Cited by 641Inflammasome and immune disordersNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

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Inflammasomes in the CNS

Walsh, John G., Muruve, Daniel A., Power, Christopher·2014·Nature Reviews Neuroscience

DOI 10.1038/nrn3638

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Abstract

Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death. Since the discovery of inflammasomes in 2002, there has been burgeoning recognition of their complexities and functions. Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.

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Self-citation
Oxygen and Glucose Deprivation Induces Expression of Aim2, ASC, Caspase-1 and NLRP3 in Primary Microglia and Bone Marrow Derived Macrophages
Zhao, J., Bernstock, J. D., Wang, S., Ye, D. G., Spatz, M., Johnson, K. R., Li, X., Li, X., & Hallenbeck, J. M. (2016) · Matters · doi:10.19185/matters.201602000017
“This finding is consistent with existing evidence that supports the activation of the NLRP3 inflammasome via exposure to extracellular ATP, reactive oxygen species, and/or necrotic cell death [23] [24], all of which are upregulated after stroke [6].”
Result
Remote Inflammatory and Metabolic Impact of Acute Injury*
West, M. A. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000292
“mental status (10) or renal function (11).”
A bioluminescence sensor of NLRP3 inflammasome activation
Winek, M. A. (2016) · Loyola eCommons (Loyola University of Chicago)
Microglia: Features of Polarization and Aging
Harry, G. J., & McPherson, C. A. (2016) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-3-319-33486-8_3
P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Subjected to Mechanical Strain
Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C.-S., McCaughey, S. A., & Mitchell, C. H. (2017) · ScholarlyCommons (University of Pennsylvania)
L’immunopsychiatrie existe-t-elle ?
Fond, G. B. (2018) · Phytothérapie · doi:10.3166/phyto-2018-0092
Nutrition in Inflammatory Lung Diseases
Aguilar-López, D. K., Sandoval, C. O., Estrada-Luna, D., Vega, J. A. I., Sharma, A. K., & Cabrera, G. B. (2019) · Springer eBooks · doi:10.1007/978-981-13-8413-4_1
Mechanisms and consequences of Staphylococcus aureus Leukocidin AB-mediated activation of the host NLRP3 inflammasome
Melehani, J. H. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/dnpd-f156
Chronic traumatic encephalopathy: the nature, mechanisms and stages of development
Eg, P., & Лисяный, Н. И. (2019) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.168890
“В последние годы появляется все больше свидетельств, указывающих на нарушение регуляции иммунных реакций при ЧМТ и потенцировании развития неврологической дисфункции иммунными факторами [26,28,30].”
The Role of Cytokines in Binge-like Ethanol Consumption and Ethanol-induced Sedation
Casachahua, J. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/bd21-xn36
Excess extracellular K + causes inner hair cell ribbon synapse degenerationPreprint
Zhao, H., Zhu, Y., & Liu, L.-M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.23.887596
Stem cells application for the treatment of traumatic brain injury
Liubich, L. D., & Михайловна, Е. Д. (2020) · Ukrainian Neurosurgical Journal · doi:10.25305/unj.189596
Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach
Onyango, I. G., & Stokin, G. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00015-2
Functional Gene Trap Mutagenesis Screen for Genes and Molecular Mechanisms Underlying Amyloid-β-induced Inflammasome-mediated Neuronal DeathPreprint
Yap, J. K. Y., Pickard, B. S., Gan, S. Y., & Chan, E. W. L. (2020) · doi:10.21203/rs.3.rs-19699/v1
References
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O papel do sistema de secreção do tipo VI (TSS6) bacteriano na ativação dos inflamassomas durante a resposta imunológica inata
Ribeiro, D. J. S. (2017) · RIUnB Institutional Repository (University of Brasília) · doi:10.26512/2017.03.d.23502
Glial Cells
Pais, T. F. (2015) · Encyclopedia of Inflammatory Diseases · doi:10.1007/978-3-0348-0620-6_111-1
Effects of Substances Released from Inflammatory Cells on the Blood-Brain Barrier after Cerebral Hemorrhage
郭, 鑫. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.1111774
Interrelation Between the Immune and the Nervous Systems in the Context of Cerebellar Development and Developmental Disorders
Eissa, N., Kermarrec, L., Tshikudi, D. M., Hesampour, F., & Ghia, J. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-23104-9_16
Expression and Purification of Inflammasome Sensor NOD-Like Receptor Protein-1 Using the Baculovirus-Insect Cell Expression System
Sivaraman, H., & Wong, W. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3331-1_15
Knockdown of Long Non-coding RNA TUG1 Suppresses pyroptosis in High Glucose-Stimulated BV-2 CellsPreprint
Pan, Y., Lu, X., Guo, W., Lei, H., & Zhang, Q. (2023) · Research Square · doi:10.21203/rs.3.rs-3260425/v1
WITHDRAWN: Liver isoform of phosphofructokinase (PFKL)-Mediated Hypoxic Preconditioned Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Cardiac Arrest-Induced Pyroptosis in Rat Cortical Neurons by Protecting Mitochondrial Function from Oxidative DamagePreprint
Tang, X., Zheng, N., Gong, Z., You, Y., Lin, Q., Zhuang, Y., Wu, J., Wang, Y., Huang, H., Chen, F., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3552856/v1
WITHDRAWN: Liver isoform of phosphofructokinase (PFKL)-Mediated Hypoxic Preconditioned Bone Marrow-Derived Mesenchymal Stem Cells Attenuate Cardiac Arrest-Induced Pyroptosis in Rat Cortical Neurons by Protecting Mitochondrial Function from Oxidative DamagePreprint
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Home Automation for Disable Person Using Gesture Control and Artificial Intelligence
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Background
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Aggan, H. A. M. E., El-Wakil, H. S., Mahmoud, S., & Saad, A. A. (2024) · Alexandria Journal of Medicine · doi:10.1080/20905068.2024.2390233
“It is anticipated that any derangement in the inflammasome activity is linked to diverse disorders that have an inflammatory mechanism, comprising cardiometabolic diseases [12], autoinflammatory diseases [13], infections, malignancies [14], and neurological disorders [15].”
Sepsis-associated encephalopathy: Understanding the brain dysfunction in sepsis
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Linking Coronary Artery Disease, Posttraumatic Stress Disorder (PTSD), and Genetic Commonality
Akóṣílè, W. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_167-1
Au 18 (L-NIBC) 14 targets ASC oligomerization for autoimmune disease treatmentPreprint
Yang, K., Zhao, X., Xiao, Z., Zeng, C., Shen, L., & Sun, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.25.645153
“The inflammasome activation and the release of IL-1β, IL -18, and caspase-1 will further activate or regulate innate immune cells, e.g. macrophages and microglia 39 , and the adaptive immune cells, e.g.”
Linking Coronary Artery Disease, Posttraumatic Stress Disorder (PTSD), and Genetic Commonality
Akóṣílè, W. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_167
Immune System Dysfunction and Multidrug-resistant Bacteria in Critically Ill Patients: Inflammasones and Future Perspectives
Girardis, M., Busani, S., & Biasi, S. D. (2015) · Annual update in intensive care and emergency medicine · doi:10.1007/978-3-319-13761-2_8
Additional file 1 of MCC950, a selective NLPR3 inflammasome inhibitor, improves neurologic function and survival after cardiac arrest and resuscitation
Jiang, M., Li, R., Lyu, J., Li, X., Wang, W., Wang, Z., Sheng, H., Zhang, W., Karhausen, J., & Yang, W. (2020) · Figshare · doi:10.6084/m9.figshare.12900187

Authors: Walsh, J. G., Muruve, D. A., & Power, C.
Affiliations: University of Alberta (CA)
University of Calgary (CA)
Corresponding author: Power, Christopher
ORCID: Muruve, Daniel A.
Power, Christopher
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-01-08
Volume: 15
Issue: 2
Pages: 84-97
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3638
OpenAlex: W1981649246
Cited by: 637
References: 149
Citations by year: 2026: 25 · 2025: 18 · 2024: 46 · 2023: 49 · 2022: 77 · 2021: 67 · 2020: 76 · 2019: 58 · 2018: 51 · 2017: 47 · 2016: 57 · 2015: 43 · 2014: 22
FWCI: 5.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inflammasome, central nervous system, caspase-1, IL-1β, IL-18, pyroptosis, microglia, macrophages, neurological disorders, meningitis, stroke, Alzheimer's disease, innate immunity, damage-associated molecular patterns
MeSH terms: Animals, Central Nervous System, Humans, Macrophages, Nervous System Diseases, Neuroglia, Inflammasomes

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