Stimulation mapping of white matter tracts to study brain functional connectivity.
Abstract
Despite advances in the new science of connectomics, which aims to comprehensively map neural connections at both structural and functional levels, techniques to directly study the function of white matter tracts in vivo in humans have proved elusive. Direct electrical stimulation (DES) mapping of the subcortical fibres offers a unique opportunity to investigate the functional connectivity of the brain. This original method permits real-time anatomo-functional correlations, especially with regard to neural pathways, in awake patients undergoing brain surgery. In this article, the goal is to review new insights, gained from axonal DES, into the functional connectivity underlying the sensorimotor, visuospatial, language and sociocognitive systems. Interactions between these neural networks and multimodal systems, such as working memory, attention, executive functions and consciousness, can also be investigated by axonal stimulation. In this networking model of conation and cognition, brain processing is not conceived as the sum of several subfunctions, but results from the integration and potentiation of parallel-though partially overlapping-subnetworks. This hodotopical account, supported by axonal DES, improves our understanding of neuroplasticity and its limitations. The clinical implications of this paradigmatic shift from localizationism to hodotopy, in the context of brain surgery, neurology, neurorehabilitation and psychiatry, are discussed.
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The inferior fronto-occipital (IFOF) and uncinate (UF) fasciculi are crucial for the ventral intra-hemispheric transfer of information between the frontal cortex and the occipital, temporal and parietal cortices.
“Both inferior fronto-occipital (IFOF) and uncinate (UF) fasciculi are crucial for the ventral intra-hemispheric transfer of information between the frontal cortex and the occipital, temporal and parietal cortices”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Duffau, 2015
Knowing the cortical terminations of the IFOF and UF is fundamental for understanding their role in mediating language semantics.
“knowing their cortical terminations is fundamental for understanding their role in mediating language semantics”
From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Duffau, 2015
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Mapping neuroplastic potential in brain-damaged patients
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“The parallel course of the two main components of dorsal stream, AF (medially) and indirect anterior SLF (also known as SLF III, laterally) that connects the ventral frontal lobe with the inferior parietal lobule (IPL) (Sarubbo, 2016; Catani et al., 2005; Martino et al., 2013), reflects the parallel and segregated dis…”
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“Such studies paired with complementary techniques such as direct electrical brain stimulation studies (Duffau, 2015), will be an important step in understanding their functional roles that will be relevant in the clinical setting.”
BackgroundNeural pathways subserving face-based mentalizing
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Self-citationMapping language networks using the structural and dynamic brain connectomes
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- Authors
- Duffau, H.
- Affiliations
- Inserm (FR)
- Corresponding author
- Duffau, Hugues
- ORCID
- Duffau, Hugues
- Venue
- Nature Reviews Neurology
- Published
- 2015-04-07
- Volume
- 11
- Issue
- 5
- Pages
- 255-265
- ISSN
- 1759-4758 (ISSN-L)
- 1759-4766
- OpenAlex
- W2075437393
- Cited by
- 437
- References
- 6
- Citations by year
- 2026: 32 · 2025: 48 · 2024: 22 · 2023: 34 · 2022: 43 · 2021: 65 · 2020: 43 · 2019: 38 · 2018: 34 · 2017: 40 · 2016: 26 · 2015: 11
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- direct electrical stimulation, white matter tracts, functional connectivity, connectomics, localizationism, awake craniotomy, sensorimotor network, language network, working memory, attention, executive function, consciousness, neuroplasticity, neurorehabilitation
- MeSH terms
- Brain Neoplasms, Electric Stimulation, Glioma, Humans, Magnetic Resonance Imaging, Mental Processes, Neural Pathways, Visual Pathways, Neurosurgical Procedures, Connectome, White Matter, Sensorimotor Cortex
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