Cited by 314Osteoarthritis Treatment and MechanismsAutophagy in Disease and TherapyHip disorders and treatments

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Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA

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Lotz, Martin K., Caramés, Beatriz·2011·Nature Reviews Rheumatology

DOI 10.1038/nrrheum.2011.109PMC PMC3192496

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Abstract

Osteoarthritis (OA) is the most prevalent joint disease, but neither preventive measures nor disease-modifying drugs are available and a continuing need exists for safe and effective symptom-modifying therapies. Clinical trials of candidate disease-modifying OA drugs in patients with established or advanced disease have not demonstrated their efficacy, but these failed trials have motivated investigation into the mechanisms that maintain joint health. The enhancement of such mechanisms could be a novel approach to reducing the risk of OA. Aging is one of the most important risk factors for OA; however, aging of joint cartilage is a process that is distinct from the subsequent cartilage changes that develop following the onset of OA. This Review focuses on the mechanisms that maintain cell and tissue homeostasis, and how these mechanisms fail during the aging process. Autophagy is a cellular homeostasis mechanism for the removal of dysfunctional organelles and macromolecules. Defective autophagy is involved in the pathogenesis of aging-related diseases and recent observations indicate that this process is compromised in aging cartilage. Augmentation of homeostasis mechanisms is discussed as a novel avenue to delay joint aging and reduce OA risk.

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Authors: Lotz, M. K., & Caramés, B.
Affiliations: Scripps Research Institute (US)
Corresponding author: Lotz, Martin K.
ORCID: Lotz, Martin K.
Caramés, Beatriz
Venue: Nature Reviews Rheumatology
Publisher: Springer Science and Business Media LLC
Published: 2011-08-02
Volume: 7
Issue: 10
Pages: 579-587
ISSN: 1759-4790 (ISSN-L)
1759-4804
DOI: 10.1038/nrrheum.2011.109
PMC: PMC3192496
OpenAlex: W1985004392
Cited by: 314
References: 99
Citations by year: 2026: 15 · 2025: 18 · 2024: 32 · 2023: 27 · 2022: 27 · 2021: 27 · 2020: 29 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 16 · 2013: 20 · 2012: 11
FWCI: 2.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Rheumatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P01AG007996, AG-007996)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR056026, R01AR056026)
Topics: Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords: autophagy, cartilage homeostasis, osteoarthritis, joint aging, cartilage aging, disease-modifying osteoarthritis drugs, joint health, age-related diseases
MeSH terms: Aging, Animals, Autophagy, Cartilage, Articular, Homeostasis, Humans, Osteoarthritis

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