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Immune attack: the role of inflammation in Alzheimer disease
Abstract
The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement.
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“In brain tissue from human AD patients, microglia display the morphology (Heppner et al., 2015) and gene expression profile (Gjoneska et al., 2015; Mathys et al., 2019) characteristic of an activated cell state and cluster around β-amyloid plaques.”
From A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation (2023) · cites this paper as Heppner et al., 2015
In the citing paper
“Immune molecules like IL-1β, IL-6 and CCL2 are produced by brain endothelial cells against Aβ plaque [18].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [18]
In the citing paper
“glial activation is an indication of pro-inflammatory changes that is commonly found in AD brains”
From ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease (2017) · cites this paper as [98]
In the citing paper
“In AD brains, microglia surrounding amyloid plaques display activated amoeboid morphologies with enlarged soma and retracted processes, indicating microglial response to protein accumulation or increased inflammatory mediators [41, 46-48].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [48]
In the citing paper
“indicating microglial response to protein accumulation or increased inflammatory mediators [41, 46-48].”
From Transcriptional and Epigenetic Regulation of Microglia in Health and Disease (2019) · cites this paper as [48]
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1 retracted
Larson, M. E., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., Aguzzi, A., & Lesné, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1858-12.2012 · Cited by 290
RetractedThe Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
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Richter, M., Vidovic, N., Biber, K. P. H., Dolga, A. M., Culmsee, C., & Dodel, R. C. (2019) · Brain Pathology · doi:10.1111/bpa.12807 · Cited by 31
Culprit or Bystander: Defective Mitophagy in Alzheimer’s Disease
Xie, C., Aman, Y., Adriaanse, B. A., Cader, M. Z., Plun‐Favreau, H., Xiao, J., & Fang, E. F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00391 · Cited by 29
Carlström, E. L., Niazi, A., Etemadikhah, M., Halvardson, J., Enroth, S., Stockmeier, C. A., Rajkowska, G., Nilsson, B., & Feuk, L. (2021) · Genes · doi:10.3390/genes12081242 · Cited by 29
Wang, Z., Zhang, Q., Lin, J.-R., Jabalameli, M. R., Mitra, J., Nguyen, N., & Zhang, Z. D. (2021) · Scientific Reports · doi:10.1038/s41598-021-99352-3 · Cited by 29
Current nano-therapeutic approaches ameliorating inflammation in cancer progression
Rehman, M. U., Khan, A., Imtiyaz, Z., Ali, S., Makeen, H. A., Rashid, S., & Arafah, A. M. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.02.006 · Cited by 29
Xiong, J., Lu, D., Chen, B.-Q., Liu, T., & Wang, Z. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08725-y · Cited by 29
Wątroba, M., & Szukiewicz, D. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.962769 · Cited by 29
Nidadavolu, L. S., Feger, D. M., Wu, Y., Grodstein, F., Gross, A. L., Bennett, D. A., Walston, J. D., Oh, E. S., & Abadir, P. M. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220301 · Cited by 30
Pierouli, K., Papakonstantinou, E., Papageorgiou, L., Diakou, I., Mitsis, Τ., Dragoumani, K., Spandidos, D. A., Bacopoulou, F., Chrousos, G. P., Goulielmos, G. N., et al. (2022) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2022.5208 · Cited by 29
Williams, J. B., Cao, Q., Wang, W., Lee, Y., Qin, L., Zhong, P., Ren, Y., Ma, K., & Yan, Z. (2023) · Nature Communications · doi:10.1038/s41467-022-35749-6 · Cited by 31
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Bieger, A., Rocha, A., Bellaver, B., Machado, L. S., Ros, L. U. D., Borelli, W. V., Therriault, J., Macedo, A. C., Pascoal, T. A., Gauthier, S. G., et al. (2023) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2023.54 · Cited by 29
Xin, Y., Fang, F., Yue, Q., Luo, Y., Tian, S., Cheng, L., Yang, X., Yang, X., Luo, L., & Meng, F. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102178 · Cited by 29
Bowyer, J. F., Sarkar, S., Tranter, K. M., Hanig, J. P., Miller, D. B., & O'Callaghan, J. P. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0526-6 · Cited by 30
Zhang, F., Zhong, R., Qi, H., Li, S., Cheng, C., Liu, X., Liu, Y., & Le, W. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00314 · Cited by 29
Xu, Y., Wei, H., Wang, J., Wang, W., & Gao, J. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.04.025 · Cited by 29
Astrocytes regulate neuronal network activity by mediating synapse remodeling
Kim, N., & Chung, W. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.09.007 · Cited by 31
Yeh, C.-W., Liu, H., Lin, L.-C., Liou, K.-T., Huang, Y., Lin, C., Tzeng, T.-T., Shie, F., Tsay, H.-J., & Shiao, Y. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.07.036 · Cited by 28
Dendritic Cells as an Alternate Approach for Treatment of Neurodegenerative Disorders
Brezováková, V., Valachova, B., Hanes, J., Novák, M., & Jadhav, S. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0598-1 · Cited by 29
Li, J., Liu, M., Gao, J. M., Jiang, Y., Wu, L., Cheong, Y., Ren, G., & Yang, Z. R. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.02.009 · Cited by 28
The Mechanistic Role of Bridging Integrator 1 (BIN1) in Alzheimer’s Disease
Gao, P.-R., Ye, L., Cheng, H.-R., & Li, H. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00926-y · Cited by 34
Lenz, M., Eichler, A., Kruse, P., Strehl, A., Rodriguez-Rozada, S., Goren, I., Yogev, N., Frank, S., Waisman, A., Deller, T., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.614509 · Cited by 30
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Buhlman, L. M., Krishna, G., Jones, T. B., & Thomas, T. C. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112079 · Cited by 29
Ren, R., Huang, Q., Xu, G., Gu, K., Dammer, E. B., Wang, C., Xie, X., Chen, W., Shao, Z., Chen, S., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12436 · Cited by 28
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Zhang, C., Han, Y., Liu, X., Tan, H. L. E., Dong, Y., Zhang, Y., Liang, F., Zheng, H., Crosby, G. J., Culley, D. J., et al. (2022) · Annals of Surgery · doi:10.1097/sla.0000000000005599 · Cited by 28
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Launay, A., Nebie, O., Shankara, J. V., Lebouvier, T., Buée, L., Faivre, É., & Blum, D. L. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109379 · Cited by 29
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Liu, Y., Wang, P., Jin, G., Shi, P., Zhao, Y., Guo, J., Yin, Y., Shao, Q.-H., Li, P., & Yang, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102021 · Cited by 30
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Dong, W., Embury, C. M., Lu, Y., Whitmire, S. M., Dyavarshetty, B., Gelbard, H. A., Gendelman, H. E., & Kiyota, T. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0646-z · Cited by 28
Zhang, Y., Jiao, G., Song, C., Gu, S., Brown, R. E., Zhang, J., Zhang, P., Gagnon, J., Locke, S. J., Stefanova, R., et al. (2017) · Marine Drugs · doi:10.3390/md15030083 · Cited by 28
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Song, W. M., & Colonna, M. (2018) · Advances in immunology · doi:10.1016/bs.ai.2018.04.002 · Cited by 30
Short-term sleep deprivation in mice induces B cell migration to the brain compartment
Korin, B., Avraham, S., Azulay‐Debby, H., Farfara, D., Hakim, F., & Rolls, A. (2019) · SLEEP · doi:10.1093/sleep/zsz222 · Cited by 28
Jiao, L., Yu, Z., Zhong, X., Yao, W., Xing, L., Ma, G., Shen, J., Wu, Y., Du, K., Liu, J., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114054 · Cited by 27
Bao, M., Bade, R., Liu, H., Tsambaa, B., Shao, G., Borjigidai, A., & Cheng, Y. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175992 · Cited by 27
Metal-organic frameworks derived emerging theranostic platforms
Zheng, N., Li, K., He, L., Wang, Q., Yang, B., Mao, C., Tang, W., Liu, S., & Liu, S. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102404 · Cited by 27
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Syme, C. A., Pelletier, S., Shin, J., Abrahamowicz, M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D., Pike, G. B., et al. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0202-2 · Cited by 30
Rose, K. N., Barlock, B. J., DaSilva, N. A., Johnson, S. L., Liu, C., Ma, H., Nelson, R. B., Akhlaghi, F., & Seeram, N. P. (2019) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1672009 · Cited by 28
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Nitsch, L., Schneider, L. H., Zimmermann, J., & Müller, M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.639353 · Cited by 27
Liang, C., Tsai, C., Lin, G., Lee, J., Lin, Y., Chu, C., Sung, Y., Tsai, C., Yeh, T., Chu, H., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.670115 · Cited by 29
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Bazard, P., Pineros, J., Frisina, R. D., Bauer, M. A., Acosta, A. A., Paganella, L. R., Borakiewicz, D., Thivierge, M., Mannering, F. L., Zhu, X., et al. (2021) · Cells · doi:10.3390/cells10102761 · Cited by 27
Siddiqui, T., Bhattarai, P., Popova, S. D., Coşacak, M. İ., Sariya, S., Zhang, Y., Mayeux, R. P., Tosto, G., & Kızıl, Ç. (2021) · Cells · doi:10.3390/cells10102748 · Cited by 27
Landscape of immune infiltration in entorhinal cortex of patients with Alzheimerʼs disease
Zhang, H., Cao, S., Xu, Y., Sun, X., Fei, M., Jing, Q., Xu, X., Tang, J., Niu, B., & Li, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.941656 · Cited by 27
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Yang, L., & Nao, J. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0121 · Cited by 28
Beyond the amyloid cascade: An update of Alzheimer's disease pathophysiology
Gouilly, D., Rafiq, M., Nogueira, L., Salabert, A., Payoux, P., Péran, P., & Pariente, J. (2023) · Revue Neurologique · doi:10.1016/j.neurol.2022.12.006 · Cited by 31
Christensen, G. M., Li, Z., Liang, D., Ebelt, S., Gearing, M., Levey, A. I., Lah, J. J., Wingo, A. P., Wingo, T. S., & Hüls, A. (2024) · Neurology · doi:10.1212/wnl.0000000000209162 · Cited by 27
Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques
Bisht, K., Hajj, H. E., Savage, J. C., Sanchez, M. G., & Tremblay, M. (2016) · Journal of Visualized Experiments · doi:10.3791/54060 · Cited by 28
Bridel, C., Hoffmann, T., Meyer, A., Durieux‐Lu, S., Simmelink, M. J. A., Orth, M., Scheltens, P., Lues, I., & Teunissen, C. E. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0266-6 · Cited by 27
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Karoutzou, O., Kwak, S., Lee, S., Martínez‐Falguera, D., Sureda, F. X., Vázquez, S., Kim, Y., & Barniol‐Xicota, M. (2018) · Molecules · doi:10.3390/molecules23010230 · Cited by 27
Souza, L. C., Jessé, C. R., Fabbro, L. D., de Gomes, M. G., Gomes, N. S., Filho, C. B., Goes, A. T. R., Wilhelm, E. A., Luchese, C., Roman, S. S., et al. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.01.005 · Cited by 27
Prolonged Drug-Releasing Fibers Attenuate Alzheimer’s Disease-like Pathogenesis
Salles, G. N., Calió, M. L., Afewerki, S., Soares, C. P., Porcionatto, M. A., Hölscher, C., & Lobo, A. O. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b12649 · Cited by 29
Maj, C., Azevedo, T., Giansanti, V., Borisov, O., Dimitri, G. M., Spasov, S., Initiative, A. D. N., Lió, P., & Merelli, I. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00726 · Cited by 27
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Wiatrak, B., & Balon, K. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02204-w · Cited by 27
de Geus, M. B., Leslie, S. N., Lam, T. T., Wang, W., Roux‐Dalvai, F., Droit, A., Kivisäkk, P., Nairn, A. C., Arnold, S. E., & Carlyle, B. C. (2023) · Scientific Reports · doi:10.1038/s41598-023-49440-3 · Cited by 28
Kato, H., Iwashita, K., Iwasa, M., Kato, S., Yamakage, H., Suganami, T., Tanaka, M., & Satoh‐Asahara, N. (2024) · Cells · doi:10.3390/cells13030284 · Cited by 26
Beckman, M., Knox, K. M., Koneval, Z., Smith, C., Jayadev, S., & Barker‐Haliski, M. L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104719 · Cited by 26
Alaaeddine, R. A., Elzahhar, P. A., AlZaim, I., Abou-Kheir, W. G., Belal, A. S. F., & EL‐Yazbi, A. F. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200820173853 · Cited by 26
Sabahi, M., Joshaghanian, A., Dolatshahi, M., Jabbari, P., Rahmani, F., & Rezaei, N. (2021) · Journal of Molecular Neuroscience · doi:10.1007/s12031-021-01818-6 · Cited by 26
Deleanu, M., Hernandez, J., Cipelletti, L., Biron, J., Rossi, E., Taverna, M., Cottet, H., & Chamieh, J. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c00527 · Cited by 26
Ye, C., Xu, R., Cao, Z., Song, Q., Yu, G., Shi, Y., Liu, Z., Liu, X., & Deng, Y. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.104895 · Cited by 26
Huang, Y., Huang, W., Yang, G., Wang, R., & Ma, L. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128092 · Cited by 26
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So, K., Li, A., Liang, Y., Zhang, L., Luo, X., Wu, L.-L., Chen, Z.-W., Wei, G.-H., Zhang, K., Du, Z.-A., et al. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.325012 · Cited by 27
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Joshi, C., Sivaprakasam, K., Christley, S., Ireland, S. J., Rivas, J. R., Zhang, W., Sader, D., Logan, R., Lambracht‐Washington, D., Rosenberg, R. N., et al. (2021) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001106 · Cited by 26
Sanjay, S., Park, M., & Lee, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137300 · Cited by 28
Mapping secretome-mediated interaction between paired neuron–macrophage single cells
Deng, J., Ji, Y., Zhu, F., Liu, L., Li, L., Bai, X., Li, H., Liu, X., Luo, Y., Lin, B., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200944119 · Cited by 26
Pini, L., Salvalaggio, A., Wennberg, A. M. V., Dimakou, A., Matteoli, M., & Corbetta, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101867 · Cited by 26
Fonseca, C., Ettcheto, M., Bicker, J., Fernandes, M. J., Falcão, A. C., Camins, A., & Fortuna, A. C. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101998 · Cited by 31
Zhang, Y., Liu, L., Wang, T., Mao, C., Shan, P., Lau, C. S., Li, Z., Guo, W., & Wang, W. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301394 · Cited by 26
Jash, S., Banerjee, S., Cheng, S., Wang, B., Qiu, C., Kondo, A., Ernerudh, J., Zhou, X. Z., Lu, K. P., & Sharma, S. (2023) · Nature Communications · doi:10.1038/s41467-023-41144-6 · Cited by 26
Umoh, I. O., Reis, H. J., & de Oliveira, A. C. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25053044 · Cited by 28
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Boulton, M., & Al-Rubaie, A. (2024) · Anatomical Science International · doi:10.1007/s12565-024-00778-2 · Cited by 26
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Ackloo, S. Z., Brown, P. J., & Müller, S. (2017) · Epigenetics · doi:10.1080/15592294.2017.1279371 · Cited by 27
Lykhmus, O., Uspenska, K., Koval, L., Lytovchenko, D., Voytenko, L. P., Tm, H., Kosiakova, H. V., Nm, G., Комісаренко, С. В., & Skok, M. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.09.023 · Cited by 27
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Guillot‐Sestier, M., & Town, T. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1792-x · Cited by 26
Jonson, M., Nyström, S., Sandberg, A., Carlback, M., Michno, W., Hanrieder, J., Starkenberg, A., Nilsson, K. P. R., Thor, S., & Hammarström, P. (2018) · Cell chemical biology · doi:10.1016/j.chembiol.2018.03.006 · Cited by 26
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Asaad, M., & Lee, J. H. (2018) · Disease Models & Mechanisms · doi:10.1242/dmm.031724 · Cited by 26
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Zhang, R., Jing, L., Zou, Y., Zhang, X., & Xiao, W. (2018) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.8b00560 · Cited by 26
Lykhmus, O., Kalashnyk, O., Uspenska, K., & Skok, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00359 · Cited by 26
Heuer, S. E., Neuner, S. M., Hadad, N., O’Connell, K. M. S., Williams, R. W., Philip, V. M., Gaiteri, C., & Kaczorowski, C. C. (2020) · Learning & Memory · doi:10.1101/lm.051839.120 · Cited by 26
Makitani, K., Nakagawa, S., Izumi, Y., Akaike, A., & Kume, T. (2017) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2017.03.008 · Cited by 25
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Vérité, J., Janet, T., Chassaing, D., Fauconneau, B., Rabeony, H., & Page, G. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1220-7 · Cited by 25
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Metadata
- Authors
- Heppner, F. L., Ransohoff, R. M., & Becher, B.
- Affiliations
- NeuroCure Cluster of Excellence (DE)
- Biogen (United States) (US)
- University of Zurich (CH)
- Corresponding author
- Heppner, Frank L.
- Ransohoff, Richard M.
- Becher, Burkhard
- Venue
- Nature Reviews Neuroscience
- Published
- 2015-05-20
- Volume
- 16
- Issue
- 6
- Pages
- 358-372
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W1841850981
- Cited by
- 2,134
- References
- 220
- Citations by year
- 2026: 121 · 2025: 157 · 2024: 166 · 2023: 173 · 2022: 211 · 2021: 264 · 2020: 221 · 2019: 192 · 2018: 225 · 2017: 205 · 2016: 153 · 2015: 43
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, neuroinflammation, innate immunity, microglia, cytokines, amyloid hypothesis, pathogenesis, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Humans, Inflammation
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