The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
Open accessAbstract
Dementia is increasingly being recognized in cases of Parkinson's disease (PD); such cases are termed PD dementia (PDD). The spread of fibrillar α-synuclein (α-syn) pathology from the brainstem to limbic and neocortical structures seems to be the strongest neuropathological correlate of emerging dementia in PD. In addition, up to 50% of patients with PDD also develop sufficient numbers of amyloid-β plaques and tau-containing neurofibrillary tangles for a secondary diagnosis of Alzheimer's disease, and these pathologies may act synergistically with α-syn pathology to confer a worse prognosis. An understanding of the relationships between these three distinct pathologies and their resultant clinical phenotypes is crucial for the development of effective disease-modifying treatments for PD and PDD.
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Kalia, L. V., & Lang, A. E. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61393-3 · Cited by 6,184
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Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003
Cognitive decline in Parkinson disease
Aarsland, D., Creese, B., Politis, M., Chaudhuri, K. R., ffytche, D. H., Weintraub, D., & Ballard, C. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.27 · Cited by 1,027
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Metadata
- Authors
- Irwin, D. J., Lee, V. M.-Y., & Trojanowski, J. Q.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-07-31
- Volume
- 14
- Issue
- 9
- Pages
- 626-636
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2040042139
- Cited by
- 869
- References
- 160
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
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