The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA
Open accessAbstract
Osteoarthritis (OA) is the most prevalent joint disease, but neither preventive measures nor disease-modifying drugs are available and a continuing need exists for safe and effective symptom-modifying therapies. Clinical trials of candidate disease-modifying OA drugs in patients with established or advanced disease have not demonstrated their efficacy, but these failed trials have motivated investigation into the mechanisms that maintain joint health. The enhancement of such mechanisms could be a novel approach to reducing the risk of OA. Aging is one of the most important risk factors for OA; however, aging of joint cartilage is a process that is distinct from the subsequent cartilage changes that develop following the onset of OA. This Review focuses on the mechanisms that maintain cell and tissue homeostasis, and how these mechanisms fail during the aging process. Autophagy is a cellular homeostasis mechanism for the removal of dysfunctional organelles and macromolecules. Defective autophagy is involved in the pathogenesis of aging-related diseases and recent observations indicate that this process is compromised in aging cartilage. Augmentation of homeostasis mechanisms is discussed as a novel avenue to delay joint aging and reduce OA risk.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“for which disease-modifying treatments are not available”
From Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy (2019) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413
Autophagy fights disease through cellular self-digestion
Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452
Lawrence, R. C., Felson, D. T., Helmick, C. G., Arnold, L. M., Choi, H. K., Deyo, R. A., Gabriel, S. E., Hirsch, R., Hochberg, M. C., Hunder, G. G., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23176 · Cited by 5,599
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766
The Long-term Consequence of Anterior Cruciate Ligament and Meniscus Injuries: Osteoarthritis
Lohmander, L. S., Englund, P. M., Dahl, L. L., & Roos, E. M. (2007) · The American Journal of Sports Medicine · doi:10.1177/0363546507307396 · Cited by 2,344
Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress
Ogata, M., Hino, S.-I., Saito, A., Morikawa, K., Kondo, S., Kanemoto, S., Murakami, T., Taniguchi, M., Tanii, I., Yoshinaga, K., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01453-06 · Cited by 1,832
Selective autophagy mediated by autophagic adapter proteins
Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,788
OARSI recommendations for the management of hip and knee osteoarthritis
Zhang, W., Nuki, G., Moskowitz, R. W., Abramson, S. B., Altman, R. D., Arden, N., Bierma‐Zeinstra, S., Brandt, K. D., Croft, P. R., Doherty, M., et al. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.01.013 · Cited by 1,726
Guccione, A. A., Felson, D. T., Anderson, J. J., Anthony, J., Zhang, Y., Wilson, P. W. F., Kelly‐Hayes, M., Wolf, P. A., Kreger, B. E., & Kannel, W. B. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.3.351 · Cited by 1,580
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–314 of 314
Yan, M., Zhang, D., & Yang, M. (2024) · Figshare · doi:10.6084/m9.figshare.25271881
Thompson, S. D., Pichika, R., Lieber, R. L., & Lavasani, M. (2021) · Figshare · doi:10.6084/m9.figshare.14746779
Zhang, Q., Naren, G., Zhang, J., Yang, P., Deng, X., Niu, H., Liu, H., & Wu, C. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116409
Zhang, X., & Zhao, X. (2026) · Environmental Geochemistry and Health · doi:10.1007/s10653-026-03066-2
Ramesh, T. M., Srinivas, Y. R., Jayappa, M. K. B., George, R., & Muddanna, P. K. C. (2026) · Asian Journal of Pharmaceutical Research and Health Care · doi:10.4103/ajprhc.ajprhc_231_25
Etude de la cycline A2 : interactions, dégradation et mise en évidence du rôle de l'autophagie
Loukil, A. (2012) · theses.fr (ABES) · doi:10.70675/82a35c88z03f3z4510zae51zbb6dd8f7d14a
Millerand, M. (2020) · theses.fr (ABES) · doi:10.70675/d5e9dae6zd9d7z4a05z8fd2zf0ff4ffab0a6
Yang, L., Feng, J., He, W., & Huang, Y. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158571
The organelle interactome in osteoarthritis: from subcellular dysfunction to joint degeneration
Guo, H., Li, X., Li, J., Zheng, H., Qin, X., & Zhu, K. (2026) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2026.9610066
Vescio, R. R., Fiordalisi, M. F., Ambrosio, L., Fiorentino, D., de Rinaldis, E., Giacomo, G. D., Russo, F., Denaro, V., Vadalà, G., & Papalia, R. (2026) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk11030343
“In OA cartilage, autophagic activity is often impaired, leading to the accumulation of cellular damage and increased susceptibility to apoptosis [79].”
Miao, X., Ren, Y., XiaoLin, Z., Tian, J., Wu, C., Liu, T., Zhang, X., & Liu, M.-Q. (2026) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2026.113564
Zhang, D., Ai, H., Tang, Y., Qu, Y., Yang, Q., Zhang, Z., Xu, J., Wu, Y., & Dou, C. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102499
Liu, L., Wang, J., liu, L., Shi, W., Gao, H., & Liu, L. (2026) · Pathology - Research and Practice · doi:10.1016/j.prp.2026.156695
Molecular Mechanisms of Osteoarthritis
Meininger, A. K., & Baydoun, H. E. (2026) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.26.00446
Metadata
- Authors
- Lotz, M. K., & Caramés, B.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Lotz, Martin K.
- Venue
- Nature Reviews Rheumatology
- Published
- 2011-08-02
- Volume
- 7
- Issue
- 10
- Pages
- 579-587
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- PMC
- PMC3192496
- OpenAlex
- W1985004392
- Cited by
- 314
- References
- 99
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 32 · 2023: 27 · 2022: 27 · 2021: 27 · 2020: 29 · 2019: 23 · 2018: 14 · 2017: 13 · 2016: 20 · 2015: 19 · 2014: 16 · 2013: 20 · 2012: 11
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P01AG007996, AG-007996)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR056026, R01AR056026)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Health Sciences › Medicine › Surgery › Hip disorders and treatments
- Keywords
- autophagy, cartilage homeostasis, osteoarthritis, joint aging, cartilage aging, disease-modifying osteoarthritis drugs, joint health, age-related diseases
- MeSH terms
- Aging, Animals, Autophagy, Cartilage, Articular, Homeostasis, Humans, Osteoarthritis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
