Immune attack: the role of inflammation in Alzheimer disease

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Mosmann, T. R., Cherwinski, H. M., Bond, M. W., Giedlin, M. A., & Coffman, R. L. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2348 · Cited by 7,553

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Astrocytes: Biology and pathology

Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide

Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744

The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244

Cerebrospinal Fluid and Plasma Levels of Inflammation Differentially Relate to CNS Markers of Alzheimer’s Disease Pathology and Neuronal Damage

Bettcher, B. M., Johnson, S. C., Fitch, R., Casaletto, K. B., Heffernan, K. S., Asthana, S., Zetterberg, H., Blennow, K., Carlsson, C. M., Neuhaus, J. M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170602 · Cited by 105

A Systematic Review of the Biological Effects of Cordycepin

Radhi, M., Ashraf, S., Lawrence, S., Arendt-Tranholm, A., Wellham, P. A. D., Hafeez, A., Khamis, A. S., Thomas, R., McWilliams, D. F., & de Moor, C. H. (2021) · Molecules · doi:10.3390/molecules26195886 · Cited by 107

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

López González, I., Garcia-Esparcia, P., Llorens, F., & Ferrer, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020206 · Cited by 101

Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes

Möhle, L., Israël, N., Paarmann, K., Krohn, M., Pietkiewicz, S., Müller, A. J., Lavrik, I. N., Buguliskis, J. S., Schott, B. H., Schlüter, D., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0293-8 · Cited by 103

Plaque‐dependent morphological and electrophysiological heterogeneity of microglia in an A lzheimer's disease mouse model

Plescher, M., Seifert, G., Hansen, J. N., Bedner, P., Steinhäuser, C., & Halle, A. (2018) · Glia · doi:10.1002/glia.23318 · Cited by 108

Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

Zhu, X., & Stephens, M. (2018) · Nature Communications · doi:10.1038/s41467-018-06805-x · Cited by 103

Physical Exercise and Alzheimer’s Disease: Effects on Pathophysiological Molecular Pathways of the Disease

López‐Ortiz, S., Pinto-Fraga, J., Valenzuela, P. L., Martín-Hernández, J., Seisdedos, M. M., García, Ó., Toschi, N., Giuliano, F. D., Garaci, F. G., Mercuri, N. B., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062897 · Cited by 107

Dioscin alleviates Alzheimer's disease through regulating RAGE/NOX4 mediated oxidative stress and inflammation

Guan, L., Mao, Z., Yang, S., Wu, G., Chen, Y., Yin, L., Qi, Y., Han, L., & Xu, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113248 · Cited by 101

Alcohol and Alzheimer's Disease—Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?

Venkataraman, A. V., Kalk, N. J., Sewell, G. W., Ritchie, C. W., & Lingford-Hughes, A. R. (2016) · Alcohol and Alcoholism · doi:10.1093/alcalc/agw092 · Cited by 104

Neuroprotective effects of INT-777 against Aβ1–42-induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

Wu, X. G., Lv, Y., Du, Y., Chen, F., Reed, M. N., Hu, M. Y., Suppiramaniam, V. D., Tang, S., & Hong, H. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.06.018 · Cited by 100

Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome‐autophagosome‐lysosome pathway dysfunction and microglia‐mediated neuroinflammation

Xie, Y., Ba, L., Wang, M., Deng, S., Chen, S., Huang, L., Zhang, M., Wang, W., & Ding, F. (2019) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13218 · Cited by 102

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

Mao, M., Xu, Y., Zhang, X., Yang, L. C., An, X., Qu, Y., Chai, Y.-N., Wang, Y.-R., Li, T., & Ai, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01919-w · Cited by 100

Overview of Traumatic Brain Injury: An Immunological Context

Nizamutdinov, D., & Shapiro, L. A. (2017) · Brain Sciences · doi:10.3390/brainsci7010011 · Cited by 104

Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice

Batarseh, Y. S., Bharate, S. S., Kumar, V., Kumar, A., Vishwakarma, R. A., Bharate, S. B., & Kaddoumi, A. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00101 · Cited by 100

A critical role of TRPM2 channel in Aβ42‐induced microglial activation and generation of tumor necrosis factor‐α

Mortadza, S. A. S., Sim, J. A., Neubrand, V. E., & Jiang, L. (2017) · Glia · doi:10.1002/glia.23265 · Cited by 102

Microglial modulation of neuronal activity in the healthy brain

York, E. M., Bernier, L., & MacVicar, B. A. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22571 · Cited by 98

The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects

Thuc, O. L., Blondeau, N., Nahon, J., & Rovère, C. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12855 · Cited by 105

Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease

Picca, A., Guerra, F., Calvani, R., Coelho‐Júnior, H. J., Bossola, M., Landi, F., Bernabei, R., Bucci, C., & Marzetti, E. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051440 · Cited by 100

The Air We Breathe: Air Pollution as a Prevalent Proinflammatory Stimulus Contributing to Neurodegeneration

Jankowska-Kieltyka, M., Roman, A., & Nalepa, I. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.647643 · Cited by 99

Dual Aggregations of a Near-Infrared Aggregation-Induced Emission Luminogen for Enhanced Imaging of Alzheimer’s Disease

Xu, L., Gao, H., Zhan, W., Deng, Y., Liu, X., Jiang, Q., Sun, X., Xu, J., & Liang, G. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c10255 · Cited by 98

Molecular imaging of neuroinflammation in Alzheimer's disease and mild cognitive impairment

Knezevic, D., & Mizrahi, R. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.05.007 · Cited by 97

Intracerebroventricular injection of resveratrol ameliorated Aβ-induced learning and cognitive decline in mice

Yu, Q., Shang, L., Liao, Z., Su, H., Jing, H., Wu, B., Bi, K., & Jia, Y. (2018) · Metabolic Brain Disease · doi:10.1007/s11011-018-0348-6 · Cited by 97

Local Sleep and Alzheimer’s Disease Pathophysiology

Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97

Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease

Lu, Q., Powles, R. L., Abdallah, S., Ou, D., Wang, Q., Hu, Y., Lu, Y., Liu, W., Li, B., Mukherjee, S., et al. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006933 · Cited by 97

Olive Oil and the Hallmarks of Aging

Fernández-del-Río, L., Gutiérrez-Casado, E., Varela‐López, A., & Villalba, J. M. (2016) · Molecules · doi:10.3390/molecules21020163 · Cited by 100

Anti-Viral Properties of Amyloid-β Peptides

Bourgade, K., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160517 · Cited by 97

Anthocyanins as a potential pharmacological agent to manage memory deficit, oxidative stress and alterations in ion pump activity induced by experimental sporadic dementia of Alzheimer's type

Pacheco, S. M., Soares, M. S. P., Gutierres, J. M., Gerzson, M. F. B., Carvalho, F. B., Azambuja, J. H., Schetinger, M. R. C., Stefanello, F. M., & Spanevello, R. M. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.014 · Cited by 99

Beta Amyloid, Tau Protein, and Neuroinflammation: An Attempt to Integrate Different Hypotheses of Alzheimer’s Disease Pathogenesis

Garbuz, D. G., Zatsepina, O. G., & Evgen’ev, M. B. (2021) · Molecular Biology · doi:10.1134/s002689332104004x · Cited by 95

Aβ plaques

Walker, L. C. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3025 · Cited by 113

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

Hunter, S., & Brayne, C. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.218 · Cited by 94

Gx‐50 reduces β‐amyloid‐induced TNF‐α, IL‐1β, NO, and PGE2 expression and inhibits NF‐κB signaling in a mouse model of Alzheimer's disease

Shi, S., Liang, D., Chen, Y., Xie, Y., Wang, Y., Wang, L., Wang, Z., & Qiao, Z. (2015) · European Journal of Immunology · doi:10.1002/eji.201545855 · Cited by 93

Amyloid plaques beyond Aβ: a survey of the diverse modulators of amyloid aggregation

Stewart, K. L., & Radford, S. E. (2017) · Biophysical Reviews · doi:10.1007/s12551-017-0271-9 · Cited by 95

Why are Functional Amyloids Non-Toxic in Humans?

Jackson, M. P., & Hewitt, E. W. (2017) · Biomolecules · doi:10.3390/biom7040071 · Cited by 98

Secretome from SH-SY5Y APPSwe cells trigger time-dependent CHME3 microglia activation phenotypes, ultimately leading to miR-21 exosome shuttling

Fernandes, A., Ribeiro, A. R., Monteiro, M., Garcia, G., Vaz, A. R., & Brites, D. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.015 · Cited by 93

The Gut-Brain Axis in Alzheimer’s Disease and Omega-3. A Critical Overview of Clinical Trials

Rosa, F. L., Clerici, M., Ratto, D., Occhinegro, A., Licito, A., Romeo, M., Iorio, C. D., & Rossi, P. (2018) · Nutrients · doi:10.3390/nu10091267 · Cited by 96

Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer’s disease

Guzmán‐Vélez, E., Diez, I. P., Schoemaker, D., Pardilla‐Delgado, E., Vila‐Castelar, C., Fox‐Fuller, J. T., Baena, A. Y., Sperling, R. A., Johnson, K. A., Lopera, F. J., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113641119 · Cited by 95

Intranasal Drug Delivery by Nanotechnology: Advances in and Challenges for Alzheimer’s Disease Management

Dighe, S., Jog, S., Momin, M. M., Sawarkar, S. P., & Omri, A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics16010058 · Cited by 95

Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse models

Neuner, S. M., Wilmott, L. A., Hoffmann, B. R., Mozhui, K., & Kaczorowski, C. C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.002 · Cited by 95

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

Park, H., Cho, B., Kim, H., Saito, T., Saido, T. C., Won, K.-J., & Kim, J. (2023) · Nature Communications · doi:10.1038/s41467-023-36519-8 · Cited by 92

Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

Sharma, A., Kazim, S. F., Larson, C. S., Ramakrishnan, A., Gray, J. D., McEwen, B. S., Rosenberg, P. A., Shen, L., & Pereira, A. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1903566116 · Cited by 92

Association of 10-Year C-Reactive Protein Trajectories With Markers of Healthy Aging: Findings From the English Longitudinal Study of Aging

Lassale, C. M., Batty, G. D., Steptoe, A., Cadar, D., Akbaraly, T. N., Mika Kivimaki, B., & Zaninotto, P. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly028 · Cited by 95

Alzheimer’s disease: natural products as inhibitors of neuroinflammation

Olajide, O. A., & Sarker, S. D. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00751-1 · Cited by 92

The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review

Matheson, J.-A. T., & Holsinger, R. M. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021001 · Cited by 96

Plasma IL-12/IFN-γ axis predicts cognitive trajectories in cognitively unimpaired older adults

Yang, H., Zhang, C., Carlyle, B. C., Zhen, S. Y., Trombetta, B. A., Schultz, A. P., Pruzin, J. J., Fitzpatrick, C. D., Yau, W. W., Kirn, D. R., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12399 · Cited by 90

Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain Axis

Xie, Z., Lu, H., Yang, S., Zeng, Y., Li, W., Wang, L., Luo, G., Fang, F., Zeng, T., & Cheng, W. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568423 · Cited by 92

Oxidative stress modulating nanomaterials and their biochemical roles in nanomedicine

Patel, K. D., Keskin‐Erdogan, Z., Sawadkar, P., Sharifulden, N. S. A. N., Shannon, M. R., Patel, M., Silva, L. V. B., Patel, R., Chau, D. Y. S., Knowles, J. C., et al. (2024) · Nanoscale Horizons · doi:10.1039/d4nh00171k · Cited by 92

Influences of dopaminergic system dysfunction on late-life depression

Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89

Impaired Resolution of Inflammation in Alzheimer’s Disease: A Review

Whittington, R. A., Planel, E., & Terrando, N. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01464 · Cited by 93

Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease

Levit, A., Hachinski, V., & Whitehead, S. N. (2020) · GeroScience · doi:10.1007/s11357-020-00164-6 · Cited by 96

Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease

Griñán‐Ferré, C., Codony, S., Pujol, E., Yang, J., Leiva, R., Escolano, C., Puigoriol‐Illamola, D., Companys‐Alemany, J., Corpas, R., Sanfeliu, C., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00854-1 · Cited by 99

Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer’s Disease

Salech, F., Ponce, D. P., Paula-Lima, A. C., SanMartín, C. D., & Behrens, M. I. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00255 · Cited by 92

Reduced β-amyloid pathology in an APP transgenic mouse model of Alzheimer’s disease lacking functional B and T cells

Späni, C., Suter, T., Derungs, R., Ferretti, M. T., Welt, T., Wirth, F., Gericke, C., Nitsch, R. M., & Kulic, L. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0251-x · Cited by 88

Role of Mitochondria-Associated Endoplasmic Reticulum Membrane in Inflammation-Mediated Metabolic Diseases

Thoudam, T., Jeon, J., Ha, C., & Lee, I. (2016) · Mediators of Inflammation · doi:10.1155/2016/1851420 · Cited by 91

Microglia communication: parallels between aging and Alzheimer's disease

Udeochu, J. C., Shea, J. M., & Villeda, S. A. (2016) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12307 · Cited by 87

Metabolic Endotoxemia: A Potential Underlying Mechanism of the Relationship between Dietary Fat Intake and Risk for Cognitive Impairments in Humans?

André, P., Laugerette, F., & Féart, C. (2019) · Nutrients · doi:10.3390/nu11081887 · Cited by 89

The Effect of Periodontitis on Dementia and Cognitive Impairment: A Meta-Analysis

Guo, H., Chang, S., Pi, X., Hua, F., Jiang, H., Liu, C., & Du, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136823 · Cited by 88

AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease

Wang, Y., Wang, H., & Chen, H. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160119094820 · Cited by 87

Drug development for Alzheimer’s disease: Review

Lao, K., Ji, N., Zhang, X., Qiao, W., Tang, Z., & Gou, X. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2018.1474361 · Cited by 86

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease

Marttinen, M., Takalo, M., Natunen, T., Wittrahm, R., Gabbouj, S., Kemppainen, S., Leinonen, V., Tanila, H., Haapasalo, A., & Hiltunen, M. O. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00963 · Cited by 86

Friend, Foe or Both? Immune Activity in Alzheimer’s Disease

Frost, G. R., Jonas, L. A., & Li, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00337 · Cited by 88

Blood–brain barrier endothelial cells in neurodegenerative diseases: Signals from the “barrier”

Yuan, Y., Sun, J., Dong, Q., & Cui, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1047778 · Cited by 90

Microglial priming and Alzheimer’s disease: a possible role for (early) immune challenges and epigenetics?

Hoeijmakers, L., Heinen, Y., van Dam, A.-M., Lucassen, P. J., & Korosi, A. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00398 · Cited by 85

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Zheng, Q., Li, G., Wang, S., Zhou, Y., Liu, K., Gao, Y., Zhou, Y., Zheng, L., Zhu, L., Deng, Q., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe1340 · Cited by 85

The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer’s Disease

Ogunmokun, G., Dewanjee, S., Chakraborty, P., Valupadas, C., Chaudhary, A., Kolli, V., Anand, U., Vallamkondu, J., Goel, P., Paluru, H. P. R., et al. (2021) · Cells · doi:10.3390/cells10102790 · Cited by 85

Neurodegenerative diseases: The immunological perspective

Molteni, M., & Rossetti, C. (2017) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2017.11.002 · Cited by 87

Microglia heterogeneity along a spatio–temporal axis: More questions than answers

Silvin, A., & Ginhoux, F. (2018) · Glia · doi:10.1002/glia.23458 · Cited by 90

Decoding Mast Cell-Microglia Communication in Neurodegenerative Diseases

Sandhu, J. K., & Kulka, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031093 · Cited by 90

Dementia and the Risk of Periodontitis: A Population-Based Cohort Study

Sheng‐Kai, K., Hastürk, H., Carreras, I., Dedeoglu, A., Veeravalli, J. J., Huang, J., Kantarcı, A., & Wei, J. C. (2021) · Journal of Dental Research · doi:10.1177/00220345211037220 · Cited by 88

The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion

Li, Z., Farias, F. H. G., Dube, U., Del-Aguila, J. L., Mihindukulasuriya, K. A., Fernandez, M. V., Ibanez, L., Budde, J. P., Wang, F., Lake, A. M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-019-02066-0 · Cited by 85

The Role of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RA) in Diabetes-Related Neurodegenerative Diseases

Cheng, D., Yang, S., Zhao, X., & Wang, G. (2022) · Drug Design, Development and Therapy · doi:10.2147/dddt.s348055 · Cited by 84

Should We Stop Saying ‘Glia’ and ‘Neuroinflammation’?

Masgrau, R., Guaza, C., Ransohoff, R. M., & Galea, E. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.04.005 · Cited by 88

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Wang, H., Li, Y., Ryder, J. W., Hole, J. T., Ebert, P. J., Airey, D. C., Qian, H.-R., Logsdon, B., Fisher, A., Ahmed, Z., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0296-y · Cited by 83

Induced pluripotent stem cells in Alzheimer’s disease: applications for disease modeling and cell-replacement therapy

Yang, J., Li, S., He, X., Cheng, C., & Le, W. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0106-3 · Cited by 86

Drug Development for Central Nervous System Diseases Using In vitro Blood-brain Barrier Models and Drug Repositioning

Morofuji, Y., & Nakagawa, S. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200224112534 · Cited by 86

Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology

Tylek, K., Trojan, E., Regulska, M., Lacivita, E., Leopoldo, M., & Basta‐Kaim, A. (2021) · Pharmacological Reports · doi:10.1007/s43440-021-00271-x · Cited by 83

Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions

Yang, M., Sun, D., Wang, Y., Yan, M., Zheng, J., & Ren, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.831734 · Cited by 83

Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease

Dias, K. S. T., de Paula, C. T., dos Santos, T., Souza, I. N. D. O., Boni, M. S., Guimarães, M. J. R., da Silva, F. M. R., Castro, N. G., Neves, G. A., Veloso, C. C., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.02.043 · Cited by 83

Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation

Jaeger, B. N., Parylak, S., & Gage, F. H. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.003 · Cited by 83

Water Quality and Brain Function

Bondy, S. C., & Campbell, A. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15010002 · Cited by 85

An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene

Roubroeks, J. A. Y., Smith, A. R., Smith, R. G., Pishva, E., Ibrahim, Z., Sattlecker, M., Hannon, E. J., Kłoszewska, I., Mecocci, P., Soininen, H., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.06.023 · Cited by 82

The Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia

Shen, K., Sidik, H., & Talbot, W. S. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.055 · Cited by 81

Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease

Gameiro‐Ros, I., Michalska, P., Tenti, G., Cores, Á., Buendía, I., Rojo, A. I., Georgakopoulos, N., Hernández-Guijo, J. M., Ramos, M. T., Wells, G., et al. (2017) · Scientific Reports · doi:10.1038/srep45701 · Cited by 83

Early Life Stress and Epigenetics in Late-onset Alzheimer’s Dementia: A Systematic Review

Lemche, E. (2018) · Current Genomics · doi:10.2174/1389202919666171229145156 · Cited by 84

Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition

Zhou, N., Liu, K., Sun, Y., Cao, Y., & Yang, J. (2019) · Protein & Cell · doi:10.1007/s13238-018-0599-3 · Cited by 81

Contribution of Neurons and Glial Cells to Complement-Mediated Synapse Removal during Development, Aging and in Alzheimer’s Disease

Luchena, C., Zuazo-Ibarra, J., Alberdi, E. M., Matute, C., & Capetillo‐Zarate, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/2530414 · Cited by 84

Olfactory neuropathology in Alzheimer's disease: a sign of ongoing neurodegeneration

Son, G., Jahanshahi, A., Yoo, S., Boonstra, J. T., Hopkins, D. A., Steinbusch, H. W. M., & Moon, C. (2021) · BMB Reports · doi:10.5483/bmbrep.2021.54.6.055 · Cited by 81

Delivering the Promise of Gene Therapy with Nanomedicines in Treating Central Nervous System Diseases

Luo, M., Lee, L. K. C., Peng, B., Choi, C. H. J., Tong, W. Y., & Voelcker, N. H. (2022) · Advanced Science · doi:10.1002/advs.202201740 · Cited by 85

Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-β1-42 peptide in mice

Souza, L. C., Jessé, C. R., Antunes, M. S., Ruff, J. R., Janner, D. E., Gomes, N. S., Donato, F., Giacomeli, R., & Boeira, S. P. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.03.002 · Cited by 83

The pericyte–glia interface at the blood–brain barrier

Giannoni, P., Badaut, J., Dargazanli, C., De Maudave, A. F., Klement, W., Costalat, V., & Marchi, N. (2018) · Clinical Science · doi:10.1042/cs20171634 · Cited by 81

Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy

Lee, J. Y., Jin, H. K., & Bae, J.-S. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.1.278 · Cited by 80

The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases

Walter, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.704981 · Cited by 80

Modeling Neurodegenerative Microenvironment Using Cortical Organoids Derived from Human Stem Cells

Yan, Y., Song, L., Bejoy, J., Zhao, J., Kanekiyo, T., Bu, G., Zhou, Y., & Li, Y. (2018) · Tissue Engineering Part A · doi:10.1089/ten.tea.2017.0423 · Cited by 84

Can exercise training teach us how to treat Alzheimer's disease?

Huuha, A. M., Norevik, C. S., Moreira, J. B. N., Kobro-Flatmoen, A., Scrimgeour, N., Kivipelto, M., Van Praag, H., Ziaei, M., Sando, S. B., Wisløff, U., et al. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101559 · Cited by 79

Translocator protein 18 kDa (TSPO) deficiency inhibits microglial activation and impairs mitochondrial function

Yao, R., Pan, R., Shang, C., Li, X., Cheng, J., Xu, J., & Li, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00986 · Cited by 79

Oleocanthal-rich extra-virgin olive oil enhances donepezil effect by reducing amyloid-β load and related toxicity in a mouse model of Alzheimer’s disease

Batarseh, Y. S., & Kaddoumi, A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.006 · Cited by 83

Molecular signature of extracellular matrix pathology in schizophrenia

Pantazopoulos, H., Katsel, P., Haroutunian, V. H., Chelini, G., Klengel, T., & Berretta, S. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.15009 · Cited by 83

Cross-Talk of the CNS With Immune Cells and Functions in Health and Disease

Matejuk, A., Vandenbark, A. A., & Offner, H. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.672455 · Cited by 81

Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection

Zatsepina, O. G., Evgen’ev, M. B., & Garbuz, D. G. (2021) · Cells · doi:10.3390/cells10071638 · Cited by 80

Tetrahydroxy stilbene glycoside ameliorates neuroinflammation for Alzheimer's disease via cGAS-STING

Gao, D., Hao, J.-P., Li, B., Zheng, C.-C., Miao, B.-B., Zhang, L., Li, Y., Li, L., Li, X., & Zhang, L. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175809 · Cited by 82

Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain

Lykhmus, O., Mishra, N., Koval, L., Kalashnyk, O., Gergalova, G., Uspenska, K., Комісаренко, С. В., Soreq, H., & Skok, M. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00019 · Cited by 79

Recent advances in Alzheimer’s disease pathogenesis and therapeutics from an immune perspective

Nguyen, T.-D., Dang, L. N., Jang, J., & Park, S. (2023) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-023-00631-0 · Cited by 9

The roles of inflammation and immune mechanisms in Alzheimer's disease

Eldik, L. J. V., Carrillo, M. C., Cole, P. E., Feuerbach, D., Greenberg, B., Hendrix, J. A., Kennedy, M. E., Kozauer, N., Margolin, R. A., Molinuevo, J. L., et al. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.05.001 · Cited by 238

Innate immunity in Alzheimer's disease

Heneka, M. T., Golenbock, D. T., & Latz, E. (2015) · Nature Immunology · doi:10.1038/ni.3102 · Cited by 902

Alzheimer’s Disease: From Immune Homeostasis to Neuroinflammatory Condition

Cariddi, L. P., Mauri, M. F., Cosentino, M., Versino, M., & Marino, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113008 · Cited by 45

Therapeutic Targets in Innate Immunity to Tackle Alzheimer’s Disease

Serradas, M. L., Ding, Y., Martorell, P., Kulińska, I., & Castro‐Gomez, S. (2024) · Cells · doi:10.3390/cells13171426 · Cited by 16