PTPN22: the archetypal non-HLA autoimmunity gene

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A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

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A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

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Genetically Distinct Subsets within ANCA-Associated Vasculitis

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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

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Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE

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Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci

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Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes

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Replication of Putative Candidate-Gene Associations with Rheumatoid Arthritis in >4,000 Samples from North America and Sweden: Association of Susceptibility with PTPN22, CTLA4, and PADI4

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Cooperative Inhibition of T-Cell Antigen Receptor Signaling by a Complex between a Kinase and a Phosphatase

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Genetics and epigenetics of rheumatoid arthritis

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Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis

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Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus

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PEST Domain-Enriched Tyrosine Phosphatase (PEP) Regulation of Effector/Memory T Cells

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A CD8+ T cell transcription signature predicts prognosis in autoimmune disease

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Genetic Variation in PTPN22 Corresponds to Altered Function of T and B Lymphocytes

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Association of a functional single‐nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus

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Association between the PTPN22 gene and rheumatoid arthritis and juvenile idiopathic arthritis in a UK population: Further support that PTPN22 is an autoimmunity gene

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The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

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A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis

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The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

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Association of inhibitory tyrosine protein kinase p50csk with protein tyrosine phosphatase PEP in T cells and other hemopoietic cells.

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Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis

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Protein tyrosine phosphatases in lymphocyte activation and autoimmunity

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Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis

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Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

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Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti–dsDNA Autoantibody Production

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Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease

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Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

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The PTPN22 R620W polymorphism associates with RF positive rheumatoid arthritis in a dose-dependent manner but not with HLA-SE status

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Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

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The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

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The PTPN22 620W allele is a risk factor for Wegener's granulomatosis

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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

Dai, X., James, R. G., Habib, T., Singh, S., Jackson, S. W., Khim, S., Moon, R. T., Liggitt, D., Wolf‐Yadlin, A., Buckner, J. H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci66963 · Cited by 183

Association analysis of the 1858C>T polymorphism in the PTPN22 gene in juvenile idiopathic arthritis and other autoimmune diseases

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Genome‐Wide Association Study of Dermatomyositis Reveals Genetic Overlap With Other Autoimmune Disorders

Miller, F. W., Cooper, R. G., Vencovský, J., Rider, L. G., Dankó, K., Wedderburn, L. R., Lundberg, I. E., Pachman, L. M., Reed, A. M., Ytterberg, S. R., et al. (2013) · Arthritis & Rheumatism · doi:10.1002/art.38137 · Cited by 140

LYP inhibits T-cell activation when dissociated from CSK

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Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations

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PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

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A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

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Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus

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Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients

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Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

Habib, T., Funk, A., Rieck, M., Brahmandam, A., Dai, X., Panigrahi, A. K., Prak, E. T. L., Meyer‐Bahlburg, A., Sanda, S., Greenbaum, C. J., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102176 · Cited by 119

PTPN22 Alters the Development of Regulatory T Cells in the Thymus

Maine, C. J., Hamilton‐Williams, E. E., Cheung, J., Stanford, S. M., Bottini, N., Wicker, L. S., & Sherman, L. A. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200150 · Cited by 114

The PTPN22 620W allele confers susceptibility to systemic sclerosis: Findings of a large case–control study of European Caucasians and a meta‐analysis

Dieudé, P., Guedj, M., Wipff, J., Avouac, J., HACHULLA, E., Diot, É., Granel, B., Sibilia, J., Cabané, J., Meyer, O., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23601 · Cited by 112

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

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Meta-analysis reveals an association of PTPN22 C1858T with autoimmune diseases, which depends on the localization of the affected tissue

Zheng, J., Ibrahim, S. M., Petersen, F., & Yu, X. (2012) · Genes and Immunity · doi:10.1038/gene.2012.46 · Cited by 111

PTPN22polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease

Johansson, M., Ärlestig, L., Hallmans, G., & Rantapää‐Dahlqvist, S. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1868 · Cited by 110

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

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Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity

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Linkage proof for PTPN22 , a rheumatoid arthritis susceptibility gene and a human autoimmunity gene

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Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

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Confirmation of the genetic association of CTLA4 and PTPN22 with ANCA-associated vasculitis

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Correction: The PTPN22 1858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden

Kokkonen, H., Johansson, M., Innala, L., Jidell, E., & Rantapää‐Dahlqvist, S. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2312 · Cited by 94

The PTPN221858C/T polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern Sweden

Kokkonen, H., Johansson, M., Innala, L., Jidell, E., & Rantapää‐Dahlqvist, S. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2214 · Cited by 93

Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families: Increased t allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease

Wu, H., Cantor, R. M., Graham, D. S. C., Lingren, C. M., Farwell, L. M., Jager, P. L. D., Bottini, N., Grossman, J. M., Wallace, D. J., Hahn, B. H., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21223 · Cited by 90

Association of PTPN22 1858 single-nucleotide polymorphism with rheumatoid arthritis in a German cohort: higher frequency of the risk allele in male compared to female patients

Pierer, M., Kaltenhäuser, S., Arnold, S., Wahle, M., Baerwald, C., Häntzschel, H., & Wagner, U. G. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1945 · Cited by 86

Association of the PTPN22 locus with rheumatoid arthritis in a New Zealand Caucasian cohort

Simkins, H. M. A., Merriman, M. E., Highton, J., Chapman, P. T., O'Donnell, J. L., Jones, P. B. B., Gow, P. J., McLean, L., Pokorny, V., Harrison, A. A., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21126 · Cited by 83

Associations between Human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study

Karlson, E. W., Chibnik, L. B., Cui, J., Plenge, R. M., Glass, R. J., Maher, N. E., Parker, A. N., Roubenoff, R., Izmailova, E. S., Coblyn, J. S., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.071662 · Cited by 83

Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis

Díaz-Gallo, L.-M., Gourh, P., Broen, J. C. A., Simeón‐Aznar, C. P., Fonollosa‐Pla, V., Ortego‐Centeno, N., Agarwal, S. K., Vonk, M. C., Coenen, M. J. H., Riemekasten, G., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.130138 · Cited by 82

Association of interleukin‐6 and interleukin‐10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status

Μαρίνου, Ι., Healy, J., Mewar, D., Moore, D., Dickson, M. C., Binks, M. H., Montgomery, D. S., Walters, K., & Wilson, A. G. (2007) · Arthritis & Rheumatism · doi:10.1002/art.22814 · Cited by 81

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

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Association of R602W in a protein tyrosine phosphatase gene with a high risk of rheumatoid arthritis in a British population: Evidence for an early onset/disease severity effect

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Association of the PTPN22 C1858T single‐nucleotide polymorphism with rheumatoid arthritis phenotypes in an inception cohort

Wesoły, J., Mil, A. H. M. V. D. H., Toes, R. E. M., Chokkalingam, A. P., Carlton, V. E. H., Begovich, A. B., & Huizinga, T. W. J. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21294 · Cited by 76

The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1

Reddy, M., Johansson, M., Sturfelt, G. K., Jönsen, A., Gunnarsson, I., Svenungsson, E., Rantapää‐Dahlqvist, S., & Alarcón-Riquelme, M. E. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364252 · Cited by 76

The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case–control samples

Rodríguez‐Rodríguez, L., Taib, W. R. W., Topless, R., Steer, S. E., González‐Escribano, M. F., Balsa, A., Pascual‐Salcedo, D., González-Gay, M. Á., Raya, E., Fernández‐Gutiérrez, B., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30145 · Cited by 74

Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis

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PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes–Associated Allele Is Not a Loss-of-Function Variant

Zheng, P., & Kissler, S. (2012) · Diabetes · doi:10.2337/db12-0929 · Cited by 67

Genome-wide analysis of histone H3 lysine 4 trimethylation by ChIP-chip in peripheral blood mononuclear cells of systemic lupus erythematosus patients.

Dai, Y., Zhang, L., Chen, H., & Zhang, Y. (2010) · PubMed · Cited by 65

Effects of PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British Caucasian rheumatoid arthritis patients

Harrison, P., Pointon, J. J., Farrar, C., Brown, M. A., & Wordsworth, B. P. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kei250 · Cited by 64

Genetic Influence of PTPN22 R620W Polymorphism in Tuberculosis

Gómez, L. M., Anaya, J., & Martin, J. J. (2005) · Human Immunology · doi:10.1016/j.humimm.2005.11.008 · Cited by 63

PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells

Maine, C. J., Marquardt, K., Cheung, J., & Sherman, L. A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302418 · Cited by 63

The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

Bayley, R., Kite, K., McGettrick, H. M., Smith, J., Kitas, G. D., Buckley, C. D., & Young, S. P. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-204796 · Cited by 63

PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes

Namjou, B., Kim-Howard, X., Sun, C.-L., Adler, A., Chung, S. A., Kaufman, K., Kelly, J., Glenn, S., Guthridge, J., Scofield, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069404 · Cited by 63

The protein tyrosine phosphatase N22 gene is associated with juvenile and adult idiopathic inflammatory myopathy independent of the HLA 8.1 haplotype in British Caucasian patients

Chinoy, H., Platt, H., Lamb, J. A., Betteridge, Z., Gunawardena, H., Fertig, N., Varsani, H., Davidson, J. E., Oddis, C. V., McHugh, N. J., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23900 · Cited by 62

PTPN22 R620W polymorphism in the ANCA-associated vasculitides

Martorana, D., Maritati, F., Malerba, G., Bonatti, F., Alberici, F., Oliva, E., Sebastio, P., Manenti, L., Brugnano, R., Catanoso, M., et al. (2012) · Lara D. Veeken · doi:10.1093/rheumatology/ker446 · Cited by 62

Discovery of a Novel Series of Inhibitors of Lymphoid Tyrosine Phosphatase with Activity in Human T Cells

Stanford, S. M., Krishnamurthy, D., Falk, M. D., Messina, R., Debnath, B., Li, S., Liu, T., Kazemi, R., Dahl, R., He, Y., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm101202j · Cited by 59

Loss of Protein Tyrosine Phosphatase Nonreceptor Type 22 Regulates Interferon-γ–Induced Signaling in Human Monocytes

Spalinger, M. R., Lang, S., Weber, A., Frei, P., Fried, M., Rogler, G., & Scharl, M. M. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.048 · Cited by 59

Contribution of PTPN22 1858T, TNFRII 196R and HLA-shared epitope alleles with rheumatoid factor and anti-citrullinated protein antibodies to very early rheumatoid arthritis diagnosis

Goëb, V., Dieudé, P., Daveau, R., Thomas-L'Otellier, M., Jouen, F., Hau, F., Boumier, P., Tron, F., Gilbert, D., Fardellone, P., et al. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken192 · Cited by 57

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

Thompson, W. S., Pękalski, M. Ł., Simons, H. Z., Smyth, D. J., Dopico, X. C., Guo, H., Guy, C., Dunger, D. B., Arif, S., Peakman, M., et al. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12362 · Cited by 56

The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses

Vang, T., Landskron, J., Viken, M. K., Oberprieler, N. G., Torgersen, K. M., Mustelin, T., Taskén, K., Tautz, L., Rickert, R. C., & Lie, B. A. (2013) · Human Immunology · doi:10.1016/j.humimm.2012.12.017 · Cited by 55

Identification of the PTPN22 functional variant R620W as susceptibility genetic factor for giant cell arteritis

Serrano, A., Márquez, A., Mackie, S. L., Carmona, F. D., Solans, R., Miranda‐Filloy, J. A., Hernández‐Rodríguez, J., Cid, M. C., Castañeda, S., Morado, I., et al. (2013) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203641 · Cited by 54

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

Budarf, M. L., Goyette, P., Boucher, G., Lian, J., Graham, R., Claudio, J. O., Hudson, T. J., Gladman, D. D., Clarke, A. E., Pope, J. E., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.47 · Cited by 50

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update

Lea, W., & Lee, Y. H. (2010) · Lupus · doi:10.1177/0961203310381774 · Cited by 50

Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients

Feitsma, A. L., Toes, R. E. M., Begovich, A. B., Chokkalingam, A. P., de Vries, R. R. P., Huizinga, T. W. J., & Mil, A. H. M. V. D. H. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem006 · Cited by 48

Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis

Orozco, G., Pascual‐Salcedo, D., López‐Nevot, M. Á., Cobo, T., Cabezón, A., Martín-Mola, E., Balsa, A., & Martin, J. J. (2007) · Lara D. Veeken · doi:10.1093/rheumatology/kem343 · Cited by 48

Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population

Lamsyah, H., Rueda‐Medina, B., Baassi, L., Aouad, R. E., Bottini, N., Sadki, K., & Martin, J. J. (2009) · Tissue Antigens · doi:10.1111/j.1399-0039.2009.01304.x · Cited by 46

Associations between the PTPN22 1858C→T polymorphism and radiographic joint destruction in patients with rheumatoid arthritis: results from a 10-year longitudinal study

Lie, B. A., Viken, M. K., Ødegård, S., van der Heijde, D. M. F. M., Landewé, R., Uhlig, T., & Kvien, T. K. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.067892 · Cited by 46

The association of the PTPN22 620W polymorphism with Behçet's disease

Baranathan, V., Stanford, M. R., Vaughan, R. W., Kondeatis, E., GRAHAM, E. M., Fortune, F., Madanat, W., Kanawati, C. A., Ghabra, M., Murray, P. I., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.073866 · Cited by 41

PTPN22.6, a Dominant Negative Isoform of PTPN22 and Potential Biomarker of Rheumatoid Arthritis

Chang, H., Tai, T.-S., Lü, B., Iannaccone, C. K., Cernadas, M., Weinblatt, M. E., Shadick, N. A., Miaw, S., & Ho, I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033067 · Cited by 40

The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population

Wesoły, J., Hu, X., Thabet, M. M., Chang, M., Uh, H., Allaart, C. F., Toes, R. E. M., Houwing‐Duistermaat, J. J., Begovich, A. B., & Huizinga, T. W. J. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel381 · Cited by 37

Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways

Cambier, J. C. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69289 · Cited by 36

Different Modulation of Ptpn22 in Effector and Regulatory T Cells Leads to Attenuation of Autoimmune Diabetes in Transgenic Nonobese Diabetic Mice

Yeh, L., Miaw, S., Lin, M.-H., Chou, F., Shieh, S., Chuang, Y., Lin, S., Chang, D., & Sytwu, H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203380 · Cited by 36

Investigation of genetic variation across the protein tyrosine phosphatase gene in patients with rheumatoid arthritis in the UK

Hinks, A., Eyre, S., Barton, A. C., Thomson, W., & Worthington, J. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.060459 · Cited by 36

A PTPN22 promoter polymorphism −1123G>C is associated with RA pathogenesis in Chinese

Huang, J.-J., Qiu, Y., Li, H., Sun, D., Yang, J. L., & Yang, C. C. (2010) · Rheumatology International · doi:10.1007/s00296-010-1705-x · Cited by 34

The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls

Ronninger, M., Guo, Y., Shchetynsky, K., Hill, A., Khademi, M., Olsson, T. P., Reddy, P. S., Seddighzadeh, M., Clark, J. D., Lin, L.-L., et al. (2012) · Genome Medicine · doi:10.1186/gm301 · Cited by 34

TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis

Daïen, C., Fabre, S., Rittore, C., Soler, S., Daïen, V., Téjédor, G., Cadart, D., Molinari, N., Daurès, J., Jørgensen, C., et al. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.10.007 · Cited by 34

Lack of association between ankylosing spondylitis and a functional polymorphism of PTPN22 proposed as a general susceptibility marker for autoimmunity

Orozco, G., Garcı́a-Porrúa, C., López‐Nevot, M. Á., Raya, E., González-Gay, M. Á., & Martín, J. (2005) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2005.046094 · Cited by 29

The PTPN22 C1858T variant as a risk factor for rheumatoid arthritis and systemic lupus erythematosus but not for systemic sclerosis in the Colombian population.

Ramirez, M. D. C., Quintana, G., Díaz-Gallo, L.-M., Caminos, J. E., Garcés, M. F., Cepeda, L. A., Rondón, F., Restrepo, J. F., Egea, E., Garavito, G., et al. (2012) · PubMed · Cited by 28

Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

Kaalla, M. J., Broadaway, K. A., Pichavant, M. R., Conneely, K. N., Whiting, A. A., Ponder, L. A., Okou, D. T., Angeles‐Han, S. T., Rouster‐Stevens, K. A., Brown, M. R., et al. (2013) · Pediatric Rheumatology · doi:10.1186/1546-0096-11-40 · Cited by 28

Interleukin 1 receptor antagonist mediates the beneficial effects of systemic interferon beta in mice: implications for rheumatoid arthritis

Corr, M., Boyle, D. L., Ronacher, L., Lew, B. R., van Baarsen, L. G. M., Tak, P. P., & Firestein, G. S. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.141077 · Cited by 28

Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study

Butt, C., Peddle, L., Greenwood, C. M. T., Hamilton, S., Gladman, D. D., & Rahman, P. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1880 · Cited by 25

Independent replication analysis of genetic loci with previous evidence of association with juvenile idiopathic arthritis

Ellis, J. A., Chavez, R. A., Pezic, A., Ponsonby, A., Akikusa, J. D., Allen, R. C., & Munro, J. E. (2013) · Pediatric Rheumatology · doi:10.1186/1546-0096-11-12 · Cited by 25

PTPN22 gene polymorphism in Behçet’s disease

Sahin, N., Bicakcigil, M., Atagündüz, P., Di̇reskeneli̇, H., & Saruhan‐Direskeneli, G. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00928.x · Cited by 22

Testing for linkage and association with rheumatoid arthritis a ptpn22 promoter polymorphism reported to be associated and linked with type 1 diabetes in the Caucasian population

Dieudé, P., Teixeira, V., Pierlot, C., Cornélis, F., & Petit, É. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2007.077180 · Cited by 21

Association between the PTPN22+1858 C/T polymorphism and psoriatic arthritis

Juneblad, K., Johansson, M., Rantapää‐Dahlqvist, S., & Alenius, G.-M. (2011) · Arthritis Research & Therapy · doi:10.1186/ar3284 · Cited by 21

PTPN22 1858C>T polymorphism is strongly associated with rheumatoid arthritis but not with a response to methotrexate therapy

Majorczyk, E., Pawlik, A., & Kuśnierczyk, P. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.09.008 · Cited by 20

PTPN22 gene polymorphism in Takayasu's arteritis

Sahin, N., Aksu, K., Kamalı, S., Bicakcigil, M., Özbalkan, Z., Fresko, İ., Ozer, H. T. E., Akar, S., Onat, A. M., Çobankara, V., et al. (2008) · Lara D. Veeken · doi:10.1093/rheumatology/ken106 · Cited by 20

Associations of the PTPN22 and CTLA-4 genetic polymorphisms with Taiwanese ankylosing spondylitis

Huang, C.-H., Wei, J. C., Chen, C., et al. (2013) · Rheumatology International · doi:10.1007/s00296-013-2894-x · Cited by 20

Evidence for PTPN22 R620W Polymorphism As the Sole Common Risk Variant for Rheumatoid Arthritis in the 1p13.2 Region

Martín, J., Alizadeh, B. Z., González-Gay, M. Á., Balsa, A., Pascual‐Salcedo, D., González‐Escribano, M. F., Rodríguez‐Rodríguez, L., Fernández‐Gutiérrez, B., Raya, E., Coenen, M. J. H., et al. (2011) · The Journal of Rheumatology · doi:10.3899/jrheum.110361 · Cited by 20

Association of the PTPN22 gene (-1123G > C) polymorphism with rheumatoid arthritis in Chinese patients

Feng, X., Li, Y.-Z., Zhang, Y., Bao, S.-L., Tong, D.-W., Zhang, S.-L., & Hu, C.-J. (2010) · Tissue Antigens · doi:10.1111/j.1399-0039.2010.01521.x · Cited by 19

Metaanalysis of the Association of Smoking andPTPN22R620W Genotype on Autoantibody Status and Radiological Erosions in Rheumatoid Arthritis

Taylor, L. H., Twigg, S., Worthington, J., Emery, P. E., Morgan, A. W., Wilson, A. G., & Teare, M. D. (2013) · The Journal of Rheumatology · doi:10.3899/jrheum.120784 · Cited by 18

Altered expression of protein tyrosine phosphatase, non-receptor type 22 isoforms in systemic lupus erythematosus

Chang, H., Tseng, W., Cui, J., Costenbader, K. H., & Ho, I. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4440 · Cited by 18

Distribution patterns of variability for 18 immune system genes in Amerindians – relationship with history and epidemiology

Lindenau, J. D., Salzano, F. M., Guimaraes, L. S. P., Callegari-Jacques, S. M., Hurtado, A. M., Hill, K. R., Petzl‐Erler, M. L., Tsuneto, L. T., & Hutz, M. H. (2013) · Tissue Antigens · doi:10.1111/tan.12183 · Cited by 17

Protein tyrosine phosphatase-22 (PTPN-22) polymorphism in the pathogenesis of chronic urticaria

Brzoza, Z., Grzeszczak, W., Trautsolt, W., & Moczulski, D. K. (2011) · Allergy · doi:10.1111/j.1398-9995.2011.02651.x · Cited by 15

A genetic marker at the OLIG3/TNFAIP3 locus associates with methotrexate continuation in early inflammatory polyarthritis: results from the Norfolk Arthritis Register

Plant, D., Farragher, T. M., Flynn, E., Martin, P., Eyre, S., Bunn, D. K., Worthington, J., Symmons, D. P. M., Barton, A. C., & Thomson, W. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2010.80 · Cited by 13

Allele and haplotype frequency distribution inPTPN22gene across variable ethnic groups: Implications for genetic association studies for autoimmune diseases

Lins, T. C. D. L., Vieira, R. G., Grattapaglia, D. G., & Pereira, R. W. (2010) · Autoimmunity · doi:10.3109/08916930903405883 · Cited by 12

Genetic evidence of PTPN22 effects on chronic lymphocytic leukemia

Hebbring, S. J., Slager, S. L., Epperla, N., Mazza, J. J., Ye, Z., Zhou, Z., Achenbach, S. J., Vasco, D. A., Call, T. G., Rabe, K. G., et al. (2013) · Blood · doi:10.1182/blood-2012-08-450221 · Cited by 11

Lack of association of a functional single nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with susceptibility to Henoch-Schönlein purpura.

Orozco, G., Miranda‐Filloy, J. A., Martin, J. J., & González-Gay, M. Á. (2008) · PubMed · Cited by 8

The PTPN22*R620W polymorphism does not confer genetic susceptibility to antiphospholipid syndrome in the Spanish population

Castro‐Marrero, J., Balada, E., Vilardell, M., & Ordi‐Ros, J. (2011) · International Journal of Immunogenetics · doi:10.1111/j.1744-313x.2011.01038.x · Cited by 8

PTPN22 620W allele is not associated with aplastic anemia

Graf, S. A., Calado, R. T., & Young, N. S. (2006) · American Journal of Hematology · doi:10.1002/ajh.20768 · Cited by 4

Drug-induced liver injury—types and phenotypes

Hoofnagle, J. H., & Björnsson, E. S. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1816149 · Cited by 652

Ncf1 polymorphism reveals oxidative regulation of autoimmune chronic inflammation

Holmdahl, R., Sareila, O., Olsson, L. M., Bäckdahl, L., & Wing, K. (2016) · Immunological Reviews · doi:10.1111/imr.12378 · Cited by 131

A missense variant in PTPN22 is a risk factor for drug-induced liver injury

Cirulli, E. T., Nicoletti, P., Abramson, K., Andrade, R. J., Bjornsson, E. S., Chalasani, N., Fontana, R. J., Hallberg, P., Li, Y. J., Lucena, M. I., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.034 · Cited by 137

Immune-mediated drug-induced liver injury: immunogenetics and experimental models

Gerussi, A., Natalini, A., Antonangeli, F., Mancuso, C., Agostinetto, E., Barisani, D., Di Rosa, F., Andrade, R., & Invernizzi, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094557 · Cited by 87

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate

Nicoletti, P., Dellinger, A., Li, Y. J., Barnhart, H. X., Chalasani, N., Fontana, R. J., Odin, J. A., Serrano, J., Stolz, A., Etheridge, A. S., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2022.11.036 · Cited by 50