Cited by 641Inflammasome and immune disordersNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

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Inflammasomes in the CNS

Walsh, John G., Muruve, Daniel A., Power, Christopher·2014·Nature Reviews Neuroscience

DOI 10.1038/nrn3638

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Abstract

Microglia and macrophages in the CNS contain multimolecular complexes termed inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as well as for host-derived danger signals that are associated with neurological diseases, including meningitis, stroke and Alzheimer's disease. Assembly of an inflammasome activates caspase 1 and, subsequently, the proteolysis and release of the cytokines interleukin-1β and interleukin-18, as well as pyroptotic cell death. Since the discovery of inflammasomes in 2002, there has been burgeoning recognition of their complexities and functions. Here, we review the current understanding of the functions of different inflammasomes in the CNS and their roles in neurological diseases.

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Additional file 4 of Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
Xie, Y., Chen, X., Li, Y., Chen, S., Liu, S., Yu, Z., & Wang, W. (2022) · Figshare · doi:10.6084/m9.figshare.20401230
Additional file 3 of Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
Xie, Y., Chen, X., Li, Y., Chen, S., Liu, S., Yu, Z., & Wang, W. (2022) · Figshare · doi:10.6084/m9.figshare.20401227
Additional file 2 of Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
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Additional file 1 of Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease
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Additional file 4 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
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Additional file 1 of Sodium para-aminosalicylic acid inhibits manganese-induced NLRP3 inflammasome-dependent pyroptosis by inhibiting NF-κB pathway activation and oxidative stress
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Additional file 6 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462430
Additional file 5 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462427
Additional file 1 of Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury
Sun, R., Peng, M., Xu, P., Huang, F., Xie, Y., Li, J., Hong, Y., Guo, H., Liu, Q., & Zhu, W. (2020) · Figshare · doi:10.6084/m9.figshare.13199076
Additional file 3 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462421
Additional file 1 of Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
Xie, Y., Chen, X., Li, Y., Chen, S., Liu, S., Yu, Z., & Wang, W. (2022) · Figshare · doi:10.6084/m9.figshare.20401221
Additional file 7 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462433
Additional file 2 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462418
Additional file 1 of Repetitive transcranial magnetic stimulation ameliorates cognitive deficits in mice with radiation-induced brain injury by attenuating microglial pyroptosis and promoting neurogenesis via BDNF pathway
Qin, T., Guo, L., Wang, X., Zhou, G., Liu, L., Zhang, Z., & Ding, G. (2024) · Figshare · doi:10.6084/m9.figshare.25538554
Additional file 1 of Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis
Jing, G., Zuo, J., Fang, Q., Yuan, M., Xia, Y., Jin, Q., Liu, Y., Wang, Y., Zhang, Z., Liu, W., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21228886
Additional file 2 of Transforming growth factor-β1 protects against LPC-induced cognitive deficit by attenuating pyroptosis of microglia via NF-κB/ERK1/2 pathways
Xie, Y., Chen, X., Li, Y., Chen, S., Liu, S., Yu, Z., & Wang, W. (2022) · Figshare · doi:10.6084/m9.figshare.20401224
Additional file 1 of Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1G93A ALS mouse model
Zhang, H., Li, H., Huang, B., Wang, S., Gao, Y., Meng, F., Chen, Y., Zhou, F., Guan, Y., & Wang, X. (2022) · Figshare · doi:10.6084/m9.figshare.20462415
Additional file 1 of Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury
Li, J., Xu, P., Hong, Y., Xie, Y., Peng, M., Sun, R., Guo, H., Zhang, X., Zhu, W., Wang, J., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23573581
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“Gasdermin D (GSDMD) is a 487-amino acid cytoplasmic protein that is activated by cleaved caspase-1 (c-CASP1) to form membrane pores and functions as a key executor of pyroptosis [44, 45].”
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Zhong, K.-Y., Zhang, Y., Wang, N., Li, G.-W., Zhang, X., & Yang, Z. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.108661
Silica Nanoparticles Induce BV-2 Cells Autophagy Via activation of NLRP3 inflammasome and CaMKK2 Signaling Pathways
Liu, T., Wang, M., Zhang, Y., Yang, L., Zhang, J., Wei, H., Li, X., Pang, H., Li, J., Luo, Z., et al. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05788-x
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“In the central nervous system (CNS), microglia are one of the major effector cell types undergoing pyroptosis and play an important role in the initiation and progression of related diseases [9].”
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BindingDB Entry 50002170: Synthesis of deuterium-labelled analogues of NLRP3 inflammasome inhibitor MCC950.
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BindingDB Entry 50047984: Identification, Synthesis, and Biological Evaluation of the Major Human Metabolite of NLRP3 Inflammasome Inhibitor MCC950.
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Authors: Walsh, J. G., Muruve, D. A., & Power, C.
Affiliations: University of Alberta (CA)
University of Calgary (CA)
Corresponding author: Power, Christopher
ORCID: Muruve, Daniel A.
Power, Christopher
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-01-08
Volume: 15
Issue: 2
Pages: 84-97
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3638
OpenAlex: W1981649246
Cited by: 637
References: 149
Citations by year: 2026: 25 · 2025: 18 · 2024: 46 · 2023: 49 · 2022: 77 · 2021: 67 · 2020: 76 · 2019: 58 · 2018: 51 · 2017: 47 · 2016: 57 · 2015: 43 · 2014: 22
FWCI: 5.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: inflammasome, central nervous system, caspase-1, IL-1β, IL-18, pyroptosis, microglia, macrophages, neurological disorders, meningitis, stroke, Alzheimer's disease, innate immunity, damage-associated molecular patterns
MeSH terms: Animals, Central Nervous System, Humans, Macrophages, Nervous System Diseases, Neuroglia, Inflammasomes

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