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Cited by 255Mitochondrial Function and PathologyAutophagy in Disease and TherapyChronic Kidney Disease and Diabetes

Oxidative Stress and Mitochondrial Dysfunction in Chronic Kidney Disease

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Ho, Hsin-Jung, Shirakawa, Hitoshi·2022·Cells
DOI 10.3390/cells12010088PMC PMC9818928
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Abstract

The kidney contains many mitochondria that generate ATP to provide energy for cellular processes. Oxidative stress injury can be caused by impaired mitochondria with excessive levels of reactive oxygen species. Accumulating evidence has indicated a relationship between oxidative stress and kidney diseases, and revealed new insights into mitochondria-targeted therapeutics for renal injury. Improving mitochondrial homeostasis, increasing mitochondrial biogenesis, and balancing mitochondrial turnover has the potential to protect renal function against oxidative stress. Although there are some reviews that addressed this issue, the articles summarizing the relationship between mitochondria-targeted effects and the risk factors of renal failure are still few. In this review, we integrate recent studies on oxidative stress and mitochondrial function in kidney diseases, especially chronic kidney disease. We organized the causes and risk factors of oxidative stress in the kidneys based in their mitochondria-targeted effects. This review also listed the possible candidates for clinical therapeutics of kidney diseases by modulating mitochondrial function.

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  • MGF has renoprotective effects across kidney injury models by modulating inflammation, oxidative stress, and fibrotic signaling pathways.

    “MGF has demonstrated renoprotective effects across a range of kidney injury models by modulating inflammation, oxidative stress and fibrotic signaling pathways (140).”

    From Mangiferin in human disease: Multifaceted mechanisms and applications (Review) (2026) · cites this paper as [140]

    Section 2.4 discusses renal protection by curcumin and other compounds, but does not identify MGF or attribute these effects to it. Searches for “MGF” and “mangiferin” found no passage in our copy addressing MGF’s effects across kidney injury models or the claimed pathways. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Ho, H.-J., & Shirakawa, H.
Affiliations
  • Hokkaido University (JP)
  • Tohoku University (JP)
Corresponding author
Ho, Hsin-Jung
ORCID
Venue
Cells
Publisher
MDPI AG
Published
2022-12-25
Volume
12
Issue
1
Pages
88
ISSN
2073-4409 (ISSN-L)
DOI
10.3390/cells12010088
PMC
PMC9818928
OpenAlex
W4312205820
Cited by
255
References
9
Citations by year
2026: 78 · 2025: 91 · 2024: 65 · 2023: 21
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Cells (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Japan Society for the Promotion of Science (JSPS) (#22K1174602)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
Keywords
oxidative stress, mitochondrial dysfunction, chronic kidney disease, reactive oxygen species, mitochondrial biogenesis, mitochondrial turnover, mitochondrial homeostasis, kidney injury
MeSH terms
Humans, Kidney, Mitochondria, Reactive Oxygen Species, Oxidative Stress, Renal Insufficiency, Chronic

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