The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mitochondrial energetics in the kidney
Open accessAbstract
The kidney requires a large number of mitochondria to remove waste from the blood and regulate fluid and electrolyte balance. Mitochondria provide the energy to drive these important functions and can adapt to different metabolic conditions through a number of signalling pathways (for example, mechanistic target of rapamycin (mTOR) and AMP-activated protein kinase (AMPK) pathways) that activate the transcriptional co-activator peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α), and by balancing mitochondrial dynamics and energetics to maintain mitochondrial homeostasis. Mitochondrial dysfunction leads to a decrease in ATP production, alterations in cellular functions and structure, and the loss of renal function. Persistent mitochondrial dysfunction has a role in the early stages and progression of renal diseases, such as acute kidney injury (AKI) and diabetic nephropathy, as it disrupts mitochondrial homeostasis and thus normal kidney function. Improving mitochondrial homeostasis and function has the potential to restore renal function, and administering compounds that stimulate mitochondrial biogenesis can restore mitochondrial and renal function in mouse models of AKI and diabetes mellitus. Furthermore, inhibiting the fission protein dynamin 1-like protein (DRP1) might ameliorate ischaemic renal injury by blocking mitochondrial fission.
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Cites
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Cited by
Zhao, M., Wang, Y., Li, L., Liu, S., Wang, C., Yuan, Y., Yang, G., Chen, Y., Cheng, J., Lu, Y., et al. (2021) · Theranostics · doi:10.7150/thno.50905 · Cited by 820
Mitochondrial quality control in kidney injury and repair
Tang, C., Cai, J., Yin, X.-M., Weinberg, J. M., Venkatachalam, M. A., & Dong, Z. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00369-0 · Cited by 513
Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities
Opazo-Ríos, L., Mas, S., Marín-Royo, G., Mezzano, S., Gómez-Guerrero, C., Moreno, J. A., & Egido, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072632 · Cited by 363
Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease
Ho, H.-J., & Shirakawa, H. (2022) · Cells · doi:10.3390/cells12010088 · Cited by 255
Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury
Tang, C., Han, H., Liu, Z., Liu, Y., Yin, L., Cai, J., He, L., Liu, Y., Chen, G., Zhang, Z., et al. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1899-0 · Cited by 219
Metadata
- Authors
- Bhargava, P., & Schnellmann, R. G.
- Venue
- Nature Reviews Nephrology
- Published
- 2017-08-14
- Volume
- 13
- Issue
- 10
- Pages
- 629-646
- ISSN
- 1745-8323 (ISSN-L)
- 1759-5061
- 1759-507X
- OpenAlex
- W2750514629
- Cited by
- 1,334
- References
- 49
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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