Cited by 109Sperm and Testicular FunctionReproductive Biology and FertilityReproductive biology and impacts on aquatic species

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Ageing of the male germ line

Paul, Catriona, Robaire, Bernard·2013·Nature Reviews Urology

DOI 10.1038/nrurol.2013.18

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Abstract

Several studies have demonstrated a decline in the male reproductive system, sperm quality, and fertility with advancing paternal age, yet many of the biological mechanisms that underlie this process remain poorly understood. It is unclear whether the problem arises from the progenitor spermatogonial stem cells (for example, from an accumulation of DNA damage and mutations), from the somatic niche present in the testis (consisting of Sertoli and peritubular myoid cells), or from a combination of the two. Current data, albeit from a small number of studies, suggest that both factors have a role in age-associated germ cell loss. What is clear, on the other hand, is that mounting evidence links paternal age to chromosomal damage and genetic problems in the children of older fathers. The frequency of de novo mutations increases markedly with age, leading to increased risk of breast cancer, cardiac defects, developmental disorders, behavioural disorders, and neurological disease in the children of older men. The current trend towards fathering children at a later age raises concerns regarding the risk of offspring developing complex multigene diseases.

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Authors: Paul, C., & Robaire, B.
Affiliations: McGill University (CA)
Corresponding author: Robaire, Bernard
ORCID: Robaire, Bernard
Venue: Nature Reviews Urology
Publisher: Springer Science and Business Media LLC
Published: 2013-02-26
Volume: 10
Issue: 4
Pages: 227-234
ISSN: 1759-4812 (ISSN-L)
1759-4820
DOI: 10.1038/nrurol.2013.18
OpenAlex: W1996219414
Cited by: 109
References: 120
Citations by year: 2026: 7 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 5 · 2020: 10 · 2019: 15 · 2018: 6 · 2017: 5 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 9
FWCI: 2.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Urology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Keywords: paternal age, spermatogonial stem cells, DNA damage, Sertoli cells, peritubular myoid cells, de novo mutations, chromosomal damage, advanced paternal age, male fertility decline, semen quality
MeSH terms: Aging, Animals, Mental Disorders, DNA Damage, Germ Cells, Humans, Infertility, Male, Male, Mutation, Paternal Age, Spermatozoa, Cellular Senescence

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