Cited by 434Mental Health and PsychiatryMental Health Research TopicsFunctional Brain Connectivity Studies

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DSM-5 and RDoC: progress in psychiatry research?

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Casey, B. J., Craddock, Nick, Cuthbert, Bruce N., Hyman, Steven E., Lee, Francis S., Ressler, Kerry J.·2013·Nature Reviews Neuroscience

DOI 10.1038/nrn3621PMC PMC4372467

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Abstract

Neuroscience studies into psychiatric disorders generally rely on disease definitions that are based on the influential Diagnostic and Statistical Manual of Mental Disorders (DSM), the fifth edition of which (DSM-5) was released earlier this year. Designed as a purely diagnostic tool, the DSM considers different disorders as distinct entities. However, boundaries between disorders are often not as strict as the DSM suggests. To provide an alternative framework for research into psychiatric disorders, the US National Institute of Mental Health (NIMH) has recently introduced its Research Domain Criteria (RDoC) project. In the RDoC, five 'domains' each reflect a brain system in which functioning is impaired, to different degrees, in different psychiatric conditions. Nature Reviews Neuroscience asked six leading investigators for their thoughts on how DSM-5 and the RDoC will influence neuroscience research into psychiatric disorders.

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Authors: Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S., & Ressler, K. J.
Affiliations: Cornell University (US)
Cardiff University (GB)
National Institutes of Health (US)
Broad Institute (US)
Weill Cornell Medicine (US)
Howard Hughes Medical Institute (US)
Corresponding author: Casey, B. J.
Craddock, Nick
Cuthbert, Bruce N.
Hyman, Steven E.
Lee, Francis S.
Ressler, Kerry J.
ORCID: Casey, B. J.
Craddock, Nick
Cuthbert, Bruce N.
Hyman, Steven E.
Lee, Francis S.
Ressler, Kerry J.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2013-10-18
Volume: 14
Issue: 11
Pages: 810-814
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3621
PMC: PMC4372467
OpenAlex: W1997159235
Cited by: 434
References: 5
Citations by year: 2026: 5 · 2025: 32 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 31 · 2020: 75 · 2019: 47 · 2018: 39 · 2017: 38 · 2016: 32 · 2015: 41 · 2014: 23 · 2013: 1
FWCI: 236.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
Funders: National Institute of Mental Health (P50MH079513)
National Institute of Neurological Disorders and Stroke (R01NS052819)
Topics: Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: DSM-5, Research Domain Criteria, psychiatric classification, dimensional psychiatry, diagnostic criteria, psychiatric neuroscience, mental illness, National Institute of Mental Health
MeSH terms: Mental Disorders, Brain, Humans, National Institute of Mental Health (U.S.), Neuropsychological Tests, Psychiatry, United States, Biomedical Research, Diagnostic and Statistical Manual of Mental Disorders

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