The DOI matches its Crossref record; 117 of the 120 references it cites were found in a registry or an index.
Ageing of the male germ line
Abstract
Several studies have demonstrated a decline in the male reproductive system, sperm quality, and fertility with advancing paternal age, yet many of the biological mechanisms that underlie this process remain poorly understood. It is unclear whether the problem arises from the progenitor spermatogonial stem cells (for example, from an accumulation of DNA damage and mutations), from the somatic niche present in the testis (consisting of Sertoli and peritubular myoid cells), or from a combination of the two. Current data, albeit from a small number of studies, suggest that both factors have a role in age-associated germ cell loss. What is clear, on the other hand, is that mounting evidence links paternal age to chromosomal damage and genetic problems in the children of older fathers. The frequency of de novo mutations increases markedly with age, leading to increased risk of breast cancer, cardiac defects, developmental disorders, behavioural disorders, and neurological disease in the children of older men. The current trend towards fathering children at a later age raises concerns regarding the risk of offspring developing complex multigene diseases.
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“However, there is limited evidence that loss of stem cell function is a major driver of age-related pathology and shortened lifespan.355–358”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [357]
In the citing paper
“Many studies have shown that the number and function of different somatic cell populations declines with age, which diminishes the regenerative potential of tissues and organs.”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [357]
Citations
Cites
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Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
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3 of the 120 references couldn’t be matched to a known paper.
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Items 101–109 of 109
Cao, M., Shao, X., Chan, P., Cheung, W., Kwan, T., Pastinen, T., & Robaire, B. (2020) · Figshare · doi:10.6084/m9.figshare.13468191
Self-citationCao, M., Shao, X., Chan, P., Cheung, W., Kwan, T., Pastinen, T., & Robaire, B. (2020) · Figshare · doi:10.6084/m9.figshare.13468205
Self-citationOzawa, M., Taguchi, J., Mori, H., Kikuchi, M., Muratani, M., Yamamoto, T., Yamada, Y., Yoshida, N., & Ikawa, M. (2026) · Communications Biology · doi:10.1038/s42003-026-09636-5
Franěk, R., Radek Sindelka, E., Torres-Martínez, A., Štundl, J., Konar, E. S. M., de Siqueira‐Silva, D. H., Sehadová, H., Psenicka, M., & Tichopád, T. (2026) · Research Square · doi:10.21203/rs.3.rs-8995976/v1
Tian, X., Kong, Y., Ma, S., Xu, C., Zhang, R., Deng, H., & Lan, H. (2026) · Toxicology · doi:10.1016/j.tox.2026.154479
Öztürk, S. (2026) · Reproduction and Fertility · doi:10.1530/raf-26-0020
The Effect of Chronic Inflammation on Cellular Aging Processes and Current Treatment Approaches
Başaran, A. (2026) · Uluslararası Sağlık Bilimlerinde Disiplinler Arası Etkileşim Dergisi · doi:10.65349/nxpt1964
Metadata
- Authors
- Paul, C., & Robaire, B.
- Affiliations
- McGill University (CA)
- Corresponding author
- Robaire, Bernard
- ORCID
- Robaire, Bernard
- Venue
- Nature Reviews Urology
- Published
- 2013-02-26
- Volume
- 10
- Issue
- 4
- Pages
- 227-234
- ISSN
- 1759-4812 (ISSN-L)
- 1759-4820
- OpenAlex
- W1996219414
- Cited by
- 109
- References
- 120
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 10 · 2019: 15 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 9
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Urology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- paternal age, spermatogonial stem cells, DNA damage, Sertoli cells, peritubular myoid cells, de novo mutations, chromosomal damage, advanced paternal age, male fertility decline, semen quality
- MeSH terms
- Aging, Animals, Mental Disorders, DNA Damage, Germ Cells, Humans, Infertility, Male, Male, Mutation, Paternal Age, Spermatozoa, Cellular Senescence
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