Cited by 641Inflammasome and immune disordersNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

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Inflammasomes in the CNS

Walsh, John G., Muruve, Daniel A., Power, Christopher·2014·Nature Reviews Neuroscience

DOI 10.1038/nrn3638

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Abstract

Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death. Since the discovery of inflammasomes in 2002, there has been burgeoning recognition of their complexities and functions. Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.

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Background
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Background
RETRACTED: Up-regulation of microRNA-223 inhibits brain injury and hippocampal neuron apoptosis of rats after febrile seizure through the NLRP3-Caspase-1 signaling pathway
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Background
Remote limb ischemic postconditioning inhibits microglia pyroptosis by modulating HGF after acute ischemia stroke
Lu, Y., Zhang, Z., Chen, H., Wang, M., Mao, W., Hu, J., Zuo, D., Lv, B., Wu, W.-F., Qi, S., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10590 · Cited by 9
“36,37,44 However, we do not deny that other types of cells also exist in pyrop-tosis and their role in the progression of AIS is still worthy of further study.”
Background
Ghrelin Inhibits Inflammasomes Activation in Astrocytes, Alleviates Pyroptosis, and Prevents Lipopolysaccharide-induced Depression-like Behavior in Mice
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MethodInfluential
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Authors: Walsh, J. G., Muruve, D. A., & Power, C.
Affiliations: University of Alberta (CA)
University of Calgary (CA)
Corresponding author: Power, Christopher
ORCID: Muruve, Daniel A.
Power, Christopher
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-01-08
Volume: 15
Issue: 2
Pages: 84-97
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3638
OpenAlex: W1981649246
Cited by: 637
References: 149
Citations by year: 2026: 25 · 2025: 18 · 2024: 46 · 2023: 49 · 2022: 77 · 2021: 67 · 2020: 76 · 2019: 58 · 2018: 51 · 2017: 47 · 2016: 57 · 2015: 43 · 2014: 22
FWCI: 5.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inflammasome, central nervous system, caspase-1, IL-1β, IL-18, pyroptosis, microglia, macrophages, neurological disorders, meningitis, stroke, Alzheimer's disease, innate immunity, damage-associated molecular patterns
MeSH terms: Animals, Central Nervous System, Humans, Macrophages, Nervous System Diseases, Neuroglia, Inflammasomes

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