Cited by 2,134Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Immune attack: the role of inflammation in Alzheimer disease

Heppner, Frank L., Ransohoff, Richard M., Becher, Burkhard·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3880

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Abstract

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement.

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RETRACTED: The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
Larson, M. E., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., Aguzzi, A., & Lesné, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1858-12.2012 · Cited by 290
Retracted
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.
Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Alzheimer’s disease
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244

Show all 220 references

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Réus, G. Z., de Moura, A. B., da Silva, R. H., Resende, W. R., & Quevedo, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170630164715 · Cited by 51
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Xiao, Y. M., Dai, Y., Li, L., Geng, F., Xu, Y., Wang, J., Wang, S., & Zhao, J. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111651 · Cited by 45
PET/MR imaging of inflammation in atherosclerosis
Senders, M. L., Calcagno, C., Tawakol, A. A., Nahrendorf, M., Mulder, W. J. M., & Fayad, Z. A. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00970-7 · Cited by 46
LilrB3 is a putative cell surface receptor of APOE4
Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023) · Cell Research · doi:10.1038/s41422-022-00759-y · Cited by 44
Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology via regulating the microbiota-gut-brain axis in 5 × FAD mice
He, C., Jiang, J., Liu, J., Zhou, L., Ge, Y., & Yang, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132372 · Cited by 46
Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study
Ahmad, S., Bannister, C. A., van der Lee, S. J., Vojinović, D., Adams, H. H. H., Ramírez, A., Escott‐Price, V., Sims, R., Baker, E. A., Williams, J. H., et al. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.01.005 · Cited by 46
Disruption of a RAC1-centred network is associated with Alzheimer’s disease pathology and causes age-dependent neurodegeneration
Kikuchi, M., Sekiya, M., Hara, N., Miyashita, A., Kuwano, R., Ikeuchi, T., Iijima, K., & Nakaya, A. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddz320 · Cited by 46
Association of glial and neuronal degeneration markers with Alzheimer’s disease cerebrospinal fluid profile and cognitive functions
Teitsdottir, U. D., Jónsdóttir, M. K., Lund, S. H., Darreh‐Shori, T., Snædal, J., & Petersen, P. H. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00657-8 · Cited by 47
Neuron loss associated with age but not Alzheimer's disease pathology in the chimpanzee brain
Edler, M. K., Munger, E. L., Meindl, R. S., Hopkins, W. D., Ely, J. J., ERWIN, J. M., Mufson, E. J., Hof, P. R., Sherwood, C. C., & Raghanti, M. A. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0619 · Cited by 45
Advanced Human BBB‐on‐a‐Chip: A New Platform for Alzheimer's Disease Studies
Yoon, J., Kim, J., Shah, Z., Awasthi, A., Mahajan, A., & Kim, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202002285 · Cited by 45
Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration
D’Anca, M., Buccellato, F. R., Fenoglio, C., & Galimberti, D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084134 · Cited by 44
Formononetin: A Pathway to Protect Neurons
Ma, X., & Wang, J. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.908378 · Cited by 44
Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease
Schröder, N., Schaffrath, A., Welter, J. A., Putzka, T., Griep, A., Ziegler, P., Brandt, E., Samer, S., Heneka, M. T., Kaddatz, H., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01816-2 · Cited by 43
Immune-mediated processes in neurodegeneration: where do we stand?
Fakhoury, M. (2016) · Journal of Neurology · doi:10.1007/s00415-016-8052-0 · Cited by 43
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease
Jana, A., Wang, X., Leasure, J. W., Magana, L., Wang, L., Kim, Y.-M., Dodiya, H., Toth, P. T., Sisodia, S. S., & Rehman, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20889-y · Cited by 43
Closest horizons of Hsp70 engagement to manage neurodegeneration
Venediktov, A. A., Bushueva, O. Y., Kudryavtseva, V. A., Kuzmin, E. A., Moiseeva, A. V., Baldycheva, A. V., Meglinski, I. V., & Piavchenko, G. A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1230436 · Cited by 44
Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway
Stone, T. W., & Williams, R. O. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16015 · Cited by 45
IFN‐γ promotes τ phosphorylation without affecting mature tangles
Li, A., Ceballos‐Diaz, C., DiNunno, N., Levites, Y., Cruz, P. E., Lewis, J., Golde, T. E., & Chakrabarty, P. (2015) · The FASEB Journal · doi:10.1096/fj.15-275834 · Cited by 43
Dexamethasone-conjugated DNA nanotubes as anti-inflammatory agents in vivo
Sellner, S., Kocabey, S., Zhang, T., Nekolla, K., Hutten, S., Krombach, F., Liedl, T., & Rehberg, M. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.031 · Cited by 43
Helicobacter pylori and the risk of dementia: A population‐based study
Fani, L., Wolters, F. J., Ikram, M. K., Bruno, M. J., Albert Hofman, D., Koudstaal, P. J., Murad, S. D., & Ikram, M. A. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.05.005 · Cited by 43
Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APPSWE/PS1ΔE9 Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease
Thygesen, C., Ilkjær, L., Kempf, S. J., Hemdrup, A. L., von Linstow, C. U., Babcock, A. A., Darvesh, S., Larsen, M. R., & Finsen, B. R. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00397 · Cited by 44
Impacts of oxidants and antioxidants on the emergence and progression of Alzheimer's disease
Goshtasbi, H., Pakchin, P. S., Movafeghi, A., Barar, J., Castejon, A. M., Omidian, H., & Omidi, Y. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105268 · Cited by 44
Adenosine receptor signalling in Alzheimer’s disease
Trinh, P. N. H., Baltos, J., Hellyer, S. D., May, L. T., & Gregory, K. J. (2022) · Purinergic Signalling · doi:10.1007/s11302-022-09883-1 · Cited by 43
Recent Development in the Understanding of Molecular and Cellular Mechanisms Underlying the Etiopathogenesis of Alzheimer’s Disease
Afsar, A., Castro, M. D. C. C., Soladogun, A. S., & Li, Z. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087258 · Cited by 45
The water maze paradigm in experimental studies of chronic cognitive disorders: Theory, protocols, analysis, and inference
Kapadia, M., Xu, J., & Šakić, B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.016 · Cited by 44
Lifestyle and Neurocognition in Older Adults With Cardiovascular Risk Factors and Cognitive Impairment
Blumenthal, J. A., Smith, P. J., Mabe, S., Hinderliter, A. L., Welsh-Bohmer, K. A., Browndyke, J. N., Lin, P., Kraus, W. E., Doraiswamy, P. M., Burke, J. R., et al. (2017) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000474 · Cited by 45
Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status
Magalhaes, C. A., Ferreira, C. N., Loures, C. M. G., Fraga, V. G., Chaves, A. C., de Oliveira, A. C. R., de Souza, L. C., Resende, E. D. P. F., Carmona, K. C., Guimarães, H. C., et al. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.08.027 · Cited by 42
The Biological Activity of Alkaloids from the Amaryllidaceae: From Cholinesterases Inhibition to Anticancer Activity
Habartová, K., Cahlíková, L., Řezáčová, M., & Havelek, R. (2016) · Natural Product Communications · doi:10.1177/1934578x1601101038 · Cited by 42
MicroRNA-181a protects against pericyte apoptosis via directly targeting FOXO1: implication for ameliorated cognitive deficits in APP/PS1 mice
Wu, Q., Yuan, X., Bai, J., Han, R., Li, Z., Zhang, H., & Xiu, R. (2019) · Aging · doi:10.18632/aging.102171 · Cited by 44
Neutrophil Extracellular Traps: A Perspective of Neuroinflammation and Complement Activation in Alzheimer’s Disease
Kretzschmar, G. C., Bumiller‐Bini, V., Filho, M. A. G., Zonta, Y. R., Yu, K. S. T., de Souza, R. L. R., Dias‐Melicio, L. A., & Boldt, A. B. W. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.630869 · Cited by 42
NLRP3 and Infections: β-Amyloid in Inflammasome beyond Neurodegeneration
Sita, G., Graziosi, A., Hrelia, P., & Morroni, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136984 · Cited by 43

Authors: Heppner, F. L., Ransohoff, R. M., & Becher, B.
Affiliations: NeuroCure Cluster of Excellence (DE)
Biogen (United States) (US)
University of Zurich (CH)
Corresponding author: Heppner, Frank L.
Ransohoff, Richard M.
Becher, Burkhard
ORCID: Heppner, Frank L.
Becher, Burkhard
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-05-20
Volume: 16
Issue: 6
Pages: 358-372
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3880
OpenAlex: W1841850981
Cited by: 2,134
References: 220
Citations by year: 2026: 121 · 2025: 157 · 2024: 166 · 2023: 173 · 2022: 211 · 2021: 264 · 2020: 221 · 2019: 192 · 2018: 225 · 2017: 205 · 2016: 153 · 2015: 43
FWCI: 16.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, neuroinflammation, innate immunity, microglia, cytokines, amyloid hypothesis, pathogenesis, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Humans, Inflammation

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