Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory
Open accessAbstract
Histone deacetylases (HDACs) are chromatin modifying enzymes that have been implicated as powerful negative regulators of memory processes. HDAC3has been shown to play a pivotal role in long-term memory for object location as well as the extinction of cocaine-associated memory, but it is unclear whether this function depends on the deacetylase domain of HDAC3. Here, we tested whether the deacetylase domain of HDAC3has a role in object location memory formation as well as the formation and extinction of cocaine-associated memories. Using a deacetylase-dead point mutant of HDAC3, we found that selectively blocking HDAC3 deacetylase activity in the dorsal hippocampus enhanced long-term memory for object location, but had no effect on the formation of cocaine-associated memory. When this same point mutant virus of HDAC3 was infused into the prelimbic cortex, it failed to affect cocaine-associated memory formation. With regards to extinction, impairing the HDAC3 deacetylase domain in the infralimbic cortex had no effect on extinction, but a facilitated extinction effect was observed when the point mutant virus was delivered to the dorsal hippocampus. These results suggest that the deacetylase domain of HDAC3 plays a selective role in specific brain regions underlying long-term memory formation of object location as well as cocaine-associated memory formation and extinction.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The deacetylase domain of HDAC3 in the hippocampus was critical for long-term OPP memory in mice.
“The deacetylase domain of HDAC3 in the hippocampus was also found to be critical for long-term OPP memory in mice”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Alaghband et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A new mathematical model for relative quantification in real-time RT-PCR
Pfaffl, M. W. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.9.e45 · Cited by 34,610 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,759 · see citing works
Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
Fanselow, M. S., & Dong, H.-W. (2010) · Neuron · doi:10.1016/j.neuron.2009.11.031 · Cited by 3,358 · see citing works
Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works
Neurobiology of Pavlovian Fear Conditioning
Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,805 · see citing works
The role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · see citing works
Fischle, W., Dequiedt, F., Hendzel, M. J., Guenther, M. G., Lazar, M. A., Voelter, W., & Verdin, E. (2002) · Molecular Cell · doi:10.1016/s1097-2765(01)00429-4 · Cited by 754 · see citing works
Burger, C., Gorbatyuk, O. S., Velardo, M. J., Peden, C. S., Williams, P., Zolotukhin, S., Reier, P. J., Mandel, R. J., & Muzyczka, N. (2004) · Molecular Therapy · doi:10.1016/j.ymthe.2004.05.024 · Cited by 741 · see citing works
Extinction circuits for fear and addiction overlap in prefrontal cortex
Peters, J., Kalivas, P. W., & Quirk, G. J. (2009) · Learning & Memory · doi:10.1101/lm.1041309 · Cited by 736 · see citing works
Prefrontal mechanisms in extinction of conditioned fear
Quirk, G. J., Garcia, R., & González-Lima, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.010 · Cited by 682 · see citing works
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680 · see citing works
One-trial object recognition in rats and mice: Methodological and theoretical issues
Ennaceur, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.036 · Cited by 676 · see citing works
The pharmacology, neuroanatomy and neurogenetics of one-trial object recognition in rodents
Dere, E., Huston, J. P., & Silva, M. A. D. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.01.005 · Cited by 669 · see citing works
Brain circuitry and the reinstatement of cocaine-seeking behavior
Kalivas, P., & McFarland, K. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1393-2 · Cited by 613 · see citing works
The SMRT and N-CoR Corepressors Are Activating Cofactors for Histone Deacetylase 3
Guenther, M. G., Barak, O., & Lazar, M. A. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6091-6101.2001 · Cited by 611 · see citing works
Object recognition memory: Neurobiological mechanisms of encoding, consolidation and retrieval
Winters, B. D., Saksida, L. M., & Bussey, T. J. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.04.004 · Cited by 568 · see citing works
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
Lahm, A., Paolini, C., Pallaoro, M., Nardi, M. C., Jones, P., Neddermann, P., Sambucini, S., Bottomley, M. J., Lo Surdo, P., Carfı́, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706487104 · Cited by 566 · see citing works
Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W., & Everitt, B. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-06-02401.1999 · Cited by 555 · see citing works
Infralimbic Prefrontal Cortex Is Responsible for Inhibiting Cocaine Seeking in Extinguished Rats
Peters, J., LaLumiere, R. T., & Kalivas, P. W. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1045-08.2008 · Cited by 537 · see citing works
Fuchs, R. A., Evans, K. A., Ledford, C. C., Parker, M. P., Case, J. M., Mehta, R. H., & See, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300579 · Cited by 517 · see citing works
HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation
McQuown, S. C., Barrett, R. M., Matheos, D. P., Post, R. J., Rogge, G. A., Alenghat, T., Mullican, S. E., Jones, S., Rusche, J. R., Lazar, M. A., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5052-10.2011 · Cited by 507 · see citing works
Zhang, J., Kalkum, M., Chait, B. T., & Roeder, R. G. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00468-9 · Cited by 414 · see citing works
Modulation of long-term memory for object recognition via HDAC inhibition
Stefanko, D. P., Barrett, R. M., Ly, A. R., Reolon, G. K., & Wood, M. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903964106 · Cited by 402 · see citing works
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner
Malvaez, M., McQuown, S. C., Rogge, G. A., Astarabadi, M., Jacques, V., Carreiro, S. T., Rusche, J. R., & Wood, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213364110 · Cited by 400 · see citing works
Perspectives on object-recognition memory following hippocampal damage: lessons from studies in rats
Mumby, D. G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00367-9 · Cited by 356 · see citing works
Distribution of histone deacetylases 1–11 in the rat brain
Broide, R. S., Redwine, J. M., Aftahi, N., Young, W. G., Bloom, F. E., & Winrow, C. J. (2007) · Journal of Molecular Neuroscience · doi:10.1007/bf02686117 · Cited by 347 · see citing works
The Role of Histone Acetylation in Memory Formation and Cognitive Impairments
Peixoto, L., & Abel, T. G. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.86 · Cited by 336 · see citing works
Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation
Mullican, S. E., Gaddis, C. A., Alenghat, T., Nair, M. G., Giacomin, P. R., Everett, L. J., Feng, D., Steger, D. J., Schug, J., Artis, D., et al. (2011) · Genes & Development · doi:10.1101/gad.175950.111 · Cited by 314 · see citing works
Laurent, V., & Westbrook, R. F. (2009) · Learning & Memory · doi:10.1101/lm.1474609 · Cited by 311 · see citing works
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology
Alenghat, T., Meyers, K. C., Mullican, S. E., Leitner, K., Adeniji‐Adele, A., Avila, J. L., Bućan, M., Ahima, R. S., Kaestner, K. H., & Lazar, M. A. (2008) · Nature · doi:10.1038/nature07541 · Cited by 293 · see citing works
HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory
Sando, R., Gounko, N., Pieraut, S., Liao, L., Yates, J., & Maximov, A. (2012) · Cell · doi:10.1016/j.cell.2012.09.037 · Cited by 274 · see citing works
Sierra‐Mercado, D., Corcoran, K. A., Lebrón‐Milad, K., & Quirk, G. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05014.x · Cited by 255 · see citing works
Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 247 · see citing works
Barrett, R. M., Malvaez, M., Kramar, E., Matheos, D. P., Arrizon, A., Cabrera, S. M., Lynch, G., Greene, R. W., & Wood, M. A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.61 · Cited by 243 · see citing works
Ciernia, A. V., Matheos, D. P., Barrett, R. M., Kramár, E. A., Azzawi, S., Chen, Y., Magnan, C. N., Zeller, M. D., Sylvain, A. S., Häettig, J., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3359 · Cited by 234 · see citing works
Roozendaal, B., Hernandez, A., Cabrera, S. M., Hagewoud, R., Malvaez, M., Stefanko, D. P., Haettig, J., & Wood, M. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5717-09.2010 · Cited by 233 · see citing works
Balderas, I., Rodriguez-Ortiz, C. J., Salgado-Tonda, P., Chavez-Hurtado, J., McGaugh, J. L., & Bermudez-Rattoni, F. (2008) · Learning & Memory · doi:10.1101/lm.1028008 · Cited by 213 · see citing works
Fuchs, R. A., Eaddy, J. L., Su, Z., & Bell, G. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05674.x · Cited by 212 · see citing works
Haettig, J., Stefanko, D. P., Multani, M. L., Figueroa, D. X., McQuown, S. C., & Wood, M. A. (2011) · Learning & Memory · doi:10.1101/lm.1986911 · Cited by 211 · see citing works
Delayed Recall of Fear Extinction in Rats With Lesions of Ventral Medial Prefrontal CortexPreprint
Lebrón‐Milad, K., Milad, M. R., & Quirk, G. J. (2004) · Learning & Memory · doi:10.1101/lm.78604 · Cited by 208 · see citing works
Histone deacetylases in memory and cognition
Penney, J., & Tsai, L. (2014) · Science Signaling · doi:10.1126/scisignal.aaa0069 · Cited by 192 · see citing works
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene
Kojima, N., Wang, J., Mansuy, I. M., Grant, S. G. N., Mayford, M. R., & Kandel, E. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4761 · Cited by 188 · see citing works
Memory: Epigenetic mechanisms: a common theme in vertebrate and invertebrate memory formation
Levenson, J. M., & Sweatt, J. D. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6026-6 · Cited by 178 · see citing works
The infralimbic cortex regulates the consolidation of extinction after cocaine self-administrationPreprint
LaLumiere, R. T., Niehoff, K. E., & Kalivas, P. W. (2010) · Learning & Memory · doi:10.1101/lm.1576810 · Cited by 175 · see citing works
Malvaez, M., Sanchis‐Segura, C., Vo, D., Lattal, K. M., & Wood, M. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.07.032 · Cited by 172 · see citing works
Pfaffl, M. W., Georgieva, T. M., Georgiev, I. P., Ontsouka, E. C., Hageleit, M., & Blum, J. W. (2002) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(01)00128-x · Cited by 172 · see citing works
Increasing Histone Acetylation in the Hippocampus-Infralimbic Network Enhances Fear Extinction
Stafford, J. M., Raybuck, J. D., Ryabinin, A. E., & Lattal, K. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.12.012 · Cited by 157 · see citing works
Assembly of the SMRT–histone deacetylase 3 repression complex requires the TCP-1 ring complex
Guenther, M. G., Yu, J., Kao, G. D., Yen, T. J., & Lazar, M. A. (2002) · Genes & Development · doi:10.1101/gad.1037502 · Cited by 138 · see citing works
Tzschentke, T., & Schmidt, W. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00834.x · Cited by 135 · see citing works
HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation
Rogge, G. A., Singh, H., Dang, R., & Wood, M. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4472-12.2013 · Cited by 124 · see citing works
HDAC3 and the molecular brake pad hypothesis
McQuown, S. C., & Wood, M. A. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.04.005 · Cited by 122 · see citing works
Malvaez, M., Mhillaj, E., Matheos, D. P., Palmery, M., & Wood, M. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2747-11.2011 · Cited by 119 · see citing works
Dorsal, but not ventral, hippocampal lesions disrupt cocaine place conditioning
Meyers, R. A., Zavala, A. R., & Neisewander, J. L. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00023 · Cited by 109 · see citing works
Ciernia, A. V., & Wood, M. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.002 · Cited by 105 · see citing works
Isaac, W. L., Nonneman, A. J., Neisewander, J. L., Landers, T. M., & Bardo, M. T. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.2.345 · Cited by 102 · see citing works
Rumbaugh, G., Daws, S. E., Ozkan, E. D., Rojas, C. S., Hubbs, C. R., Aceti, M., Kilgore, M., Kudugunti, S., Puthanveettil, S. V., Sweatt, J. D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.93 · Cited by 89 · cited 1× · see citing works
“Further, Rumbaugh et al. (2015) showed that RGFP963 and another HDAC-1, -2, and -3 inhibitor, RGFP968, were most effective at stimulating synaptogenesis, while RGFP966 was ineffective.”
BackgroundBaltan, S., Bachleda, A., Morrison, R. S., & Murphy, S. P. (2011) · Translational Stroke Research · doi:10.1007/s12975-011-0087-z · Cited by 85 · see citing works
López, A. J., Kramár, E. A., Matheos, D. P., White, A. O., Kwapis, J. L., Ciernia, A. V., Sakata, K., Espinoza, M. E., & Wood, M. A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3682-15.2016 · Cited by 80 · see citing works
Tzschentke, T. (1998) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00034-5 · Cited by 77 · see citing works
Comparison of the rates of associative change during acquisition and extinction.
Rescorla, R. A. (2002) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.28.4.406 · Cited by 68 · see citing works
Cynthia Marie-claire, A., Laurendeau, I., Canestrelli, C., Courtin, C., Vidaud, M., Roques, B. P., & Noble, F. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(03)00307-0 · Cited by 62 · see citing works
Kwapis, J. L., Alaghband, Y., López, A. J., White, A. O., Campbell, R. R., Dang, R., Rhee, D., Tran, A. V., Carl, A. E., Matheos, D. P., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.274 · Cited by 62 · see citing works
White, A. O., Kramár, E. A., López, A. J., Kwapis, J. L., Doan, J., Saldana, D., Davatolhagh, M. F., Alaghband, Y., Blurton-Jones, M. M., Matheos, D. P., et al. (2016) · Nature Communications · doi:10.1038/ncomms11725 · Cited by 56 · see citing works
The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinctionPreprint
Bowers, M. E., Xia, B., Carreiro, S. T., & Ressler, K. J. (2015) · Learning & Memory · doi:10.1101/lm.036699.114 · Cited by 50 · see citing works
Haettig, J., Sun, Y., Wood, M. A., & Xu, X. (2013) · Learning & Memory · doi:10.1101/lm.027847.112 · Cited by 41 · see citing works
Transcriptional responses to reinforcing effects of cocaine in the rat hippocampus and cortex
Krasnova, I. N., Li, S. M., Wood, W. H., McCoy, M. T., Prabhu, V. V., Becker, K. G., Katz, J. L., & Cadet, J. L. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00338.x · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Kwapis, J. L., Alaghband, Y., Kramár, E. A., López, A. J., Ciernia, A. V., White, A. O., Shu, G., Rhee, D., Michael, C. M., Montellier, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05868-0 · Cited by 162 · see citing works
Chao, O. Y., de Souza Silva, M. A., Yang, Y.-M., & Huston, J. P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.007 · Cited by 158 · see citing works
Neuroprotection of Radiosensitive Juvenile Mice by Ultra-High Dose Rate FLASH Irradiation
Alaghband, Y., Cheeks, S. N., Allen, B. D., Montay‐Gruel, P., Doan, N.-L., Petit, B., Jorge, P. G., Giedzinski, E., Acharya, M. M., Vozenin, M., et al. (2020) · Cancers · doi:10.3390/cancers12061671 · Cited by 141 · see citing works
A neuroscientist’s guide to transgenic mice and other genetic tools
Navabpour, S., Kwapis, J. L., & Jarome, T. J. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.013 · Cited by 101 · see citing works
Schueller, E., Paiva, I., Blanc, F., Wang, X., Cassel, J., Boutillier, A., & Bousiges, O. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.01.015 · Cited by 91 · see citing works
Sartor, G. C., Malvezzi, A. M., Kumar, A., Andrade, N. S., Wiedner, H. J., Vilca, S. J., Janczura, K. J., Bagheri, A., Al‐Ali, H., Powell, S. K., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1604-18.2018 · Cited by 77 · see citing works
The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors
Cao, F., Zwinderman, M., & Dekker, F. (2018) · Molecules · doi:10.3390/molecules23030551 · Cited by 66 · see citing works
Kwapis, J. L., Alaghband, Y., López, A. J., Long, J. M., Li, X., Shu, G., Bodinayake, K. K., Matheos, D. P., Rapp, P. R., & Wood, M. A. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2799-18.2019 · Cited by 60 · see citing works
Amin, S. A., Adhikari, N., Kotagiri, S., Jha, T., & Ghosh, B. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.01.077 · Cited by 44 · see citing works
Zhao, H., Li, G., Zhang, S., Li, F., Wang, R., Tao, Z., Ma, Q., Han, Z., Yan, F., Fan, J., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19875201 · Cited by 44 · see citing works
D’Souza, M. S. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00509 · Cited by 46 · see citing works
Burgdorf, C. E., Schierberl, K. C., Lee, A. S., Fischer, D. K., Kempen, T. A. V., Mudragel, V., Huganir, R. L., Milner, T. A., Glass, M. J., & Rajadhyaksha, A. M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2397-17.2017 · Cited by 36 · see citing works
Malvaez, M. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24552 · Cited by 33 · see citing works
Nuclear receptor corepressors in intellectual disability and autism
Kong, Y., Zhou, W., & Sun, Z. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0667-y · Cited by 29 · see citing works
Hitchcock, L. N., Raybuck, J. D., Wood, M. A., & Lattal, K. M. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5122-2 · Cited by 26 · see citing works
Keiser, A. A., Kramár, E. A., Dong, T. N., Shanur, S., Pirodan, M., Ru, N., Acharya, M. M., Baulch, J. E., Limoli, C. L., & Wood, M. A. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107367 · Cited by 24 · see citing works
The discovery of novel HDAC3 inhibitors via virtual screening and <i>in vitro</i> bioassay
Xia, J., Hu, H., Xue, W., Wang, X. S., & Wu, S. (2018) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2018.1437156 · Cited by 24 · see citing works
López, A. J., Hemstedt, T. J., Jia, Y., Hwang, P. H., Campbell, R. R., Kwapis, J. L., White, A. O., Chitnis, O., Scarfone, V. M., Matheos, D. P., et al. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.04.016 · Cited by 24 · see citing works
HDAC3 of dorsal hippocampus induces postoperative cognitive dysfunction in aged mice
Li, Y., Hao, J., Gao, Y., Yang, X., Shen, X., Wang, H.-Y., Sun, N., & Gao, C. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114002 · Cited by 21 · see citing works
Epigenetic pharmacotherapy for substance use disorder
Sartor, G. C. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.07.012 · Cited by 14 · see citing works
Regulation of HDAC1 and HDAC2 during consolidation and extinction of fear memory
Siddiqui, S. A., Singh, S. K., Ugale, R. R., Ranjan, V., Kanojia, R., Saha, S., Tripathy, S., Kumar, S., Mehrotra, S., Modi, D. R., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.05.011 · Cited by 13 · see citing works
Alaghband, Y., Kramár, E. A., Kwapis, J. L., Kim, E. S., Hemstedt, T. J., López, A. J., White, A. O., Al-Kachak, A., Aimiuwu, O. V., Bodinayake, K. K., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2911-17.2018 · Cited by 12 · see citing works
Epigenetics and Pharmacoepigenetics of Neurodevelopmental and Neuropsychiatric Disorders
Cacabelos, R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813939-4.00022-x · Cited by 11 · see citing works
Regulation of NR4A2 Gene Expression and Its Importance in Neurodegenerative and Psychiatric Diseases
Ruiz-Sánchez, E., Rojas, C., Gómez, P. Y., Martínez‐Rodríguez, N., Ruíz-Chow, Á. A., Nava-Ruíz, C., Ibáñez-Cervantes, G., Arciniega-Martínez, I. M., Reséndiz‐Albor, A. A., & Rojas, P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189162 · Cited by 9 · see citing works
McClarty, B. M., Rodríguez, G., & Dong, H. (2024) · Brain Research · doi:10.1016/j.brainres.2024.148951 · Cited by 9 · see citing works
Pharmacological HDAC3 inhibition alters memory updating in young and old male mice
Smies, C. W., Bellfy, L., Wright, D. S., Bennetts, S. G., Urban, M. W., Brunswick, C. A., Shu, G., & Kwapis, J. L. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1429880 · Cited by 8 · see citing works
Impaired extinction of operant cocaine in a genetic mouse model of schizophrenia risk
Chesworth, R., Visini, G., & Karl, T. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06386-8 · Cited by 7 · see citing works
Gobira, P. H., Roncalho, A. L., Silva, N. R., Silote, G. P., Sales, A. J., & Joca, S. R. L. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05926-4 · Cited by 6 · see citing works
Study on the Role of Dnmt3a Expression in the Dentate Gyrus of the Hippocampus in Reward Memory
Zheng, X., Ma, R., He, E., Peng, X., Ma, W., Zhang, X., Li, Y., Li, H., Li, Y., & Gong, Z. (2024) · ALPHA PSYCHIATRY · doi:10.5152/alphapsychiatry.2024.241602 · Cited by 2 · see citing works
Pharmacological HDAC3 inhibition alters memory updating in young and old micePreprint
Smies, C. W., Bellfy, L., Wright, D. S., Bennetts, S. G., Urban, M. W., Brunswick, C. A., Shu, G., & Kwapis, J. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.08.593015
Vera, V. A., Childs, J. E., Kim, J., Matheos, D. P., & Wood, M. A. (2025) · eNeuro · doi:10.1523/eneuro.0590-24.2025
The epigenetic constellation of neurodevelopment disorders
Cacabelos, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00031-1
Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6
Mohan, A. S., Narayanan, J., Kashid, V. A., Patel, R. J., & Prajapati, B. G. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167313
Robles, A. J., D'hers, S., Feld, M., & Romano, A. G. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06268-y
- Authors
- Alaghband, Y., Kwapis, J. L., López, A. J., White, A. O., Aimiuwu, O. V., Al-Kachak, A., Bodinayake, K. K., Oparaugo, N. C., Dang, R., Astarabadi, M., Matheos, D. P., & Wood, M. A.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Wood, Marcelo A.
- ORCID
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 145
- Pages
- 94-104
- ISSN
- 1074-7427 (ISSN-L)
- PMC
- PMC5698127
- OpenAlex
- W2750755494
- Cited by
- 34
- References
- 68
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 10 · 2018: 6 · 2017: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Drug Abuse
- National Institute of Mental Health (DA025922, DA036984, MH101491)
- National Institute on Aging (F32 DA043998, T32 AG000096-33)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- HDAC3, histone deacetylase, object location memory, memory extinction, dorsal hippocampus, prelimbic cortex, infralimbic cortex, viral gene delivery
- MeSH terms
- Histone Deacetylase 3, Animals, Cocaine, Conditioning, Classical, Extinction, Psychological, Hippocampus, Histone Deacetylases, Male, Memory, Mice, Inbred C57BL, Prefrontal Cortex, Recognition, Psychology, Drug-Seeking Behavior, Spatial Learning
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
