Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease

Feng, Shu; Liu, Yongzhen; Zhou, Yu; Shu, Zhenfeng; Cheng, Zhuxi; Brenner, Charles; Feng, Pinghui

doi:10.3389/fnagi.2023.1245904

Cited by 36Alzheimer's disease research and treatmentsHerpesvirus Infections and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease

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Feng, Shu, Liu, Yongzhen, Zhou, Yu, Shu, Zhenfeng, Cheng, Zhuxi, Brenner, Charles, Feng, Pinghui·2023·Frontiers in Aging Neuroscience

DOI 10.3389/fnagi.2023.1245904PMC PMC10512732

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Abstract

Alzheimer’s Disease (AD) is an aging-associated neurodegenerative disorder, threatening millions of people worldwide. The onset and progression of AD can be accelerated by environmental risk factors, such as bacterial and viral infections. Human herpesviruses are ubiquitous infectious agents that underpin numerous inflammatory disorders including neurodegenerative diseases. Published studies concerning human herpesviruses in AD imply an active role HSV-1 in the pathogenesis of AD. This review will summarize the current understanding of HSV-1 infection in AD and highlight some barriers to advance this emerging field.

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Neurotropic pathogens such as human herpes virus, herpes simplex virus, hepatitis C virus, cytomegalovirus, varicella-zoster virus, and Epstein-Barr virus are associated with Alzheimer's disease neuropathology.
“For example, neurotropic pathogens, such as human herpes virus (HHV), herpes simplex virus (HSV), hepatitis C virus (HCV), cytomegalovirus, varicella-zoster virus, and Epstein–Barr virus are associated with Alzheimer’s disease (AD) neuropathology [10,11,12,13].”
From VEEV TC-83 Triggers Dysregulation of the Tryptophan–Kynurenine Pathway in the Central Nervous System That Correlates with Cognitive Impairment in Tg2576 Mice (2024) · cites this paper as [12]
The Introduction (page unavailable) links HSV-1 and HSV-2 infection to AD and AD-like neurodegeneration, and identifies HSV-1 as human herpesvirus 1. It does not establish an AD-neuropathology association for hepatitis C virus, cytomegalovirus, varicella-zoster virus, or Epstein–Barr virus; it discusses Epstein–Barr virus in relation to multiple sclerosis instead. (LLM, conf=0.87)
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Authors: Feng, S., Liu, Y., Zhou, Y., Shu, Z., Cheng, Z., Brenner, C., & Feng, P.
Affiliations: City Of Hope National Medical Center (US)
University of Southern California (US)
Corresponding author: Feng, Shu
Feng, Pinghui
ORCID: Feng, Shu
Liu, Yongzhen
Zhou, Yu
Brenner, Charles
Feng, Pinghui
Venue: Frontiers in Aging Neuroscience
Publisher: Frontiers Media SA
Published: 2023-09-07
Volume: 15
Pages: 1245904-1245904
ISSN: 1663-4365 (ISSN-L)
DOI: 10.3389/fnagi.2023.1245904
PMC: PMC10512732
OpenAlex: W4386497898
Cited by: 36
References: 165
Citations by year: 2026: 14 · 2025: 9 · 2024: 13
FWCI: 1.28
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Aging Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Infectious Diseases Society of America
National Institutes of Health
National Institute on Aging (R01AG070904)
National Cancer Institute (R01CA285192)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: herpes simplex virus type 1, Alzheimer's disease, viral infection, neurodegeneration, neuroinflammation, human herpesviruses, pathogenesis, infection risk factors

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Mechanistic insights into the role of herpes simplex virus 1 in Alzheimer’s disease

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