Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain
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OBJECTIVE: The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. METHODS: We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. RESULTS: The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. CONCLUSIONS: We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans' neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
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Combining tractography atlases with intraoperative electrical stimulation has produced probabilistic atlases of white matter pathways and structural hubs defining a minimal common brain connectome with low inter-individual variability and low potential for post-lesional compensation.
“By combining tractography atlases with intraoperative electrical stimulation for functional mapping, researchers have constructed probabilistic atlases of white matter pathways and structural hubs that define a minimal common brain connectome with a low inter-individual variability and a low potential of post-lesional compensation (Herbet et al., 2016; Sarubbo et al., 2020).”
From Quantitative mapping of the brain’s structural connectivity using diffusion MRI tractography: A review (2022) · cites this paper as Sarubbo et al., 2020
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“Spatial cognition was assessed with a line bisection task, according to the technique previously described, where the patient is presented with a standard length line and asked to mark the midpoint with a pen (Thiebaut de Schotten et al., 2005; Bartolomeo et al., 2007).”
MethodSelf-citationMaffei, C., Jovicich, J., Benedictis, A. D., Corsini, F., Barbareschi, M., Chioffi, F., & Sarubbo, S. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1471-6 · Cited by 46 · see citing works
Self-citationZacà, D., Corsini, F., Rozzanigo, U., Dallabona, M., Avesani, P., Annicchiarico, L., Zigiotto, L., Faraca, G., Chioffi, F., Jovicich, J., et al. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00405 · Cited by 37 · see citing works
Self-citationMontemurro, N., Herbet, G., & Duffau, H. (2016) · Brain Topography · doi:10.1007/s10548-016-0490-6 · Cited by 30 · cited 2× · see citing works
“These data support the hypothesis of a hemispheric segregation between verbal and non-verbal semantics (Moritz-Gasser et al., 2013; Han et al., 2013), with the latter mediated by the right IFOF (Herbet et al., 2017).”
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Sorted by citations
Zhang, F., Daducci, A., He, Y., Schiavi, S., Seguin, C., Smith, R. E., Yeh, C.-H., Zhao, T., & O’Donnell, L. J. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2021.118870 · Cited by 302 · see citing works
“probabilistic atlases of white matter pathways and structural hubs that define a minimal common brain connectome with a low inter-individual variability and a low potential of postlesional compensation [193, 370].”
The Role of the Dorsolateral Prefrontal Cortex for Speech and Language Processing
Hertrich, I., Dietrich, S., Blum, C., & Ackermann, H. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.645209 · Cited by 189 · see citing works
White matter variability, cognition, and disorders: a systematic review
Forkel, S. J., Friedrich, P., de Schotten, M. T., & Howells, H. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02382-w · Cited by 138 · see citing works
Lu, J., Zhao, Z., Zhang, J., Wu, B., Zhu, Y., Chang, E. F., Wu, J., Duffau, H., & Berger, M. S. (2021) · Brain · doi:10.1093/brain/awab125 · Cited by 109 · see citing works
“Interestingly, an recent electrocorticography study showed that the cerebral regions for non-spoken sign language might differ from those of monolingual spoken language in terms of language production (Shum et al., 2020).”
Self-citationDuffau, H. (2021) · Neurosurgery · doi:10.1093/neuros/nyaa363 · Cited by 88 · see citing works
Self-citationCho, Y. U., Lee, J. Y., Jeong, U., Park, S., Lim, S. L., Kim, K. Y., Jang, J. W., Park, J. H., Kim, H. W., Shin, H., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202105568 · Cited by 84 · see citing works
Reducing the Cognitive Footprint of Brain Tumor Surgery
Dadario, N. B., Brahimaj, B. C., Yeung, J. T., & Sughrue, M. E. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.711646 · Cited by 93 · see citing works
“Recent improvements in connectomic data has also allowed others to expand the clinical utility of DES in identifying critical hubs on an individualized basis (89, 102).”
BackgroundDuffau, H. (2021) · Acta Neurochirurgica · doi:10.1007/s00701-021-04752-z · Cited by 69 · see citing works
Self-citationDuffau, H. (2020) · Cancers · doi:10.3390/cancers12092611 · Cited by 64 · see citing works
“Another atlas of essential nodal architecture of the connectome was also elaborated, reporting a normalized dataset of 1821 cortical and subcortical functional DEM-driven responses collected in awake LGG patients, and revealing the critical structures in 16 functional domains [30].”
BackgroundSelf-citationTowards a tractography-based risk stratification model for language area associated gliomas
Tuncer, M., Salvati, L., Grittner, U., Hardt, J., Schilling, R., Bährend, I., Silva, L. L., Fekonja, L., Faust, K., Vajkoczy, P., et al. (2020) · NeuroImage: Clinical · doi:10.1016/j.nicl.2020.102541 · Cited by 61 · see citing works
“Recently more evidence derived from intraoperative stimulation mapping and MEG connectivity studies was published on the outstanding importance of certain functional nodes within the cortico-subcortical networks to preserve neurological functioning (Lee et al., 2020; Sarubbo et al., 2020).”
BackgroundZigiotto, L., Annicchiarico, L., Corsini, F., Vitali, L., Falchi, R., Dalpiaz, C., Rozzanigo, U., Barbareschi, M., Avesani, P., Papagno, C., et al. (2020) · Journal of Neuro-Oncology · doi:10.1007/s11060-020-03494-9 · Cited by 61 · see citing works
Self-citationCatalino, M., Yao, S., Green, D. L., Laws, E., Golby, A., & Tie, Y. (2020) · Neurosurgical Focus · doi:10.3171/2019.11.focus19773 · Cited by 55 · see citing works
Minimal Phrase Composition Revealed by Intracranial RecordingsPreprint
Murphy, E., Woolnough, O., Rollo, P., Roccaforte, Z. J., Segaert, K., Hagoort, P., & Tandon, N. (2021) · Journal of Neuroscience · doi:10.1101/2021.04.30.442171 · Cited by 54 · see citing works
The inferior fronto-occipital fasciculus: bridging phylogeny, ontogeny and functional anatomy
Giampiccolo, D., Herbet, G., & Duffau, H. (2025) · Brain · doi:10.1093/brain/awaf055 · Cited by 53 · see citing works
“This has been confirmed in an atlas of cortical and subcortical stimulation, 43 which combined 1162 cortical and 659 subcortical stimulation sites in 256 patients undergoing awake surgery and showed that semantic paraphasia and non-verbal comprehension disorders were linked to the IFOF but not to…”
InfluentialSelf-citationMiddle Frontal Gyrus and Area 55b: Perioperative Mapping and Language Outcomes
Hazem, S., Awan, M., Lavrador, J., Patel, S., Wren, H., Lucena, O., Semedo, C., Irzan, H., Melbourne, A., Ourselin, S., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.646075 · Cited by 49 · see citing works
“The involvement of this area in both semantic processing (12) and speech articulation (40) has been well recognized.”
BackgroundStructure and function of language networks in temporal lobe epilepsy
Binding, L., Dasgupta, D., Giampiccolo, D., Duncan, J., & Vos, S. (2022) · Epilepsia · doi:10.1111/epi.17204 · Cited by 48 · see citing works
Duffau, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855587 · Cited by 45 · see citing works
Self-citationElectrical Stimulation Mapping of Brain Function: A Comparison of Subdural Electrodes and Stereo-EEG
Grande, K. M., Ihnen, S., & Arya, R. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.611291 · Cited by 45 · see citing works
“This is particularly relevant with SEEG because it allows direct stimulation of white matter containing axonal pathways (Sarubbo et al., 2020).”
BackgroundPasquini, L., Napoli, A. D., Espagnet, M. C. R., Visconti, E., Napolitano, A., Romano, A., Bozzao, A., Peck, K., & Holodny, A. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.747215 · Cited by 44 · see citing works
de Albuquerque, L. A. F., Almeida, J. P., Filho, L. D. M., Joaquim, A. F., & Duffau, H. (2020) · Neurosurgical Review · doi:10.1007/s10143-020-01362-8 · Cited by 46 · see citing works
“Although the SpTR is not possible in most cases because of the proximity with eloquent areas, it should be pursued whenever possible, because it might positively change the natural history of DLGG, by decreasing the risk of malignant transformation (MT) for a long period”
BackgroundInfluentialSelf-citationPetit, L., Ali, K., Rheault, F., Boré, A., Cremona, S., Corsini, F., Benedictis, A., Descoteaux, M., & Sarubbo, S. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02551-5 · Cited by 34 · see citing works
Self-citationKourtidou, E., Kasselimis, D., Angelopoulou, G., Karavasilis, E., Velonakis, G., Kelekis, N., Zalonis, I., Evdokimidis, I., Potagas, C., & Petrides, M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.635750 · Cited by 34 · see citing works
“Brodmann areas 44 and 45 which occupy the cortex of the pars opercularis and pars triangularis of the inferior frontal gyrus, respectively, are often referred to as Broca’s area and play a critical role in the planning and execution of language production in coordination with specific posterior parietal and temporal a…”
BackgroundSilva, M., Vivancos, C., & Duffau, H. (2022) · Brain Science · doi:10.3390/brainsci12040504 · Cited by 31 · see citing works
“In clinical prac‐ tice, this novel concept led to a paradigmatic shift, that is, to achieve a surgical resection up to the identification of the neural circuits critical for brain processing identified by DES [67], and not according to the data provide by neuroimaging, which underestimates gli‐ oma infiltration.”
BackgroundInfluentialSelf-citationDuffau, H. (2020) · Critical reviews in oncology/hematology · doi:10.1016/j.critrevonc.2020.103073 · Cited by 30 · see citing works
“critical neural networks (Sarubbo et al., 2020), as well as atlases of potentials and limitations”
BackgroundSelf-citationBerro, D. H., Herbet, G., & Duffau, H. (2021) · Brain Structure and Function · doi:10.1007/s00429-020-02186-4 · Cited by 29 · see citing works
Self-citationIntegrating direct electrical brain stimulation with the human connectome
Coletta, L., Avesani, P., Zigiotto, L., Venturini, M., Annicchiarico, L., Vavassori, L., Ng, S., Duffau, H., & Sarubbo, S. (2023) · Brain : a journal of neurology · doi:10.1093/brain/awad402 · Cited by 28 · see citing works
“8 More details about LNM implementation can be found in the Supplementary material.”
InfluentialSelf-citationDuffau, H. (2021) · Revue neurologique (Paris) · doi:10.1016/j.neurol.2021.07.016 · Cited by 27 · see citing works
Self-citationVavassori, L., Sarubbo, S., & Petit, L. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02265-0 · Cited by 27 · see citing works
Self-citationDuffau, H. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00315 · Cited by 27 · see citing works
“Furthermore, DES offers two major interests in comparison with the commonly used FNI to study the human connectome.”
BackgroundResultInfluentialSelf-citationNeural control of lexical tone production in human laryngeal motor cortex
Lu, J., Li, Y., Zhao, Z., Liu, Y., Zhu, Y., Mao, Y., Wu, J., & Chang, E. F. (2023) · Nature Communications · doi:10.1038/s41467-023-42175-9 · Cited by 26 · see citing works
Duffau, H. (2021) · Cancers · doi:10.3390/cancers13194759 · Cited by 31 · see citing works
Self-citationLocalization patterns of speech and language errors during awake brain surgery: a systematic review
Collée, E., Vincent, A. J. P. E., Visch-Brink, E. G., Witte, E. D., Dirven, C. M. F., & Satoer, D. (2023) · Neurosurgical Review · doi:10.1007/s10143-022-01943-9 · Cited by 31 · see citing works
Segregated circuits for phonemic and semantic fluency: A novel patient-tailored disconnection study
Zigiotto, L., Vavassori, L., Annicchiarico, L., Corsini, F., Avesani, P., Rozzanigo, U., Sarubbo, S., & Papagno, C. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103149 · Cited by 25 · see citing works
Self-citationGiampiccolo, D., Howells, H., Bährend, I., Schneider, H., Raffa, G., Rosenstock, T., Vergani, F., Vajkoczy, P., & Picht, T. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa158 · Cited by 25 · see citing works
“…patients undergoing awake surgery described how cortical and subcortical stimulation of the anterior segment using DES causes interference particularly with speech articulation and speech output over other facets of language, for example reading and non-verbal comprehension (Sarubbo et al. , 2020).”
Recent Advances in the Diagnosis and Treatment of Brain Tumors
Delaidelli, A., & Moiraghi, A. (2024) · Brain Science · doi:10.3390/brainsci14030224 · Cited by 23
Ng, S., & Duffau, H. (2023) · Cancers · doi:10.3390/cancers15143698 · Cited by 21 · see citing works
“Moreover, various plasticity atlases obtained from intraoperative electrostimulation findings [70,85] and functional resections [68] may help clinicians to guide presurgical planning and appreciate the probabilistic degree of functional compensation depending on the WM infiltration.”
BackgroundSelf-citationVasileiadi, M., Schuler, A.-L., Woletz, M., Linhardt, D., Windischberger, C., & Tik, M. (2023) · Brain Stimulation · doi:10.1016/j.brs.2023.06.014 · Cited by 21 · see citing works
“Using DCS [11,12] could show probabilistic evidence for different qualitative errors (i.e. semantic errors, phonological errors, anomia and speech arrest) due to stimulation, to be mapped to the STG and middle temporal gyrus (MTG).”
BackgroundInfluentialPhysical distance to sensory-motor landmarks predicts language function
Wang, X.-Y., Krieger-Redwood, K., Zhang, M.-C., Cui, Z., Wang, X.-K., Karapanagiotidis, T., Du, Y.-J., Leech, R., Bernhardt, B., Margulies, D., et al. (2022) · Cerebral Cortex · doi:10.1093/cercor/bhac344 · Cited by 20 · see citing works
Duffau, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.947933 · Cited by 20 · see citing works
Self-citationVecchio, T. G., Neimantaite, A., Corell, A., Bartek, J., Jensdottir, M., Reinertsen, I., Solheim, O., & Jakola, A. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.748229 · Cited by 20 · see citing works
“Despite its simplicity, the linear registration method has been previously benchmarked showing comparably accurate results as nonlinear registration for glioma localization (21, 62).”
MethodDuffau, H. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.582489 · Cited by 20 · see citing works
“Consequently, neurosurgeons should find the optimal compromise between the dynamics of neural networks allowing compensation after glioma resection and limitations of brain reshaping based on the knowledge of critical cortical hubs and axonal pathways (22, 23).”
BackgroundSelf-citationRoux, A., Lemaître, A.-L., Deverdun, J., Ng, S., Duffau, H., & Herbet, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.683348 · Cited by 19 · see citing works
Self-citationWei, X.-Y., Chen, H., Guo, C., Tan, W., & Zhan, S. (2021) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s307083 · Cited by 19 · see citing works
Moritz-Gasser, S., & Herbet, G. (2021) · Intraoperative Mapping of Cognitive Networks · doi:10.1007/978-3-030-75071-8_15 · Cited by 19 · see citing works
Self-citationThe arcuate fasciculus: Combining structure and function into surgical considerations
Vavassori, L., Venturini, M., Zigiotto, L., Annicchiarico, L., Corsini, F., Avesani, P., Petit, L., Benedictis, A. D., & Sarubbo, S. (2023) · Brain and Behavior · doi:10.1002/brb3.3107 · Cited by 17 · see citing works
Self-citationSame, Same but Different? A Multi-Method Review of the Processes Underlying Executive Control
Toba, M. N., Malkinson, T. S., Howells, H., Mackie, M., & Spagna, A. (2023) · Neuropsychology Review · doi:10.1007/s11065-023-09577-4 · Cited by 24 · see citing works
“No intraoperative studies have yet demonstrated interference on visual attention or executive control tasks following application of subcortical DES to the SLF I (see Sarubbo et al., 2020).”
Plasticity of the Primary Motor Cortex in Patients with Primary Brain Tumors
Kong, N., Gibb, W., Badhe, S., Liu, B. P., & Tate, M. C. (2020) · Journal of Neural Transplantation and Plasticity · doi:10.1155/2020/3648517 · Cited by 17
“Additionally, we utilized linear transformation methods which have been shown to be accurate in normalization datasets that have high degrees of local mass effect, resection cavity distortion, or ventricular changes [23].”
MethodSelf-citationSarubbo, S., Tate, M. C., Benedictis, A. D., Merler, S., Moritz-Gasser, S., Herbet, G., & Duffau, H. (2019) · Data in Brief · doi:10.1016/j.dib.2019.104892 · Cited by 17
“In this data article, we provide the dataset which served as the basis for our related research article “Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain” [1], which represents the first probabilistic cortical and subcortical atl…”
BackgroundMethodSelf-citationWhite matter disconnectivity fingerprints causally linked to dissociated forms of alexia
Ng, S., Moritz‐Gasser, S., Lemaitre, A., Duffau, H., & Herbet, G. (2021) · Communications Biology · doi:10.1038/s42003-021-02943-z · Cited by 19 · see citing works
Self-citationHardy, S., Jensen, O., Wheeldon, L., Mazaheri, A., & Segaert, K. (2021) · bioRxiv · doi:10.1093/cercor/bhac080 · Cited by 16 · see citing works
“24 subserved by deep white matter pathways and which communicate through frequencyspecific networks (Sarubbo et al., 2020; Schoffelen et al., 2017; White et al., 2018).”
Sarubbo, S., Annicchiarico, L., Corsini, F., Zigiotto, L., Herbet, G., Moritz-Gasser, S., Dalpiaz, C., Vitali, L., Tate, M. C., Benedictis, A. D., et al. (2020) · Operative Neurosurgery · doi:10.1093/ons/opaa396 · Cited by 16 · see citing works
Self-citationBoerger, T. F., Pahapill, P. A., Butts, A. M., Arocho-Quinones, E. V., Raghavan, M., & Krucoff, M. O. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1170419 · Cited by 17 · see citing works
“One group with extensive experience in this area has generated a probabilistic atlas of numerous functional perturbations across sensorimotor and language domains throughout the brain (Sarubbo et al., 2020).”
BackgroundLanders, M., Sitskoorn, M., Rutten, G., Mandonnet, E., & Baene, W. D. (2021) · Acta Neurochirurgica · doi:10.1007/s00701-021-05012-w · Cited by 15 · see citing works
Bu, L., Lu, J., Zhang, J., & Wu, J. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.612891 · Cited by 21 · see citing works
“In our institute, the Snodgrass and Vanderwart picture set (Snodgrass and Vanderwart, 1980) is adopted, since the test contains 260 easily recognizable drawings of common objects from different categories and, more importantly, has norms for Mandarin Chinese available (Liu et al., 2011).”
MethodOhlerth, A.-K., Bastiaanse, R., Negwer, C., Sollmann, N., Schramm, S., Schröder, A., & Krieg, S. (2021) · Brain Science · doi:10.3390/brainsci11091190 · Cited by 14 · see citing works
“Both the mMTG and vPrG mirror the pattern of higher error rates of the LH and align with findings from nTMS [6,81] and intraoperative DES [68,77,80].”
BackgroundMethodResultInfluentialLatini, F., Axelson, H., Fahlström, M., Jemstedt, M., Munkhammar, Å. A., Zetterling, M., & Ryttlefors, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051108 · Cited by 14 · see citing works
“Second, the intraoperative pictures of the surgical field were used as a control to navigation to confirm the exact location of the eloquent spots as described by other authors [64,81].”
MethodMartín-Monzón, I., Amores-Carrera, L., Sabsevitz, D., & Herbet, G. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1415523 · Cited by 13 · see citing works
Self-citationGasa-Roqué, A., Rofes, A., Simó, M., Juncadella, M., Rico-Pons, I., Camins, À., Gabarrós, A., Rodríguez-Fornells, A., & Sierpowska, J. (2023) · Journal of Neuropsychology · doi:10.1111/jnp.12343 · Cited by 13 · see citing works
Duffau, H. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101621 · Cited by 13 · see citing works
Self-citationDuffau, H. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1901583 · Cited by 13 · see citing works
“Furthermore, a more diffuse pattern of the tumor, with a wider invasion of the white matter tracts, is correlated with more severe deterioration due to the low plastic potential of axonal fibers [27,28].”
BackgroundSelf-citationA Novel Intraoperative Brain Mapping Integrated Task-Presentation Platform.
Hameed, N. F. F., Zhao, Z.-H., Zhang, J., Bu, L., Zhou, Y., Jin, L., Bai, H., Li, W.-P., Tang, J., Lu, J., et al. (2021) · Operative Neurosurgery · doi:10.1093/ons/opaa476 · Cited by 13 · see citing works
Huang, Y., Tan, Y., Hao, H.-L., Li, J., Liu, C.-Y., Hu, Y.-F., Wu, Y.-M., Ding, Q.-Y., Zhou, Y., Li, Y., et al. (2023) · Journal of neural transmission · doi:10.1007/s00702-023-02594-w · Cited by 12 · see citing works
Validation of direct cortical stimulation in presurgical evaluation of epilepsy.
Ley, M., Peláez, N., Principe, A., Langohr, K., Zucca, R., & Rocamora, R. (2022) · Clinical Neurophysiology · doi:10.1016/j.clinph.2022.02.006 · Cited by 12 · see citing works
Where is the speech production area? Evidence from direct cortical electrical stimulation mapping
Zhao, Z.-H., Liu, Y., Zhang, J., Lu, J., & Wu, J. (2021) · Brain : a journal of neurology · doi:10.1093/brain/awab178 · Cited by 12 · see citing works
Rech, F., Wassermann, D., & Duffau, H. (2020) · Brain and Cognition · doi:10.1016/j.bandc.2020.105583 · Cited by 12 · see citing works
Self-citationPreoperative assessment of eloquence in neurosurgery: a systematic review
Rammeloo, E., Schouten, J., Krikour, K., Bos, E., Berger, M. S., Nahed, B., Vincent, A., & Gerritsen, J. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04509-x · Cited by 11
Zhu, W., Deng, S., Jiang, H.-L., Zhang, J.-Y., Li, B.-X., Liu, W., Jia, Q., & Meng, Z. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1140588 · Cited by 11 · see citing works
“In the inferior frontal gyrus, Broca’s area consists of the perisylvian and deltoid cortices, including Brodmann’s area 44 and 45, and is responsible for language production planning and execution, coordinated with posterior parietal and temporal areas through specific bidirectional fiber tracts (Indefrey and Levelt,…”
BackgroundSubject-Specific Automatic Reconstruction of White Matter Tracts
Meesters, S. P. L., Landers, M., Rutten, G., & Florack, L. (2023) · Journal of digital imaging · doi:10.1007/s10278-023-00883-0 · Cited by 11 · see citing works
“An approach that has emerged in recent years, and potentially could be useful for tuning tractography results in patients, is comparing the results of tractography to intraoperative electrical stimulation mapping [58–60].”
ResultDuffau, H. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2021.824003 · Cited by 11 · see citing works
“Indeed, despite mechanisms of neural reconfiguration which may be elicited by slow-growing LGG (29), such a potential of neuroplasticity is very limited at the level of the white matter connectivity, thus with a high risk of permanent deficit in the event of tracts injury (16, 30, 31).”
BackgroundSelf-citationPallud, J., Roux, A., Trancart, B., Peeters, S. M., Moiraghi, A., Edjlali, M., Oppenheim, C., Varlet, P., Chrétien, F., Dhermain, F., et al. (2021) · Neurosurgery · doi:10.1093/neuros/nyab255 · Cited by 11
Sellier, A., Moritz-Gasser, S., Lemaître, A.-L., Herbet, G., & Duffau, H. (2020) · Journal of Neurosurgery · doi:10.3171/2020.6.jns201071 · Cited by 11 · see citing works
Self-citationFunctional anatomy and topographical organization of the frontotemporal arcuate fasciculus
Basile, G. A., Nozais, V., Quartarone, A., Giustiniani, A., Ielo, A., Cerasa, A., Milardi, D., Abdallah, M., de Schotten, M. T., Forkel, S. J., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-07274-3 · Cited by 10 · see citing works
“In keeping with these fi ndings, DES in the middle and superior temporal gyrus and peri-insular white matter results in word deafness and phonemic paraphasia 18,66 – 68 , strengthening the hypothesis that the ventral AF may be involved in sensory and motor phonological processes.”
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“Marchina et al. and Wang et al. (2013) did not specify the nature of the errors, but it is likely that they were mainly phonological errors, as observed with direct electrical stimulation of the AF (Giampiccolo and Duffau 2022; Sarubbo et al. 2020).”
White matter tracts contribute selectively to cognitive functioning in patients with glioma
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Self-citationOncological and functional neurosurgery: Perspectives for the decade regarding diffuse gliomas.
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Self-citationDynamics in cognition and health-related quality of life in grade 2 and 3 gliomas after surgery
Wettervik, T. S., Munkhammar, Å. A., Jemstedt, M., Ersson, M., Latini, F., Ryttlefors, M., & Zetterling, M. (2022) · Acta Neurochirurgica · doi:10.1007/s00701-022-05408-2 · Cited by 10 · see citing works
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“Deconvolution of the dMRI signal measured on the streamlines is similar in LiFE [33], COMMIT [15, 16, 38], COMMIT 2 [37], and COMMIT2tree [31] utilising traditional multicompartment models [32] assign a single contribution, or "weight," to each of them.”
InfluentialGobbo, M., de Pellegrin, S., Bonaudo, C., Semenza, C., della Puppa, A., & Salillas, E. (2020) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2020.107727 · Cited by 9 · see citing works
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Zigiotto, L., Venturini, R., Coletta, L., Venturini, M., Monte, D. D., Vavassori, L., Corsini, F., Annicchiarico, L., Avesani, P., Papagno, C., et al. (2025) · Neurosurgery · doi:10.1227/neu.0000000000003591 · Cited by 8 · see citing works
“15-21 However, not all patients can undergo AwS and not all cognitive functions can be monitored during surgery, 22-25 such as attention.”
Self-citationSauvageot, S., Boetto, J., & Duffau, H. (2023) · Journal of Neurosurgery · doi:10.3171/2023.2.jns222755 · Cited by 8 · see citing works
Self-citationPatient-reported quality of life in grade 2 and 3 gliomas after surgery, can we do more?
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“The tumors were considered eloquent in case of infiltration of the white matter pathways in the “minimal common brain” (inferior fronto-occipital fascicle (IFOF), arcuate fasciculus (AF), corticospinal tract (CST), and optic radiation (OR)) [23,24].”
BackgroundOhlerth, A., Bastiaanse, R., Negwer, C., Sollmann, N., Schramm, S., Schröder, A., & Krieg, S. M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.748274 · Cited by 11 · see citing works
“The dorsal stream’s main function in phonological processing, typically seen in induced phonological errors through stimulation of the AF, is mostly found in the LH (Silva and Citterio, 2017; Sarubbo et al., 2020).”
BackgroundMethodInfluentialMorales, H. (2021) · Seminars in Ultrasound CT and MRI · doi:10.1053/j.sult.2021.07.005 · Cited by 8 · see citing works
Bifurcation and Oscillations of a Multi-ring Coupling Neural Network with Discrete Delays
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Delineation of organs at risk in radiotherapy and perspectives.
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Structural networking of the developing brain: from maturation to neurosurgical implications
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Self-citationDuffau, H. (2023) · Neurosurgery · doi:10.1227/neu.0000000000002508 · Cited by 7 · see citing works
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“However, the two indirect effects through the mediators-damage in MTG or ITG cortices-were significant elicit phonological error without disruption of comprehension further supported the above statement (Corina et al., 2010; Sarubbo et al., 2019).”
ResultThe connectivity-based parcellation of the angular gyrus: fiber dissection and MR tractography study
Yakar, F., Çeltikçi, P., Doğruel, Y., Egemen, E., & Güngör, A. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02555-1 · Cited by 7 · see citing works
“In a recent study (Sarubbo et al. 2020), human neural functions, cortical and subcortical structures were evaluated by real-time neurophysiological testing.”
BackgroundTractography in brain tumor surgery: current clinical impact and future challenges
Sarubbo, S., Vergani, F., & Yang, J. Y. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-02956-y · Cited by 6 · see citing works
“…fasciculus, inferior fronto-occipital fasciculus and inferior longitudinal fascicle, subserving in different modalities of language process - ing (Sarubbo et al. 2020 ) superior longitudinal fascicle and frontal-aslant tract, crucial for language and motor planning (Zigiotto et al. 2020 ;…”
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Self-citationBala, A., Olejnik, A., Dziedzic, T., Piwowarska, J., Podgórska, A., & Marchel, A. (2023) · Journal of Neuropsychology · doi:10.1111/jnp.12311 · Cited by 6 · see citing works
Extended testing for cognition: has awake brain mapping moved to the next level?
Samandouras, G. (2021) · Acta Neurochirurgica · doi:10.1007/s00701-021-05010-y · Cited by 6 · see citing works
“Fortunately, a wealth of initial DES data is emerging from high-quality cognitive studies [22, 27, 32].”
BackgroundInfluentialDEBATE: is tractography accurate enough to be used to inform surgery?
Vergani, F., Sarubbo, S., & Yang, J. Y. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-02948-y · Cited by 5 · see citing works
Self-citationMore widespread functionality of posterior language area in patients with brain tumors
Nakajima, R., Osada, T., Kinoshita, M., Ogawa, A., Okita, H., Konishi, S., & Nakada, M. (2024) · Human Brain Mapping · doi:10.1002/hbm.26801 · Cited by 5 · see citing works
“The types of positive responses in the naming task included anomia, perseveration, phonemic aphasia, repetition disorder, and semantic aphasia (Leonard et al., 2019; Sarubbo et al., 2020).”
BackgroundMethodFahlström, M., Mirza, S., Munkhammar, Å. A., Zetterling, M., & Latini, F. (2024) · Brain Science · doi:10.3390/brainsci14030213 · Cited by 5
“The mechanisms of cortical–subcortical plasticity at the individual level, with important anatomical-functional variability, are not fully understood [13–15].”
BackgroundMethodZigiotto, L., Amorosino, G., Saviola, F., Jovicich, J., Annicchiarico, L., Rozzanigo, U., Olivetti, E., Avesani, P., & Sarubbo, S. (2023) · Journal of Neuropsychology · doi:10.1111/jnp.12339 · Cited by 5 · see citing works
Self-citation
- Authors
- Sarubbo, S., Tate, M., De Benedictis, A., Merler, S., Moritz-Gasser, S., Herbet, G., & Duffau, H.
- Affiliations
- Provincia Autonoma di Trento (IT)
- Northwestern University (US)
- Fondazione Bruno Kessler (IT)
- Inserm (FR)
- Corresponding author
- Sarubbo, Silvio
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 205
- Pages
- 116237
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC7217287
- OpenAlex
- W2981249254
- Cited by
- 206
- References
- 81
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 18 · 2023: 35 · 2022: 35 · 2021: 41 · 2020: 18 · 2019: 2
- FWCI
- 15.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Iris (University of Trento) (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences (KL2TR001424, MT)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- direct electrical stimulation, cortical hubs, white matter tracts, subcortical structures, awake craniotomy, eloquent brain areas, probabilistic mapping, brain networks, language, visuospatial cognition, movement, semantics, neurosurgical planning
- MeSH terms
- Adult, Atlases as Topic, Brain Mapping, Cerebral Cortex, Electric Stimulation, Humans, Magnetic Resonance Imaging, Neural Pathways, Neurosurgical Procedures, Preoperative Period, White Matter
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