The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1
Open accessAbstract
The PHD finger protein 1 (PHF1) is essential in epigenetic regulation and genome maintenance. Here we show that the Tudor domain of human PHF1 binds to histone H3 trimethylated at Lys36 (H3K36me3). We report a 1.9-Å resolution crystal structure of the Tudor domain in complex with H3K36me3 and describe the molecular mechanism of H3K36me3 recognition using NMR. Binding of PHF1 to H3K36me3 inhibits the ability of the Polycomb PRC2 complex to methylate Lys27 of histone H3 in vitro and in vivo. Laser microirradiation data show that PHF1 is transiently recruited to DNA double-strand breaks, and PHF1 mutants impaired in the H3K36me3 interaction exhibit reduced retention at double-strand break sites. Together, our findings suggest that PHF1 can mediate deposition of the repressive H3K27me3 mark and acts as a cofactor in early DNA-damage response.
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Cites
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Cited by
Transcriptional regulation by Polycomb group proteins
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Molecular mechanisms directing PRC2 recruitment and H3K27 methylation
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Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524
Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
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Targeting Polycomb systems to regulate gene expression: modifications to a complex story
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Metadata
- Authors
- Musselman, C. A., Avvakumov, N., Watanabe, R., Abraham, C. G., Lalonde, M.-E., Hong, Z., Allen, C., Roy, S., Nuñez, J. K., Nickoloff, J., Kulesza, C. A., Yasui, A., Côté, J., & Kutateladze, T. G.
- Venue
- Nature Structural & Molecular Biology
- Published
- 2012-11-11
- Volume
- 19
- Issue
- 12
- Pages
- 1266-1272
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2075494379
- Cited by
- 189
- References
- 8
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- green
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- Musselman, C. A., Avvakumov, N., Watanabe, R., Abraham, C. G., Lalonde, M.-E., Hong, Z., Allen, C., Roy, S., Nuñez, J. K., Nickoloff, J., Kulesza, C. A., Yasui, A., Côté, J., & Kutateladze, T. G. (2012). Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1. Nature Structural & Molecular Biology. https://doi.org/10.1038/nsmb.2435
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