Spreading of pathology in neurodegenerative diseases: a focus on human studies

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Items 101–200 of 797

1. Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis
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2. Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease?
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3. Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases
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4. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases
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5. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain
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6. Polyphenols Beyond Barriers: A Glimpse into the Brain
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7. Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation
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8. The Role of Microglia in the Spread of Tau: Relevance for Tauopathies
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9. An integrative memory model of recollection and familiarity to understand memory deficits
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10. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples
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11. Complexation as an approach to entrap cationic drugs into cationic nanoparticles administered intranasally for Alzheimer's disease management: preparation and detection in rat brain
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12. Cell Death and Neurodegeneration
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13. Multiphysics of Prionlike Diseases: Progression and Atrophy
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14. Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy
    Jesse A. Brown, Jersey Deng, John M Neuhaus, Isabel J. Sible, Ana C. Sias, Suzee E. Lee, John Kornak, Gabe A. Marx, Anna M. Karydas, Salvatore Spina et al. · 2019 · Neuron
15. Astroglia and Tau: New Perspectives
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16. Chronic Pain After Traumatic Brain Injury: Pathophysiology and Pain Mechanisms
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17. The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
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18. 3‐O‐Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
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19. Imaging transcriptomics of brain disorders
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20. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy
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21. Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains
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22. Dura mater is a potential source of Aβ seeds
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23. Disease modification and Neuroprotection in neurodegenerative disorders
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24. Re‐imagining Alzheimer's disease – the diminishing importance of amyloid and a glimpse of what lies ahead
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25. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
    Rik Ossenkoppele, Leonardo Iaccarino, Daniel R. Schonhaut, Jesse A. Brown, Renaud La Joie, James P. O’Neil, Mustafa Janabi, Suzanne L. Baker, Joel H. Kramer, Maria‐Luisa Gorno‐Tempini et al. · 2019 · NeuroImage Clinical
26. Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation
    Christopher Mezias, Nolwen L. Rey, Patrik Brundin, Ashish Raj · 2019 · Neurobiology of Disease
27. Tau physiology and pathomechanisms in frontotemporal lobar degeneration
    Bodea, Liviu‐Gabriel, Eckert, Anne, Ittner, Lars Matthias, Piguet, Olivier, Götz, Jürgen · 2016 · Journal of Neurochemistry
28. Structure, Dynamics and Function of the 26S Proteasome
    Youdong Mao · 2020 · Sub-cellular biochemistry/Subcellular biochemistry
29. Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
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30. Extracellular vesicles as trans‐genomic agents: Emerging roles in disease and evolution
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31. A Nigro−Vagal Pathway Controls Gastric Motility and Is Affected in a Rat Model of Parkinsonism
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32. Speech and language impairments in dementia
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33. Data-driven modelling of neurodegenerative disease progression: thinking outside the black box
    Alexandra L. Young, Neil P. Oxtoby, Sara Garbarino, Nick C. Fox, Frederik Barkhof, Jonathan M. Schott, Daniel C. Alexander · 2024 · Nature reviews. Neuroscience
34. The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
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35. Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation
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36. Current Concepts of Mixed Pathologies in Neurodegenerative Diseases
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37. Potential Therapies by Stem Cell‐Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
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38. The function of the cellular prion protein in health and disease
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39. TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease
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40. Targeting tau: clinical trials and novel therapeutic approaches
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41. Phosphorylation modifies the molecular stability of β-amyloid deposits
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42. Functional MRI of brain physiology in aging and neurodegenerative diseases
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43. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies
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44. Modulation of Amyloid States by Molecular Chaperones
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45. Prions and Protein Assemblies that Convey Biological Information in Health and Disease
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46. Immunotherapies for Aging-Related Neurodegenerative Diseases—Emerging Perspectives and New Targets
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47. Effectiveness of gamification for the rehabilitation of neurodegenerative disorders
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48. Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker
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49. Protein astrogliopathies in human neurodegenerative diseases and aging
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50. Three-dimensional mapping of neurofibrillary tangle burden in the human medial temporal lobe
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51. A randomized, single ascending dose study of intravenous BIIB092 in healthy participants
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52. Mirror trends of plasticity and stability indicators in primate prefrontal cortex
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53. Targeting α-Synuclein in Parkinson’s Disease: Progress Towards the Development of Disease-Modifying Therapeutics
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54. Brain Molecular Connectivity in Neurodegenerative Diseases: Recent Advances and New Perspectives Using Positron Emission Tomography
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55. Extracellular Vesicles from Ovarian Carcinoma Cells Display Specific Glycosignatures
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56. Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions
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57. Targeting Biomolecular Condensation and Protein Aggregation against Cancer
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58. Review: Somatic mutations in neurodegeneration
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59. A human-derived antibody targets misfolded SOD1 and ameliorates motor symptoms in mouse models of amyotrophic lateral sclerosis
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60. Caenorhabditis elegans as a model system for target identification and drug screening against neurodegenerative diseases
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61. Somatic variants in autosomal dominant genes are a rare cause of sporadic Alzheimer’s disease
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62. Synaptic Paths to Neurodegeneration: The Emerging Role of TDP-43 and FUS in Synaptic Functions
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63. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates
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64. The Neurotoxic Role of Extracellular Tau Protein
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65. Medial Temporal Lobe Networks in Alzheimer's Disease: Structural and Molecular Vulnerabilities
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66. Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer’s Disease Stages
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67. In Vitro Modulation of TrkB Receptor Signaling upon Sequential Delivery of Curcumin-DHA Loaded Carriers Towards Promoting Neuronal Survival
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68. All (animal) models (of neurodegeneration) are wrong. Are they also useful?
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69. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of α-synuclein aggregates
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70. ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
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71. Aberrant brain network connectivity in presymptomatic and manifest Huntington's disease: A systematic review
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72. Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation
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73. Effective connectivity in the default mode network is distinctively disrupted in Alzheimer's disease—A simultaneous resting‐state FDG‐PET/fMRI study
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74. Molecular Imaging of Neuroinflammation in Neurodegenerative Dementias: The Role of In Vivo PET Imaging
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75. Simultaneous quantitative susceptibility mapping and Flutemetamol-PET suggests local correlation of iron and β-amyloid as an indicator of cognitive performance at high age
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76. Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis
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77. A critical appraisal of tau‐targeting therapies for primary and secondary tauopathies
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78. Tau and Amyloid Relationships with Resting-state Functional Connectivity in Atypical Alzheimer’s Disease
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79. Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
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80. FV 12 The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance
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81. Photobiomodulation as a treatment for neurodegenerative disorders: current and future trends
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82. Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?
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83. The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
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84. The Gypsy Endogenous Retrovirus Drives Non-Cell-Autonomous Propagation in a Drosophila TDP-43 Model of Neurodegeneration
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85. The “Jekyll and Hyde” Actions of Nucleic Acids on the Prion-like Aggregation of Proteins
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86. Bent out of shape: α‐Synuclein misfolding and the convergence of pathogenic pathways in Parkinson's disease
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87. Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics for neurodegeneration and behavior disorders
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88. Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
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89. Prion-like mechanisms and potential therapeutic targets in neurodegenerative disorders
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90. Mathematical Modeling of Protein Misfolding Mechanisms in Neurological Diseases: A Historical Overview
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91. The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases
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92. Guarana (Paullinia cupana) Extract Protects Caenorhabditis elegans Models for Alzheimer Disease and Huntington Disease through Activation of Antioxidant and Protein Degradation Pathways
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93. A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases
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94. Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology
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95. The Properties of α-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain
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96. Novel conformation‐selective alpha‐synuclein antibodies raised against different in vitro fibril forms show distinct patterns of Lewy pathology in Parkinson's disease
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97. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease
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98. Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions
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99. Coordination and redox properties of copper interaction with α-synuclein
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100. Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis
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