The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.
The microbiome and rheumatoid arthritis
Open accessAbstract
Humans are not (and have never been) alone. From the moment we are born, millions of micro-organisms populate our bodies and coexist with us rather peacefully for the rest of our lives. This microbiome represents the totality of micro-organisms (and their genomes) that we necessarily acquire from the environment. Micro-organisms living in or on us have evolved to extract the energy they require to survive, and in exchange they support the physiological, metabolic and immune capacities that have contributed to our evolutionary success. Although currently categorized as an autoimmune disorder and regarded as a complex genetic disease, the ultimate cause of rheumatoid arthritis (RA) remains elusive. It seems that interplay between predisposing genetic factors and environmental triggers is required for disease manifestation. New insights from DNA sequence-based analyses of gut microbial communities and a renewed interest in mucosal immunology suggest that the microbiome represents an important environmental factor that can influence autoimmune disease manifestation. This Review summarizes the historical clues that suggest a possible role for the microbiota in the pathogenesis of RA, and will focus on new technologies that might provide scientific evidence to support this hypothesis.
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Cites
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Cited by
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Self-citationIntestinal permeability – a new target for disease prevention and therapy
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Metadata
- Authors
- Scher, J. U., & Abramson, S. B.
- Venue
- Nature Reviews Rheumatology
- Published
- 2011-08-23
- Volume
- 7
- Issue
- 10
- Pages
- 569-578
- ISSN
- 1759-4790 (ISSN-L)
- 1759-4804
- OpenAlex
- W2149952321
- Cited by
- 474
- References
- 77
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
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