Cited by 2,134Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

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Immune attack: the role of inflammation in Alzheimer disease

Heppner, Frank L., Ransohoff, Richard M., Becher, Burkhard·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3880

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Abstract

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with AD has been assumed to be merely a response to pathophysiological events. However, new data from preclinical and clinical studies have established that immune system-mediated actions in fact contribute to and drive AD pathogenesis. These insights have suggested both novel and well-defined potential therapeutic targets for AD, including microglia and several cytokines. In addition, as inflammation in AD primarily concerns the innate immune system - unlike in 'typical' neuroinflammatory diseases such as multiple sclerosis and encephalitides - the concept of neuroinflammation in AD may need refinement.

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Authors: Heppner, F. L., Ransohoff, R. M., & Becher, B.
Affiliations: NeuroCure Cluster of Excellence (DE)
Biogen (United States) (US)
University of Zurich (CH)
Corresponding author: Heppner, Frank L.
Ransohoff, Richard M.
Becher, Burkhard
ORCID: Heppner, Frank L.
Becher, Burkhard
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-05-20
Volume: 16
Issue: 6
Pages: 358-372
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3880
OpenAlex: W1841850981
Cited by: 2,134
References: 220
Citations by year: 2026: 121 · 2025: 157 · 2024: 166 · 2023: 173 · 2022: 211 · 2021: 264 · 2020: 221 · 2019: 192 · 2018: 225 · 2017: 205 · 2016: 153 · 2015: 43
FWCI: 16.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: Alzheimer's disease, neuroinflammation, innate immunity, microglia, cytokines, amyloid hypothesis, pathogenesis, therapeutic target
MeSH terms: Alzheimer Disease, Animals, Humans, Inflammation

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