The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
APOBEC3 proteins mediate the clearance of foreign DNA from human cells
Open accessAbstract
Bacteria evolved restriction endonucleases to prevent interspecies DNA transmission and bacteriophage infection. Here we show that human cells possess an analogous mechanism. APOBEC3A is induced by interferon following DNA detection, and it deaminates foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are converted by the uracil DNA glycosylase UNG2 to abasic lesions, which lead to foreign DNA degradation. This mechanism is evident in cell lines and primary monocytes, where up to 97% of cytidines in foreign DNA are deaminated. In contrast, cellular genomic DNA appears unaffected. Several other APOBEC3s also restrict foreign gene transfer. Related proteins exist in all vertebrates, indicating that foreign DNA restriction may be a conserved innate immune defense mechanism. The efficiency and fidelity of genetic engineering, gene therapy, and DNA vaccination are likely to be influenced by this anti-DNA defense system.
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Cites
Recognition of microorganisms and activation of the immune response
Medzhitov, R. (2007) · Nature · doi:10.1038/nature06246 · Cited by 2,862
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Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627
Interferon-inducible antiviral effectors
Sadler, A. J., & Williams, B. R. G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2314 · Cited by 2,160
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831
Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts
Mangeat, B., Turelli, P., Caron, G., Friedli, M., Perrin, L., & Trono, D. (2003) · Nature · doi:10.1038/nature01709 · Cited by 1,486
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Metadata
- Authors
- Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J., & Harris, R. S.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2010-01-10
- Volume
- 17
- Issue
- 2
- Pages
- 222-229
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2115819181
- Cited by
- 328
- References
- 5
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Stenglein, M. D., Burns, M. B., Li, M., Lengyel, J., & Harris, R. S. (2010). APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.1744
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