Cited by 314Osteoarthritis Treatment and MechanismsAutophagy in Disease and TherapyHip disorders and treatments

The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

Open access

Lotz, Martin K., Caramés, Beatriz·2011·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2011.109PMC PMC3192496

Open this paper in CoChat — free account

Abstract

Osteoarthritis (OA) is the most prevalent joint disease, but neither preventive measures nor disease-modifying drugs are available and a continuing need exists for safe and effective symptom-modifying therapies. Clinical trials of candidate disease-modifying OA drugs in patients with established or advanced disease have not demonstrated their efficacy, but these failed trials have motivated investigation into the mechanisms that maintain joint health. The enhancement of such mechanisms could be a novel approach to reducing the risk of OA. Aging is one of the most important risk factors for OA; however, aging of joint cartilage is a process that is distinct from the subsequent cartilage changes that develop following the onset of OA. This Review focuses on the mechanisms that maintain cell and tissue homeostasis, and how these mechanisms fail during the aging process. Autophagy is a cellular homeostasis mechanism for the removal of dysfunctional organelles and macromolecules. Defective autophagy is involved in the pathogenesis of aging-related diseases and recent observations indicate that this process is compromised in aging cartilage. Augmentation of homeostasis mechanisms is discussed as a novel avenue to delay joint aging and reduce OA risk.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrrheum.2011.109

Cites

99 of 99 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries: Osteoarthritis
Lohmander, L. S., Englund, P. M., Dahl, L. L., & Roos, E. M. (2007) · The American Journal of Sports Medicine · doi:10.1177/0363546507307396 · Cited by 2,344
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832
Selective autophagy mediated by autophagic adapter proteins
Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,788
OARSI recommendations for the management of hip and knee osteoarthritis
Zhang, W., Nuki, G., Moskowitz, R. W., Abramson, S. B., Altman, R. D., Arden, N., Bierma‐Zeinstra, S., Brandt, K. D., Croft, P. R., Doherty, M., et al. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.01.013 · Cited by 1,726
The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.
Guccione, A. A., Felson, D. T., Anderson, J. J., Anthony, J., Zhang, Y., Wilson, P. W. F., Kelly‐Hayes, M., Wolf, P. A., Kreger, B. E., & Kannel, W. B. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.3.351 · Cited by 1,580

Show all 99 references

Sorted by citations

Items 201–300 of 314

Intermittent cyclic mechanical compression promotes endplate chondrocytes degeneration by disturbing Nrf2/PINK1 signaling pathway-dependent mitophagy
Zheng, Q., Wang, C.-D., Shao, S., Wu, M.-F., Dou, Q., Wang, Q., & Sun, L. (2023) · Human Cell · doi:10.1007/s13577-023-00959-7 · Cited by 12
“Autophagy principally serves an adaptive role to be protective in the pathological status of many degenerative diseases, including IVDD and osteoarthritis [42, 43].”
Background
Saikosaponin D alleviates inflammatory response of osteoarthritis and mediates autophagy via elevating microRNA-199-3p to target transcription Factor-4
Yan, M., Zhang, D., & Yang, M. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04607-0 · Cited by 12
“Consequently, the modulation of chondrocyte autophagy is hypothesized to potentially delay or modify the degenerative process of cartilage in OA [17, 18].”
Background
Mitochondrial Role on Cellular Apoptosis, Autophagy, and Senescence during Osteoarthritis Pathogenesis
Dalmao‐Fernández, A., Hermida‐Gómez, T., Nogueira-Recalde, U., Rego‐Pérez, I., Blanco, F. J., & Fernández-Moreno, M. (2024) · Cells · doi:10.3390/cells13110976 · Cited by 13
Progress and Challenges of Topical Delivery Technologies Meditated Drug Therapy for Osteoarthritis
Shentu, C., Wang, H., Peng, X., Xu, D.-C., Qian, L.-N., Chen, Y., & Peng, L. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466437 · Cited by 12
Mesenchymal stem cells and their extracellular vesicles: new therapies for cartilage repair
Yang, H., Yang, H., Wang, Q., Ji, H., Qian, T., Qiao, Y., Shi, J., & Meng, C. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1591400 · Cited by 12
“In mammals, the cartilage injury directly leads to a decrease in autophagy depending on the mammalian target of rapamycin (mTOR) and an increase in cell death (Lotz and Caramés, 2011).”
Tougu Xiaotong capsule promotes chondrocyte autophagy by regulating the Atg12/LC3 conjugation systems
Li, X., LIU, F., Liang, W., Ye, H., Li, H., YU, F., Chen, J., Chen, W., Lin, R., Zheng, C., et al. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1794 · Cited by 12
Diazoxide ameliorates severity of experimental osteoarthritis by activating autophagy via modulation of the osteoarthritis‐related biomarkers
Meng, Z.-L., Shen, B., Gu, Y., Wu, Z., Yao, J., Bian, Y., Zeng, D., Chen, K.-W., Cheng, S., Fu, J., et al. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27145 · Cited by 12
Maximising the output of osteoarthritis research: the ARRIVE guidelines
du Sert, N. P. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2011.12.017 · Cited by 12
Effects of osteoblast autophagy on glucocorticoid-induced femoral head necrosis
Zhou, M. S. (2020) · Joint Diseases and Related Surgery · doi:10.5606/ehc.2020.73036 · Cited by 12
Circulating miR-146b and miR-27b are efficient biomarkers for early diagnosis of Equidae osteoarthritis
Yassin, A. M., AbuBakr, H. O., Abdelgalil, A. I., Ahmed-Farid, O. A.-H., EL-Behairy, A. M., & Gouda, E. M. (2023) · Scientific Reports · doi:10.1038/s41598-023-35207-3 · Cited by 11
Effects of food hardness on temporomandibular joint osteoarthritis: Qualitative and quantitative micro-CT analysis of rats in vivo
Tran, T. T.-N., Wang, D., Yang, M., Chen, J.-C., Wu, P.-H., Yang, C., Hsu, W.-E., & Hsu, M. (2022) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2022.152029 · Cited by 11
Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis
Zhao, S., Wang, J., Xue, M., Wu, B., Sheng, L., Wen, Y., Wang, G., Song, J., Du, D., & Xu, J. (2026) · Bone Research · doi:10.1038/s41413-025-00502-4 · Cited by 11
“52,53 Autophagy is essential to maintain normal chondrocyte function and survival of the cartilage, a postmitotic tissue with an extremely slow cell rate turnover.”
Oxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
Lu, J., Bian, J., Wang, Y., Zhao, Y., Zhao, X., Wang, G., & Yang, J. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-04667-2 · Cited by 10
The Implications of Brain-Derived Neurotrophic Factor in the Biological Activities of Platelet-Rich Plasma
Malange, K. F., de Souza, D. M., Lemes, J. B. P., Fagundes, C. C., Oliveira, A. L. L., Pagliusi, M., Carvalho, N. S., Nishijima, C. M., da Silva, C. R. R., Consonni, S. R., et al. (2024) · Inflammation · doi:10.1007/s10753-024-02072-9 · Cited by 10
“It has been widely reported that therapeutic approaches capable of interfering with oxidative damage and modulate autophagy mechanisms in chondrocytes can improve tissue healing in OA joints [89–91].”
Ethanolic Extract of Propolis Modulates Autophagy-Related microRNAs in Osteoarthritic Chondrocytes
Arias, C., & Salazar, L. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914767 · Cited by 10
“In the context of OA, where the available drugs have limitations and many clinical trial candidate drugs have failed to show efficacy or have adverse effects [15], researchers are exploring alternative approaches.”
Background
Intra-articular Injection of Chloramphenicol Reduces Articular Cartilage Degeneration in a Rabbit Model of Osteoarthritis
Wu, X., Cai, Y., Lu, S., Xu, K., Shi, X., Yang, L., Huang, Z., & Xu, P. (2019) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000001016 · Cited by 10
“Age-related OA in humans and mice is associated with reduced autophagy and increased apoptosis in chondrocytes, and autophagy may help maintain joint health and prevent OA progression [2, 6-7, 9, 21, 30].”
Background
Identification of genes and pathways associated with subchondral bone in osteoarthritis via bioinformatic analysis
Yang, Z., Ni, J., Kuang, L., Gao, Y., & Tao, S. (2020) · Medicine · doi:10.1097/md.0000000000022142 · Cited by 10
Cartilage and Chondrocytes
Goldring, M. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00003-7 · Cited by 10
ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A
Zhao, S., Liu, Y., Wang, J., Wen, Y., Wu, B., Yang, D., Wang, G., Xiu, G., Ling, B., Du, D., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110390 · Cited by 9
IKKα affects the susceptibility of primary human osteoarthritis chondrocytes to oxidative stress-induced DNA damage by tuning autophagy
Neri, S., Guidotti, S., Panichi, V., Minguzzi, M., Cattini, L., Platano, D., Ursini, F., Arciola, C. R., & Borzı̀, R. M. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.10.299 · Cited by 9
Adenosine A2A receptor null chondrocyte transcriptome resembles that of human osteoarthritic chondrocytes
Castro, C. M., Corciulo, C., Friedman, B., Li, Z., Jacob, S. T., Fenyö, D., & Cronstein, B. N. (2021) · Purinergic Signalling · doi:10.1007/s11302-021-09788-5 · Cited by 9
Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing
Thompson, S. D., Pichika, R., Lieber, R. L., & Lavasani, M. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00239-8 · Cited by 9
An Insight on the Biomedical Potential of Portuguese Propolis from Gerês
Araújo, C., Oliveira, R. D., Pinto‐Ribeiro, F., & Aguiar, C. A. (2022) · Foods · doi:10.3390/foods11213431 · Cited by 8
“Despite all he advances nd research ver the last years, none of the proposed strategies has been effective in generating functional and long-lasting tissue [1,14].”
Background
The comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management
Hu, Z., Wang, C., Wang, C., He, J., Yan, Y., Xu, Z., Yu, Y., Yu, Y., Huan, C., Liu, L., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-93357-y · Cited by 9
The influence of PPARγ mediated MAPK and NF-κB activation in AGEs stimulated apoptosis and autophagy in human chondrocytes
Wang, Z., Wang, W., Jia, K.-X., Zhang, H., Wang, J.-A., & Chen, C. (2025) · Journal of Orthopaedics · doi:10.1016/j.jor.2025.05.022 · Cited by 7
Geroprotectors and Skeletal Health: Beyond the Headlines
Rayson, A., Boudiffa, M., Naveed, M., Griffin, J., Dall’Ara, E., & Bellantuono, I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.682045 · Cited by 8
“OA, the most common age-related joint pathology, is characterized by cartilage degradation and inflammation in the joint, thickening of the bone plate, changes in subchondral bone and formation of osteophytes (Lotz and Caramés, 2011).”
Background
Recent development in understanding the role of lipids in cartilage lubrication
Xue, Y., Niu, X., Zhou, J., Wang, L., & Fan, Y. (2024) · Friction · doi:10.26599/frict.2025.9441014 · Cited by 6
Harnessing the dual immunomodulatory function of myeloid-derived suppressor cells to reshape the inflammatory microenvironment for osteoarthritis therapy
Guo, Z., Chen, T., Wen, X., Fu, Q., Lai, J., Chen, J., Weng, J., Zheng, L., Wang, W. J., Cao, Q., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102332 · Cited by 6
“Such devastating consequences of OA are deeply rooted in the failure of cartilage regeneration, which is initiated by prolonged pro-inflammatory response caused by various factors including injury, age, lifestyle, etc [3 – 5].”
Nanotherapeutic Strategies for Osteoarthritis: Targeting Aging, Metabolism and Inflammation
He, Z., Chen, Y., Zhao, K., Jiao, Y., Ji, Y., Mao, D., Wan, R., Zhang, J., & Hu, Y. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s584027 · Cited by 7
“79,80 During OA pathogenesis, compromised autophagic flux results in the accumulation of damaged organelles and misfolded proteins, thereby exacerbating chondrocyte dysfunction, accelerating cartilage matrix degradation, and ultimately promoting cell death.”
MicroRNAs and Regulation of Autophagy in Chondrocytes
Ramos, Y. F., & Mobasheri, A. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-1119-7_13 · Cited by 6
Muti-factor analysis of sport activity level after high tibial osteotomy
Huang, T., Kang, K., Qi, Q., Li, T., Liu, T., Ji, C., & Gao, S. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04305-3 · Cited by 6
“OA poses significant challenges for mid - dle-aged and elderly individuals, considerably deterio-rates their athletic ability and life quality [2, 3].”
Background
Histological Evaluation and Gene Expression Profiling of Autophagy-Related Genes for Cartilage of Young and Senescent Rats
Arias, C., Saavedra, N., Leal, K., Vásquez, B., Abdalla, D. S. P., & Salazar, L. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228607 · Cited by 6
“showed a significant reduction in the basal autophagy in cartilage of aged mice, emphasizing that the alteration occurred before of structural damage related to aging [9,13,14].”
Background
Hyperglycemia and Hyperinsulinemia-Like Conditions Independently Induce Inflammatory Responses in Human Chondrocytes
Rufino, A. T., Ribeiro, M. P., Ferreira, J. P. S., Judas, F., & Mendes, A. F. (2017) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk2020015 · Cited by 6
Nordihydroguaiaretic acid microparticles are effective in the treatment of osteoarthritis
Dhanabalan, K. M., Padhan, B., Dravid, A. A., Agarwal, S., Pancheri, N. M., Lin, A., Willett, N. J., Padmanabhan, A. K., & Agarwal, R. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01342e · Cited by 5
Kat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway
Liu, Z., Qiu, L., Zhang, Y., Zhao, G., Sun, X., & Luo, W. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02519-y · Cited by 5
Shedding light on experimental intra-articular drugs for treating knee osteoarthritis
Zhao, Y., Ou, Q., Cai, Y., Ruan, G., Zhang, Y., & Ding, C. (2023) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2023.2225214 · Cited by 5
“Autophagy is an important mechanism for the cell to adapt to the altered environment during pathological processes [89].”
Background
Ginkgolide K delays the progression of osteoarthritis by regulating YAP to promote the formation of cartilage extracellular matrix
Liu, R., Liu, Z., Chen, H., He, S., Wang, S., Dai, J., & Li, X. (2023) · Phytotherapy Research · doi:10.1002/ptr.7953 · Cited by 5
“Excessive chondrocyte apoptosis and insufficient protective autophagy may largely contribute to the pathogenesis of OA (Hwang & Kim, 2015; Lotz & Carames, 2011; Shi et al., 2020; Yang et al., 2020).”
Background
Comparison of the Therapeutic Efficacy and Autophagy-Mediated Mechanisms of Action of Urine-Derived and Adipose-Derived Stem Cells in Osteoarthritis
Xu, T., Zhang, K., Hu, Y., Yang, R., Tang, J., & Fu, W. (2024) · The American Journal of Sports Medicine · doi:10.1177/03635465241277176 · Cited by 5
“1,20 As such, the modulation of autophagy has emerged as a potential therapeutic strategy for OA.”
Bioreactor Tissue Engineering for Cartilage Repair
Salzmann, G. M., & Stoddart, M. J. (2013) · Springer eBooks · doi:10.1007/978-1-4471-5385-6_5 · Cited by 5
OSTEOARTHRITIS – А MODERN CONCEPT OF ETIOLOGY AND PATHOGENESIS
Sapundzhiev, L., Sapundzhieva, T., & Klinkanov, K. (2021) · Rheumatology (Bulgaria) · doi:10.35465/29.1.2021.pp21-43 · Cited by 5
“All of these features of early and late changes in OA can be induced in a model of human AC explants, stimulated by FGF-2 [34, 37-42].”
Background
Maintaining high levels of HIF-1α protects osteoarthritis cartilage by activating autophagy
Chen, X., Feng, G., Shao, L., Lin, X., He, X., Yang, Y., Zhao, X. S., Yan, J., Ma, L., Zhou, Y., et al. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103027 · Cited by 5
SPTLC2 ameliorates chondrocyte dysfunction and extracellular matrix metabolism disturbance in vitro and in vivo in osteoarthritis
Lü, G., Wu, R., Wang, B., Li, L., Li, Y., Li, X., He, H., Wang, X., & Kuang, L. (2023) · Experimental Cell Research · doi:10.1016/j.yexcr.2023.113524 · Cited by 4
Miao medicine Gu Yan Xiao tincture inhibits mTOR to stimulate chondrocyte autophagy in a rabbit model of osteoarthritis
Cai, H., Zheng, Y., Chen, Y., Lü, Q., Hong, W., Guo, Q., & Zheng, S. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118095 · Cited by 4
Cartilage and Chondrocytes
Goldring, M. B., Culley, K. L., Wondimu, E. B., & Otero, M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-31696-5.00003-6 · Cited by 5
Transdermal delivery of traditional Chinese medicine patch vs. NSAIDs patch for alleviating inflammation and relieving pain for early-stage knee osteoarthritis: a retrospective case control study
Wang, S., Guan, J., Gong, W., & Bao, B. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1549883 · Cited by 3
Type I Collagen/Hyaluronic Acid Hydrogels as Delivery System for Adipose-Derived Stem Cells for Osteoarthritis Treatment
Ivirico, J. L. E., Bhattacharjee, M., Ude, C. C., Kan, H.-M., Carey, D., Barajaa, M. A., Nagiah, N., Chapman, J. H., Nair, L. S., & Laurencin, C. T. (2024) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-023-00327-9 · Cited by 3
Osteopontin inhibits autophagy via CD44 and avβ3 integrin and promotes cell proliferation in osteoarthritic fibroblast-like synoviocytes
Li, M., Wei, C.-B., Li, H., He, K., Bai, R., & Zhang, F. (2025) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-025-08509-y · Cited by 3
“Importantly, autophagy is implicated in slowing the aging process and enhancing autophagy activity has been shown to significantly reduce the incidence and severity of age-related diseases, such as osteoarthritis (OA) [22].”
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling
Han, W., Guan, M., Liao, B., Han, X., Li, K., Chen, Q., Guo, X., Niu, Y., Zhu, Y., & Bai, D. (2025) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e14408 · Cited by 3
Neuropeptide Y1 receptor antagonist alleviated osteoarthritis by restoring chondrocyte autophagy through PI3K/AKT/mTOR signaling pathway
Liu, S., Wu, J., Lin, Y., Liang, H., Cai, Y., Wang, L., Wang, Z., & Sang, H. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.08.003 · Cited by 3
“Autophagy, a cellular self-degradation process, is a critical mechanism for maintaining cartilage homeostasis and preventing OA [11,12].”
[Research progress on the role of chondrocyte mitochondrial homeostasis imbalance in the pathogenesis of osteoarthritis].
Chen, Q., Wu, L., Dawa, C., & Shen, B. (2023) · PubMed Central · doi:10.7507/1002-1892.202303006 · Cited by 3
In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes
Köck, H., Striegl, B., Kraus, A., Zborilova, M., Christiansen, S. H., Schäfer, N., Grässel, S., & Hornberger, H. (2023) · Bioengineering · doi:10.3390/bioengineering10070767 · Cited by 3
“The initial parallel orientation of the collagen fibers, typical for the SZ, could not be found, which might be due to increasing degradation of the SZ during OA progression, as described in former studies [43,69,70].”
Result
Antioxidants in the Treatment of Osteoarthritis and Bone Mineral Loss
Mobasheri, A., Shakibaei, M., Biesalski, H. K., & Henrotin, Y. E. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_15 · Cited by 4
The Importance of the mTOR Regulatory Network in Chondrocyte Biology and Osteoarthritis
Tchetina, E. V. (2014) · EMJ Rheumatology · doi:10.33590/emjrheumatol/10311971 · Cited by 3
WITHDRAWN: The dysregulated autophagy in osteoarthritis: Revisiting molecular profile
Liu, L., Wang, J., Liu, L., Shi, W., Gao, H., & Liu, L. (2024) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2024.03.004 · Cited by 3
Retracted
Nanomedicine constructed with plant-derived aromatic aldehydes treats low back pain by reversing the progression of lumbar facet joint osteoarthritis
Yang, M., Lv, H., Tang, Z., Zhou, J., Yang, Q., Cai, J., Gui, Y., Yu, B., Huang, R., Yang, J., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.162445 · Cited by 2
Flux-Based Assay for the Identification of Autophagy Modulators for Osteoarthritis
Nogueira-Recalde, U., Lorenzo-Gómez, I., Loza, M. I., Domínguez, E., & Caramés, B. (2020) · Journal of Visualized Experiments · doi:10.3791/61078 · Cited by 3
Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Pandey, A., Singla, M., Geller, A., Goodman, S. B., & Bhutani, N. (2024) · Arthritis Research & Therapy · doi:10.1186/s13075-024-03284-y · Cited by 2
Articular Cartilage Metabolism: Biochemical Markers and Dynamic Loading
Gahunia, H. K., & Pritzker, K. P. H. (2020) · Springer eBooks · doi:10.1007/978-1-4939-7587-7_4 · Cited by 2
Nutrigenomics, Inflammaging, and Osteoarthritis
Mobasheri, A., Barrett‐Jolley, R., Staunton, C. A., Ford, C., & Henrotin, Y. E. (2015) · Wiley eBooks · doi:10.1002/9781118930458.ch7 · Cited by 2
The Physiopathology of Osteoarthritis: Applying Bioarchaeological Measures to a Modern Surgical Population
Scott, M. (2019) · HARVEST (University of Saskatchewan) · Cited by 2
Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of OsteoarthritisPreprint
Dhanabalan, K. M., Dravid, A. A., Agarwal, S., Sharath, R. K., Padmanabhan, A. K., & Agarwal, R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.20.453073 · Cited by 2
“Failure in autophagy upregulation during these stress conditions, can make the cells apoptotic leading to diminished repair and remodelling capability in cartilage(12, 13, 17-19).”
Background
Effectiveness of ultrasound-guided platelets rich plasma injection in knee osteoarthritic cases
Safwat, L., Khalifa, G. E. E., Aziz, A. A., & Alshabrawy, H. (2021) · Journal of Medicine in Scientific Research · doi:10.4103/jmisr.jmisr_15_21 · Cited by 1
Conditioned Medium of Infrapatellar Fat Stem Cells Alleviates Degradation of Chondrocyte Extracellular Matrix and Delays Development of Osteoarthritis
He, S., Wang, S., Liu, R., Chen, H., Wang, Q., Jia, D., Chen, L., Dai, J., & Li, X. (2024) · Gerontology · doi:10.1159/000540505 · Cited by 1
Phytomolecule Epimedin C Mitigates Cartilage Extracellular Matrix Degradation and Osteoarthritis Progression in Rats
Yang, W., Meng, X., Li, J., Cao, H., Li, L., Huang, C., Wang, Y., Chang, W., Grad, S., Li, Z., et al. (2025) · Advanced Biology · doi:10.1002/adbi.202400685 · Cited by 2
USP15-dependent modulation of TGF-β/Smad2/3 signaling: implications for chondrocyte matrix degradation and autophagy in osteoarthritis
Yuan, Z., He, J., Zhao, Z., Chen, G., Li, Y., & Li, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-21847-0 · Cited by 1
“Autophagy plays crucial roles in cellular homeostasis and OA pathogenesis 25,27,28 .”
Peptide p[63–82] induces transcriptomic alterations associated with processes involved in cartilage repair in osteoarthritic human chondrocytes
Steijns, J., van den Akker, G., Welting, T. J. M., & Caron, M. M. J. (2026) · Connective Tissue Research · doi:10.1080/03008207.2026.2649000 · Cited by 1
Targeted synergistic therapy for bone and brain disorders using hydrogel microneedles loaded with exosomes and drugs
Shi, H., Chen, Y., Huang, Z., Shen, C., Xiao, J., Zhao, H., Zou, Z., Zhang, W., Feng, K., Ou, Z., et al. (2026) · Microstructures · doi:10.20517/microstructures.2025.132 · Cited by 1
From Joint Loading to Osteoarthritis: A Multiscale Review of Knee Mechanobiology and Digital Modelling
Stańczak, M., Kacprzak, B., & Hagner-Derengowska, M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167462 · Cited by 2
“…turnover of intracellular constituents, which is protective in healthy cartilage and declines with age; the loss of autophagy is associated with the cell death and matrix loss of ageing and osteoarthritic cartilage, and mitochondrial dysfunction features prominently in this decline [191,192,205].”
MiR-140 in cancer and beyond: a brief update
Zhang, Y. (2012) · Journal of Solid Tumors · doi:10.5430/jst.v3n1p38 · Cited by 1
Evaluation of CXCL2 and autophagy genes expression in rheumatoid arthritis patients and its relation to cardiovascular diseases
Elhelaly, M., Nassar, D. K., Nassar, M. K., Abdelalim, K. T., & Tharwat, S. (2023) · Mansoura Medical Journal · doi:10.58775/2735-3990.1373 · Cited by 1
“Furthermore, it may have a crucial role in the progression of atherosclerosis (Mohanty et al., 2010; McPherson and Davies, 2012).”
Background
Osteoarthritis: Novel Insights in Treatment
Aashaq, S., Rafiq, A., Jan, I., Ali, M., Reshi, B. A., Shah, Z. A., Sheikh, F. A., Majeed, S., & Beigh, M. A. (2023) · Springer eBooks · doi:10.1007/978-981-99-2119-5_19 · Cited by 1
Association between serum Klotho and the prevalence of osteoarthritis: A cross-sectional study from NHANES 2007–2016
Qiu, Y., Yin, H., Meng, J., Cai, Y., Huang, J., Zheng, X., Yao, J., & Li, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312562 · Cited by 1
“In addition, the aging of cartilage is thought to be associated with defective autophagy, manifested explicitly in the decreased ability of the body to process dysfunctional organelles and proteins [38–40].”
Regulation of Cartilage and Bone Metabolism by Oxidative Stress
Niehoff, A., & Ziskoven, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-6166-1_5 · Cited by 1
Circulating microRNAs Signature as a promising epigenetic diagnostic biomarker of equine osteoarthritisPreprint
Yassin, A. M., AbuBakr, H. O., Abdelgalil, A. I., Ahmed-Farid, O. A.-H., EL-Behairy, A. M., & Gouda, E. M. (2022) · Research Square · doi:10.21203/rs.3.rs-1398719/v1 · Cited by 1
DNA Damage and Checkpoint Responses in Adult Stem Cells
Romanov, V. S., Shukla, A., & Ju, Z. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366568
Nature Reviews UNCORRECTED PROOF
Andı́a, I., & Maffulli, N. (2013)
Amniotic Fluid Stem Cells for the Treatment of Articular Cartilage Defects
Preitschopf, A., Busch, J., Zwickl, H., Nehrer, S., Hengstschläger, M., & Mikula, M. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1118-9_8
Potential Mechanisms of PTA: Cell Death
Grogan, S. P., Lotz, M., & DʼLima, D. D. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7606-2_15
Aging and Post-Traumatic Arthritis
Loeser, R. F., Ferguson, C. M., & Lotz, M. (2015) · Springer eBooks · doi:10.1007/978-1-4899-7606-2_14
Autophagy Regulates Osteoarthritis-Like Gene Expression Changes
Takayama, K., & Matsushita, T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405529-2.00021-4
The Role of Platelet-Rich Plasma in Cartilage Repair
Kon, E., Filardo, G., Matteo, B. D., & Marcacci, M. (2017) · Springer eBooks · doi:10.1007/978-3-319-53316-2_7
Future Treatment Strategies
Le, H. V., Metkar, U. S., Razi, A. E., & Hershman, S. H. (2020) · Springer eBooks · doi:10.1007/978-3-030-33861-9_20
Articular Cartilage Development
Athanasiou, K. A., Darling, E. M., DuRaine, G. D., Hu, J. C. Y., & Reddi, A. H. (2017) · doi:10.1201/9781315194158-2
Role of autophagy in building and maintaining the skeletal system
Camuzard, O., Trojani, M.-C., Carle, G. F., & Pierrefite‐Carle, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822003-0.00015-2
黒谷流に至る以前の伝戒 : 良忍・叡空・源空・恵[ギ]について
加島, 亮. (1990) · Medical Entomology and Zoology
Articular Cartilage Development
(2013) · CRC Press eBooks · doi:10.1201/b14183-3
Faculty Opinions recommendation of Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage.
Young, D. A. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726151992.793556148
The articular cartilage: biomechanics and damage in diabetes-induced Charcot neuroarthropathy
Pierre-Jerome, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-99352-4.00025-5
Role of chondrocyte antigen presentation in osteoarthritis
Sengprasert, P., & Reantragoon, R. (2020) · doi:10.58837/chula.the.2020.308
Cell biology and pathology of cartilage and meniscus
Mange, T. R., Lai, W. C., & Wang, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-90597-8.00036-0
O fator de neurotrófico derivado do cérebro (BDNF) como proteína importante para os efeitos terapêuticos do plasma rico em plaquetas em modelo de osteoartrite experimental
Malange, K. F. (2021) · doi:10.47749/t/unicamp.2021.1235306
The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate.Preprint
Cheng, W., Hu, Z., Wang, C., Wang, C., He, J., Yan, Y., xu, Z., Yu, Y., Zhang, C., Yu, H., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-3986159/v1
CaMKII induces an autophagy-dependent anabolic response in Articular ChondrocytesPreprint
Day, N. J., Dutta, A., Heluany, C. S., Asopa, V., Sochart, D. H., Fielding, B. A., & Nalesso, G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.04.606243
Extracellular Matrix Remodeling in Physiological and Pathological Conditions: Insight into Extracellular Vesicles Contribution
Poppa, G., Giusti, I., & Dolo, V. (2024) · Biology of extracellular matrix · doi:10.1007/978-3-031-68811-9_2
Biomaterials for Tissue Engineered Cartilage Product for Orthopedic (Osteoarthritis) Reconstruction
Kumar, S., Malviya, R., & Sridhar, S. B. (2025) · Springer eBooks · doi:10.1007/978-3-031-79110-9_3
Trehalose Alleviates the Advancement of Temporomandibular Joint Osteoarthritis via Regulating the AMPK / ULK1 Autophagy Pathway
Xu, J., Liu, Y., Zhu, S., Yu, W., Kang, H., & Bao, G. (2025) · Oral Diseases · doi:10.1111/odi.70122
Additional file 1 of Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis
Zhao, S., Xiu, G., Wang, J., Wen, Y., Lu, J., Wu, B., Wang, G., Danjing, Y., Ling, B., Du, D., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24186079
Additional file 1 of Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Pandey, A., Singla, M., Geller, A., Goodman, S. B., & Bhutani, N. (2024) · Figshare · doi:10.6084/m9.figshare.25239397
Additional file 1 of Comorbidity phenotypes and risk of mortality in patients with osteoarthritis in the UK: a latent class analysis
Zemedikun, D. T., Lee, H., Nirantharakumar, K., Raza, K., Chandan, J. S., Lord, J. M., & Jackson, T. (2022) · Figshare · doi:10.6084/m9.figshare.21332809
Additional file 2 of Targeting an inflammation-amplifying cell population can attenuate osteoarthritis-associated pain
Pandey, A., Singla, M., Geller, A., Goodman, S. B., & Bhutani, N. (2024) · Figshare · doi:10.6084/m9.figshare.25239430

Authors: Lotz, M. K., & Caramés, B.
Affiliations: Scripps Research Institute (US)
Corresponding author: Lotz, Martin K.
ORCID: Lotz, Martin K.
Caramés, Beatriz
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2011-08-02
Volume: 7
Issue: 10
Pages: 579-587
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2011.109
PMC: PMC3192496
OpenAlex: W1985004392
Cited by: 314
References: 99
Citations by year: 2026: 15 · 2025: 18 · 2024: 32 · 2023: 27 · 2022: 27 · 2021: 27 · 2020: 29 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 16 · 2013: 20 · 2012: 11
FWCI: 2.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01AG007996, AG-007996)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR056026, R01AR056026)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords: autophagy, cartilage homeostasis, osteoarthritis, joint aging, cartilage aging, disease-modifying osteoarthritis drugs, joint health, age-related diseases
MeSH terms: Aging, Animals, Autophagy, Cartilage, Articular, Homeostasis, Humans, Osteoarthritis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks