonredundant Function of the Catalytic Activity of Histone Deacetylase 2 in Mouse Development

Hagelkrüys, A., Mattes, K., Moos, V., Rennmayr, M., Ringbauer, M., Sawicka, A., & Seiser, C. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00639-15 · Cited by 23 · see citing works

Neuronal gene repression in Niemann–Pick type C models is mediated by the c-Abl/HDAC2 signaling pathway

Contreras, P. S., Gonzalez-Zuñiga, M., González-Hódar, L., Yañez, M. J., Dulcey, A. E., Marugán, J., Seto, E., Alvarez, A. R., & Zanlungo, S. (2015) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2015.11.006 · Cited by 22 · see citing works

Chronic restraint stress impairs cognition via modulating HDAC2 expression

Wu, J., Liu, C., Zhang, L., He, B., Shi, W.-P., Shi, H., & Qin, C. (2021) · Translational Neuroscience · doi:10.1515/tnsci-2020-0168 · Cited by 21 · see citing works

Restoration of HDAC1 Enzymatic Activity after Stroke Protects Neurons from Ischemia/Reperfusion Damage and Attenuates Behavioral Deficits in Rats

Chen, J., Wang, H., Su, Y.-T., Hsu, C.-Y., Chen, J., Liang, C., Wu, C., & Kwan, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910654 · Cited by 17 · see citing works

Histone deacetylase 1 (HDAC1); HDAC2

(2009) · Science-Business eXchange · doi:10.1038/scibx.2009.780 · Cited by 1 · see citing works

Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain

Lyons, L. C., Vanrobaeys, Y. S., & Abel, T. G. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15787 · Cited by 62 · see citing works

Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy

Cao, D., Zhou, X., Guo, Q., Xiang, M.-Y., Bao, M., He, B., & Mao, X. (2024) · Biomarker Research · doi:10.1186/s40364-024-00687-6 · Cited by 59 · see citing works

HDAC3 as an Emerging Therapeutic Target for Alzheimer's Disease and other Neurological Disorders

Li, Y., Izhar, T., & Kanekiyo, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04866-w · Cited by 19 · see citing works

Incubation of methamphetamine craving in punishment-resistant individuals is associated with activation of specific gene networks in the rat dorsal striatum

Daiwile, A. P., McCoy, M. T., Ladenheim, B., Jayanthi, S., & Cadet, J. L. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02455-2 · Cited by 15 · see citing works

Targeting histone deacetylase 1: Inhibition and activation as promising therapeutic strategies for diverse disorders

Costanzo, G., Buccheri, R., Cosentino, G., Reale, C., Zuccalà, S., Marrazzo, A., Amata, E., Rescifina, A., & Pasquinucci, L. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117998 · Cited by 14 · see citing works

Elucidation of the working principle of a gene-directed caged HDAC inhibitor with cell-type selectivity

Sakamoto, K., Hirano, A., Hidaka, R., Suzuki, A. Z., Ueno, T., & Furuta, T. (2022) · Chemical Communications · doi:10.1039/d2cc03552a · Cited by 11 · see citing works

Discovery and Development of HDAC Inhibitors: Approaches for the Treatment of Cancer a Mini-review

Patel, R. R., Modi, A., & Vekariya, H. (2024) · Current Drug Discovery Technologies · doi:10.2174/0115701638286941240217102948 · Cited by 9 · see citing works

HDAC1 dysregulation promotes pro-inflammatory microglial activation and aggravates post-stroke neuroinflammation

Chen, J.-S., Wang, H., Su, Y.-T., Ho, Y., Liang, C., Lee, Y., Chu, T., Lin, Y., & Wu, C. (2025) · Annals of Medicine · doi:10.1080/07853890.2025.2597624 · Cited by 7 · see citing works

Gut microbiota regulates hepatic ischemia–reperfusion injury‐induced cognitive dysfunction via the HDAC2‐ACSS2 axis in mice

Liu, Y. J., Li, Z., Sun, T., Li, Z., Manyande, A., Xiang, H., & He, Z. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14610 · Cited by 7 · see citing works

Identification of differentially expressed exosome proteins in serum as potential biomarkers for cognitive impairments in cerebral small vessel disease

Feng, Q., Lu, Y., Zhang, R., Li, Y., Zhao, Z. Y., & Zhou, H. (2024) · Neuroscience Letters · doi:10.1016/j.neulet.2024.137631 · Cited by 6 · see citing works

Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma

Lu, F., Jiang, X., Lin, K., Zheng, P., Wu, S., Zeng, G., & Wei, D. (2024) · Molecular Biotechnology · doi:10.1007/s12033-024-01223-5 · Cited by 6 · see citing works

Computational insights in repurposing a cardiovascular drug for Alzheimer's disease: the role of aromatic amino acids in stabilizing the drug through π–π stacking interaction

Rubavathy, S. M. E., & Prakash, M. (2024) · Physical Chemistry Chemical Physics · doi:10.1039/d4cp03291h · Cited by 6 · see citing works

Isoflurane impairs GluN2B‐containing NMDA receptors trafficking and cognition via decreasing histone acetylation and EphB2 expression in aged hippocampal neurons

Hao, J., Hu, Q., Yang, X., Wei, P., Wang, H.-Y., Sun, N., & Gao, C. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13812 · Cited by 6 · see citing works

CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease

Lu, W., Kawatani, K., Ren, Y., Nambara, T., Jia, L., Jeevaratnam, S., Lee, E., Martinez, P. R., Izhar, T., Wang, N., et al. (2026) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-026-01982-0 · Cited by 4 · see citing works

Exploration of novel hydroxamate zinc binding group inhibitors against HDAC-1-3 enzymes by AI-based virtual screening: atomistic insights from steered molecular dynamics

Rubavathy, S. M. E., Rajapandian, V., & Prakash, M. (2024) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2024.2325104 · Cited by 4 · see citing works

The impact of sex on memory during aging and Alzheimer's disease progression: Epigenetic mechanisms

Scheinman, S. B., & Dong, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241288709 · Cited by 3 · see citing works

Epigenetic changes and neurogenesis associated with socio-sexual behaviors

Rivera-Bautista, G. D., Arzate, D. M., Ávila‐González, D., Castro, A. E., Vázquez-Martínez, E. R., Díaz, N. F., & Portillo, W. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106359 · Cited by 3 · see citing works

Sex-specific Alterations in the mRNA Expression of Histone Deacetylases (HDACs) in the Rat Brain Following Prolonged Abstinence from Methamphetamine Self-administration

McCoy, M. T., Daiwile, A. P., Ladenheim, B., & Cadet, J. L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04869-7 · Cited by 2 · see citing works

A neuronal cell-based reporter system for monitoring the activity of HDAC2

Unemura, K., Kawano, M., Takakura, M., Iwata, I., Hyakkoku, K., Horiguchi, N., Okuda, T., & Hirano, Y. (2022) · SLAS DISCOVERY · doi:10.1016/j.slasd.2022.10.001 · Cited by 1 · see citing works

Discovery of Highly Selective HDAC2 Inhibitors in Cells That Elevate Histone Acetylation In Vivo without Adverse Effects from Dual Inhibition of HDAC1 and 2

Suzuki, N., Yamakawa, H., Yoshihara, K., Niidome, K., Anan, K., Takaya, K., Kouki, K., Fujimoto, K., Ono, H., Izumi, T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c02022 · Cited by 1 · see citing works

Design and Synthesis of Potent First-in-Class Histones Acetyltransferase ModulatorsPreprint

Zuccarello, E., Mori, M., Calcagno, E., Purgatorio, R., Feng, Y., Acquarone, E., Francis, Y. I., Fà, M., Staniszewski, A., Argyrousi, E. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.03.641271 · Cited by 1 · see citing works

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00501

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.2c00434

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01386

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.2c00169

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00393

Virtual Special Issue: Epigenetics 2022

Aldrich, C. C., Calderón, F., Conway, S. J., He, C., Hooker, J. M., Huryn, D. M., Lindsley, C. W., Liotta, D. C., & Müller, C. E. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00661

CoREST3 exhibits isoform specific expression in Alzheimer’s disease and regulation of HDAC2

Maksour, S., Anastacio, H. T. D., Lum, J. S., Walpole, S. J., Newell, K. A., Turner, C., Kaban, A., Balez, R., Lim, J., Sutherland, G. T., et al. (2025) · BMC Biology · doi:10.1186/s12915-025-02349-x

A battleship between hydroxamates versus non-hydroxamates: Exploring semi-empirical quantum properties, chemical space network, activity landscape, scaffold diversity of HDAC3 inhibitors to improve memory and learning

Sessa, L., Mallick, C., Concilio, S., Gayen, S., Piotto, S., & Amin, S. A. (2025) · Journal of Molecular Graphics and Modelling · doi:10.1016/j.jmgm.2025.109199

Downregulation of ClC-3 chloride channels in dorsal root ganglia neurons contributes to bone metastasis-induced pain

Zhang, Z.-X., Qiu, Y.-S., Yin, X.-Z., Xi, J., You, Q., Xu, G., & Guan, J.-Z. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111268

Discovery of a CI-994 derivative as a dual modulator of class I HDACs and Wnt/β-catenin signaling for Alzheimer’s disease therapyPreprint

Lü, W., Caulfield, T. R., Lee, E., Jeevaratnam, S., Wang, N., Bu, G., Kanekiyo, T., & Li, Y. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.30.721954

Discovery of a CI-994 derivative as a dual modulator of class I histone deacetylases and Wnt/β-catenin signaling for Alzheimer’s disease therapy

Lu, W., Caulfield, T. R., Lee, E., Jeevaratnam, S., Wang, N., Bu, G., Kanekiyo, T., & Li, Y. (2026) · Neurotherapeutics · doi:10.1016/j.neurot.2026.e00974

Targeting Histone Deacetylase 2 in Alzheimer’s Disease: From Molecular Insights to Epigenetic Therapeutic Opportunities

Anand, A., Sania, A., Singh, S. K., & Bajad, N. G. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06078-2

Prenatal PFOS impairs offspring cognition via HDAC and translational repression

Niu, X., Xi, R., Tan, Y., Shao, J., & Liu, X. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120958

A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memoryPreprint

Mahgoub, M., & Monteggia, L. M. (2014) · Learning & Memory · doi:10.1101/lm.036012.114 · Cited by 46 · see citing works

The roles of class I histone deacetylases (HDACs) in memory, learning, and executive cognitive functions: A review

Schmauss, C. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.10.004 · Cited by 43 · see citing works

Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms

Mungenast, A. E., & Tsai, L. (2012) · Neurodegenerative Diseases · doi:10.1159/000334602 · Cited by 8 · see citing works

Histone deacetylase 1 (HDAC1); HDAC2

(2009) · Science-Business eXchange · doi:10.1038/scibx.2009.839

Inhibit Histone Deacetylase Type 2 to Improve Memory

Geller, B. (2009) · Journal watch · doi:10.1056/jp200906220000005