Cited by 797Alzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingAmyotrophic Lateral Sclerosis Research

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Spreading of pathology in neurodegenerative diseases: a focus on human studies

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Brettschneider, Johannes, Tredici, Kelly Del, Lee, Virginia M.-Y., Trojanowski, John Q.·2015·Nature Reviews Neuroscience

DOI 10.1038/nrn3887PMC PMC4312418

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Abstract

The progression of many neurodegenerative diseases is thought to be driven by the template-directed misfolding, seeded aggregation and cell-cell transmission of characteristic disease-related proteins, leading to the sequential dissemination of pathological protein aggregates. Recent evidence strongly suggests that the anatomical connections made by neurons - in addition to the intrinsic characteristics of neurons, such as morphology and gene expression profile - determine whether they are vulnerable to degeneration in these disorders. Notably, this common pathogenic principle opens up opportunities for pursuing novel targets for therapeutic interventions for these neurodegenerative disorders. We review recent evidence that supports the notion of neuron-neuron protein propagation, with a focus on neuropathological and positron emission tomography imaging studies in humans.

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Authors: Brettschneider, J., Tredici, K. D., Lee, V. M.-Y., & Trojanowski, J. Q.
Affiliations: Universität Ulm (DE)
University of Pennsylvania (US)
Corresponding author: Trojanowski, John Q.
ORCID: Tredici, Kelly Del
Lee, Virginia M.-Y.
Trojanowski, John Q.
Venue: Nature Reviews Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2015-01-15
Volume: 16
Issue: 2
Pages: 109-120
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3887
PMC: PMC4312418
OpenAlex: W1973319971
Cited by: 790
References: 187
Citations by year: 2026: 40 · 2025: 64 · 2024: 50 · 2023: 54 · 2022: 63 · 2021: 78 · 2020: 79 · 2019: 86 · 2018: 83 · 2017: 88 · 2016: 70 · 2015: 35
FWCI: 11.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P30AG010124, P01AG017586)
National Institute of Neurological Disorders and Stroke (P50NS053488)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Prion Diseases and Protein Misfolding
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: neurodegenerative diseases, protein aggregation, seeded aggregation, cell-to-cell transmission, neuropathology, positron emission tomography, therapeutic target
MeSH terms: Brain, Humans, Neurons, Disease Progression, Neurodegenerative Diseases

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Spreading of pathology in neurodegenerative diseases: a focus on human studies

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