The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
DSM-5 and RDoC: progress in psychiatry research?
Open accessAbstract
Neuroscience studies into psychiatric disorders generally rely on disease definitions that are based on the influential Diagnostic and Statistical Manual of Mental Disorders (DSM), the fifth edition of which (DSM-5) was released earlier this year. Designed as a purely diagnostic tool, the DSM considers different disorders as distinct entities. However, boundaries between disorders are often not as strict as the DSM suggests. To provide an alternative framework for research into psychiatric disorders, the US National Institute of Mental Health (NIMH) has recently introduced its Research Domain Criteria (RDoC) project. In the RDoC, five 'domains' each reflect a brain system in which functioning is impaired, to different degrees, in different psychiatric conditions. Nature Reviews Neuroscience asked six leading investigators for their thoughts on how DSM-5 and the RDoC will influence neuroscience research into psychiatric disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“most phenotypes are based on clinical and behavioural symptomatology rather than on biological mechanism or aetiology22–24.”
From Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders (2015) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Toward the future of psychiatric diagnosis: the seven pillars of RDoC
Cuthbert, B. N., & Insel, T. R. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-126 · Cited by 3,053
Self-citationA Genetic Variant BDNF Polymorphism Alters Extinction Learning in Both Mouse and Human
Soliman, F., Glatt, C. E., Bath, K. G., Levita, L., Jones, R. M., Pattwell, S. S., Jing, D., Tottenham, N., Amso, D., Somerville, L. H., et al. (2010) · Science · doi:10.1126/science.1181886 · Cited by 585
Self-citationNeuroscience, Clinical Evidence, and the Future of Psychiatric Classification in DSM-5
Kupfer, D. J., & Regier, D. A. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020219 · Cited by 245
Felmingham, K. L., Dobson‐Stone, C., Schofield, P. R., Quirk, G. J., & Bryant, R. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.033 · Cited by 167
Kupfer, D. J., Kuhl, E. A., & Regier, D. A. (2013) · JAMA · doi:10.1001/jama.2013.2298 · Cited by 82
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 432
Prevention and Treatment of “Food Addiction”
Davis, C., & Mason, A. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.023 · Cited by 42
Human Neurobiological Approaches to Hedonically Motivated Behaviors
Burger, K. S., Shearrer, G. E., & Sadler, J. R. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.009 · Cited by 42
Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.034 · Cited by 42
Aligning physiology with psychology: Translational neuroscience in neuropsychiatric drug discovery
McArthur, R. A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.02.004 · Cited by 42
“…seeking to coordinate with the World Health Organization development of ICD-11 International Classification of Diseases in the process of being published http://apps.who.int/classifications/icd11/browse/ f/en (Casey et al., 2013; Cuthbert and Insel, 2013; Kupfer et al., 2008; Regier, 2007).”
Bridging the gap between the neurocognitive lab and the addiction clinic
Franken, I. H. A., & van de Wetering, B. J. M. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.11.034 · Cited by 47
Pre-clinical models of reward deficiency syndrome: A behavioral octopus
Gondré‐Lewis, M. C., Bassey, R. B., & Blum, K. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.021 · Cited by 42
Moran, M., Blum, K., Ponce, J. V., Lott, L., Gondré‐Lewis, M. C., Badgaiyan, S., Brewer, R., Downs, B. W., Fynman, P., Weingarten, A., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02312-1 · Cited by 42
“The US National Institute of Mental Health (NIMH) has introduced the Research Domain Criteria (RDoC) project [28] to overcome inadequacies of the DSM involved in focus on symptoms, and the division of psychiatric disorders, including pain issues, into distinct categories.”
BackgroundUnderstanding Psychological Symptoms of Endometriosis from a Research Domain Criteria Perspective
van Stein, K., Schubert, K., Ditzen, B., & Weise, C. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12124056 · Cited by 40
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 41
“Indeed, critics have argued that the DSM is now seriously hindering research in psychopathology (Phillips et al., 2012; Casey et al., 2013; Hengartner and Lehmann, 2017); for instance, Hyman (2010) has characterized DSM diagnostic criteria as an “unintended epistemic prison… palpably impeding…”
BackgroundCarpenter, J. S., Iorfino, F., Cross, S. P. M., Nichles, A., Zmicerevska, N., Crouse, J. J., Palmer, J. R., Whitton, A. E., White, D., Naismith, S. L., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-030985 · Cited by 41
Fitzgerald, E., Parent, C. I., Kee, M. Z. L., & Meaney, M. J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635304 · Cited by 41
Lee, R. S. C., Hermens, D. F., Scott, J. L., O’Dea, B., Glozier, N., Scott, E. M., & Hickie, I. B. (2017) · Psychological Medicine · doi:10.1017/s0033291717000484 · Cited by 41
“As endorsed by the National Institute of Mental Health Research Domain Criteria initiative in order to advance psychiatric research (Casey et al. 2013), a transdiagnostic approach is ideal in that it permits the identification of cognitive and clinical factors that cut across diagnostic boundaries…”
MethodFingelkurts, A. A., & Fingelkurts, A. A. (2022) · Applied Sciences · doi:10.3390/app12199560 · Cited by 43
Spielberg, J. M., Miller, G. A., Warren, S. L., Sutton, B. P., Banich, M. T., & Heller, W. (2014) · Depression and Anxiety · doi:10.1002/da.22271 · Cited by 37
“This is at odds with recent recognition that dimensional, transdiagnostic approaches will likely have more utility when translating basic neuroscience into clinical treatments.[15-17] Furthermore, relevant studies have rarely examined anxiety and depression simultaneously, despite high comorbidity,[18] leaving unclear…”
Youth at-risk for serious mental illness: methods of the PROCAN study
Addington, J., Goldstein, B. I., Wang, J., Kennedy, S. H., Bray, S., Lebel, C. A., Hassel, S., Marshall, C., & MacQUEEN, G. M. (2018) · BMC Psychiatry · doi:10.1186/s12888-018-1801-0 · Cited by 37
Commentary on evidence in support of a grief‐related condition as a DSM diagnosis
Simon, N. M., Shear, M. K., Reynolds, C. F., Cozza, S. J., Mauro, C., Zisook, S., Skritskaya, N. A., Robinaugh, D. J., Malgaroli, M., Spandorfer, J., et al. (2020) · Depression and Anxiety · doi:10.1002/da.22985 · Cited by 40
“Studies regularly show high levels of comorbidity across depressive, anxiety, and trauma‐related conditions and this has spurred transdiagnostic research (American Psychiatric Association, 2013; Casey et al., 2013).”
BackgroundMachine Learning and the Digital Measurement of Psychological Health
Galatzer‐Levy, I. R., & Onnela, J.-P. “. (2023) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-080921-073212 · Cited by 39
Mapping brain-behavior space relationships along the psychosis spectrum
Ji, J. L., Helmer, M., Fonteneau, C., Burt, J. B., Tamayo, Z., Demšar, J., Adkinson, B. D., Savić, A., Preller, K. H., Moujaes, F., et al. (2021) · eLife · doi:10.7554/elife.66968 · Cited by 42
The computational psychiatry of antisocial behaviour and psychopathy
Pauli, R., & Lockwood, P. L. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104995 · Cited by 34
Hinton, D. E., & Jalal, B. (2014) · Intervention · doi:10.1097/wtf.0000000000000069 · Cited by 35
Ethical Challenges in Digital Psychology and Cyberpsychology
Parsons, T. D. (2019) · Cambridge University Press eBooks · doi:10.1017/9781108553384 · Cited by 33
Lee, R. S. C., Hermens, D. F., Naismith, S. L., Kaur, M., Guastella, A. J., Glozier, N., Scott, J. L., Scott, E. M., & Hickie, I. B. (2018) · BMJ Open · doi:10.1136/bmjopen-2018-022659 · Cited by 32
Computational approaches and machine learning for individual-level treatment predictions
Paulus, M. P., & Thompson, W. K. (2019) · Psychopharmacology · doi:10.1007/s00213-019-05282-4 · Cited by 30
Wortzel, J. R., Turner, B. E., Weeks, B. T., Fragassi, C., Ramos, V., Truong, T., Li, D., Sahak, O., & Lee, H. B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233996 · Cited by 31
Li, H., Kawatake-Kuno, A., Inaba, H., Miyake, Y., Itoh, Y., Ueki, T., Oishi, N., Murai, T., Suzuki, T., & Uchida, S. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.004 · Cited by 36
Filho, A. J. M. C., Eyres, C., Blöbaum, L., Landwehr, A., & Tremblay, M. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16098 · Cited by 33
The computational psychiatry of reward: broken brains or misguided minds?
Moutoussis, M., Story, G. W., & Dolan, R. J. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01445 · Cited by 28
“To be more specific if the Reward processing domain of the otherwise promising ‘Research Domain Criteria’ framework (Casey et al., 2013) is applied too simplistically we may end up with exactly the same mistakes as in previous biological or psychoanalytic normative straightjackets.”
BackgroundIbrahim, K., Kalvin, C. B., Li, F., He, G. S., Pelphrey, K. A., McCarthy, G., & Sukhodolsky, D. G. (2020) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2020.100884 · Cited by 33
Future Directions for Examination of Brain Networks in Neurodevelopmental Disorders
Uddin, L. Q., & Karlsgodt, K. H. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2018.1443461 · Cited by 31
“Consistent with the RDoC framework (Casey et al., 2013; Insel, 2014), future work may go beyond traditional Diagnostic and Statistical Manual of Mental Disorder–based diagnoses to identify aspects of cognitive dysfunction that cut across diagnostic categories (Dajani, Llabre, Nebel, Mostofsky, &…”
MethodBrain space and time in mental disorders: Paradigm shift in biological psychiatry
Fingelkurts, A. A., & Fingelkurts, A. A. (2018) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217418791438 · Cited by 30
The Need for a Developmentally Based Measure of Social Communication Skills
Bishop, S. L., Farmer, C., Kaat, A. J., Georgiades, S., Kanne, S. M., & Thurm, A. E. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.12.010 · Cited by 32
Reilly, E. E., Whitton, A. E., Pizzagalli, D. A., Rutherford, A. V., Stein, M. B., Paulus, M. P., & Taylor, C. T. (2020) · Depression and Anxiety · doi:10.1002/da.23081 · Cited by 28
“Given increasing evidence regarding shared phenotypes across traditional diagnostic boundaries (Insel et al., 2010), as well as heterogeneity within traditional DSM‐5 categories (Casey et al., 2013), shifting toward transdiagnostic conceptualizations and targets may improve treatment outcomes.”
BackgroundCurley, K., Colman, R., Rushforth, A., & Kotera, Y. (2023) · Youth · doi:10.3390/youth3010017 · Cited by 27
“We drew this cut-off because the latest version of the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5) was published in 2013, where the definition and understanding of autism were updated [36,37].”
MethodNeurobiology of maternal mental illness
Maguire, J., McCormack, C., Mitchell, A., & Monk, C. E. (2020) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64239-4.00005-9 · Cited by 28
Neuroimaging Markers of Risk and Pathways to Resilience in Autism Spectrum Disorder
Molnar-Szakacs, I., Kupis, L. B., & Uddin, L. Q. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.06.017 · Cited by 29
Understanding the nature of face processing in early autism: A prospective study.
Tye, C., BASIS team, Bussu, G., Gliga, T., Elsabbagh, M., Pasco, G., Johnsen, K., Charman, T., Jones, E. J. H., Buitelaar, J. K., et al. (2022) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000648 · Cited by 26
“…for psychopathology from an RDoC perspective, a diagnostic outcome retains a high clinical interest for decisionmaking in a medical system (Casey et al., 2013), and thus provided an opportunity to explore predictive power of altered face processing for ASD at different, complementary…”
BackgroundA new conception and subsequent taxonomy of clinical psychological problems
Bakker, G. (2019) · BMC Psychology · doi:10.1186/s40359-019-0318-8 · Cited by 30
Chen, Y., Zhao, W., Yi, S., & Liu, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1174080 · Cited by 25
Classification of Behaviorally Defined Disorders: Biology Versus the DSM
Rapin, I. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2127-5 · Cited by 27
“’’ This is true of even the most robust, for example atypical trajectory of brain growth in autism spectrum disorders (Courchesne et al. 2011) or variable strength of working memory on and off psychostimulants in attention deficit hyperactivity disorder (Wong and Stevens 2012). Miller and Rockstroh go so far as to que…”
BackgroundGrasser, L. R., Saad, B., Bazzi, C., Wanna, C., Suhaiban, H. A., Mammo, D. F., Jovanović, T., & Javanbakht, A. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2022.2083375 · Cited by 25
“Currently, there are no validated and reliable biomarkers for any psychiatric condition (Casey et al., 2013; Macaluso & Preskorn, 2012), and diagnoses are made based solely on clinical interviews (Casey et al., 2013; Kupfer & Regier, 2011).”
BackgroundQuantitative Trait Loci and a Novel Genetic Candidate for Fear Learning
Knoll, A. T., Halladay, L. R., Holmes, A., & Levitt, P. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0177-16.2016 · Cited by 24
“As proposed by the National Institute of Mental Health (National Institutes of Health) Research Domain Criteria initiative and others, understanding the biological origins of heterogeneity in key intermediate phenotypes such as cognition and emotion that are affected in trauma- and stress-related disorders has the pot…”
BackgroundHippocampal development in youth with a history of childhood maltreatment
Paquola, C., Bennett, M. R., Hatton, S. N., Hermens, D. F., Groote, I. R., & Lagopoulos, J. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.03.019 · Cited by 25
“The advantages of using this trans-diagnostic approach in research are discussed at length elsewhere (Casey et al., 2013; Cuthbert, 2014; Cuthbert and Insel, 2013).”
MethodHerzog, D. P., Beckmann, H., Lieb, K., Ryu, S., & Müller, M. B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00512 · Cited by 26
“However, we have to admit that despite decades of research, scientists have been unable to find any genetic or neurological evidence to support the breakdown of psychiatric disorders into the diagnostic categories such as provided in the DSM or ICD (33).”
BackgroundIneichen, C., & Baumann‐Vogel, H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.720921 · Cited by 25
Data-driven analysis of gaze patterns in face perception: Methodological and clinical contributions
Masulli, P., Galazka, M. A., Eberhard, D., Johnels, J. Å., Gillberg, C., Billstedt, E., Hadjikhani, N. K., & Andersen, T. (2021) · Cortex · doi:10.1016/j.cortex.2021.11.011 · Cited by 23
“This underscores the importance and prevalence of “comorbidity” or the co-existence of disorders, probably with shared symptoms (Astle et al., 2021; Casey et al., 2013; Gillberg, 2010) with some disorders co-occurring at higher rates than others (Antshel et al.”
Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics
Blum, K., Badgaiyan, R. D., & Gold, M. S. (2015) · Cureus · doi:10.7759/cureus.348 · Cited by 25
“proposed that while the DSM considers different disorders as distinct entities, “boundaries between disorders are often not as strict as the DSM suggests” [97].”
BackgroundA hierarchical model for integrating unsupervised generative embedding and empirical Bayes
Raman, S., Deserno, L., Schlagenhauf, F., & Stephan, K. E. (2016) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2016.04.022 · Cited by 21
“These disease definitions likely group together heterogeneous patient groups characterised by a diversity of pathophysiological mechanisms (Casey et al. 2013; Krystal & State 2014).”
Is Adolescent Suicidal Ideation Continuous or Categorical? A Taxometric Analysis
Liu, R. T., Jones, R. N., & Spirito, A. (2015) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-015-0022-y · Cited by 24
“2011; 120:779–796.10.1037/a0025441 [PubMed: 21928863] Casey BJ, Craddock N, Cuthbert BN, Hyman SE, Lee FS, Ressler KJ. DSM-5 and RDoC: progress in psychiatry research?”
BackgroundInfluentialThe Utility of Research Domain Criteria in Diagnosis and Management of Dual Disorders: A Mini-Review
Hakak‐Zargar, B., Tamrakar, A., Voth, T., Sheikhi, A., Multani, J., & Schütz, C. G. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.805163 · Cited by 21
“Studies into genetic factors that may predispose individuals to SUD link impulsivity behaviors related to addiction with genes encoding cannabinoid brain receptor type 1 andmu-opioid receptor type 1, which both play a role in the corticolimbic reward pathway (6).”
BackgroundMethodInfluentialEpigenetic mechanisms linking early-life adversities and mental health
Cánepa, E. T., & Berardino, B. G. (2024) · Biochemical Journal · doi:10.1042/bcj20230306 · Cited by 22
Genes, Brains, and Behavior: Imaging Genetics for Neuropsychiatric Disorders
Arslan, A. (2015) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.13080185 · Cited by 25
The Changing REM Sleep Signature of Posttraumatic Stress Disorder
Ross, R. J. M. (2014) · SLEEP · doi:10.5665/sleep.3912 · Cited by 21
Paquola, C., Bennett, M. R., Hatton, S. N., Hermens, D. F., & Lagopoulos, J. (2017) · Human Brain Mapping · doi:10.1002/hbm.23554 · Cited by 22
“The advantages of using this trans diagnostic approach in research, in contrast to categorical diagnostic grouping, are discussed at length elsewhere [Casey et al., 2013, Cuthbert, 2014, Cuthbert and Insel, 2013].”
MethodTwenty years of progress in paediatric psychopharmacology: accomplishments and unmet needs
Vitiello, B., & Davico, C. (2018) · Evidence Based Mental Health · doi:10.1136/ebmental-2018-300040 · Cited by 21
Research domain criteria: a final paradigm for psychiatry?
Glannon, W. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00488 · Cited by 20
“The aim of the RDoC is to identify brain mechanisms that can explain the etiology and pathophysiology of psychiatric disorders, provide earlier and more accurate diagnosis, and predict treatment responses and outcomes (Insel et al., 2010; Casey et al., 2013).”
BackgroundInfluentialNi, M. Y., Jiang, C., Cheng, K. K., Zhang, W., Gilman, S. E., Lam, T. H., Leung, G. M., & Schooling, C. M. (2015) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4370 · Cited by 20
“, 2009) and the poor correlation of DSM-5 diagnostic categories with the neurobiology of psychiatric illness (Casey et al., 2013; Cuthbert and Insel, 2013).”
BackgroundAssessing neurocognitive function in psychiatric disorders: A roadmap for enhancing consensus
Ahmari, S. E., Eich, T. S., Cebenoyan, D., Smith, E. E., & Simpson, H. B. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.06.011 · Cited by 20
Fellowes, S. (2017) · Metamedicine · doi:10.1007/s11017-017-9416-x · Cited by 21
Mind-Brain Dualism in Psychiatry: Ethical Implications
Glannon, W. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00085 · Cited by 21
Sparse deep neural networks on imaging genetics for schizophrenia case–control classification
Chen, J., Li, X., Calhoun, V. D., Turner, J. A., van Erp, T. G. M., Wang, L., Andreassen, O. A., Agartz, I., Westlye, L. T., Jönsson, E. G., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25387 · Cited by 19
“It has now been widely acknowledged that objective biological markers are needed to quantify abnormalities underlying phenotypic manifestation, which allows characterizing disorders based on a multitude of dimensions and along a spectrum of functioning, so as to improve patient stratification and inform treatment plan…”
BackgroundBlum, K., Dennen, C. A., Elman, I., Bowirrat, A., Thanos, P. K., Badgaiyan, R. D., Downs, B. W., Bagchi, D., Baron, D. A., Braverman, E. R., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101719 · Cited by 19
“[69], the central nervous system rewarding properties of ethanol, heroin, and cocaine might stimulate a common catecholaminergic reward system in the mesolimbic circuitry of the brain.”
BackgroundBreen, M. S., Stein, D. J., & Baldwin, D. S. (2016) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2546 · Cited by 20
“Finally, it is relevant to consider the National Institute of Mental Health’s Research Domain Criteria definition of a “biosignature” (Casey et al., 2013): an integrated multi-marker test based on the use of several different readouts (self-reported, cognitive, genetic, transcriptomic, epigenomic,…”
BackgroundHermens, D. F., Hatton, S. N., White, D., Lee, R. S. C., Guastella, A. J., Scott, E. M., Naismith, S. L., Hickie, I. B., & Lagopoulos, J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.08.032 · Cited by 19
“One application of a transdiagnostic approach is to sample widely across a given clinical service, in order to include individuals with the necessary variance along a dimension of interest (Casey et al., 2013).”
Shackman, A. J., Fox, A. S., & Seminowicz, D. A. (2015) · Behavioral and Brain Sciences · doi:10.1017/s0140525x14001010 · Cited by 22
Glannon, W. (2018) · doi:10.1093/med/9780198758853.001.0001 · Cited by 29
Identifying genes for neurobehavioural traits in rodents: progress and pitfalls
Baud, A., & Flint, J. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.027789 · Cited by 18
Xu, S., Deng, W.-F., Qu, Y., Lai, W., Huang, T.-Y., Rong, H., & Xie, X. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.120 · Cited by 17
Lawn, T., Giacomel, A., Martins, D., Veronese, M., Howard, M. A., Turkheimer, F., & Dipasquale, O. (2024) · Communications Biology · doi:10.1038/s42003-024-06391-3 · Cited by 22
“For example, the Research Domain Criteria (RDoC) framework aims to re-examine mental disorders from the perspective of neurobehavioral functioning, regardless of conventional diagnostic categories 15 – 17 .”
Olfactory function in neuropsychiatric disorders
Ryo, Y., Takeuchi, M., Ueda, N., Ohi, K., Kihara, H., Shimada, T., Uehara, T., & Kawasaki, Y. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.02.058 · Cited by 17
“To provide an alternative framework for research into neuropsychiatric disorders, the National Institute of Mental Health (NIMH) has recently developed the Research Domain Criteria (RDoC) (Casey et al., 2013).”
BackgroundSievers, B., & Thornton, M. A. (2024) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsae014 · Cited by 16
“There is widespread consensus in the neuroscientific community that existing diagnostic categories do not reflect the underlying structures or mechanisms of mental health conditions (Casey et al ., 2013).”
BackgroundA theoretical and empirical modeling of anxiety integrated with RDoC and temporal dynamics
Frank, B. E., Jacobson, N. C., Hurley, L., & McKay, D. (2017) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2017.09.002 · Cited by 18
Clementz, B. A., Chattopadhyay, I., Trotti, R. L., Parker, D., Gershon, E. S., Hill, S. K., Ivleva, E. I., Keedy, S., Keshavan, M. S., McDowell, J. E., et al. (2023) · Schizophrenia Research · doi:10.1016/j.schres.2023.08.006 · Cited by 15
Woody, E. Z., Hoffman, K. L., & Szechtman, H. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.003 · Cited by 16
The Limitations and Potential of Neuroimaging in the Criminal Law
Glannon, W. (2014) · The Journal of Ethics · doi:10.1007/s10892-014-9169-y · Cited by 15
O projeto Research Domain Criteria e o abandono da tradição psicopatológica
Zorzanelli, R., Dalgalarrondo, P., & Banzato, C. E. M. (2014) · Revista Latinoamericana de Psicopatologia Fundamental · doi:10.1590/1984-0381v17n2a12 · Cited by 15
HCN channels in the hippocampus regulate active coping behavior
Fisher, D. W., Han, Y. S., Lyman, K. A., Heuermann, R. J., Bean, L. A., Ybarra, N., Foote, K. M., Dong, H., Nicholson, D. A., & Chetkovich, D. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14539 · Cited by 16
Wang, J., Sun, W., Tang, X., Xu, L., Wei, Y., Cui, H., Tang, Y., Hui, L., Jia, Q., Zhu, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47754-9 · Cited by 14
Scott, E. M., Carpenter, J. S., Iorfino, F., Cross, S. P. M., Hermens, D. F., White, D., Lee, R. S. Z., Naismith, S. L., Guastella, A. J., Glozier, N., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813176-3.00005-5 · Cited by 13
Yen, J., Chou, W., Liao, H.-Y., & Ko, C. (2022) · Current Addiction Reports · doi:10.1007/s40429-022-00459-y · Cited by 14
Empirische Untersuchung veränderter Bewusstseinszustände
Schmidt, T. T., & Majić, T. (2016) · Springer eBooks · doi:10.1007/978-3-642-55214-4_65-1 · Cited by 14
Understanding trajectories of underlying dimensions of posttraumatic psychopathology
Sumner, J. A., Rünger, D., Robles, T. F., Lowe, S. R., Elashoff, D. A., & Shetty, V. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.01.086 · Cited by 15
“Growing research in posttraumatic psychopathology suggests that discrete and more homogeneous dimensions, which align more closely with underlying biological mechanisms, underlie several traditional psychiatric diagnoses (Armour et al., 2016; Casey et al., 2013; Forbes et al., 2010; McLean et al., 2019).”
BackgroundInfluentialChen, Y., Chen, Y., Zheng, R., Xue, K., Li, S., Pang, J., Li, H., Zhang, Y., Cheng, J., & Han, S. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.091 · Cited by 13
Nichles, A., Zmicerevska, N., Song, Y. J. C., Wilson, C. E., McHugh, C. M., Hamilton, B. A., Crouse, J. J., Rohleder, C., Carpenter, J. S., Ho, N., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-044731 · Cited by 11
Transforming Neuroscience Education in Psychiatry
Akil, M., & Etkin, A. (2014) · Academic Psychiatry · doi:10.1007/s40596-014-0065-3 · Cited by 14
“Other commentaries have addressed what form this coming together may take and what may be required to get there [2–8].”
Le serious game : applications thérapeutiques en psychiatrie
Fovet, T., Micoulaud‐Franchi, J., Vaïva, G., Thomas, P., Jardri, R., & Amad, A. (2016) · L Encéphale · doi:10.1016/j.encep.2016.02.008 · Cited by 13
Subcortical Volume Correlates of Psychological Distress in Early Adolescence
Broadhouse, K. M., Boyes, A., Winks, N., Dokonal, T., McLoughlin, L. T., Parker, M. J., Beaudequin, D. A., Simcock, G. P., Lagopoulos, J., & Hermens, D. F. (2019) · Developmental Neuroscience · doi:10.1159/000502339 · Cited by 13
PTSD subtypes and their underlying neural biomarkers: a systematic review
Zhang, C., Haim‐Nachum, S., Prasad, N., Suarez‐Jimenez, B., Zilcha‐Mano, S., Lazarov, A., Neria, Y., & Zhu, X. (2025) · Psychological Medicine · doi:10.1017/s0033291725001229 · Cited by 18
“Consequently, the field has faced challenges in reliably translating knowledge from neuroimaging into clinical practice (Casey et al., 2013).”
Appetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12
Manzanares, J., Sala, F., García‐Gutiérrez, M. S., & Rueda, F. N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00060-8 · Cited by 12
Chen, J., Liu, J., & Calhoun, V. D. (2019) · Proceedings of the IEEE · doi:10.1109/jproc.2019.2913145 · Cited by 13
McCoy, T. H., Pellegrini, A. M., & Perlis, R. H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237698 · Cited by 10
Melo, H. M., Guarnieri, R., Vascouto, H. D., Formolo, D. A., de Carvalho, C. R., Campos, W. K., Sousa, D. S., Dionisio, S. A., Wolf, P., Lin, K., et al. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107548 · Cited by 12
Korem, N., Duek, O. A., Spiller, T. R., Ben‐Zion, Z., Levy, I., & Harpaz‐Rotem, I. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.6813 · Cited by 14
EEG Source Imaging Indices of Cognitive Control Show Associations with Dopamine System Genes
McLoughlin, G., Palmer, J., Makeig, S., Bigdely-Shamlo, N., Banaschewski, T., Laucht, M., & Brandeis, D. (2017) · Brain Topography · doi:10.1007/s10548-017-0601-z · Cited by 9
Paquola, C., Bennett, M. R., & Lagopoulos, J. (2018) · Brain Connectivity · doi:10.1089/brain.2018.0584 · Cited by 12
“The advantages of such a transdiagnostic approach are discussed at length elsewhere (Casey et al., 2013; Cuthbert, 2014; Cuthbert and Insel, 2013).”
Shackman, A. J., Fox, A. S., & Seminowicz, D. A. (2015) · Behavioral and Brain Sciences · doi:10.1017/s0140525x15000679 · Cited by 11
What is Mental Disorder? Developing an Embodied, Embedded, and Enactive Psychopathology
Nielsen, K. (2020) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17145938.v1 · Cited by 15
“Alternative classification systems are being developed, and the DSM’s continued position as the bedrock document of psychopathology is in serious doubt (Casey et al., 2013; Cuthbert, 2014; Insel et al., 2010).”
BackgroundConvergent neurobiological predictors of mood and anxiety symptoms and treatment response
Jabbi, M., & Nemeroff, C. B. (2019) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2019.1620604 · Cited by 10
Dopaminergic dysfunction: Role for genetic & epigenetic testing in the new psychiatry
Blum, K., Ashford, J. W., Kateb, B., Sipple, D., Braverman, E. R., Dennen, C. A., Baron, D. A., Badgaiyan, R. D., Elman, I., Cadet, J. L., et al. (2023) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2023.120809 · Cited by 15
Culturally Sensitive CBT for Refugees: Key Dimensions
Hinton, D. E., & Patel, A. (2018) · Springer eBooks · doi:10.1007/978-3-319-97046-2_10 · Cited by 13
Metadata
- Authors
- Casey, B. J., Craddock, N., Cuthbert, B. N., Hyman, S. E., Lee, F. S., & Ressler, K. J.
- Affiliations
- Cornell University (US)
- Cardiff University (GB)
- National Institutes of Health (US)
- Broad Institute (US)
- Weill Cornell Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Casey, B. J.
- Craddock, Nick
- Cuthbert, Bruce N.
- Hyman, Steven E.
- Lee, Francis S.
- Ressler, Kerry J.
- Venue
- Nature Reviews Neuroscience
- Published
- 2013-10-18
- Volume
- 14
- Issue
- 11
- Pages
- 810-814
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC4372467
- OpenAlex
- W1997159235
- Cited by
- 434
- References
- 5
- Citations by year
- 2026: 5 · 2025: 32 · 2024: 21 · 2023: 22 · 2022: 27 · 2021: 31 · 2020: 75 · 2019: 47 · 2018: 39 · 2017: 38 · 2016: 32 · 2015: 41 · 2014: 23 · 2013: 1
- FWCI
- 236.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Funders
- National Institute of Mental Health (P50MH079513)
- National Institute of Neurological Disorders and Stroke (R01NS052819)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- DSM-5, Research Domain Criteria, psychiatric classification, dimensional psychiatry, diagnostic criteria, psychiatric neuroscience, mental illness, National Institute of Mental Health
- MeSH terms
- Mental Disorders, Brain, Humans, National Institute of Mental Health (U.S.), Neuropsychological Tests, Psychiatry, United States, Biomedical Research, Diagnostic and Statistical Manual of Mental Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
