Microstructural Organization of the Cingulum Tract and the Level of Default Mode Functional Connectivity
Open accessAbstract
The default mode network is a functionally connected network of brain regions that show highly synchronized intrinsic neuronal activation during rest. However, less is known about the structural connections of this network, which could play an important role in the observed functional connectivity patterns. In this study, we examined the microstructural organization of the cingulum tract in relation to the level of resting-state default mode functional synchronization. Resting-state functional magnetic resonance imaging and diffusion tensor imaging data of 45 healthy subjects were acquired on a 3 tesla scanner. Both structural and functional connectivity of the default mode network were examined. In all subjects, the cingulum tract was identified from the total collection of reconstructed tracts to interconnect the precuneus/posterior cingulate cortex and medial frontal cortex, key regions of the default mode network. A significant positive correlation was found between the average fractional anisotropy value of the cingulum tract and the level of functional connectivity between the precuneus/posterior cingulate cortex and medial frontal cortex. Our results suggest a direct relationship between the structural and functional connectivity measures of the default mode network and contribute to the understanding of default mode network connectivity.
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Cingulum FA correlates with default-mode functional connectivity.
“e.g., cingulum FA correlates with default-mode functional connectivity (van den Heuvel et al., 2008).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as van den Heuvel et al., 2008
Higher FA is associated with better functional connectivity between anatomically distant gray matter regions using resting-state fMRI.
“higher FA has been associated with better functional connectivity between anatomically distant gray matter regions using resting-state fMRI (functional MRI) 35,47,48”
From Physical exercise keeps the brain connected: biking increases white matter integrity in patients with schizophrenia and healthy controls. (2015) · cites this paper as [35]
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- Authors
- van den Heuvel, M., Mandl, R., Luigjes, J., & Hulshoff Pol, H.
- Affiliations
- Utrecht University (NL)
- ORCID
- Mandl, René
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-10-22
- Volume
- 28
- Issue
- 43
- Pages
- 10844-10851
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6671361
- OpenAlex
- W1997491128
- Cited by
- 349
- References
- 63
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 15 · 2023: 14 · 2022: 13 · 2021: 20 · 2020: 16 · 2019: 12 · 2018: 25 · 2017: 33 · 2016: 21 · 2015: 22 · 2014: 29 · 2013: 27 · 2012: 24
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Mind wandering and attention
- Keywords
- default mode network, resting-state functional connectivity, structural connectivity, fractional anisotropy, precuneus, posterior cingulate cortex, medial frontal cortex, white matter tracts
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Neural Pathways, Oxygen, Rest
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