Cited by 925Genomics and Chromatin DynamicsChromatin Remodeling and CancerEpigenetics and DNA Methylation

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Regulation of nucleosome dynamics by histone modifications

Zentner, Gabriel E, Henikoff, Steven·2013·Nature Structural & Molecular Biology

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Abstract

Chromatin is a dynamic structure that must respond to myriad stimuli to regulate access to DNA, and chemical modification of histones is a major means by which the cell modulates nucleosome mobility and turnover. Histone modifications are linked to essentially every cellular process requiring DNA access, including transcription, replication and repair. Here we consider properties of the major types of histone modification in the context of their associated biological processes to view them in light of the cellular mechanisms that regulate nucleosome dynamics.

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“The strategy adopted by the cell to respond to such different stimuli is through different chemical modiﬁcations of the histones that mark the speciﬁc reprogramming of the gene expression to be used (Zentner and Henikoff, 2013).”
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“It is regulated to a large extent by the composition, localization, and posttranslational modification of nucleosomes (Struhl and Segal, 2013; Zentner and Henikoff, 2013).”
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“Histone acetylation of lysine residues will neutralize the positive charge of the histone core and as a result make the DNA more accessible for transcription factors facilitating gene transcription (6).”
Background

Authors: Zentner, G. E., & Henikoff, S.
Affiliations: Fred Hutch Cancer Center (US)
Howard Hughes Medical Institute (US)
Corresponding author: Henikoff, Steven
ORCID: Zentner, Gabriel E
Henikoff, Steven
Venue: Nature Structural & Molecular Biology
Publisher: Springer Science and Business Media LLC
Published: 2013-03
Volume: 20
Issue: 3
Pages: 259-266
ISSN: 1545-9985 (ISSN-L)
1545-9993
DOI: 10.1038/nsmb.2470
OpenAlex: W2034340491
Cited by: 923
References: 111
Citations by year: 2026: 22 · 2025: 33 · 2024: 57 · 2023: 39 · 2022: 45 · 2021: 60 · 2020: 63 · 2019: 82 · 2018: 75 · 2017: 84 · 2016: 76 · 2015: 106 · 2014: 125 · 2013: 52
FWCI: 11.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Structural & Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
National Institutes of Health (5u01hg004274-04)
National Human Genome Research Institute (5U01 HG004274)
National Cancer Institute (T32CA009657, U54CA143862)
National Institute of Environmental Health Sciences (R01ES020116)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: nucleosome dynamics, histone modifications, chromatin, nucleosome mobility, nucleosome turnover, transcription, DNA replication, DNA repair
MeSH terms: Acetylation, Acylation, Adenosine Diphosphate, Chromatin, DNA, DNA Replication, Gene Expression Regulation, Glycosylation, Histones, Lysine, Methylation, Nucleosomes

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Regulation of nucleosome dynamics by histone modifications

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