Perisylvian language networks of the human brain
Open accessAbstract
Early anatomically based models of language consisted of an arcuate tract connecting Broca's speech and Wernicke's comprehension centers; a lesion of the tract resulted in conduction aphasia. However, the heterogeneous clinical presentations of conduction aphasia suggest a greater complexity of perisylvian anatomical connections than allowed for in the classical anatomical model. This article re-explores perisylvian language connectivity using in vivo diffusion tensor magnetic resonance imaging tractography. Diffusion tensor magnetic resonance imaging data from 11 right-handed healthy male subjects were averaged, and the arcuate fasciculus of the left hemisphere reconstructed from this data using an interactive dissection technique. Beyond the classical arcuate pathway connecting Broca's and Wernicke's areas directly, we show a previously undescribed, indirect pathway passing through inferior parietal cortex. The indirect pathway runs parallel and lateral to the classical arcuate fasciculus and is composed of an anterior segment connecting Broca's territory with the inferior parietal lobe and a posterior segment connecting the inferior parietal lobe to Wernicke's territory. This model of two parallel pathways helps explain the diverse clinical presentations of conduction aphasia. The anatomical findings are also relevant to the evolution of language, provide a framework for Lichtheim's symptom-based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language.
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The anterior segment of the arcuate fasciculus connects the posterior inferior frontal cortex with the parieto-temporal cortex.
“the anterior segment of the arcuate fasciculus (also referred to as the third branch of the superior longitudinal fasciculus or SLF III) that connects the posterior inferior frontal cortex with the parieto-temporal cortex”
From Damage to Broca’s area does not contribute to long-term speech production outcome after stroke (2021) · cites this paper as Catani et al., 2005
The IPL is immediately adjacent to the posterior STG, and may be part of an alternative pathway that runs laterally to the arcuate fasciculus between Wernicke's and Broca's area.
“The IPL is immediately adjacent to the posterior STG (including the planum temporale and Wernicke's area), and may be part of an alternative pathway that runs laterally to the arcuate fasciculus between Wernicke's and Broca's area”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Catani et al., 2005
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- Authors
- Catani, M., Jones, D. K., & ffytche, D. H.
- Affiliations
- King's College London (GB)
- National Institutes of Health (US)
- Corresponding author
- Catani, Marco
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2004-12-13
- Volume
- 57
- Issue
- 1
- Pages
- 8-16
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2072923434
- Cited by
- 1,832
- References
- 57
- Citations by year
- 2026: 54 · 2025: 57 · 2024: 81 · 2023: 65 · 2022: 88 · 2021: 100 · 2020: 94 · 2019: 81 · 2018: 96 · 2017: 114 · 2016: 107 · 2015: 117 · 2014: 127 · 2013: 109 · 2012: 106
- FWCI
- 18.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- arcuate fasciculus, conduction aphasia, Broca's area, Wernicke's area, inferior parietal lobule, diffusion tractography, language evolution
- MeSH terms
- Adult, Brain, Brain Mapping, Frontal Lobe, Humans, Language, Male, Neural Pathways, Temporal Lobe, Neural Networks, Computer, Imaging, Three-Dimensional, Diffusion Magnetic Resonance Imaging
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