DNA methylation dynamics in health and disease
Abstract
DNA methylation is an epigenetic mark that is erased in the early embryo and then re-established at the time of implantation. In this Review, dynamics of DNA methylation during normal development in vivo are discussed, starting from fertilization through embryogenesis and postnatal growth, as well as abnormal methylation changes that occur in cancer.
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Alterations of methylation patterns are associated with disease development and allow to distinguish healthy from diseased states, including cancer.
“Importantly, alterations of methylation patterns are associated with disease development and allow to distinguish healthy from diseased states, including cancer [8, 12, 31].”
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984 · see citing works
Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536 · see citing works
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267 · see citing works
Self-citationInduction of tumors in mice by genomic hypomethylation
Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499 · see citing works
Schlesinger, Y., Straussman, R., Keshet, I., Farkash, S., Hecht, M., Zimmerman, J., Eden, E., Yakhini, Z., Ben-Shushan, E., Reubinoff, B. E., et al. (2007) · Nature Genetics · doi:10.1038/ng1950 · Cited by 1,226 · see citing works
Self-citationOhm, J. E., McGarvey, K. M., Yu, X., Cheng, L., Schuebel, K. E., Cope, L., Mohammad, H. P., Chen, W., Daniel, V. C., Yu, W., et al. (2007) · Nature Genetics · doi:10.1038/ng1972 · Cited by 1,130 · see citing works
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
Sasaki, M., Knobbe, C. B., Munger, J. C., Lind, E. F., Brenner, D., Brüstle, A., Harris, I. S., Holmes, R., Wakeham, A., Haight, J., et al. (2012) · Nature · doi:10.1038/nature11323 · Cited by 513 · see citing works
DNA methylation represses transcription in vivo
Siegfried, Z., Eden, S., Mendelsohn, M., Feng, X., Tsuberi, B.-Z., & Cedar, H. (1999) · Nature Genetics · doi:10.1038/9727 · Cited by 354 · see citing works
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Charting a dynamic DNA methylation landscape of the human genome
Ziller, M. J., Gu, H., Müller, F., Donaghey, J., Tsai, L. T.-Y., Kohlbacher, O., De Jager, P. L., Rosen, E. D., Bennett, D. A., Bernstein, B. E., et al. (2013) · Nature · doi:10.1038/nature12433 · Cited by 1,357 · see citing works
N6-Methyladenine DNA Modification in the Human Genome
Xiao, C.-L., Zhu, S., He, M., Chen, D., Zhang, Q., Chen, Y., Yu, G., Liu, J., Xie, S.-Q., Luo, F., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.015 · Cited by 531 · see citing works
DNA methylation loss in late-replicating domains is linked to mitotic cell division
Zhou, W., Dinh, H. Q., Ramjan, Z., Weisenberger, D. J., Nicolet, C. M., Shen, H., Laird, P. W., & Berman, B. P. (2018) · Nature Genetics · doi:10.1038/s41588-018-0073-4 · Cited by 405 · see citing works
The epigenetics of aging and neurodegeneration
Lardenoije, R., Iatrou, A., Kenis, G., Kompotis, K., Steinbusch, H. W. M., Mastroeni, D., Coleman, P., Lemere, C. A., Hof, P. R., van den Hove, D. L. A., et al. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.002 · Cited by 381 · see citing works
New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis
Li, H., Wang, D., Yuan, Y., & Min, J. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1454-2 · Cited by 293 · see citing works
Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases
Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00024 · Cited by 226 · see citing works
Zeybel, M., Hardy, T., Robinson, S. M., Fox, C., Anstee, Q. M., Ness, T., Masson, S., Mathers, J. C., French, J., White, S., et al. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0056-6 · Cited by 180 · see citing works
Origins of human disease: the chrono-epigenetic perspective
Oh, E. S., & Petronis, A. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-021-00348-6 · Cited by 108 · see citing works
Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis
Houshdaran, S., Nezhat, C. R., Vo, K. C., Zelenko, Z., Irwin, J. C., & Giudice, L. C. (2016) · Biology of Reproduction · doi:10.1095/biolreprod.116.140434 · Cited by 113 · see citing works
Daskalakis, N. P., & Yehuda, R. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00369 · Cited by 108 · see citing works
Serpeloni, F., Radtke, K., de Assis, S. G., Henning, F., Nätt, D., & Elbert, T. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.153 · Cited by 98 · see citing works
Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study
Cecil, C. A. M., Walton, E., Jaffee, S. R., O'Connor, T., Maughan, B., Relton, C. L., Smith, R. G., McArdle, W., Gaunt, T. R., Ouellet-Morin, I., et al. (2018) · Development and Psychopathology · doi:10.1017/s095457941700092x · Cited by 46 · see citing works
Age-associated changes in DNA methylation across multiple tissues in an inbred mouse model
Spiers, H., Hannon, E., Wells, S., Williams, B., Fernandes, C., & Mill, J. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.02.001 · Cited by 43 · see citing works
García-Campayo, J., Puebla-Guedea, M., Labarga, A., Urdánoz, A., Roldán, M., Pulido, L., de Morentin, X. M., Perdones-Montero, Á., Montero-Marín, J., & Mendioroz, M. (2018) · Mindfulness · doi:10.1007/s12671-017-0851-6 · Cited by 42 · see citing works
Bilbao, I., Recalde, M., Daian, F., Herranz, J. M., Elizalde, M., Iñarrairaegui, M., Canale, M., Fernández-Barrena, M. G., Casadei-Gardini, A., Sangro, B., et al. (2024) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-024-01045-8
- Authors
- Bergman, Y., & Cedar, H.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Bergman, Yehudit
- Cedar, Howard
- Venue
- Nature Structural & Molecular Biology
- Published
- 2013-03
- Volume
- 20
- Issue
- 3
- Pages
- 274-281
- ISSN
- 1545-9985 (ISSN-L)
- 1545-9993
- OpenAlex
- W2080324830
- Cited by
- 592
- References
- 8
- Citations by year
- 2026: 16 · 2025: 30 · 2024: 43 · 2023: 28 · 2022: 44 · 2021: 41 · 2020: 60 · 2019: 40 · 2018: 56 · 2017: 45 · 2016: 45 · 2015: 53 · 2014: 56 · 2013: 34
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-10-04)
- Open access
- closed
- Locations
- Nature Structural & Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- DNA methylation, epigenetics, embryonic development, fertilisation (biology), implantation, postnatal development, cancer epigenetics, genome-wide methylation
- MeSH terms
- Humans, Neoplasms, Embryo Implantation, Gene Expression Regulation, Developmental, CpG Islands, DNA Methylation, Epigenesis, Genetic, Embryonic Development
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